Syphilis

制作人： 陈永　冯斌　时迎斌 张伟强　孙景福　 陈娜　徐平　周强　　 于晓宁　叶茜

主讲人：叶茜

Syphilis There are more than 7

0,000 new cases of syphilis （梅毒） each year .

Syphilis, chronic and slowly progressive, is the third most common sexually transmitted disease.

SpirochetesSpirochetes Gram negative bacteria

long, thin, helical and motile Axial filaments - (a form of flagella) -

are the locomotory organelles

• found between the peptidoglycan layer and outer membrane and running parallel to them

T.Pallidum

Mechanism

The antibodies result from tissue injury, with autoimmunity developing to self components.

TransmissionTransmission

T. pallidum is generally transmitted by genital/genital contact.

Transmission in utero or during birth can also occur.

It can also be transmitted through blood transfusion.

Congenital syphilis

Blood Transfusion

The main manifestation

Fever Robeola Symptoms like secondary

stage of syphilis

Pathogenic process

Primary syphilis

Secondary syphilis

Tertiary syphilis

Primary syphilis

After initial infection hard chancre present.

Mainly seen in outer genital organ.

Last for 4 to 8 weeks.

Secondary syphilis

The organisms has penetrate and systemically spread during this time period.

The patient has flu-like symptoms with secondary lesion particularly affecting the skin(2-10 weeks later)

Mainly in trunk and limbs.

Secondary SyphilisSecondary Syphilis

Secondary SyphilisSecondary Syphilis

Common features of primary and secondary syphilis

In these two stages large numbers of T. Pallidum often present.

Strong infection , weak damage.

Self-limited

Tertiary syphilis The final stage is tertiary syphilis ( after

several years later). As the disease progresses immunity co

ntrols the bacterial replication and few organisms are seen.

Main manifestation are chronic granuloma and tissue necrosis.

Tertiary SyphilisTertiary Syphilis

Tertiary SyphilisTertiary Syphilis

Diagnosis(1) The organisms are often present in

sufficient numbers in exudates detected by dark field microscopy.

The actively motile organisms appears brightly lit against the dark backdrop.

The FTA-ABS （荧光密螺旋体抗体吸收试验 ) is often used.

Diagnosis(2)Diagnosis(2)

3.VDRL and RPR are also widely used.

1. Serological methods are usually used to detect syphilis.

2. Screening methods are based on detecting serum antibodies to cardiolipin in patients (including VDRL test).

Therapy

No vaccine exists, but antibiotic therapy

(usually penicillin G) is usually highly effective.

That is all .Thank you!