Components of Metabolic Syndrome as Predictors of Total and Cardiovascular Disease Mortality Kinmen study

923.8

4011-13%

35-749.0 -9.8/1,000

4%6%(1998)

19986.2%

1923

1988ReavenSyndrome X(Metabolic Syndrome, MS)

(MS)1998WHO (1999BP160/90140/90mmHg)

2001National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP )

1999The European Group for the study of Insulin Resistance (EGIR) (p.6) MSmorbiditymortality (components of MS, no. of abnormalities)

DM,HPBMIWHRTGChol.HDLSBPDBPHbA1cinsulin

Wang YY (2004)MSWBC, RBC (RBC, WBC MS3-4)Lin RT (2004) (non-DM+CADMS52%non-DM+non-CADMS19%)Chuang SY (2002)MSChien KL (1999)high LDL_Clow HDL_C

MSmortality

1976-92,NHANES II(925230-7513.5)MSCVD(OR=1.2)CHD(OR=1.7)(OR=1.2)

1978-87, (41,05620-697)MSCVDHazard ratio(1,2,3,4,5HR11.21.41.82)

1984-89,(120942-6011.6)ATP IIIMSCHD(RR=4.3) CVA(RR=2.3)(RR=1.7)

()MS()MS()MS()MS()MS()

1991-9312,49030

1991-95 1996-01

1997DMHP

9,117 ()

MS HDL-CTg()

() (DM=32)

logistic regressionC statistic

> =3

C Haffner et al (69) 95 mmHg / 58.565.0Liese et al (71)/ 140/90 mmHg/ 62.967.7Cook et al (44)90 percentile(160/97.4 mmHg)58.263.4Wilson et al (54) (quintile)( 148 mmHg 146.7 mmHg)61.567.4

Chen et al (73)

(quartile)( 144/90.7 mmHg 140.7/86.7 mmHg )61.467.6

ATP III

MS MS 5. MS

1.

Chart1

26.8423.5

24.4223.24

20.5227.27

17.5217.25

10.718.74

Sheet1

P

No.%No.%No.%

30-39230525.28130826.899723.5

> > >CVD+DM > CVD > CHD

Chart3

10.966.78

3.551.63

2.912.75

2.592.22

0.440.23

Sheet1

10.966.78

3.551.63

CVD+DM2.912.75

CVD2.592.22

CHD0.440.23

Sheet1

Sheet2

Sheet3

2. MS

MS MS

MS > > >Tg > HDL-C ATP III: > =Tg > > HDL-C

Chart1

1.471.52

1.681.45

1.061.07

1.371.44

1.411.16

ATP III

OR

Sheet1

ATP III

1.471.52

1.681.45

HDL_C1.061.07

TG1.371.44

1.411.16

Sheet1

00

00

00

00

00

ATP III

OR

Sheet2

Sheet3

3. MS

MS

OR

Chart3

1.261.21

1.651.42

2.031.41

32.07

ATP III

multivariate-adjusted OR

Sheet1

123>=4

1.261.652.033

ATP III1.211.421.412.07

Sheet1

ATP III

Number of MS disorders

multivariate-adjusted OR

Sheet2

Sheet3

4. MS

ATP III

50 MSC

50MS50140/90 mmHg98 cm

3.5

140/90 mmHg98 cm

1/2premature death

>= 140/85 mmHg>=98 cm(45%) >= 140/85 mmHg>=98 cm(87%)

10,000(50+120)*10,000 =1,700,000

1.5509(55%)5509(50+120)*5509=936,53055%(936,530/1,700,000=55%)

2.1,340 (13.4%)(50+120)*1340=227,80013.4%

12372.4%

ATP MSMSCHD(OR=2.8) (OR=2.3) OR=1.7MS(OR=1.7) (OR=1.5) (OR=1.4)(0=4.41=9.02=14.63=19.04=31.1)MS3(OR: 0=11=1.32=1.73=2.04=3)

s06