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  • MEETING SUPPLEMENT

    1

    135

    Dr. Jan A. Nolta Ph.D.

    (in vivo)

    (SCID mice)

    CD34+

    ()

    (FISH)

    X

    (H9)(iPSC)

    Human cells engrafted into the pigment epithelial layer of the mouse retina.

  • STEM CELL DISCOVERY

    2

    (pinocytosis)

    X

    12()48

    7

    ()

    Blood(Capoccia et al. 2009)

    (FDA)

    21(PAD)

    (hydroxyapatite)

    2003

    (albumin)

    (luciferase reporter gene)

    ()

    Progress of intravenous infusion of human stem cells at time of 0, 12 and 48 hours

    Transplantation of human stem cells augments the recovery of blood ow to damaged tissue The collaboration by using human adult and embryonic

    stem cells

  • MEETING SUPPLEMENT

    3

    (Blood Brain Barrier)

    (Synapse)()

    (MPS-7)

    (beta glucuronidase) ()

    (induced pluripotent stem cells - iPSC)

    Yamanaka2006

    Oct4Sox2Klf4c-Myc

    ()

    ()

    skin fibroblasts-From the patient

    Induced pluripotent stem cells Differentiated to neural precursor cells

    Reprogrammed human neurons in culture

    MSC delivering a protein product throught the liver tissue

    MSC can migrate rapidly to damaged neuron cells and secrete factors to repair them.

    iPSC has the potential to directly generate all tissues

    Stem cell reserach provides us with the necessary models

  • STEM CELL DISCOVERY

    4

    (iPSC)?

    iPSC

    CD34+

    (teratoma)

    ?

    48

    ?

    (VGF)

    (paracrine effect)

    ?

    BioArchive30

    20

    ( h o m o l o g o u s

    recombination)

    (

    )

    (Dallas

    Hextell)

    20092

    ()

    ?

    (Osiris)

    (Scleroderma)

    A

    A

    A

    A

    A

    Q

    Q

    Q

    Q

    Q

    25130800-333-668

    Q&A