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200 49(2010)

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(Physical-Chemical Properties and Material Characterization)

/(Agglomeration/aggregation) (Water solubility) (Crystalline phase)(Dustiness)(Crystallite size)TEM (Representative TEM picture(s)) (Particle size distribution)(Specific surface area) / (Zeta potentiall; surface charge) (Surface chemistry, where appropriate) (Photocatalytic activity) (Pour density)(Porosity)/ (Octanol-water partition coefficient, where relevant) (Redox potential) (Radical formation potential)

(Environmental Fate)

(Dispersion stability in water) (Biotic degradability)(Ready biodegradability) (Simulation testing on ultimate degradation in surface water)(Soil simulation testing) (Sediment simulation testing) (Sewage treatment simulation testing) (Identification of degradation product(s)) ( Further testing of degradation product(s) as required) (Abiotic degradability and fate) (Hydrolysis, for surface modified nanomaterials)-(Adsorption-desorption) (Adsorption to soil or sediment) (Bioaccumulation potential)

(Environmental Toxicology)

/ (Effects on pelagic species; short term/long term) / (Effects on sediment species; short term/long term)/ (Effects on soil species; short term/long term) (Effects on terrestrial species) (Effects on microorganisms)

(Mammalian Toxicology)

(Pharmacokinetics; ADME) (Acute toxicity)(Repeated dose toxicity)(Chronic toxicity)(Reproductive toxicity)(Developmental toxicity)(Genetic toxicity)

: OECD, GUIDANCE MANUAL FOR THE TESTING OF MANUFACTURED NANOMATERIALS: OECD SPONSORSHIP PROGRAMME; FIRST REVISION, ENV/JM/MONO(2009) 20/REV, 2010.

203

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204 49(2010)

structure-toxicity relationship, QSTR) .

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. ,

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.

.

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.

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.

, 2009, , , 12(3): 98-107.

, 2009,

, , 12(2): 59-73.

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