Synopsis Dr.vasundhra

8/12/2019 Synopsis Dr.vasundhra

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SYNOPSIS FOR THE THESIS

A CLINICAL STUDY ON “RAJONIVRITI KALAJ

LAKSHAN” AND ITS MANAGEMENT WITHINDIGENOUS DRUGS “SHATAVARI, GUDUCHI

AND YASTIMADHU.”

TITLE SUBMITTED FOR THE DEGREE OF AYURVEDDHANVANTARI (M.S. AYU)

IN PRASUTI TANTRA AND STRI ROGUNDER

CHHATRAPATI SHAHU JI MAHARAJ UNIVERSITY

KANPUR (U.P.)

SUBMITTED BY:DR. VASUNDHRA CHAUDHARY

B.A.M.S.M.S. (SCHOLAR) S.A.M.C., ALIGARH

GUIDE

DR. RANI GUPTAM.S. (AYURVEDA)READER, PRASUTI TANTRA EVAM STRI ROGA

S.S.A.M.C. & HOSPITAL, ALIGARH

POST GRADUATE DEPARTMENT OF PRASUTI TANTRAEVAM STRI ROGA

SRI SAI AYURVEDIC MEDICAL COLLEGE & HOSPITALALIGARH- 202001, U.P.

SESSION 2010-11



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From

Dr. Vasundhra Chaudhary B.A.M.S

I Year M.S. (Ayu)

Department of post graduate studies in prasuti tantra evam stri rog

Sri sai ayurvedic medical P.G. college and hospital Aligarh – 202001

To,

The Registar,

Chatrapati Sahuji Maharaj University

Kanpur, Uttar Pradesh.

Through: The Principal and Head of department in Prasuti Tantra evam Stri Rog

Sri Sai Ayurvedic Medical P.G. College And Hospital

ALIGARH – 202001

Respected Sir/Madam,

Subject: Submission of complete Performa for registration of subject for dissertation.

I request you to register the below mentioned subject in my name for the

registration of subject for dissertation to the Chatrapati Sahuji Maharaj University Kanpur for

partial fulfillment of M.S [ Ay].

Title of the Dissertation:

A CLINICAL STUDY ON “RAJONIVRITI KALAJ LAKSHAN” AND ITS

MANAGEMENT WITH INDIGENOUS DRUGS “SHATAVARI ,GUDUCHI AND

YASTIMADHU”.

Herewith I am enclosing completed Performa for registration of subject dissertation.

Thanking You Yours faithful

Place : ALIGARH Dr. Vasundhra ChaudharyDate :



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ANNEXURE - 11

Completed preformed for registration of subject for dissertation

1. Name of the Candidate : Dr. VASUNDHRA CHAUDHARY

and address I YEAR M.S. POST GRADUATE STUDIES IN

PRASUTI TANTRA EVAM STRI ROG

S.S.A.M.C. H ALIGARH

Dr.VASUNDHRA CHAUDHARYW/O Dr. BALRAJ SINGH

C- 2 / 170, MANSAROVER COLONY,

DELHI ROAD, MORADABAD, U.P.

2. Name of Institution : SRI SAI AYURVEDIC MEDICAL P.G. COLLEGE

ALIGARH

3. Course of study : M.S. IN PRASUTI TANTRA EVAM STRI ROG

4. Title of Topic : A CLINICAL STUDY ON “RAJONIVRITI

KALAJ LAKSHAN” AND ITS

MANAGEMENT WITH INDIGENOUS

DRUGS “SHATAVARI , GUDUCHI AND

YASTIMADHU”.



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5. BRIEF RESUME OF INTENDED WORK

5.1. Need for the study

Problems of different age group of women are still present and the most suffering age group

is forty-plus due to change in reproductive life by permanent cessation of menstruation

causing untoward physical and mental agonies called as menopause. Every woman faces

varies physiological and psychological changes during this "change of life" as a part of

hormonal derangement. Sometimes such disturbances attain the stage of disease or syndrome

called as "Menopausal Syndrome" which is accompanied by various vasomotor,

psychological, genital, locomotors and GIT related symptoms.

Normally, menopause occurs at a median age of 51 years, so a woman spends up to one third

of her life in menopause About 75% of women are having uncomfortable physical symptoms

and 50% experience psychological manifestations during menopause. About 50-60% of

women seek

medical help for that. Though menopause is a natural event as a part of the normal process of

aging, it is turning into a major health problem in recent years in developed as well as

developing countries like India.Being an alarming problem, it needs an effective and safe

treatment.

In modern science, Hormone Replacement Therapy (HRT) is one and only alternative for this

health hazard by which one can get spectacular achievement in combating the disease, but it

has a wider range of secondary health complications like vaginal bleeding, breast cancer,

endometrical cancer, gallbladder diseases etc. On the other hand, this therapy is not mucheffective in the psychological manifestations of this stage. They manage them by the long

term use of Sedative, Hypnotics and Anxiolytic drugs, which may lead to various side effects

like drowsiness, impaired motor functions, loss of memory, allergic reactions, non social

behaviors, drug dependence etc.

Therefore, there is a wide scope of research to find out safe, potent, cost effective remedy

from Ayurveda for the management of rajonivritijanya lakshana. From the previous works, it

is well proved that this health hazard can be well managed with certain Ayurvedic

therapeutics having Medhya and Rasayana properties. so, considering this view, some known

rasayana drugs like shatavari, Yastimadhu, Guduchi (A.H. Ut. 39/60-61 ) is taken for present

work in an attempt to search effective remedy for rajonivriti kalaj lakshana.

Rasayanam cha tajgeyam yajjara vyadhi nashanam. Sharangdhar



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5.2 References

1. Sushruta samhita with Ayurveda Tatvasandipika Commentary, edited by kaviraj dr.

Ambika Dutta Shastri.

2. Astang Hridyam Nirmala Hindi Vyakhya by Dr. Brahmananda Tripathi

3. Ayurvediya Prasuti Tantra evam Stri Rog Part I by Prof Premvati Tivari.

4. Bhavaprakasha - Jayakrishnadas Haridas Gupta Kashi Sanskrit Granthmala.5. Charaka Samhita - Ayurved Dipika Commentary of Chakrapanidatta, Edited by Vaidya

Jadavaji Trikamji Acharya; Chaukhamba Surbharti Prakashan, Varanasi.

6. Dravyaguna Vignana by Dr. Gyanendra Pandey, Chaukhamba Prakashan, Varanasi.

7. Text book of Gynaecology by C. S. Dawn, 9th Edition, Calcutta.

8. Text book of Gynaecology by D. C. Dutta, Third Edition

9. Howkins and Bourne Shaw’s Text book of Gynecology 14th edition .

5.3 PREVIOUS WORKS :

AT JAMNAGAR :

1. In 1993-95; A clinical study on Rajonivritti with special reference to menopausal

syndrome by Dr. Kirtidevi

2. In 1996-98; A clinical study on the management of climacteric stage in women with

special reference to menopausal syndrome by using certain Ayurvedic formulations by Dr.

Kirtidevi Gohil (Ph. D. Thesis).

3. In 1998-2000, Comparative study between Rasayankalpavati & Shankhpushpi Vati in

clinical study on Rajonivritti by Dr. Ajay Sood.

4. In 2000-2002, A comparative Pharmaco-clinical study of Rasayankalpvati and masyadivati

on rajonivritti avastha janya Lakshana (Menopausal Syndrome) by Dr. Ami P. Modi.

5. In 2000-2002; A clinical study on Manas bhavas in Menopausal syndrome and itsmanagement by Medhya Rasayana Vati & Shirodhara by Dr. Manju Pateria.

At B.H.U :

1. In 1999, Effect of Vacha, Ashwagandha, Ulatakambala & Jatamansi on manopausal

syndrome by Dr. Shipra Dhar.

5.4 • OBJECTIVES OF THE STUDY

• A literary work on rajonivriti janya lakshana in both ayurveda and modern literature.• To evaluate the efficacy of indigenous use of shatavari, guduchi and yastimadhu in

management of rajonivriti janya lakshan.

6.1 • MATERIALS AND METHODS:

• The patients: The patients attending the O.P.D. & I.P.D. of the S.S.A.M.C.H Aligarh will

be registered for the present study.

• The drugs : The test drug 'chalk churna' with placebo capsules and the

standard drug "guduchi,shatavariand yastimadhu churna" will be prepared in Pharmacy ofS.S.A.M.C.H Aligarh



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6.2 PLAN OF STUDY:

Criteria of Selection

•Patients willing to participate in the study and who agreed to give the written consent.

• Women aged between 40 - 55 years, having cardinal symptom i.e. cessation of

Menstruation will be selected.

• Women having clinical features of Menopausal syndrome along with psychological

disturbances will be selected.

Criteria of Exclusion:

•Patients not willing to participate in the study

• Crippling conditions like malignancy etc.

• The cases of primary amenorrhea and other complicated cases.

• Menopausal women with untoward effects of HRT will be excluded from the present study.

Criteria of Assessment:

Subjective Criteria:

• Results of the treatment will be assessed on the basis of relief in the sings and

symptoms of the menopausal syndrome assessed before and after the treatment.

Sign and symptoms to be assessed are Hot Flushes, Excessive

sweating,Fatigue,Palpitation,Pain in joints, Backache, Loss of appetite, Flatulence,Constipation, Loss of urinary control ,Dryness of vagina, Headache, Irritability, Mood swing,

Depression, Sleep disturbances, Loss of confidence, Forgetfulness, Decrease Libido.

Objective Criteria:

• Routine hematological, urine and stool investigations.

Sample Size:

Total number of patients taken for study will be 30 excluding dropouts. The patients selected

for study will be divided into 2 groups Group ‘A’ and Group ‘B’ consisting of 15 patients

each.



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6.3 Drug dose and duration of treatment

Group „A‟

Drug: Churna of shatavari ,yastimadhu and guduchi.

Dose: 3 gms twice a dayRoute: Oral

Anupana :Go Cheer (A.H.Ut 39/44), (A. H. Su 5/21)

Duration: Three month.

Group „B‟

Drug: Chalk churna capsules

Dose: 1 capsules twice a day

Route: Oral

Anupana : Sterile water

Duration: Three month.

Assessment will be done every 30 days interval after administration of the treatment.

6.4 Layout of Design :

Control Group A

Group A Treatment 1(T1) 15 cases will be treated with trial drug.

Group B Treatment 2(T2) 15 cases will be treated with placebo.

Design - 1

B.T T1/VS A.T - Effectiveness of T1 will be assesed

B.T T2/VS A.T - Effectiveness of T2 will be assesed

Design - 2

Effectiveness of T1 will be assessed with T2.



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7. Signature of Candidate :

8. Remarks of Guide :

9. Name and designation of :

9.1 Guide Dr Rani Gupta

Reader

Department of post graduates study

In Prasuti Tantra evam Stri Rog

S.S.A.M.C.H Aligarh

9.2 Signature

9.3 Head of the Department : Dr Balen Vaishaiya

Professor

Department of post graduates study

in Prasuti Tantra evam Stri Rog

S.S.A.M.C.H Aligarh

9.4 Signature

10.1 Remarks of the Principal

10.2 Signature

Synopsis Dr.vasundhra

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