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Chemical biology

Biomedical Technology

2009111565 Yiem Young Jae

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TOPICS

1. DNA Recombination

- Recombinant carbon anhydrase for making carbonic

acid compound ()

2. Stem cell treatments

3. Nano DNA Robot- Target Cancer With DNA Robots

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1. DNA Recombination : Recombinant carbon

anhydrase

for

making carbonic acid compound

production of Recombinant carbon anhydrase

1. Host plasmid is spilt by restrict enzyme

2. Gene that express carbon anhydrase insert

to Host plasmid.

3. Recombinant DNA can make carbon anhydrase

Gene that express carbon anhydrase

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1. DNA Recombination : Recombinant carbon

anhydrase

for

making carbonic acid compound

Recombinant carbon anhydrase function :

Recombinant carbon anhydrase can convert COwith H2Oto carbonic acidcompound HCO( Carbonic acid ) CO+ H2O

Cabonic acid compounds use for artificial bone synthesis

Advantage of using Recombinant carbon anhydrase is mass production of

Cabonic acid compounds

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2. Stem cell treatments

-

Treatment for myocardial infarction

Stem cell treatments : medical strategy that inject(or insert) new cells

from embryo, bone marrow into damaged tissue treats disease or injury.

The ability of stem cells is self-renew and stimulation of variable

differentiation .

Possible Application : adult and embryonic stem cells will soon be able

to treat cancer, Type 1 diabetes mellitus, Parkinson's disease,

Huntington's disease, Celiac Disease, cardiac failure, muscle damage

and neurological disorders.

Adult stem cell treatment for myocardial infarction is developed by korean

research team.

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2

. Stem cell treatments

-

Treatment for myocardial infarction

Step ofAMI function

1. Take myocardial infarction patients

Adult cell from Bone marrow

2. Take culure of patients adult cell

( This process need high culture

skill and purification)

3. Take coronary arteries stent (

) treatment for extension

vessel

3. Inject the cultured adult cell to

coronary arteries

The effect of medicine (-AMI)-AMI improves the blood stream through coronary arteries inleft ventricle of heart() .

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3. Nano DNA Robot - Target Cancer With DNA Robots

concept of nano robot : An autonomous DNA nanorobot

can transport molecular payloads to cancer cells

step of nano robot function

1 step nano robot sense the cancer cell surface inputs(= cancer cell

protein at cancer cell) .

2 step nanorobot complex (nanorobot + cancer cell ) is triggeredactivation and reconfiguring its structure for payload delivery.

3 step nanoroot release payload to cancer cell

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3. Nano DNA Robot

- Target Cancer With DNA Robots

composition of DNA nanorobot :

structural DNA

+

Antibodies

+

aptamers metal atomic clusters (= specific

targeting of human cancers and T-cells.)

: http://wyss.harvard.edu/viewpressrelease/75/

http://wyss.harvard.edu/viewpressrelease/75/http://wyss.harvard.edu/viewpressrelease/75/