生醫材料實驗室
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林睿哲 教授. 生醫材料實驗室. 生醫高分子材料及其應用 (I). 生醫高分子材料及其應用 (II). 簡介. 影響生醫材料之生物相性的重要表面性質 : 表面親疏水性 表面化學組成 表面微相分離 材料之吸水量. 人工生醫材料與血液接觸時之血液塞機制 :. Surface group. Alkyl, or derivatized-alkyl group. Interchain van der Waals and electrostatic interactions. Chemisorption at the surface. - PowerPoint PPT Presentation
Transcript of 生醫材料實驗室
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(I)
PUSiliconePVCPETPMMA
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(II)
PHEMA(Hemoperfusion)PTFEPEPVP(poly(N-vinyl-2-pyrrolidinone)PPPCEVA
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::
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(Self-Assembled Monolayer, SAM)(alkanethiol with specific functionality)(chemisorption) (SAM) :
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(Heparin)PU
(Sulfonic Acid Functionality )(Phosphonic Acid and Phosphonate Functionality)Apatite
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Au control-COOH-SO3H-CH3-OH-PO3H2-PO3(C2H5)2SEM (1000)SEM (2000)SEM (2000)
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SEM (2000)XOH=1XOH=0.8XOH=0.6XOH=0.2XOH=0XOH=0.4
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biliary stent
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Polyurethanecationomer PU synthesis2 (DEP+TEPI)(QPUQ-10%Q-25%)Q-10% (x500)Q-10% (x3000)Q-25% (x500) Q-25% (x3000) in vitro 48 hr PUPEU
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PEU (x500)PEU (x3000)S-6% (x500)S-6% (x3000)S-15% (x500)S-15% (x3000) in vitro 48 hr PU PEU Polyurethaneanionomer
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Chitosan
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chitin)(chitosan)
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Photocurable chitosan
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Motivations of This Study Abundant material resource
Biocompatible and biodegradable
Photocurable -- provide convenience for application
GelLiquidUV irradiation
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Surface sulfonation
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Butyration
