Society for Biomaterials Annual Meeting and Exposition ...toc.proceedings.com/26876webtoc.pdf ·...

ISBN: 978-1-5108-0727-3

Society for Biomaterials Annual Meeting and Exposition 2015 Driving Biomaterial Innovation and the Race to Translation

Charlotte, North Carolina, USA 15-18 April 2015

Transactions of the 39th Annual Meeting Volume XXXVII

Copyright and Disclaimer

�� 9�� II

�� !"""#� ��$%��&��#��'��&()"*"!+,*!-.+�/0"*1-

#�2��31" 5�� &4��6��(7 !1-08!+8

��:��;(�2��2�� 2�� & �� &��:�� &�� &%��%��2�� 2��;�� 2��:�� 2��22��2��2��;�� 2��<2��2��:��%��;�� <2�� 2��22��:�� &��&��%�� 2��:��%�� ;(�� 2�� ;

=:�� 2�� ;(��2�� >��?��@��A�� 2��2��2�� 2��&��%��&�� 2�� &2��&�� ;��2��:��&%�� 2��:�� 2�� ;

��2��%��2�� > ��2��;

B�2��2��2�� 2��2��%��2��%��2�� ;

6��:��%��> ��2��22��C�� %��%�� A��2��;

(�2��2��:��DE��2D�� 2��%��%��2�� > ��2��;31" 5> ��2��0��:��;

TABLE OF CONTENTS

ADVANCED HYDROGELS WITH HIERARCHAL STRUCTURES FOR BIOLOGICAL APPLICATIONS A Strategy for Reversible Control of Hydrogel Modulus to Probe Myofibroblast Activation .................................................................. 1

A. M. Rosales, K. M. Mabry, C. B. Rodell, J. A. Burdick, K. S. Anseth

Dual-Layer PEG Hydrogels Promote Islet Engraftment and Function in an Alternative Transplant Site ............................................. 2J. D. Weaver, D. M. Headen, A. J. Garcia

Microporous Annealed Particle Hydrogels for Hierarchical Tissue Mimetics ........................................................................................... 3W. M. Weaver, D. R. Griffin, D. Di Carlo, T. Segura

Hierarchically Structured Protein Hydrogels for Controlled Nanoparticle Release .................................................................................. 4J. Simon, A. Ghoorchian, A. Chilkoti, G. Lopez

Ultrastiff Nanocomposite Hydrogels for Biomedical Applications ............................................................................................................... 5M. Jaiswal, J. Xavier, P. Desai, J. Carrow, A. K. Gaharwar

Photopatterned Immobilization of Site-Specifically Modified Proteins within 3D Gels ............................................................................ 6J. A. Shadish, C. K. Arakawa, C. A. Deforest

BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) Fabrication of Biomimetic µfluidic Networks Using Image-Guided Photocavitation-Mediated Hydrogel Degradation ......................................................................................................................................................................................................... 7

K. A. Heintz, J. L. West, J. H. Slater

Patterned Tissue Precursors Microcontact Printed from Shape-Changing Hydrogel Stamps ................................................................. 8O. O. Akintewe, R. G. Toomey, N. D. Gallant

Impact of Collagen-Incorporation within Electrospun Vascular Conduits on Lipid Oxidation and Conduit Mechanics ............................................................................................................................................................................................................ 9

K. Birthare, M. Shojaee, C. G. Jones, J. Brenner, C. A. Bashur

In Situ Deposition of Polymer Sealants via Solution Blow Spinning .......................................................................................................... 10A. M. Behrens, B. J. Casey, M. J. Sikorski, A. D. Sandler, P. Kofinas

Design of a Sugar-responsive Hydrogel for a Sacrificial Template to Create Vascularized Tissue Constructs. ................................... 11M. Yamamoto, K. Arimoto, Y. Tabata

Airbrushing Polymer Fibers for Tissue Engineering Applications: Impact of a Device Design on Fiber Quality ............................... 12X. Palmer, W. Tutak

BIOLOGICALLY DERIVED MATERIALS FROM NATURAL SOURCES Eumelanin As Biologically Derived Cathodes for Aqueous Sodium Ion Energy Storage........................................................................ 13

Y. J. Kim, J. F. Whitacre, C. J. Bettinger

Porcine Acellular Muscle Matrix Scaffolds Enhance Restoration of Contractility in a Murine Model of Muscle Injury ................................................................................................................................................................................................................. 14

M. M. Stern, A. R. Stern, E. E. Goff, C. R. Bergman, O. L. Latham, B. T. Corona

Degradable GAG-based Microparticles with Tunable Sulfation for Growth Factor Delivery within MSC Aggregates ......................................................................................................................................................................................................... 15

L. E. Tellier, T. Miller, T. E. Rinker, T. C. McDevitt, J. S. Temenoff

Mechanically Dynamic Hyaluronic Acid Hydrogels for Investigating Cellular Mechanotransduction................................................. 16S. R. Caliari, M. Perepelyuk, R. G. Wells, J. A. Burdick

Combination Approach for Limiting Epithelial Downgrowth Around the Percutaneous Implants: Use of Biomimetic Coatings in Conjunction with Negative Pressure Wound Therapy ....................................................................................... 17

K. N. Bachus, S. Jeyapalina, S. Cook, F. R. Nichols

Delivery of BMP-2 from Keratin Hydrogels with Tunable Rates of Degradation.................................................................................... 18S. Haque, M. Li, K. Lasance, J. M. Saul

BIOMATERIALS FOR REGENERATIVE ENGINEERING Nanofibrous Bicomponent Scaffolds for the Dual Delivery of NGF and GDNF: Controlled Release of Growth Factors and their Biological Effects................................................................................................................................................................ 19

C. Liu, M. Wang

RGD Functionalized Polyethylene Glycol Hydrogels Support Proliferation and In Vitro Chondrogenesis of Human Periosteum Derived Cells................................................................................................................................................................................. 20

A. K. Kudva, J. Patterson

Functional Muscle Regeneration by Delivery of Mesenchymal Stem Cells and Basic Fibroblast Growth Factor ............................... 21Y. Xu, M. Fu, Z. Li, X. Li, Z. Fan, P. Anderson, Z. Liu, J. Guan

Combination Therapy of Stem Cell Derived Neural Progenitors and Drug Delivery of Anti-Inhibitory Molecules for Spinal Cord Injury ..................................................................................................................................................................................... 22

T. Wilems, S. Sakiyama-Elbert

Antimicrobial Oxygen-Generating Injectable Scaffold for Wound Healing ............................................................................................. 23W. Lv, Y. Sun, Y. Deng

Evaluation of a Pre-Vascularized Osteoinductive Polymeric Scaffold for Bone Tissue Regeneration................................................... 24B. L. Taylor, J. Freeman

Thiol-Maleimide Reaction Speed Effects on Hydrogel Homogeneity......................................................................................................... 25N. Darling, T. Segura

3D Printed Bioactive Nanocomposite Scaffolds for Osteochondral Regeneration.................................................................................... 26N. J. Castro, L. G. Zhang

CARDIOVASCULAR BIOMATERIALS Characterization of Host Cellular Response to Bioprostheses in Rat Subdermal Implant Calcification Model .................................. 27

H. Tam, N. Parchment, N. Vyavahare

Transcatheter Fiber Heart Valve: Effect of Crimping on Material Performances .................................................................................. 28F. Khoffi, F. Heim

Surface Chemistry Induction of Activation and Osteoblastic Differentiation of Valvular Interstitial Cells ......................................... 29M. N. Rush, E. L. Hedberg-Dirk

Bioactive Microparticle Assembly in Microchanneled Hydrogel for Guided Vascular Network Formation........................................ 30M. K. Lee, M. H. Rich, A. Shkumatov, J. Lee, H. Kong

Fetuin-A Therapy: A New Approach for the Treatment of Vascular Calcification ................................................................................. 31J. L. Cunningham, E. S. Vasquez, K. B. Walters, C. L. Simpson

Application of Corrosion-Resistive Polyetherimide Coating to Vascular Magnesium Stent................................................................... 32M. Kang, S. Kim, J. Song, H. Kim

Conductive Polypyrrole-polycaprolactone Scaffolds for Electrophysiological Maturation of Cardiomyocytes ................................... 33B. Spearman, J. Porter, E. A. Lipke, A. J. Hodge

A Shape Memory External Support to Improve Vein Graft Patency ........................................................................................................ 34T. Boire, C. Brophy, H. Sung

RECENT ADVANCES IN SURFACE MODICATION OF BIOMATERIALS Aminated Elastin-Like Polypeptide Copolymer Coatings for Liver Cell Culture .................................................................................... 35

A. V. Janorkar, C. A. Weeks, E. Vasquez, K. Walters

Molecularly Imprinted Polymers on Surface-Modified Gold Nanoparticles for Biosensing Applications ............................................ 36C. N. Koepke, H. R. Culver, N. A. Peppas

Improving Silicone Elastomer Hydrophilicity .............................................................................................................................................. 37R. L. Koch, D. A. Prawel, S. P. James

Multi-scale Surface Modification of Ti for Orthopedic Implant Application ........................................................................................... 38T. Jang, S. Kim, B. Moon, J. Song, H. Kim

Surface Polymerization of Oligonucleotide Aptamers for the Enhanced Capture and Release of Target Cells ................................... 39E. Richards, S. Li, N. Chen, M. Battig, Y. Wang

Improved MC3T3 Cellular Growth on Nano-grained 316L Stainless Steel Obtained by Linear-plane Machining Severe Plastic Deformation.............................................................................................................................................................................. 40

M. Shayan, M. Moradi, R. Shankar, Y. Chun

Shape Memory Polymer Recovery Activates Nano-scale Polyelectrolyte Multi-layer Topographical Wrinkles .................................. 41A. Ash-Shakoor, E. B. Finkelstein, J. H. Henderson, P. T. Mather

Capture of Circulating Tumor Cells Using Heteromultivalently Decorated Microfluidic Surfaces ...................................................... 42P. Siva, C. Modery-Pawlowski, U. Sekhon, A. Gupta

VACCINE DELIVERY VEHICLES Self-assembling Peptide-based Vaccines for Cocaine Addiction ................................................................................................................. 43

J. Rudra, R. Appavu, Y. Ding, C. Ding, S. Stutz, K. Cunningham, J. Zhou

Polyanhydride Nanovaccines Against Viral Infections in Shrimp .............................................................................................................. 44Y. Phanse, S. Puttamreddy, D. Loy, K. Ross, J. Vela Ramirez, B. Narasimhan, L. Bartholomay

Dendritic Cell Subsets Interact with CpG-carrying Pathogen Mimicking Particles in a Phenotype Specific Manner ........................ 45J. Leleux, P. Pradhan, K. Roy

Carbohydrate Modification of Polyanhydride Nanoparticles and Polymer Chemistry Influence Interactions with Dendritic Cells................................................................................................................................................................................................... 46

J. Goodman, J. Vela Ramirez, P. Boggiatto, R. Roychoudhury, N. Pohl, M. Wannemuehler, B. Narasimhan

Design of “Carrier-Free” Polyelectrolyte Multilayer Vaccines Assembled from Immune Signals......................................................... 47Y. Chiu, P. Zhang, J. M. Gammon, C. M. Jewell

PROMPT: Polyanhydride-Releasing Oral Microparticle Technology as an Oral Vaccine Strategy ..................................................... 48L. A. Sharpe, O. Haddadin, J. Thirumavalavan, Y. Khairandish, N. A. Peppas

Immunogenicity of a Polyinosinic-Polycytidylic Acid (Poly(I:C))-Adjuvanted Microparticle Vaccine for Leishmaniasis .................................................................................................................................................................................................... 49

Q. Wang, M. Barry, C. Seid, E. Hudspeth, C. McAtee, M. Heffernan

Polyanhydride Nanovaccine Elicits Germinal Center Formation and Isotype Switching ....................................................................... 50J. E. Vela Ramirez, L. T. Tygrett, J. Hao, H. H. Habte, M. W. Cho, N. S. Greenspan, T. J. Waldschmidt, B. Narasimhan

PANEL DISCUSSION: INDUSTRIAL INNOVATIONS IN BIOMATERIALS Industrial Innovations in Biomaterials .......................................................................................................................................................... 51

A. Salamone, B. Ratner, D. L. Kaplan, C. E. Schmidt, R. S. Ward, L. Pinchuk

BENCHTOP MODELS TO SUPPORT MEDICAL DEVICE AND PHARMACEUTICAL INVENTION AND COMMERCIALIZATION Degradation of PLLA Tubes in a Pulsatile Flow Loop as a Model for Cardiovascular Stent Degradation .......................................... 52

M. L. Dreher, S. Nagaraja, Q. Lu, R. Malinauskas, B. Batchelor

Effects of Fatigue Loading on Absorbable Stent Sub-Unit Degradation ................................................................................................... 53M. L. Dreher, S. Nagaraja, B. Batchelor

Ventilator-Endotracheal Tube-Lung Benchtop Model for Luminal Occlusion ........................................................................................ 54C. M. Magin, R. M. May, M. R. Mettetal, A. Potthoff, M. D. Twite, S. T. Reddy

Development of a High-Throughput Ultrasound Technique for the Analysis of Tissue Engineering Constructs ................................ 55M. Goss, J. Stukel, R. Willits, A. Exner

Bench-Top Assay of Inflammation with Human Macrophages on Biomaterials...................................................................................... 56C. E. Witherel, K. L. Spiller

Platelet and Leukocyte Counts as Hemocompatibility Indicators for Biomaterials: An Evaluation of ASTM Standard Test Method F2888-13 .................................................................................................................................................................... 57

Q. Lu, J. M. Nehrer, R. Malinauskas

CHARACTERIZATION OF MICROENVIRONMENT OF IMMUNE CELLS IN WOUND HEALING Affinity-based Controlled Release Scaffolds for Modulation of Macrophage Phenotype in Chronic Diabetic Ulcers......................... 58

S. Nassiri, K. L. Spiller

Microstructural and Functional Analysis of Polymeric Composite Materials for Near Infrared Imaging ........................................... 59A. Stevenson Jr., L. Reese, T. Hill, J. McGuire, A. Mohs, R. Shekhar, L. Bickford, A. Whittington

Chemical Imaging of the Breast Tumor Microenvironment ....................................................................................................................... 60L. Gamble, B. Bluestein, D. Graham, F. Morrish, D. Hockenbery, P. Porter

Effects of Adhesive Cues on Macrophage Cytokine Secretions: A Single Cell Analysis .......................................................................... 61F. Y. McWhorter, T. D. Smith, T. Chung, W. F. Liu

Mechanically- & Biologically-Tunable Polyethylene Glycol Hydrogels for Quantitative Neutrophil Migration Assays................................................................................................................................................................................................................. 62

B. J. Walker, A. L. Gonzalez, H. M. Lauridsen

Study the Effect of Electrical Stimulation Through the Conductive Membranes on the Wound Healing Gene Expression in Normal Human Dermal Fibroblasts ...................................................................................................................................... 63

H. Park, M. R. Rouabhia, D. L. Lavertu, Z. Zhang

Investigating the Migratory Behavior of Macrophage Subtypes ................................................................................................................ 64T. Smith, W. F. Liu, J. Hsieh

The Response of Progenitor Cells and Macrophages on a Bone Substitute to Biologically Relevant pH Levels .................................. 65C. O. Horton, W. Bridges Jr., K. Burg

DRUG DELIVERY FOR IMMUNOMODULATION Molecular Dissemination into Local and Systemic Tissues is Regulated by Molecular Size and Tumor Vascular Status: Implications for Targeted Drug Delivery in Cancer Immunotherapy .......................................................................................... 66

N. Rohner, S. N. Thomas

Dextran Coated Cerium Oxide Nanoparticles Act as Antioxidants ........................................................................................................... 67E. Alpaslan, M. Vargas, A. K. Roy, T. J. Webster

On-demand Immunomodulation Centers for Reducing Inflammation in Osteoarthritis........................................................................ 68Y. F. Tian, R. S. Schneider, D. Holyoak, M. C. H. Van Der Meulen, A. Singh

S-nitrosated Poly(Propylene Sulfide) Nanoparticles Exhibit Thiol-Dependent Transnitrosation and Toxicity Against Adultfemale B. Malayi Filarial Worms ........................................................................................................................................... 69

A. Schudel, S. Thomas, T. Kassis, B. Dixon

Nanoparticle Mediated Delivery of Glutamate Enhancers to Restrain Autoimmune Reactions ............................................................ 70J. M. Gammon, L. H. Tostanoski, Y. Chiu, C. M. Jewell

Development of a Cytokine-Loaded Layer by Layer Coating on Polypropylene Meshes to Modulate Macrophage Polarization at the Tissue-Implant Interface................................................................................................................................................. 71

D. Hachim, S. T. Lopresti, B. N. Brown

Polymersome-templated Porous and Hollow Nanogels for Dual Intracellular Delivery.......................................................................... 72F. Du, E. A. Scott

Modulation of the Immune Response Via the NF-kB Signaling Pathway in Rheumatoid Arthritis in Vitro Models .......................... 73P. R. Wardwell, R. A. Bader

MACROMOLECULAR DRUG DELIVERY Inhalable Dry Powder Microparticles for Delivery of Bacteriophages to Treat Cystic Fibrosis Associated Bacterial Lung Infections ................................................................................................................................................................................................. 74

R. Agarwal, C. Johnson, A. J. Garcia

Intracellular Trafficking of Alginate-graft-Poly (Ethylene Glycol) Microspheres for Promoting Mesenchymal Stem Cell Osteogenic Differentiation ....................................................................................................................................................................... 75

T. Miao, R. A. Oldinski

Cholera Toxin Subunit B-Modified Mesoporous Silica Nanoparticles as Vehicles for the Improved Intracellular Delivery of Proteins .......................................................................................................................................................................................... 76

W. A. Walker, J. L. Vivero-Escoto

Reactive Oxygen Species (ROS)-responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy ................................................................................................................................................................................................ 77

Q. Xu, M. Wang

Bioorthogonal Hyaluronate Hydrogels for Therapeutic Protein Delivery................................................................................................. 78A. Famili, J. G. Aaronson, K. Rajagopal

Self-Assembled Tannin Complexes for Redox Responsive Drug Delivery ................................................................................................ 79H. A. Cheng, C. T. Drinnan, E. Yoo, A. L. Doiron, O. Z. Fisher

Controlled Local Delivery of Therapeutic Antibodies from Injectable Hydrogels ................................................................................... 80N. A. Fletcher, M. D. Krebs

pH-Responsive Polymeric Vehicles for the Oral Delivery of Hemophiliac Factor IX .............................................................................. 81S. D. Horava, N. A. Peppas

MULTISCALE BIOMATERIAL DESIGN A Generalized Large Deformation Structural Constitutive Model for Forming Tissues in Needled Non-woven Scaffolds............................................................................................................................................................................................................. 82

M. S. Sacks

Carbon Nanotube-Based Bio-impedimetric Bone Marker Sensors ............................................................................................................ 83M. S. Patil, M. Ramanathan, V. Shanov, P. N. Kumta

Synthesis of Large Pore Sized Mesoporous Silica Nanoparticles Embedded with Magnetic Nanoparticles for Loadingof Large Sized Molecules ................................................................................................................................................................... 84

B. G. Cha, J. Kim

A Protease-Activatable Nanoparticle Contrast Agent for Molecular Imaging by Dual Energy Computed Tomography ...................................................................................................................................................................................................... 85

J. Ashton, C. Badea, J. West

Fiber Reinforced Collagen-GAG Scaffolds for Tendon Bone Junction Repair ........................................................................................ 86L. Mozdzen, R. Rodgers, J. Banks, B. A. Harley

Tissue Formation and Remodeling in Tissue Engineered Pulmonary Conduits....................................................................................... 87M. S. Sacks

NANOBIOMATERIAL AND DRUG DELIVERY STRATEGIES FOR DENTAL/CRANIOMAXILLOFACIAL REPAIR/REGENERATION Improved Mechanical Properties of 3D Printed Calcium Phosphate Scaffolds for Craniofacial Reconstruction................................ 88

J. Vella II, R. Trombetta, M. Hoffman, J. Inzana, H. Awad, D. Benoit

Partially Demineralized Macroporous (PDM) Allografts for Cranial Tissue Engineering ..................................................................... 89A. M. Emmakah, H. Arman, R. Almousa, N. Bhimireddy, S. Musgrove, J. Syed, A. Tovar, C. Wunderlin, T. G. Chu

Evaluation of Two Types of Chitosan Nanofiber and Collagen Membranes in Critical Size Rat Calvarial Defect ............................. 90H. Su, K. Liu, D. Abebe, C. Wu, A. Karydis, K. Anderson, P. Adatrow, T. Fujiwara, W. Haggard, J. Bumgardner

In Vitro Degradation and Physical Characterization of Antimicrobial Electrospun Polyurethane Scaffolds ...................................... 91M. E. E. Wright, M. Yang, P. Santerre

High Throughput Genotoxicity Assay of Nanomaterials with Single Cell Halochip Assay ..................................................................... 92Y. Qiao, L. Ma

Synthesis of Antimicrobial Di-Vinyl Monomers for Dental Restorative and Adhesive Systems............................................................. 93Y. Delaviz, M. A. Nascimento, M. Yang, J. P. Santerre

ORTHOPAEDIC BIOMATERIALS High Strength Magnesium-Yttrium based Alloys Exhibiting Controlled Degradation for Musculoskeletal Medical Implant Application ......................................................................................................................................................................................... 94

D. Chou, D. Hong, B. Lee, Y. Chen, Z. Xu, P. N. Kumta

Safety and Efficacy of PEEK Intramedullary Nail Fixation System using an Ovine Tibial Fracture Repair Model........................... 95M. Assad, D. Beaudry, J. Wilson, B. Lussier, M. Chagnon, E. Pluhar, M. Cantwell

Long-Term Effects of Poly (ε–caprolactone) Implantation in a Bone Defect Model ................................................................................ 96A. C. Petticoffer, A. Recber, L. Boure, D. Arens, X. Liu, M. Fulmer, R. Harten

An In Situ Forming, Injectable PLGA Composite for Orthopedic Applications ...................................................................................... 97P. Fisher, T. Milbrandt, Z. Hilt, D. Puleo

A Three Dimensional Rotating Bioreactor for the Production of Micro Engineered Bone Tissue in Large Scale-feasibility Study ................................................................................................................................................................................................ 98

A. Grottkau, B. Grottkau, Y. Pang

In Vivo Performance of Resorbable Polymer Scaffolds with Calcium Phosphate Coatings Tested in a Rabbit Critical-Sized Calvaria Model......................................................................................................................................................................... 99

J. Kim, S. McBride, O. Ortiz, M. H. R. Mango, A. Darr, J. Kohn, J. O. Hollinger

Ca2+ and cAMP Signaling in Chondrocytes is Sensitive to Hydrogel Composition and Permeability .................................................100A. E. Donius, S. V. Bougoin, J. M. Taboas

3D Printing of Scaffolds with Tunable Modulus and Pore Size for Investigating the Progression of Cancer-Induced Bone Disease In Vitro .....................................................................................................................................................................................101

U. Dadwal, J. M. Page, A. R. Merkel, M. Kessler, J. Sterling, S. Guelcher

TARGETED AND TARGET-ACTIVATED DRUG DELIVERY Bioresponsive Hydrogel Embedded Dark-gold Nanoswitch to Sense and Overcome Cancer Multidrug Resistance.........................102

N. Artzi, J. Conde, N. Oliva

Antibody-targeting of Drug-loaded Micelles to Acute Myeloid Leukemia Cells ....................................................................................103M. P. Baranello, S. Tau, D. S. W. Benoit

Structure-Inherent Targeted Contrast Agents for Parathyroid Glands ..................................................................................................104H. Hyun, M. H. Park, E. A. Owen, M. Henary, H. S. Choi

Tunable Spatiotemporal Control of Angiogenic and Osteogenic Growth Factor Delivery Via Hydrogel Encapsulation and Covalent Conjugation ...................................................................................................................................................105

M. J. Meagher, R. K. Roeder

Modular Effect on Click Chemicals for Bioorthogonal Ligation ..............................................................................................................106J. H. Lee, H. Koo, K. Bao, G. Park, S. H. Yun, H. S. Choi

Human Fetuin-A Treatment for Demineralization of Arteriosclerosis ....................................................................................................107J. L. Cunningham, E. S. Vasquez, K. B. Walters, C. L. Simpson

Development of a Novel Targeted Microparticle Drug Delivery System for Cancer Medication.........................................................108T. Dorney, C. Clark, N. Comolli

Dendrimers For Local, Targeted And Selective Treatment Of Breast Cancer .......................................................................................109N. Oliva, M. Atilano, E. Edelman, N. Artzi

BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) 2 Computer Aided Biomanufacturing of Protein Scaffolds with Controlled Macroporosity ...................................................................110

A. Islam, K. Chapin, M. Younesi, O. Akkus

Supramolecular, Guest-Host Hydrogels for 3D Bioprinting of Material and Cellular Structures .......................................................111C. B. Highley, C. B. Rodell, J. A. Burdick

A Multi-Material Bioink Method for 3D Printing Tunable and Cell-Compatible Hydrogels ...............................................................112A. L. Rutz, K. E. Hyland, A. E. Jakus, W. R. Burghardt, R. N. Shah

Bioprinted Liver Organoid for Toxicology Testing ....................................................................................................................................113H. Kang, S. J. Lee, A. Skardal, I. Mead, M. Devarasetty, T. Shupe, C. Bishop, J. Jackson, S. Soker, J. Yoo, A. Atala

3-D Bioprinting of Skeletal Muscle Tissue Constructs for Accelerated Restoration of Muscle Function ............................................114J. H. Kim, Y. Seol, I. K. Ko, H. Kang, H. S. Kim, J. S. Lee, S. J. Lee, A. Atala, J. J. Yoo

Collagen NanoFiber Coating on Cell Surfaces for Construction of Cell-Density Controlled 3D-Thick Tissues.................................115M. Matsusaki, C. Liu, M. Akashi

BIO-NANOMATERIALS FOR CANCER THERANOSTIC TREATMENT Therapeutic In Vivo RNAi-based Nanoparticle Silencing in Lung Tumor-Associated Macrophages .................................................116

J. Conde, C. Bao, Y. Tan, D. Cui, E. R. Edelman, H. S. Azevedo, H. J. Byrne, F. Tian, N. Artzi

Biodegradable Photoluminescent Nanoparticles for Immune Cell-Mediated Melanoma Targeting and Theranostic Drug Delivery ..................................................................................................................................................................................................117

Z. Xie, Y. Su, E. Selvi, G. B. Kim, V. A. Sanabria, C. Ma, C. Dong, J. Yang

Multiplexed Biomarker Detection Using Phase Change Nanoparticles ...................................................................................................118J. An, M. Su

Azole-functionalized Nanoparticles for Imaging & Drug Delivery ..........................................................................................................119R. J. Cavazos Jr., R. A. Petros

Single Cell Array Based Toxicity Assay for Personalized Medicines .......................................................................................................120Y. Qiao, L. Ma

Cancer Specific and Multicolor Bioimaging Using Triple-triplet Annihilation Upconversion Nanocapsules.....................................121H. S. Song, O. S. Kwon, J. Conde, J. Kim, N. Artzi

ENGINEERING CELLS & THEIR MICROENVIRONMENTS Scaffold Fiber Diameter and Alignment Co-Regulate Tendon Fibroblast Response .............................................................................122

W. Levine, C. Erisken, H. Lu, N. Lee

Identifying Localized Shear Forces and Nutrient Gradients in 3D Flow Perfusion MSC Cultures .....................................................123C. Williams, A. Simmons, D. Papavassiliou, R. Voronov, V. Sikavitsas

Poly(dimethyl siloxane)-Containing Nanofiber Meshes as a Platform for Studying Stem Cell Behavior............................................124D. R. Bogdanowicz, P. J. Chuang, L. C. Kam, H. H. Lu

Conducting Polymer Films with Biomolecular Gradients for Cell Adhesion Control ...........................................................................125S. Park, D. Nocera, M. R. Abidian, S. Majd

Anisotropically Stiff Micropillars as a Unidirectional Cell Entrapment and Alignment Niche for Cardiomyocytes.........................126Y. Alapan, M. Younesi, O. Akkus, U. Gurkan

Maxwell Stress Field Induced Biological Cell Deformation in an Electric Field Stimulated Medium .................................................127R. Krishnamurthy, V Kumaran, B. Basu

PC12 Cell Attachment, Proliferation, and Differentiation on Polymer Spherulites ...............................................................................128X. Wu, S. Wang

The Direction of Stretch-Induced Cell and Stress Fiber Orientation Depends on Collagen Matrix Stress .........................................129R. Kaunas, A. Tondon

LOCAL DELIVERY OF DRUGS AND GROWTH FACTORS FROM IMPLANT COATINGS Dextran Sulfate Thin Films: A Novel Drug Delivery Platform for Drug-Eluting Balloon Applications..............................................130

S. Lamichhane, G. Mani

Hydrogel Implant Coatings for Peripheral Nerve Regeneration ..............................................................................................................131D. Bhatnagar, J. Bushman, B. A. Clements, S. Murthy, J. Kohn

Porous Dexamethasone-relasing Coatings Improve the Performance of Implantable Glucose Sensors in Normal and Diabetic Rats............................................................................................................................................................................................132

S. G. Vallejo-Heligon, N. L. Brown, B. Klitzman, W. M. Reichert

Engineering Drug-eluting Coatings to Design Next Generation Devices for Locally Treat Pancreatic Cancer. ................................133L. Indolfi, M. Ligorio, D. Ting, R. Tzafriri, C. Ferrone, J. Clark, R. Langer, E. Edelman

Local Delivery of Paclitaxel Using Infusion Balloon Catheters.................................................................................................................134J. Anderson, G. Mani, T. Remund, P. Kelly, L. Danielson, M. Nykamp, K. Pohlson, R. Evans, K. Egland, M. Clark

Surface Modification of Ti with Micro/Nano Multi-scale Roughness for the Growth Factor Loaded Implant..................................135S. W. Kim, T. Jang, B. Moon, J. Song, H. Kim

Photoluminescent Antioxidant Oligomers with Potent UV-absorbing Properties..................................................................................136J. Yang, R. Van Lith, G. A. Ameer

Vancomycin Release from Point-of-care Phosphatidylcholine Implant Coatings ..................................................................................137D. Carpenter, K. Troxel, W. Haggard, J. A. Jennings

NANOMATERIALS Cellular Protease-Mediated Programmed Delivery of Anticancer Cytokine and Small-Molecule Drug.............................................138

W. Sun, T. Jiang, R. Mo, Z. Gu

Neural Cell Functionality Modulation and Bacterial Growth Deactivation on Patterned Carbon Substrates ...................................139B. Basu Sr., S. Jain Jr., A. Sharma Sr.

3D-Printed Osteo-Electro Hydroxyapatite-Graphene Composites...........................................................................................................140A. E. Jakus, R. N. Shah

Superparamagnetic Iron Oxide Nanocomposites and Autophagy Response from Macrophage Cells.................................................141C. Wu, H. Ai, L. Yang, R. Jin

Preparation of a Nano-patterned Polymer Replica for Reducing Catheter Associated Infections .......................................................142L. Liu, B. Ercan, L. Sun, T. Webster

An Anti-inflammatory Drug Delivery System Based on Chitosan/Poly-(γ-Glutamic Acid) Nanoparticles to Treat Inflammation and Degeneration of Intervertebral Disc: An Ex Vivo Study ...........................................................................................143

G. Teixeira, A. C. L. Pereira, H. Wilke, C. Neidlinger-Wilke, M. A. Barbosa, C. Neidlinger-Wilke, R. M. Gonçalves, A. Ignatius

Visualizing Structure of Bio-Functional Magnetic Nano-Particles with Analytical Electron Microscopy .........................................144J. Wang, L. Wang, A. M. Ferrie, Y. Jin

Increased Cell Functions Using BMP-7 Functionalized Rosette Nanotubes............................................................................................145G. Mi, L. Sun, A. Alsbaiee, U. Hemraz, J. Cho, H. Fenniri, T. Webster

ORTHOPAEDIC BIOMATERIALS 2 An Analysis of Corrosion Products caused by Fretting/Wear-Accelerated Crevice Corrosion on Retrieved Co-Cr-Mo Implants ....................................................................................................................................................................................................146

M. A. Di Prima, O. Vesnovsky, L. T. Topoleski, R. Hopper, C. A. Engh Jr., P. Kovacs

Development of Biodegradable Polyurethane-ureas as Gradient Scaffolds for Ligament and Tendon Repair ..................................147T. Touchet, A. Kishan, M. Detamore, E. Cosgriff-Hernandez

Effect of Recombinant Fibronectin Fragment Coating on Osseointegration of Stainless Steel Screws in Healthy and Osteoporotic Rats ...........................................................................................................................................................................................148

R. Agarwal, C. González-García, B. Torstrick, R. E. Guldberg, M. Salmeron-Sanchez, A. J. Garcia

The Novel Use of Acoustic Radiation Force to Mechanically Load Hydrogel-Encapsulated Osteoblasts for Bone Repair...............................................................................................................................................................................................................149

J. Veronick, V. Vyas, B. Huey, Y. Khan

Pilot In Vivo Evaluation of a Resorbable, Antibiotic-Eluting Bone Void Filler to Prevent Periprosthetic Joint Infection ...........................................................................................................................................................................................................150

K. D. Sinclair, A. E. Brooks, Z. Ferrell, D. W. Grainger

A Non-Weight Bearing Model of Osteoporosis for Histomorphometric and Mechanical Evaluation of Bone Repair Using Bone Graft Substitutes ........................................................................................................................................................................151

D. J. Hall, T. M. Turner, S. M. McCarthy, S. Gitelis, R. M. Urban

Growth Factor Incorporated Collagen Threads as Suturable Therapeutic for Tendon Repair ...........................................................152M. Younesi, B. Ozgur Donmez, O. Akkus

Corrosion Behavior of Ti-6Al-4V Orthopaedic Alloy Under Tensile Stress............................................................................................153P. Panigrahi, A. Poursaee, M. K. Harman

TISSUE ENGINEERING Comparison of Tissue Engineered Intestine Produced from Non-woven Polyglycolic Acid, CollaTape Collagen, and Nanofiber Poly (ε-caprolactone) Scaffolds...................................................................................................................................................154

Y. Liu, T. Rager, J. Johnson, J. Lannutti, J. Enmark, T. Nelson, G. E. Besner

Vibratory Stimulation for Anti-Fibrotic Therapy ......................................................................................................................................155S. Bae, J. S. Lee, J. L. Barth, K. Webb

Bi-Layer Silk Fibroin Grafts Support Functional Tissue Regeneration in a Rat Model of Onlay Esophagoplasty ...........................156K. Algarrahi, D. Franck, C. Ghezzi, V. Cristafaro, X. Yang, M. P. Sullivan, Y. G. Chung, D. L. Kaplan, C. R. Estrada Jr., J. R. Mauney

Integrin Activation as a Tool to Modulate Vascular Patterning ...............................................................................................................157S. Li, T. Barker, T. Segura

New Method for Evaluation of Nano-Drug Carriers by 3D-Arterial Wall Models for Atherosclerosis Treatment ...........................158P. Chetprayoon, M. Matsusaki, U. Yokoyama, Y. Ishikawa, M. Akashi

Silk-PLA Bio-composite Materials for Medical Applications ...................................................................................................................159X. Hu

The Effect of Cyclic Loading on the Material Properties of Isolated Arterial Elastin ...........................................................................160T. Topoleski, J. B. Washington III

Swelling and Rheological Characterization of Biodegradable Dextran-based Hydrogels .....................................................................161D. R. Janagam, G. L. Ndifon, T. L. Lowe

BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING Construction of iPS-Derived 3D-Cardiac Myoblast Tissues Containing Blood Capillary Network by Cell Accumulation Technique ...............................................................................................................................................................................162

Y. Amano, A. Nishiguchi, M. Matsusaki, S. Miyagawa, Y. Sawa, M. Akashi

Highly Transparent Dense Collagen Sheets for Corneal Tissue Engineering Applications ..................................................................163R. Iyer, V. Kishore

Microribbon-like Hydrogels with Diverse Biological Cues for Forming 3D Scaffolds: a “Lego-building” approach........................164F. Yang, X. Tong, L. Han, S. Lee

Biomimetic Materials Modulate Specific Growth Factor Signaling In Vitro and In Vivo ....................................................................165D. G. Belair, M. J. Miller, A. V. Kellner, S. Wang, N. Sheibani, W. L. Murphy

Bridging the Gap: Assessing an Engineered Biomimetic Periosteum on Bone Allografts for the Reconstruction of Large Segmental Bone Defects in Mice ........................................................................................................................................................166

R. Romero, L. S. Chubb, J. K. Travers, R. Rose, A. Pennybaker, E. Asbury, N. P. Ehrhart, M. J. Kipper

Three Dimensional Multiphase Biomimetic Scaffold for Tissue Engineering Muscle-Tendon Junctions ...........................................167T. He, S. J. Lee, J. Chen, X. Tang, M. W. King

Electrospinning Degradable Hydrogel Nanofibres for Tissue Engineering............................................................................................168H. Sheardown, T. Hoare, F. Xu

Electrochemically Aligned Collagen-Elastin Fibers for Vascular Tissue Engineering ..........................................................................169T. Nguyen, C. A. Bashur, V. Kishore

CARDIOVASCULAR BIOMATERIALS 2 EPC Capturing Technology for Improving Patency of Small-diameter (2mm ID) and Long (30 Cm Length) Acellular Blood Vessels ..................................................................................................................................................................................170

T. Yamaoka, S. Somekawa, M. Kitai, Y. Ohya, Y. Kimura, T. Fujisato, A. Mahara

Hemocompatibility of Crosslinked or Thrombomodulin-modified Decellularized Matrix ...................................................................171J. J. Glynn, E. G. Polsin, M. T. Hinds

Peptide-grafted Hydrogels to Capture Endothelial Progenitor Cells under Shear for Endothelialization..........................................172W. J. Seeto, E. A. Lipke

Mechanocompatible Polymer-Extracellular Matrix Composites for Vascular Tissue Engineering.....................................................173B. Jiang, J. Wertheim, G. Ameer

Catheters Prepared with Nitric Oxide (NO) Releasing Lumen for Improved Hemocompatibility ......................................................174E. J. Brisbois, H. Handa, T. C. Major, J. Wu, J. Brownstein, C. Xi, M. E. Meyerhoff, R. H. Bartlett

Syndesomes Microencapsulated in Alginate for Revascularization in Peripheral Ischemia .................................................................175S. Das, G. Singh, A. J. Monteforte, M. E. Martinez, C. S. Wright, P. E. Martin, A. K. Dunn, A. B. Baker

3D Structured Biomaterials to Induce Vascularization after Ischemic Cardiovascular Events. ..........................................................176F. Munarin, K. Coulombe

Platelet-inspired Biomaterials Engineering for Synthetic Intravenous Hemostat ..................................................................................177A. Sen Gupta, C. Modery-Pawlowski, C. Kos, A. Anselmo, S. Mitragotri

CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY Effect of Tricalcium Phosphate-based Paste- and Foam-like Bone Grafting Materials on Bone Regeneration and Osteogenic Marker Expression In Vivo .......................................................................................................................................................178

M. Lopez Heredia, D. Barnewitz, A. Genzel, F. Peters, A. Kuhr, B. Stang, W. Huebner

Fabrication of Porous Carbonate Apatite and Its In Vivo Evaluation.....................................................................................................179K. Ishikawa, N. X. T. Tram, K. Tsuru

Phage-derived Peptides Improve hBMSC Adhesion Contact Distribution and Proliferation on Biomimetic Apatite.......................180H. Ramaraju, D. H. Kohn

Biomimetic Calcium Phosphate-Polycarbonate Composite Scaffolds for Bone Tissue Engineering....................................................181S. S. Chen, J. Kohn

Anti-cancer and Anti-microbial Selenium Nanoparticle Bone Scaffolds .................................................................................................182M. Stolzoff, T. J. Webster

Simvastatin-Releasing Calcium Sulfate and Calcium Phosphate Bioceramics .......................................................................................183Y. Gu, B. R. Orellana, D. A. Puleo

Effect of Mannitol Porogen Addition on Magnesium Phosphate Cements..............................................................................................184N. J. Ostrowski, B. Lee, A. Roy, P. Kumta

Twinning Induced Enhancement of Fracture Toughness in Ultra-fine Grained Hydroxyapatite-Calcium Titante Composites ......................................................................................................................................................................................................185

R. Krishnamurthy, P. K. Mallik, S. Pramanik, S. Suwas, K. Balani, B. Basu

DELIVERY OF NUCLEIC ACIDS AND OTHER MOLECULES THAT MODULATE GENE EXPRESSION NF-κB Decoy Oligodeoxynucleotide Increases Bone Mineral Density in the Murine Femur during Continuous Infusion of Polyethylene Particles.................................................................................................................................................................186

T. Lin, T. Sato, J. Pajarinen, C. Fan, F. Loi, R. Zhang, Z. Yao, K. Egahishira, S. Goodman

Elucidating Structure-Function Relationships of Poly(β-amino ester)s for Non-viral Gene Delivery via Principal Component Analysis.......................................................................................................................................................................................187

C. J. Bishop, B. Abubaker-Sharif, T. Guiriba, J. J. Green

Surface-associated DNA Presentation for Sustained Gene Delivery with Porous Hyaluronic Acid Hydrogels ..................................188N. F. Truong, T. Segura

Porous Silicon Nanoparticle Delivery of Peptide Nucleic Acid Anti-MicroRNA Therapeutics ............................................................189K. R. Beavers, J. W. Mares, S. M. Weiss, C. L. Duvall

Nanoceria-miRNA As a Modulator of Inflammation in Diabetic Wounds..............................................................................................190I. Kalashnikova, J. Xu, S. Das, C. Zgheib, K. W. Liechty, S. Seal

Conjugation of Palmitic Acid Improves Potency and Longevity of siRNA Delivered via Endosomolytic Polymer Nanoparticles ..................................................................................................................................................................................................191

S. M. Sarett, K. V. Kilchrist, M. Miteva, C. L. Duvall

CXCR4-Overexpressing Adipose-derived Stem Cells Enhanced Brain Tumor Tropism In Vitro.......................................................192X. Jiang, C. Wang, F. Yang

Photocleavable Hydrogels for Light-Triggered siRNA Release ................................................................................................................193C. T. Huynh, M. K. Nguyen, G. Y. Tonga, V. M. Rotello, E. Alsberg

HARNESSING BIOMATERIALS TO ENGINEER THE ADAPTIVE RESPONSE FOR IMMUNITY OR TOLERANCE Determining the Specificity of a Multivalent Polymeric Antigen-Specific Immunotherapy for Multiple Sclerosis ...........................194

B. L. Hartwell, J. O. Sestak, B. P. Sullivan, H. Shinogle, C. Berkland

Intra-Lymph Node Delivery of Biomaterial Depots Prevents and Reverses Experimental Autoimmune Encephalomyelitis...........................................................................................................................................................................................195

L. H. Tostanoski, Y. Chiu, J. M. Gammon, C. M. Jewell

Current Translation Efforts for a Microparticle-based Vaccine Against Type 1 Diabetes ...................................................................196J. Lewis, M. Carstens, N. Dolgova, G. Marshall, S. Morshed, C. Xia, M. Clare-Salzler, B. Keselowsky

Anti-Cytokine Responses Elicited by Self-assembling Peptide Vaccines .................................................................................................197C. Mora Solano, R. Pompano, J. Collier

Tuning CD8+ T cell Multifunctionality with Peptide Self-assemblies.......................................................................................................198C. B. Chesson, R. J. Nusbaum, J. J. Endsley, J. S. Rudra

Electrospun Poly(dimethyl siloxane)-based Meshes as a Platform for T Cell Expansion ......................................................................199A. Dang, S. De Leo, D. Bogdanowicz, H. Lu, L. Kam

MULTIFUNCTIONAL NANOMATERIALS FOR ENGINEERING COMPLEX TISSUES AND DRUG DELIVERY Collagenase Delivery from Multi-Polymer Fibrous Scaffolds To Promote Cellular Mobility and Meniscus Repair.........................200

J. L. Holloway, F. Qu, I. L. Kim, R. L. Mauck, J. A. Burdick

Nanoengineered Bioactive Hydrogels for Cells-based Tissue Engineering..............................................................................................201J. R. Xavier, T. Thakur, P. Desai, A. K. Gaharwar

Fluorogen-Activating Proteins as Retention Modules for Local Deposition of Antibodies ...................................................................202W. S. Meng, W. Liu, M. Saunders, A. Waggoner

Engineering Micropores in Nanoparticle-bacterial Cellulose Scaffolds using a Laser-cutting Instrument: Preparation, hMSCs Proliferation and Osteogenic Differentiation for Bone Tissue Regeneration .....................................................203

P. M. Favi, S. P. O. Alvarez, T. J. Webster

Self-Assembly of Highly Asymmetric Polypeptide Amphiphiles ..............................................................................................................204I. Weitzhandler, J. R. McDaniel, S. Prevost, M. Gradzielski, A. Chilkoti

Investigation of Dendrimer-based Nanoparticles Cellular Uptake and Cell Tracking in a Semi-automated Microfluidic Platform ....................................................................................................................................................................................205

M. R. Carvalho, J. Mano Sr., R. L. Reis, J. M. Oliveira Sr.

Designing Recombinant Baculovirus/Nanomaterial based Hybrid Hydrogels for Gene Delivery Application...................................206A. Paul Jr., W. Shao, R. M. Waters, S. Prakash

Folate-functionalized Polymeric Micelle for Combinatorial Therapy to Overcome Drug Resistant Breast Cancer .........................207J. S. Lee, G. Temples

STEM CELL AND BIOMATERIAL INTERACTIONS Integrin α2β1-Specific Hydrogels Enhance Human Mesenchymal Stem Cell Survival and Bone Repair in Vivo .............................208

A. Y. Clark, A. J. Garcia

In Situ Vascularization of Injectable Fibrin/Poly(Ethylene Glycol) Hydrogels by Human Amniotic Fluid Stem Cells ..................................................................................................................................................................................................................209

O. M. Benavides, A. R. Brooks, S. Cho, J. Petsche Connell, R. Ruano, J. G. Jacot

Engineering 3D Sliding Hydrogels with Mobile Molecular Ligands to Direct Stem Cell Differentiation............................................210X. Tong, F. Yang

Disruption of Cell-Cell Contact-mediated Notch Signaling via Hydrogel Encapsulation Reduces Mesenchymal Stem Cell Chondrogenic Potential................................................................................................................................................................211

A. Chen, M. Hoffman, C. Chen, A. D. Shubin, D. S. Reynolds, D. S. W. Benoit

Heparin Cell Coating Maintains Cell Number During Mesenchymal Stem Cell Aggregate Culture ..................................................212J. Lei, J. S. Temenoff

Direct Hydrogel Encapsulation of Pluripotent Stem Cells Enables Formation of Engineered Cardiac Tissues.................................213P. Kerscher, I. C. Turnbull, A. J. Hodge, J. Kim, D. Seliktar, C. J. Easley, K. D. Costa, E. A. Lipke

ACADEMIC- INDUSTRY COLLABORATIONS IN BIOMATERIALS RESEARCH High Temperature Aging of Polyurethanes in the Prediction of In Vivo Biostability ............................................................................214

T. Touchet, N. Sears, E. Tkatchouk, C. Jenney, E. Cosgriff-Hernandez

Assessment of Antimicrobial Treatment on Cotton and Polyester Compression Bandages..................................................................215T. He, C. Augilar, B. Rose, N. Lamba, M. King, R. Jindani

Effect of Terminal Sterilization on Bioresorbable Tyrosine Derived Polycarbonates for Medical Device Applications.....................................................................................................................................................................................................216

D. Bhatnagar, V. B. Damodaran, K. Dube, G. Subramanian, S. Murthy, K. Aston, F. Halperin, M. Mao, K. Pricer, D. I. Devore, J. Kohn

Rheologically Modified Methoxypropyl-Based Cyanoacrylate Tissue Adhesives: A Preliminary Study ............................................217K. J. Garcia, J. T. Corbett, K. J. L. Burg

ADVANCES IN OPHTHALMIC BIOMATERIALS The Monthly Eye Drop: Preclinical Testing of Long-term, Hydrogel/Microsphere Eye Drops for Glaucoma..................................218

M. V. Fedorchak, I. P. Conner, J. S. Schuman, S. R. Little

Nanofibrous Scaffolds for Orderly Corneal Wound Healing ....................................................................................................................219A. Fu, G. Tae, J. A. Kornfield

Development of Biomimetic Materials for Sutureless Ocular Surface Repair ........................................................................................220C. Tison, L. Costella, A. Eiseman

A Synthetic Hydrogel Scaffold to Mimic the Bruch's Membrane for Retinal Tissue Engineering.......................................................221C. White, R. M. R. Olabisi

ADVANCES IN PROGRAMMABLE BIOMATERIALS FOR DRUG DELIVERY AND REGENERATIVE MEDICINE Towards Degradable Protein Patterns for the Characterization of Temporal Stem Cell Behavior .....................................................222

B. Almeida, A. Shukla

Phase Behavior of Smart Peptide Polymers Shows Remarkable Tolerance to Structured Domains ...................................................223S. Roberts, J. Li, F. García Quioroz, T. Oas, A. Chilkoti

Light-triggered In Vivo Activation of Adhesive Peptide Regulates Cell Adhesion and Vascularization of Biomaterials ....................................................................................................................................................................................................224

J. R. Garcia, T. Lee, J. Paez, A. Singh, E. A. Phelps, S. Weiss, Z. Shafiq, A. Shekaran, A. Del Campo, A. J. Garcia

Improving Transdermal Drug Delivery Using Gellan Gum Hydrogels and Temperature Responsive Nanospheres ........................225C. A. Carmona-Moran, O. Zavgorodnya, S. L. Bridges, Jr., R. W. Hergenrother, J. Murphy-Ullrich, B. Ntsikoussalabongui, A. D. Penman, E. Kharampieva, T. M. Wick

A Sustainable Material for Capturing and Killing Circulating Tumor Cells .........................................................................................226S. Li, N. Chen, E. Richards, Y. Wang

Tuning Stiffness of Cell-laden Hydrogel by Photo-reversible Host-guest Interactions ..........................................................................227H. Shih, C. Lin

DENTAL/CRANIOFACIAL Development of Customized Patient-Specific Cranio-maxillofacial Scaffolds Fabricated by Binder-Jetting 3D Printing of Biodegradable Fe-based Alloys .................................................................................................................................................228

D. Hong, D. Chou, I. Issaev, A. Roy, P. N. Kumta

Local Delivery of rhBMP-2 from a Compression-Resistant Graft in a Canine Lateral Ridge Augmentation Model ........................229A. D. Talley, K. N. Kalpakci, K. J. Zienkiewicz, D. L. Cochran, S. A. Guelcher

Osseointegration of 3D Titanium Alloy Implants Fabricated by Additive Manufacturing and Etched to Create a Microstructured Surface ...............................................................................................................................................................................230

D. J. Cohen, A. Whitehead, S. L. Hyzy, G. Yachkir, M. Aviram, B. D. Boyan, Z. Schwartz

Synthesis and Characterization of a Novel Polymerizable Amine Co-Initiator for Dental Application: Evaluation of Polymerization Kinetics and Quantification of Leachables ..................................................................................................................231

Q. Ye, X. Ge, L. Song, F. Abedin, P. C. Burris, C. B. Tamerler, A. Misra, C. L. Berrie, J. S. Laurence, P. Spencer

Effect of Recrystallization Heat Treatment on Flexural Strength and Aging Resistance of Zirconia.................................................232I. Denry, O. Goudouri, J. Holloway

Development of Bioactive Dental Nanomaterials for Anticaries Therapy ...............................................................................................233M. A. S. Melo, M. D. Weir, L. C. Chow, H. H. K. Xu

IMMUNOMODULATION IN REGENERATIVE MEDICINE In Vitro Modulation of Macrophage Behavior by Ceramic-based Scaffolds ..........................................................................................235

P. L. Graney, S. Roohani-Esfahani, H. Zreiqat, K. L. Spiller

Using Amniotic Membrane Matrix to Alter the Inflammatory Response in Collagen-based Scaffolds for Tendon Regeneration ...................................................................................................................................................................................................236

R. A. Hortensius, B. A. Harley

Immunostimulatory Peptide Biomaterials as Scaffolds for Defect Repair ..............................................................................................237Y. Vigneswaran, H. Han, J. Handley, T. Sun, J. Collier

Scaffolds Engineered to Release TGF-β1 Improve Islet Graft Function .................................................................................................238R. M. Gower, J. Zhang, J. M. Liu, X. Zhang, L. D. Shea

Utilizing PEG Hydrogels to Investigate the Role of Macrophage Phenotype on Vascular Development ............................................239E. Moore, J. L. West

Biomaterial-based Microparticle Vaccine Modulates Cellular Tolerance in Type 1 Diabetes..............................................................240J. M. Stewart, J. S. Lewis, B. G. Keselowsky

MATERIALS AND MATRICES FOR OSTEOCHONDRAL TISSUE ENGINEERING In Vivo Evaluation of Bilayered Silk/Silk-Nano CaP Scaffolds for Osteochondral Regeneration........................................................241

J. M. Oliveira Sr., L. Yan Sr., J. Silva-Correia, C. Vilera, H. Pereira, R. A. Sousa, A. L. Oliveira, R. L. Reis

Hypothermically Stored Human Amniotic Membrane Allograft as a Substrate for Articular Cartilage Regeneration ...................................................................................................................................................................................................242

J. B. Vines, H. P. Walthall Jr., H. Jun

Developmentally Inspired Zone-Specific Chondrogenic Differentiation of Human Mesenchymal Stem Cells...................................243E. Jabbari

Novel Biointegrative Cross-linked Degradable Polyurethane Scaffold for Cartilage Repair................................................................244H. Liang, A. Datta, D. Grande, L. Lavelle

Mesenchymal Stem Cell Pellet Delivery Platform for Functional Repair of Cartilage ..........................................................................245M. Younesi, A. Islam, V. M. Goldberg, O. Akkus

Sympathetic Nerve-Like PC12 Cells Alter Osteoblast Phenotype in the Context of Osteoarthritis .....................................................246J. D. Erndt-Marino, M. S. Hahn

MODULATING THE NEURAL MICROENVIRONMENT Priming Neural Stem Cell Transplants to Dynamically Respond to Brain Injury Induced SDF-1α Gradients .................................247

C. P. Addington, J. M. Heffernan, C. Millar-Haskell, E. Tucker, R. Sirianni, S. Stabenfeldt

Poly(Ethylene Glycol) Diacrylate (PEGDA) Multiluminal Scaffold for Spinal Cord Repair Functionalized with Layer-by-layer Controlled Protein Release .................................................................................................................................................248

D. Shahriari, D. A. Lynam, Y. Koffler, M. Tuszynski, J. S. Sakamoto

Modulating Stromal Derived Factor-1α Release from Nanoparticles Via Affinity-Based Matrices ....................................................249D. Dutta, C. Fauer, S. Stabenfeldt

Integrating Low Level Light Therapy with 3D Printed Scaffolds for Improved Neural Tissue Regeneration ...................................250C. M. O'Brien, J. K. George, V. Sorger, L. G. Zhang

TECHNOLOGY DEVELOPMENT / NEW BIOMATERIALS FOR IMMUNE ENGINEERING Artificial Antigen Presenting Cells for Tumor Immunotherapy: Shape and Size Matter .....................................................................251

J. J. Green, R. A. Meyer, R. S. Meyer, J. Sunshine, K. Perica, A. Kosmides, K. Aje, J. P. Schneck

Immunomodulatory Material for the Attenuation of Multiple Sclerosis .................................................................................................252A. Thomas, J. L. Blanchfield, B. Evavold, J. Babensee

Dendritic Cell Microarrays for Screening Immunomodulatory Compounds in the Development of Tolerogenic Vaccines ...........................................................................................................................................................................................................253

M. Carstens, B. Keselowsky, A. Acharya, J. Lewis

Design of Polyelectrolyte Multi-layer Vaccines Assembled from Immune Signals on Gold Nanoparticle Templates .......................254P. Zhang, Y. Chiu, J. M. Gammon, J. I. Andorko Iv, C. M. Jewell

ADVANCED ANTIMICROBIAL MATERIALS Bacteriophage Encapsulation in Poly(Ethylene Glycol) Hydrogels Significantly Reduces Bacteria Numbers in an Implant-Associated Infection Model of Bone Repair .................................................................................................................................255

C. T. Johnson, N. Dinjaski, M. Auxiliadora Prieto, A. J. Garcia

Tunable Antibacterial Gellan Hydrogels for Burn Wounds .....................................................................................................................256S. Shukla, A. Shukla

Click Chemistry and Implantable Biomaterial for Local Enhancement of Systemic Small Molecules ...............................................257J. M. Mejia Oneto, M. Gupta, J. K. Leach, L. Lindsay, J. Sykes, M. Royzen

Platelet Adhesion and Bacterial Adhesion on PEG-Modified Textured Biomaterial Surfaces .............................................................258L. Xu, C. A. Siedlecki

Chitosan Immobilized Titanium Surface in Co-Culture System ..............................................................................................................259B. Foss, Y. Sun, Y. Deng

Surface Modification by Antibiotic-Loaded Microgels Inhibits Bacterial Colonization........................................................................260J. Liang, Y. Wu, M. Libera

Ionic Liquids Deliver Antibiotic Into Skin and Neutralize Biofilm-Protected Pathogens......................................................................261M. Zakrewsky, K. S. Lovejoy, T. L. Kern, T. E. Miller, V. Le, A. Nagy, A. M. Goumas, R. S. Iyer, R. E. Del Sesto, A. T. Koppisch, D. T. Fox, S. Mitragotri

Removal of Drug-Resistant Bacteria and Ebola Virus from Whole Blood with a Sorbent Hemoperfusion Device: Carbapenum-Resistant Enterobacteriaceae ................................................................................................................................................262

R. S. Ward, K. M. McCrea

BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Micropatterning Directional Extracellular Matrix Cues in Hydrogel-based Scaffolds for Cardiac Tissue Engineering .....................................................................................................................................................................................................263

Q. Jallerat, V. S. Palayekar, A. W. Feinberg

Single-step Chemistry to Independently Control Matrix Stiffness and Conjugation of Pro-angiogenic Peptides..............................264L. Cai, S. Heilshorn, C. Dinh

Sequential Delivery of VEGF165 and PDGF-BB to Repair Myocardial Infarction ...............................................................................265H. K. Awada, Y. Wang

Biomimetic Micropatterns Based on the Embryonic Heart for 2D Cardiac Tissue Engineering .........................................................266I. Batalov, S. Kim, Q. Jallerat, A. W. Feinberg

Hydrogels to Support 3D Microvessel Formation by Blood-derived Endothelial Progenitor Cells .....................................................267E. Brown Peters, N. Christoforou, K. W. Leong, G. A. Truskey, J. L. West

Assessing the Calcification Potential of Engineered Vascular Grafts with Surface Enhanced Raman Spectroscopy........................268K. R. Kerney, N. Roki, M. Fenn, C. Bashur

Promoting Neonatal Cardiomyocyte Proliferation Using a Cryptic Matrikine Derived from Fibrillin-1 ...........................................269K. J. Edmunds, J. S. Weinbaum, L. D. Black III, C. Williams

Temporal Regulation of GSK3/Wnt Signaling Molecules within a 3D Gelatin/chitosan Scaffold Promoting Cardiac Differentiation of Amniotic Fluid Derived Induced Pluripotent Stem Cells for Congenital Heart Defect Repair .............................270

C. Tsao, S. Pok, A. Velasquez-Mao, J. Jacot

INJECTABLE BIOMATERIALS FOR TISSUE REGENERATION Injectable Gelatin Derivative Hydrogels with Sustained Vascular Endothelial Growth Factor Release for Induced Angiogenesis ....................................................................................................................................................................................................271

Z. Li, X. H. Liu

In Situ Cross-linkable Gelatin Hydrogels for Vasculogenic Delivery of Mesenchymal Stem Cells ......................................................272S. H. Lee, Y. Lee, P. P. Young, K. D. Park, H. Sung

Injectable Dual-Crosslinking Hydrogels to Decouple Material Retention and Mechanical Properties In Vivo .................................273C. B. Rodell, J. W. Macarthur Jr., R. J. Wade, S. M. Dorsey, J. A. Burdick

Smooth Muscle Cells on Photo-cured Poly(ε-caprolactone) Substrates with Varied Stiffness and Micro-grooves ............................274J. Dou, S. Wang

Subretinal Injection of Micropatterned Nanosheets for Effective Cell Delivery ....................................................................................275H. Kaji, Y. Mori, T. Fujie, N. Nagai, T. Abe

Strong Injectable Thermosensitive Scaffolds for Cell Therapy ................................................................................................................276C. Ceccaldi, E. Assaad, L. Bonneton, S. Lerouge

Injectable Microporous Scaffolds from Annealed Building Blocks for Accelerated Wound Healing ..................................................277D. R. Griffin, W. M. Weaver, P. Scumpia, D. Dicarlo, T. Segura

Mineralization and Bone Regeneration of Injectable, Dual-Gelling Hydrogel-Cell Constructs ...........................................................278T. N. Vo, S. R. Shah, S. Lu, E. J. Lee, A. M. Tatara, A. G. Mikos

MECHANICAL CHARACTERIZATION OF BIOMATERIALS Tensile Mechanical Property Evaluation of Two Absorbable Sutures: Effects of Size and Types .......................................................279

N. D’Aversa, D. Burkley, L. Vailhe, M. Deng

Experimental and Computational Study of Process-Property Relationships for Bioabsorbable Polymers ........................................280C. R. Gajjar, B. Singhi, M. A. Pasquinelli, M. W. King

Strengthening of Ti-6Al-7Nb Alloy for Dental Narrow Implants .............................................................................................................281T. Hanawa, M. Ashida, P. Chen, H. Doi, Y. Tsutsumi, Z. Horita

Improving Fatigue and Fracture Resistance of 45S5 Bioactive Glass/Polyurethane Biocomposites for Repairing Bone Defects ....................................................................................................................................................................................................282

A. J. Harmata, S. Uppuganti, S. A. Guelcher, J. S. Nyman

Tailoring the Mechanical Characteristics of PEG-based Hydrogels for the Production of High-performance Soft Tissue Expander .............................................................................................................................................................................................283

M. Jamadi, P. Shokrollahi, B. Houshmand, M. Daliri

Burst Properties and Adhesion Strength of Oxidized Methacrylated Alginate Lung Sealants.............................................................284P. Charron, A. Poniz, S. Fenn, D. Weiss, R. Oldinski

Relevance of the Spatial Distribution Pattern of Mechanical Properties of Articular Cartilage in Animal Studies ..........................285S. Sim, I. Hadjab, M. Garon, E. Quenneville, M. D. Buschmann

Characterization of Soft Tissue Transmural Microstructure ...................................................................................................................286J. G. Lesicko, K. R. Feaver, M. S. Sacks

RECENT ADVANCES IN SURFACE MODICATION OF MIOMATERIALS 2 Surface Modification of Ceramic Biomaterials After In Vivo Exposure to the Physiological Environment .......................................287

A. Wusylko, K. Kornev, M. Harman

Biological Tethering of N-Cadherin to Substrates Promotes Cell-Cell Adhesion ...................................................................................288J. Vega, M. K. Lee, D. E. Leckband, H. Kong

Organic-Inorganic Hybrid Coating for Deformable and Biioactive Magnesium Implants ...................................................................289G. Cheon, J. Song, S. Kim, M. Kang, H. Kim

Glow-discharge RF Plasma Polyether and Fluoropolyether Substrates Prevent Protein Adsorption .................................................290M. Mecwan, B. Ratner

Rapid Coating of AZ31 Magnesium Alloy with Calcium Deficient Hydroxyapatite Using Microwave Energy .................................291Y. Ren, H. Zhou, S. Bhaduri

Bioinspired Hydrogels for Transfer Printing of Ultracompliant Medical Electronics ..........................................................................292H. Wu, C. Zhu, C. Bettinger Jr.

Life-long Durability of Orthopedic Bearings by Phospholipid Polymer Grafting and Antioxidant Blending ....................................293M. Kyomoto, T. Moro, S. Yamane, K. Watanabe, K. Ishihara

Hydroxyapatite/Poly(Ether Imide) Micro-patterned Protective Coating on Magnesium for Biomedical Applications.....................................................................................................................................................................................................294

S. Kim, J. Song, M. Kang, G. Chun, H. Kim

SMALL MOLECULE DRUG DELIVERY Sustained Release of Short Peptides Using Guest-host Complex Formation in Injectable Hydrogels .................................................295

J. E. Mealy, C. B. Rodell, J. A. Burdick

PEG Hydrogel Nanoparticles for Controlled Release of Angiogenic Peptides ........................................................................................296D. A. Young, G. Papavasiliou

Synthesis of Protein-polymer Conjugates with Controllable Properties .................................................................................................297H. Chen, L. Wang, X. Li, L. Yuan, H. Wang, G. Chen

Injectable In Situ Forming Depot Systems for Long Acting Contraception ...........................................................................................298D. R. Janagam, L. Wu, K. Chaudhry, T. D. Mandrell, J. R. Johnson, T. L. Lowe

Design and Construction of Hypoxically Activated Drug Release System...............................................................................................299Y. Ikeda, H. Hisano, Y. Nagasaki

Gap Junction Liposomes for Direct Therapeutic Delivery to the Cellular Cytoplasm ..........................................................................300D. J. Busch, J. Stachowiak

Amorphous Magnesium Phosphate Nanoparticles As Nonviral DNA Carriers .....................................................................................301M. Nabiyouni, S. B. Bhaduri

Scaffolds with Incorporated Photo-Carbon Monoxide Releasing Materials for Engineering Vascular Grafts ..................................302E. K. Michael, N. Abeyrathna, K. Birthare, Y. Liao, C. Bashur

STEM CELL AND BIOMATERIAL INTERACTIONS 2 Towards Engineering a Multi-Niche Functional Human Bone Marrow: Advancing Basic Studies and Aiding Clinical Translation........................................................................................................................................................................................303

M. R. Nelson, K. Bai, K. Roh

3D Stem Cell Morphotyping of Tissue Engineering Scaffold Niches .......................................................................................................304S. J. Florczyk, M. Simon, D. Juba, S. Sarkar, D. Chen, P. J. Baker, A. Cardone, M. Brady, P. Bajcsy, C. G. Simon Jr.

Eliminating Dexamethasone from Osteogenic Media Leads to the Production of Angiogenic Factors by Microencapsulated Adipose Stem Cells .......................................................................................................................................................305

Z. Schwartz, B. D. Boyan, S. K. Leslie

Multivalent Platform for Spatial Control of Arterial Venous Differentiation of Pluripotent Stem Cells ............................................306T. B. Dorsey, G. Dai

Polyethylene Glycol Hydrogels Functionalized with a Continuous Ile-Lys-Val-Ala-Val Concentration Gradient for Optimizing Neural Differentiation of Murine Embryonic Stem Cells in 2D ...........................................................................................307

L. Smith Callahan, H. Yang

Bioinstructive Scaffolds Through a Multiscale Approach Mimicking Tissue Mechanics and Regulating Differentiation .................................................................................................................................................................................................308

B. L. Banik, J. L. Brown

Maintaining the Pluripotency of Mouse Embryonic Stem Cells on Gold Nanoparticle Layers with Nanoscale But Not Microscale Surface Roughness ..............................................................................................................................................................309

Z. Lyu, H. Wang, Y. Wang, K. Ding, H. Liu, L. Yuan, X. Shi, M. Wang, Y. Wang, H. Chen

Electric Field Induced Lineage Commitment of Mesenchymal Stem Cells Towards Neural-like Cells on Conducting Polyaniline Substrates...............................................................................................................................................................310

G. Thrivikraman, G. Madras, B. Basu

2ND ANNUAL SFB BUSINESS PLAN COMPETITION Ancure, LLC: Controlled Release Solutions for Treating Brain Aneurysms..........................................................................................311

M. Cramer, A. Iftikhar, M. Horowitz, C. Bettinger

Marauder Medical Devices: Novel Lung Assist Device for Preterm and Term Neonates .....................................................................312D. Sandejas, H. Matharoo

Evoke Medical: Stimulating a Pathway to Bone Healing ..........................................................................................................................313N. Galvis, E. Cadel, H. Sis, B. Wong, P. M. Arnold, E. A. Friis

MacroTheranostics: A Macrophage-based Therapeutic and Diagnostic Wound Care Company .......................................................314S. Nassiri, K. L. Spiller

Nanochon: Novel 3D Printed Joint Repair Scaffolds .................................................................................................................................315B. Holmes, N. Castro, L. G. Zhang

OsteoInk: Bioactive Bone Cements ..............................................................................................................................................................316J. Chari, L. C. Rodriguez, D. C. Rodrigues

BIO-INSPIRED CELLULAR MICROENVIRONMENTS Selectin-mediated Cell Adhesion on Glycoprotein-conjugated Hydrogels ..............................................................................................317

Y. Iwasaki, A. Matsunaga, S. Sugimoto

Altered Extracellular Matrix Properties Drive Tumor Progression ........................................................................................................318K. Wang, M. Quien, L. Hsu, W. Lewis, C. Fischbach, D. Gourdon

PEG-fibrinogen Hydrogel Microspheres Support 3D Tumorigenic Growth of MCF7 Breast Cancer Cells ......................................319S. Pradhan, J. Clary, D. Seliktar, E. A. Lipke

Bio-inspired Lymphoid Tissues for Immune Cell Cancers........................................................................................................................320Y. F. Tian, R. S. Schneider, L. Cerchietti, A. Singh

Cell Guidance Into Quiescent State Through Chromatin Remodelling Induced by Elastic Modulus of Substrate ...........................321M. Rabineau, F. Flick, B. Senger, P. Lavalle, P. Schaaf, J. Freund, D. Vautier

Hydrogel Arrays to Screen Angiogenesis Inhibitors and Vascular Disrupting Compounds.................................................................322D. G. Belair, M. P. Schwartz, W. L. Murphy

Micro/Nano Modified Titanium Alloy Induces MSCs Osteogenesis and Reduces Inflammatory Interleukin Production .......................................................................................................................................................................................................323

R. Olivares-Navarrete, S. L. Hyzy, S. Ortman, P. Ullrich Jr., Z. Schwartz, B. D. Boyan

Bioinspired Silicate Nanocomposites for Osteoarthritis Therapy.............................................................................................................324J. Carrow, G. Lokhande, A. K. Gaharwar

BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING 2 Creating Liver-Mimicking Tissue Constructs in a 3D Biomimetic Hydrogel .........................................................................................325

H. Bearat, J. West

Surface Grafting of Chitosan-Coated Electrospun Fibers to Promote Cell Adhesion ...........................................................................326A. S. Goldstein, P. Vaidya, T. Z. Grove

A 3D Hydrogel Model of Tumor Angiogenesis to Study the Role of Vascular Cells in Tumor Progression .......................................327L. C. Roudsari, A. S. Witt, J. M. Kurie, J. L. West

Culture Platform to Assess the Effect of Hydroxyapatite Properties on Breast Cancer Cells ..............................................................328S. Choi, L. A. Estroff, C. Fischbach

Regulating Endothelial Cell Dynamics through Peptide-Encoded Material Compliance .....................................................................329R. M. Schweller, J. L. West

Biomimetic Fibrous Hydrogels with Aligned Hierarchical Structure Promote Biomineralization in Vitro........................................330A. Patel, V. Sant, S. Sant

Plastically Compressed Bioglass Incorporated Collagen Matrices for Orthopedic Applications .........................................................331G. Liu, M. B. Fenn, L. L. Hench, V. Kishore

Hyaluronic Acid Hydrogels that Emulate the Pro-osteogenic Niche Enhance the Osteogenesis of hMSCs ........................................332L. Bian, M. Zhu, Q. Feng

CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY 2 Biologically Inspired Scaffold Mimicking Trabecular Bone in a Rabbit Spinal Fusion Model ............................................................333

S. Minardi, B. Corradetti, F. Taraballi, M. Sandri, J. Van Eps, F. Cabrera, B. Weiner, A. Tampieri, E. Tasciotti

Reinforced Magnesium Phosphate Cement with Wet-spun PCL Fibers .................................................................................................334N. J. Ostrowski, V. Sharma, J. Ohodnicki, A. Roy, P. N. Kumta

Longitudinal Evaluation of Bioactive Strip Implanted into the Distal Condyle of New Zealand White Rabbits ...............................335Z. Tosun, G. Pomrink

Preparation and Characterization of Poly (hydroxybutyrate co hydroxyvalerate) Nanofibers Containing Sol-gel Derived Bredigite for Bone Regeneration Applications .............................................................................................................................336

M. Kouhi, M. Fathi, M. Shamanian, M. P. Prabhakaran, S. Ramakrishna

Release and Activity of Adenosine Incorporated Into Calcium Sulfate ...................................................................................................337E. C. Duncan, D. Carpenter, W. Haggard, J. A. Jennings

Reinforcement of Injectable Calcium Phosphate Cement by Gelatinized Starches ...............................................................................338L. Yang, H. Liu, Y. Guan, H. Yang, D. Wei, C. Gao

Hydroxyapatite-Titanium Composites with Outstanding Fracture Toughness and Cytocompatibility Properties for the Bone Tissue Engineering Applications ..................................................................................................................................................339

A. Kumar, M. Saxena, K. Biswas, B. Basu

Multifunctionality and Electrical Stimulation Induced Cellular Response of Hydroxyapatite-Barium Titanate Piezobiocomposite...........................................................................................................................................................................................340

B. Basu, A. K. Dubey, G. Thrivikraman

DRUG DELIVERY Selectively Decreasing Malignant Melanoma Cell Viability with Polymersomes Loaded with Protoporphyrin IX (PPIX) ..............................................................................................................................................................................................................341

M. Wang, B. Geilich, H. Homayoni, E. Ebong, T. Webster

Sustained Suppression of Mitochondrial Oxidative Stress using Curcumin conjugated Poly (β- Amino Esters) Nanogels...........................................................................................................................................................................................................342

P. Gupta, J. Z. Hilt, T. D. Dziubla, M. Mitov

Poly(Beta-Amino Ester) Nanoparticles for Selective and Combinatorial Delivery of siRNA to Brain Cancer...................................343K. L. Kozielski, H. Vaughan, B. H. Kim, S. Y. Tzeng, H. Guerrero-Cazares, A. Quinones-Hinojosa, J. J. Green

Photo-polymerized Keratin-PEG Sponge for Growth Factor Delivery in Bone Tissue Engineering ...................................................344R. De Guzman

ON-OFF Fluorescent Micelles as a Transdermal Drug & Vaccine Delivery System .............................................................................345D. Velluto

Modeling of Drug Release Kinetics from Porous Ceramic Disks..............................................................................................................346A. U. Joshi, H. P. Cherukuri, A. R. El-Ghannam

An Injectable and Thermosensitive Hydrogel Capable of Delivering Matrix Metalloproteinases 2 Inhibitor to Control Myocardial Remodeling ..................................................................................................................................................................347

Z. Fan, M. Fu, B. Zhang, Z. Li, X. Li, Y. Xu, J. Guan

Evaluation of Controlled Delivery of Carboplatin from a Poly-Ether-Ester Urethane System in a Murine Model...........................348D. R. Ingram, J. M. Olbrich, J. T. Corbett

ENGINEERING TISSUES INTERFACES Recapitulating the Architecture of Cells of Interest Using Cell-Derived, Biomimetic Patterning ........................................................349

J. H. Slater, J. C. Culver, B. L. Long, C. W. Hu, J. Hu, T. F. Birk, A. A. Qutub, M. E. Dickinson, J. L. West

Dose-Dependent Effects of CDA on Chondrocyte Response on Polymer-Ceramic Composite Scaffolds ............................................350M. K. Boushell, K. R. Caparino, H. H. Lu

Patterning Biochemical Signals into Nanofibrous Hydrogels to Spatially Control Cell Behavior........................................................351R. J. Wade, E. J. Bassin, W. M. Gramlich, J. A. Burdick

Mechanical Loading of 3D multi-Compartment Scaffolds for Spatial Control of hMSC Fate for Regeneration of Orthopedic Interfaces ....................................................................................................................................................................................352

W. K. Grier, S. R. Caliari, A. S. Moy, B. A. Harley

Cartilage Lubrication through Peptide-mediated Hyaluronic Acid Binding and Retention.................................................................353A. Singh, M. Corvelli, H. Jacobs, J. Elisseeff

Evaluation of Anterior Cruciate Ligament Insertion Site Fibrochondrocytes on Nanofiber Scaffolds ...............................................354D. Qu, H. Park, J. P. Zhu, H. H. Lu

Influence of Sparse Electrospun Fibers on the Differentiation of Mesenchymal Stem Cells in Collagen Gels ...................................355P. Thayer, E. Tong, N. Butler-Abisrror, A. Goldstein

Rotational Dual Chamber Bioreactor for Interfaced Engineered Tissue Models...................................................................................356R. F. Canadas, A. P. Marques, J. M. Oliveira, R. L. Reis

MOLECULAR MECHANISMS GOVERNING PROTEIN-SURFACE AND CELL-SURFACE INTERACTIONS Angiogenic Methacrylic Acid Copolymers Adsorb Different Proteins and Result in Lower Complement Activation in Comparison to Poly (Methyl Methacrylate)............................................................................................................................................357

L. A. Wells, H. Guo, A. Emili, M. V. Sefton

Factor XII Contact Activation Products Show Self-Inhibition .................................................................................................................358L. Xu, Y. Xu, E. A. Vogler, C. A. Siedlecki

Interfacial Segregation of PEG in Hydrophobic Polymers and Its Influence on Protein Adsorption ..................................................359N. S. Murthy, W. Wang, W. R. Lindemann, N. A. Anderson, D. Vaknin, J. Kohn

Influence of Chemical Additives on the Structure and Biological Activity of Proteins Pre-adsorbed on Material Surfaces Using an Improved Circular Dichroism Methodology ...............................................................................................................360

A. A. Thyparambil, Y. Wei, R. A. Latour

Molecular Insights into the Gel to Liquid-Crystalline Phase Transition of Phospholipid Bilayers ......................................................361L. Weng, G. D. Elliott

FXIIa Products Produced by Surface Contact Activation.........................................................................................................................362Y. Yan, L. Xu, C. A. Siedlecki

The Phosphoproteomics Landscape of the Interaction between Biomaterials and Cells .......................................................................363M. D. Chamberlain, L. Wells, A. Lisovsky, M. Sefton

Surface Design of Heparin-Functionalized Thermoresponsive Cell Culture Substrates for Maintaining Hepatic Functions and Harvesting Cultured Hepatocyte Sheets ............................................................................................................................364

J. Kobayashi, Y. Arisaka, K. Ohashi, K. Tatsumi, K. Kim, Y. Akiyama, M. Yamato, T. Okano

ADVANCED ANTIMICROBIAL MATERIALS 2 Assessment of Bacteriophage Activity in Poly(Ethylene Glycol) Hydrogels............................................................................................365

M. E. Díaz Ortiz, C. T. Johnson, A. J. García, M. A. Prieto, N. Dinjaski

Characterization of In-vitro Release of Gentamicin from Biodegradable Polymer Thin Films - Microstructure-Function Relationship by Confocal Raman Microscopy............................................................................................................................366

A. Pandey, D. Armbruster, L. Hughes, S. Nielsen, A. Mantz

Testing Leading to a “De Novo” (I.E., No Predicate) FDA Cleared Antimicrobial Wound Dressing ..................................................367C. Batich, G. Schultz, W. Toreki, J. Olderman, B. Mast, D. Moore, D. Mozingo, B. Liesenfeld

Silver Nanoparticle-Embedded Polymersome Nanocarriers for the Treatment of Antibiotic-Resistant Infections...........................368B. M. Geilich, A. L. Van De Ven, G. L. Singleton, S. Sridhar, T. J. Webster

Introduction of Antibacterial Function Into Biomedical TiNi Shape Memory Alloy by the Addition of Element Ag .......................369Y. F. Zheng

Examining the Amount and Form of Silver Release from Antimicrobial Medical Devices...................................................................370E. M. Sussman, P. Jayanti, B. J. Casey, B. J. Dair

Mitigation of MRSA Infection in Vivo by Dual Local Controlled Delivery of Anti-infective Agents...................................................371S. Bhattacharyya, H. Qu, N. Sheth, C. Knabe, P. Ducheyne

Bactericide Action of a Titanium Surface Biofunctionalized with a Novel Bioactive Glass ..................................................................372C. R. Chinaglia, L. A. Campanini, L. H. Pitaluga, N. S. M. Silva, C. W. O. Souza, O. Peitl, E. D. Zanotto

BIOMATERIALS FOR REGENERATIVE ENGINEERING 2 Improved Cellular Recruitment and Mass Transport for Large Bone Defect Regeneration ................................................................373

S. M. Tabbaa, A. Mlynarczyk, K. J. L. Burg

Accelerated Bone Regeneration of BMP-2 Loaded Hydroxyapatite Microspheres for Bone Filler Applications ..............................374J. Baek, H. Jung, T. Jang, S. W. Kim, M. Kang, J. Song, H. Kim

Optimization of Mesenchymal Stem Cells Performance on Biomimetic Ligament Scaffolds for ACL Regeneration .......................375X. Yu, P. Mengsteab, L. S. Nair, C. T. Laurencin

Anisotropic Network Formation of Neurons and Endothelial Cells in Engineered Muscle Tissue Construct ....................................376H. Takahashi, T. Shimizu, M. Nakayama, M. Yamato, T. Okano

VEGF-Functionalized Integrin-Specific Hydrogels for Increased Stem Cell Proliferation, Vascularization and Regeneration of Critically-sized Bone Defects ............................................................................................................................................377

J. R. Garcia, A. J. Garcia

Human Plasma Based Composite Muscle ECM Directs Adipose Derived Stem Cells to Vasculogenic and Myogenic Lineage.............................................................................................................................................................................................................378

A. Aurora, R. J. Christy, T. J. Walters, S. Natesan

DRUG DELIVERY 2 Local and Sustained Drug Delivery for the Treatment of Cavernous Nerves Post-Prostate Cancer Surgery ....................................379

R. Goyal, N. Patel, A. Salmasi, I. Kim, J. Kohn

Prolonged Delivery of a P2X7R Antagonist Using an Injectable Nanostructured Hydrogel Improves Bladder Function After SCI .........................................................................................................................................................................................380

I. K. Yazdi, A. Munoz, N. Taghipour, T. B. Boone, E. Tasciotti

Nanoparticle-Engineered Adipose-Derived Stem Cells Enhanced Migration towards Brain Tumors In Vivo ..................................381X. Jiang, C. Wang, F. Yang

Click-Chemistry Customizable Polyhydroxyalkanoate Nanoparticles for Drug Delivery.....................................................................382R. A. Bader, P. M. Choiniere, A. Levine, A. Pinto, C. T. Nomura

Avidity-Driven Targeting of a Novel Biohybrid Nanoscale Carrier Engineered for High Therapeutic Payload and Extended Release of Anticancer Drugs to Treat Small Cell Lung Cancer ..............................................................................................383

R. J. Whitener, K. A. Windham, J. Wower, M. E. Byrne

Nanoparticle Delivery of a Highly Toxic Metal Chelator to Cancer Cells...............................................................................................384Y. J. Kang, C. Kuo, S. Majd

Implications Towards Targeted Delivery of Pentagalloyl Glucose for Regenerating Elastin in Emphysematous Lungs................................................................................................................................................................................................................385

V. Parasaram, N. Nosoudi, N. Vyavahare

Targeted Delivery of Antioxidant-loaded Biodegradable Nanoparticles for Neuroprotection .............................................................386T. M. Brenza, S. Ghaisas, J. Vela-Ramirez, B. Kalyanaraman, V. Anantharam, A. Kanthasamy, B. Narasimhan

INNATE IMMUNITY AND INFLAMMATION IN BIOMATERIALS CONTEXTS Local IL-4 Delivery Increases Systemic Macrophage Trafficking and Prevents Bone-loss in a Mouse Model of Wear Particle Induced Osteolysis .................................................................................................................................................................387

J. Pajarinen, T. Sato, T. Lin, F. Loi, R. Zhang, C. Fan, Z. Yao, S. Goodman

Degradation Kinetics Determine Intrinsic Immune Activity of Rapidly Degradable Polycations........................................................388J. I. Andorko, C. M. Jewell

Characterization of the Immune Response Associated with Bone Regeneration Induced by Fibrinogen Implants...........................389D. M. Vasconcelos, C. R. Almeida, R. M. Gonçalves, I. Odila, M. I. Oliveira, N. Neves, A. M. Silva, A. C. Ribeiro, E. Seebach, K. L. Kynast, T. Niemietz, W. Richter, M. Lamghari, S. G. Santos, M. A. Barbosa

Combining Human Monocytes in Co-culture with Vascular Smooth Muscle Cells Enhances Vascular Tissue Production under Biomechanical Stimulation ............................................................................................................................................390

K. Battiston, R. Labow, C. Simmons, P. Santerre

PEEK Induces an Inflammatory Environment and Reduces Osteogenic Potential in Comparison to TiAlV ....................................391R. Olivares-Navarrete, S. L. Hyzy, S. Ortman, P. J. Slosar, P. Ullrich Jr., Z. Schwartz, B. D. Boyan

Biomimetic Approaches for Tissue Healing and Restoration....................................................................................................................392E. Tasciotti, F. Taraballi, B. Corradetti, S. Minardi, L. Pandolfi, F. J. Cabrera, C. Corbo, J. L. Van Eps, X. Wang, B. K. Weiner, S. Powell

Camouflaging PLGA Microspheres in a 3D Biomimetic Collagen Scaffold to Escape Macrophage Internalization.........................393S. Minardi, B. Corradetti, F. Taraballi, S. Powell, M. Sandri, B. Weiner, A. Tampieri, E. Tasciotti

Extracellular Matrix Coatings Decrease the Foreign Body Response to Silicon Microelectrode Arrays Chronically Implanted in Rat Motor Cortex ....................................................................................................................................................................394

R. S. Oakes, M. D. Polei, J. L. Skousen, M. B. Christensen, P. A. Tresco

NEXT GENERATION BIOMATERIAL AND DRUG DELIVERY TECHNOLOGIES FOR WOUND HEALING Syndesome-Based Alginate Dressings for Enhanced Wound Healing in a Diabetic Mice Model .........................................................395

S. Das, G. Singh, M. E. Martinez, A. K. Dunn, C. S. Wright, P. E. Martin, A. B. Baker

Enzymatically-Responsive Delivery of Pro-Angiogenic Peptides for Therapeutic Vascularization .....................................................396A. H. Van Hove, D. S. W. Benoit

Intravenously-Administered Polymers for Modulating Clot Properties and Inducing Hemostasis .....................................................397L. W. Chan, X. Wang, H. Wei, L. D. Pozzo, N. J. White, S. H. Pun

Microencapsulated Insulin-Producing Cells Accelerate Diabetic Wound Closure.................................................................................398A. Aijaz, R. Faulknor, F. Berthiaume, R. Olabisi, A. Parekh

Chitosan Based Hydrogels for Delivering Oxygen and Sequestering Reactive Oxygen Species in Wound Healing ..........................399P. Patil, N. D. Leipzig, N. Fountas-Davis, P. Joshi, H. Huang, L. Shriver

A Synergistic Polydiolcitrate-Copper Metal-Organic Framework Nanocomposite Improves Wound Healing .................................400J. Xiao, G. Ameer

MSC-Laden Anti-inflammatory Hydrogel Improving Wound Healing of Diabetic Skin Ulcer ...........................................................401M. Xing, S. Chen, J. Shi, L. Zhang

Mitigation of Hypertrophic Scar Contraction and Stiffening Via an Elastomeric Biodegradable Scaffold ........................................402E. R. Lorden, K. J. Miller, L. Bashirov, M. Ibrahim, E. Hammett, Y. Jung, M. A. Medina, A. Rastegarpour, M. A. Selim, K. W. Leong, H. Levinson

TISSUE ENGINEERING 2 Hydrogel-Electrospun Mesh Composite for Prevention of Anastomosis Leakage .................................................................................403

A. Kishan, T. Touchet, C. Whitfield, N. Cohen, E. Cosgriff-Hernandez

A Biomaterial Strategy for Treatment of Ulcerative Colitis......................................................................................................................404T. J. Keane Jr., S. F. Badylak, S. Shaffiey, D. Hackam, D. Nagle

An Engineered Protein Hydrogel for Promoting Neurite Growth ...........................................................................................................405K. J. Lampe

3D Printed Bone Scaffolds with Biomimetic Nanomaterials and Vascular Mimicking Microchannels...............................................406B. Holmes, K. Bulusu, M. Plesniak, L. G. Zhang

Isolating the Effect of Stiffness on Valvular Interstitial Cells and its Role in Phenotype Control........................................................407K. E. Coombs, E. L. Hedberg-Dirk, M. N. Rush, A. Leonard

A Bio-inspired Hybrid Nanosack for Pancreatic Islet Transplantation in the Omentum .....................................................................408P. Tj Hwang, D. Lim, S. Gilbert, L. Tian, A. Shalev, H. Jun

Development of Surface Modified Polymeric Conduits for Nerve Regeneration....................................................................................409M. Uz, A. D. Sharma, D. S. Sakaguchi, S. K. Mallapragada

Engineering Tendons Using Adult Stem Cells Seeded in Mechanostimulated HUV ..............................................................................410B. Engebretson, S. Bonhoure, Z. Mussett, V. Sikavitsas

VASCULAR AND BLOOD CELLS RESPONSES TO NOVEL CARDIOVASCULAR BIOMATERIALS Surface Modified Poly(Vinyl Alcohol) Vascular Grafts Maintain Hemocompatibility..........................................................................411

M. T. Hinds, D. E. J. Anderson, M. F. A. Cutiongco, E. K. Yim

Microgel-based Materials for Augmentation of Hemostasis in Neonatal Cardiac Surgery Patients....................................................412A. C. Brown, S. Saxena, K. Ahlstedt, B. Ahn, W. Lam, N. Guzzetta, T. H. Barker, A. Lyon

Glypisomes: A Novel Construct for Enhancing Angiogenic Activity of Delivered Growth Factors.....................................................413A. J. Monteforte, B. Lam, S. Das, C. S. Wright, P. E. Martin, A. Dunn, A. B. Baker

Interaction of Endothelial Cells and Smooth Muscle Cells with ePTFE and Electrospun PTFE .........................................................414S. Lamichhane, T. Remund, M. Larson, P. Kelly, G. Mani

A Platelet-Inspired Nanomedicine Approach for Targeted Thrombolytic Therapy ..............................................................................415C. Kos, K. Ravichandran, W. Li, C. Modery-Pawlowski, A. Sen Gupta

Contributions of Prekallikrein and High Molecular Weight Kininogen to the Intrinsic Pathway of Coagulation ............................416Y. Yan, A. Moyer, L. Xu, C. A. Siedlecki

ACADEMIC-INDUSTRY COLLABORATIONS IN BIOMATERIALS RESEARCH Accelerated Thermoplastic Polyurethane Hydrolytic Stability Screening ..............................................................................................417

D. K. Dempsey, N. Aumsuwan, H. Swen, J. Zupancich, P. Gray, T. Touchet, E. Cosgriff-Hernandez, C. P. Chawla

Reversible Dose-Based Drug Release Mediated by Azobenzene/?-Cyclodextrin Complexation to Study Myofibroblast Activation...............................................................................................................................................................................418

E. M. Nehls, A. M. Rosales, K. S. Anseth

ADVANCED ANTIMICROBIAL MATERIALS Antimicrobial-tolerant Bacterial Biofilms Are Inhibited by Sharklet Microtopography ......................................................................419

E. E. Mann, M. C. Drinker, M. R. Mettetal, S. T. Reddy

Ultrasmall Gold Nanoparticles As Bactericidal Agents Against Planktonic and Biofilm Enveloped Staphylococci ..........................420S. K. Boda, U. Simon, B. Basu, W. Jahnen-Dechent

Multifunctional Peptides for Infections Free Implant Surfaces ................................................................................................................421D. Khvostenko, K. Boone, S. Vanoosten, D. Yucesoy, J. Ferracane, H. Davis, J. Mitchell, P. Arnold, C. Tamerler

ADVANCED ANTIMICROBIAL MATERIALS 2 Micro-Arc Oxidation Treatment for Improvement of Antibacterial Property of Titanium .................................................................422

Y. Tsutsumi, N. Niizeki, P. Chen, M. Ashida, H. Doi, K. Noda, T. Hanawa

Detachable Polymeric Films for Applications in Drug Delivery ...............................................................................................................423S. Gates, A. Shukla

PEO-Tethered Peptides for Capture of Circulating Bacteria and Endotoxin in Sepsis.........................................................................424K. F. Schilke, R. Raman

Synthesis of Zwitterionic Sol-Gel Films to Prevent Bacterial Adhesion ..................................................................................................425H. Qu, R. Moya, P. Ducheyne

Antimicrobial Nanotextured Dental Implant Surfaces Against Porphyromonas Gingivalis.................................................................426A. Au, S. Patel, W. Li, C. Wu, C. Sukotjo, T. Shokuhfar

ADVANCED HYDROGELS WITH HIERARCHAL STRUCTURES FOR BIOLOGICAL APPLICATIONS Hierarchical Macroporous Multifunctional Hydrogel Formation Via Thermally-induced Phase Separation for Neuronal Regeneration ..................................................................................................................................................................................427

S. Tang, B. Wing, E. Morin, S. Goddard, W. He

PEG/Poly(Acrylic Acid) Semi-IPN Hydrogels for Post-Synthesis Electrostatic Antibiotic Loading and Controlled Release .............................................................................................................................................................................................................428

Y. Wu, M. Libera

Chitosan-Containing Bioadhesive Hydrogels as Hemostatics ...................................................................................................................429Y. Koyama, S. Yamaguchi, Y. Kurachi, M. Eriguchi, T. Ito

Characterization of a Multi-Functional Tetronic Surgical Adhesive Containing Chitosan for Soft Tissue Applications.....................................................................................................................................................................................................430

L. Sanders, K. Webb, T. Mefford, J. Nagatomi

Robust Approaches to Interface External Tubing to Freestanding Microfluidic Hydrogels ................................................................431S. Faley, B. Baer, T. Larsen, L. M. Bellan

Photopatterning Hyaluronic Acid into Mechanically Robust Hydrogels Based on Melt-Assembled Networks of Sphere-Forming Block Copolymers .............................................................................................................................................................432

J. T. Lewis, T. S. Bailey

Thermoreversible Scaffolds Improve Transient Three-dimensional Culture by Facilitating Rapid Cell Recovery ..........................433J. M. Heffernan, D. J. Overstreet, S. Srinivasan, B. L. Vernon, R. W. Sirianni

Enzyme Resistance and Mechanical Stability of Genipin-Crosslinked Films .........................................................................................434A. Iftikhar, M. Cramer, C. Bettinger

High-Throughput Drop-Based Microfluidics To Prepare Stable Agarose Hydrogels ...........................................................................435E. Davé, C. Muus, D. A. Weitz

ADVANCES IN PROGRAMMABLE BIOMATERIALS FOR DRUG DELIVERY AND REGENERATIVE MEDICINE PLGA-Porous Silicon Composite Microspheres: Optimization Insights of a Double Controlled Release Platform for Tissue Engineering Applications ............................................................................................................................................................436

L. Pandolfi, S. Minardi, F. Taraballi, L. Xaewu, E. Tasciotti

Gamma Irradiation-Controlled Burst Release Of Curcumin From Chitosan to Counteract Radiation Damage ..............................437R. Chauhan, M. J. Graves, B. Nunn, A. Akalkotkar, R. S. Keynton, P. A. Soucy, M. G. O'Toole

Elastin-like Polypeptide Microspheres: A Stimuli-Responsive Vehicle for Controlled Drug Delivery ................................................438Aniket, N. Tang, J. Rosenberg, A. Chilkoti, D. Needham

Examination of Radio-opacity Enhancing Additives in Shape Memory Polyurethane Foams .............................................................439A. C. Weems, J. E. Raymond, T. Gustavson, K. T. Wacker, B. Keller, K. L. Wooley, D. J. Maitland

pH Responsive Nanoparticles-in-Microparticles System for Oral Delivery of siRNA ...........................................................................440L. E. Strong, J. M. Knipe, N. A. Peppas

Self-Assembly of Heterochiral Peptides with Varied Sequence Patterns.................................................................................................441A. Koyfman, R. Appavu, S. Sheller, J. Rudra

Differential Rates of Oxanorbornadiene-Mediated Drug Tethering and Release from Thiolated Nanoparticles ..............................442A. Schudel, C. Higginson, M. Bellavia, M. Finn, S. N. Thomas

BASIC SCIENCE PROGRESS AND CLINICAL APPLICATIONS OF MULTI-FUNCTIONAL BIOMATERIALS: A FOCUS ON MULTI-DRUG BIOMATERIALS AND DEVICES Design, Fabrication and Functional Evaluation of Textile Packing Material for Tissue Debridement ...............................................443

Y. Fu, S. Tao, L. Wang, M. W. King

BENCHTOP MODELS TO SUPPORT MEDICAL DEVICE AND PHARMACEUTICAL INVENTION AND COMMERCIALIZATION Neck Impingement Testing of a Novel Hard on Hard Hip Bearing..........................................................................................................444

D. Rister, A. Parikh

Novel UKR Micromotion Assessment Method Utilizing Optical Measurement Techniques in Correlation with Finite Element Analysis .................................................................................................................................................................................445

R. Davignon, A. Gopalakrishnan, G. Yildirim

BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) Effects of 3D Modeling Parameters on Dimensional Accuracy of 3D-Printed Anatomical Structure .................................................446

K. Ogden, C. Aslan, G. Tillapaugh-Fay, D. D. Diallo, N. O. Ordway, P. Soman

Automatic Filter Layer-by-Layer Coating System for Construction of iPS-Derived 3D Tissues by Cell Accumulation Technique ...............................................................................................................................................................................447

D. Takagi, S. Kamono, Y. Amano, M. Matsusaki, S. Miyagawa, M. Akashi

BIOFABRICATION AND BIOMANUFACTURING IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE (TERM) 2 Polymer-Based “Glue Scaffold” with Nanometer-Sized Extracellular Matrix Films for Tissue Engineering ....................................448

N. Uchida, S. Sivaraman, N. Amoroso, W. Wagner, A. Nishiguchi, M. Matsusaki, M. Akashi, J. Nagatomi

Engineering Alginate As Bioink for Bioprinting.........................................................................................................................................449Y. Mei, J. Jia, D. J. Richards, S. Pollard, Y. Tan, J. Rodriguez, R. P. Visconti, T. C. Trusk, M. J. Yost, H. Yao, R. R. Markwald

Highly Moldable 3D Nanofibrous Elastomeric Scaffolds with Enhanced Mechanical Properties........................................................450S. Lee, W. Choi, J. Jang

3D Printing of Bone-Templated Scaffolds ...................................................................................................................................................451S. J. Fernando, J. A. Sterling, S. A. Guelcher

Bioengineering an Artificial Ovary with 3D Printing ................................................................................................................................452A. L. Rutz, M. M. Laronda, K. A. Whelan, T. K. Woodruff, R. N. Shah

Perfusable 3D Microchannel Networks Made From Sacrificial Fibers Increase Cell Viability in Gelatin Scaffolds .........................453X. Wang, S. Faley, B. Baer, D. Bird, L. M. Bellan

Biofabrication of Tissue Constructs for Craniomaxillofacial Reconstruction ........................................................................................454C. Kengla, Y. J. Seol, H. Kang, J. J. Yoo, A. Atala, S. J. Lee

Fabrication of Multi-Material Tissue Scaffolds via Additive Manufacturing .........................................................................................455N. A. Chartrain, A. R. Schultz, M. Price, T. E. Long, C. B. Williams, A. R. Whittington

Using Electric Fields to Introduce Pores in Bacterial Cellulose Scaffolds for Tissue Engineering .......................................................456A. Rolong, P. Gatenholm, R. V. Davalos, A. Baah-Dwomoh

Exploring Methods for Controlling the Quality of Random and Aligned Electrospun Nanofibers .....................................................457C. F. Rediguieri, P. A. De Bank, G. L. B. Araujo, T. J. A. Pinto

Hybrid Scaffold-reinforced Extracellular Matrix Hydrogels for Cartilage Tissue Engineering ..........................................................458S. Sonnenberg, M. A. Taylor, L. Mellor, S. Mehendale, R. Shirwaiker, E. Loboa

Development of 3D Printed Hydrogel Scaffold with Core-shell Nanoparticles for Nerve Regeneration .............................................459S. Lee, W. Zhu, L. G. Zhang

BIO-INSPIRED CELLUAR MICROENVIRONMENTS In Vitro Tumor Intravasation Assays Using 3D-Human Blood- and Lymph-Capillary Models ..........................................................460

A. Nishiguchi, M. Matsusaki, M. Akashi

Induction of Intrafusal Muscle Fibers from Human Satellite Cells and Their Innervations by Human Stem Cell-derived Sensory Neurons ...............................................................................................................................................................................461

X. Guo, A. Colon, C. Martin, H. Vandenburgh, J. Hickman

The Correlation Between Substrate Stiffness and TGF-β1-Induced Hepatic Stellate Cell Activation.................................................462J. Narang, C. Lemmon, S. Marampudi

High Throughput Screening Format Identifies Synthetic Mimics of Matrigel for Tubulogenesis Screening .....................................463E. H. D. Nguyen, W. T. Daly, D. G. Belair, N. N. Le, W. L. Murphy

Material Properties and Differentiation Potential of Collagen-II Based 3D Microbeads for Cartilage Tissue Engineering .....................................................................................................................................................................................................464

R. Tiruvannamalai-Annamalai, D. Mertz, E. Daley, J. Stegemann

Effects of Preparation Condition of Tumor Cell-derived Matrices on Chemoresistance ......................................................................465T. Hoshiba, M. Tanaka

Dynamic Topographical Imprinting of Cellular Substrates......................................................................................................................466M. Ali, J. B. Shear

High Resolution Silica Tissue Replica As Cell Culture Scaffold for the Differentiation of Human Mescenchymal Stem Cells ........................................................................................................................................................................................................467

S. W. Tang, F. Lv, V. Leung, Y. W. Lam

Design of Facile and Tunable Hydrogels to Understand the Microenvironment’s Role in Breast Cancer Recurrence.....................468L. A. Sawicki, A. M. Kloxin

BIOLOGICALLY DERIVED MATERIALS FROM NATURAL SOURCES Aligned 3D Amino Acid Nanofiber Biomaterials........................................................................................................................................469

B. Li, X. Wang

Engineered Collagen-Mimetic Proteins for Wound Healing .....................................................................................................................470M. B. Browning, B. Russell, J. Rivera, M. Hook

Modular Gelatin Hydrogels Formed by Orthogonal Thiol-ene Photochemistry for 3D Hepatocyte Culture .....................................471T. Greene, C. Lin

Mechanical-stress Assisted Modulation of the Properties of Temperature-responsive Cell Culture Surface .....................................472Y. Akiyama, M. Matsuyama, N. Takeda, M. Yamato, T. Okano

Bioactive Modification of End-functionalized Multi-arm Poly(ethylene glycol) Affects Macroscopic Properties and Cellular Behavior............................................................................................................................................................................................473

J. Kim, S. M. Niedzielski, R. Singh, A. J. Putnam, A. Shikanov

Development of a Tissue Specific Acellular Extracellular Matrix for Intervertebral Disc Regeneration Using a Gentle Decellularization Process...................................................................................................................................................................474

R. A. Wachs, A. Hyyti, R. C. Cornelison, C. E. Schmidt

Acellular Collagen-Hydroxyapatite Scaffolds Support Osteoinduction After Subcutaneous Ectopic Implantation..........................475M. J. Meagher, H. E. Weiss-Bilka, D. R. Wagner, R. K. Roeder

In Vitro Cytocompatibility Study of Nanocellulose ....................................................................................................................................476L. Huang, Y. Lu, S. Ozcan, W. He

Optimization of Alginate Templated Polypyrrole Composites for Tissue Engineering Scaffolds.........................................................477C. J. Wright, B. Zhang, C. Yore, T. Pannell, T. W. Hanks

Characterization of Chitosan and the Effects of Cleaning ........................................................................................................................478J. D. Bumgardner, O. Jenkins, T. Martin, G. McGraw, W. O. Haggard

Decellualrized Cow-derived Diaphragm ECM Scaffold for Tissue Engineered Diaphragm ................................................................479H. Yi, Y. Zhang, L. Xue, B. Yang, G. Niu, Y. Zhang, A. Atala

Diffusion-Reaction Models of Genipin Incorporation into Fibrin Networks ..........................................................................................480M. Cramer, A. Iftikhar, C. Bettinger

Fabrication of Biodegradable β-TCP Scaffolds Using Natural Biogenic Magnesian Calcite Skeletons ...............................................481X. Zhang, L. Yang, L. Cao, W. Cui, Z. Guo, Y. Bai, R. Yang

Electrospun Chitosan Fibers for Insulin Delivery ......................................................................................................................................482M. G. Lancina III, L. Xu, N. D. Sheybani, H. Yang

BIOMATERIALS EDUCATION Modeling Biomaterial Research for Middle School Science Teachers .....................................................................................................483

C. Nelson, N. Bhattarai, S. Rahman, N. Rijal

Assessment Modality for Biomaterial Education Outreach to Improve Pedagogical Methods ............................................................484C. J. Gehrmann, G. S. McGraw, G. Schreyack, J. A. Jennings

Biomaterials Research Projects for Undergraduate Students: Exploring the Correlation between Silk Fibroin Protein Aggregation and Intrinsic Fluorescence.........................................................................................................................................485

S. Alibeik, P. Valverde, C. Bennett

BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Inter-species Variation in the Decellularization of Aortic Valves .............................................................................................................486

M. C. Vedepo, E. E. Buse, M. Armstrong, M. Detamore, G. L. Converse, R. A. Hopkins

Mechanical and Biological Evaluation of Small Diameter Blood Vessels with Weft-Knitted and Electrospun Bilayer Structure ............................................................................................................................................................................................487

M. W. King, Y. Xie, S. Kim, R. M. Hanel

Biomaterial Topography Promotes Endothelial Cell Migration via Disrupted VE-Cadherin Signaling.............................................488S. Mascharak, P. Benitez, S. Heilshorn

Stromal Cell-Derived Factor-1a Releasing Metallic Stent for Accelerated Re-endothelialization Mediated by Mobilization and Recruitment of Endothelial Progenitor Cells................................................................................................................489

S. N. Kang, Y. K. Joung, D. K. Han

In Vivo Assessment of Engineered Cardiac Patches for Repairs of Congenital Heart Defects .............................................................490J. G. Jacot, S. Pok, S. Igor, C. Tsao, A. Annapragada

Functional Materials: Functionalization of Ultrabithorax Materials with Vascular Endothelial Growth Factor Enhances Primary Human Endothelial Cell Survival and Activation .....................................................................................................491

D. W. Howell, C. Duran, S. Tsai, S. E. Bondos, K. J. Bayless

Preparation and Physical Properties of a Small Diameter Decellularized Vascular Graft Covered with Electrospun Fibers ...............................................................................................................................................................................................................492

T. Kimura, H. Morita, P. Wu, N. Nakamura, K. Nam, T. Fujisato, A. Kishida

BIOMATERIALS FOR REGENERATIVE ENGINEERING Human Recombinant Chimeric Protein COMP-Ang1 Promotes Angiogenesis and Bone Regeneration in a Rat Mandible Bone Defect Model ........................................................................................................................................................................493

G. Bhattarai, S. B. Poudel, S. Kook, J. Lee

Engineered Polycaprolactone-magnesium Hybrid Porous Scaffold for Bone Regeneration .................................................................494K. W. K. Yeung, H. Wong, P. Chu, K. D. K. Luk, K. M. C. Cheung

Mechanical Improvement of Hyaluronic Acid (HA) Hydrogels and Incorporation of Polyethylene Glycol (PEG) ...........................495H. Lee, S. Jeong, J. Baek, J. Song, H. Kim

PCL Reinforcement of a Mineralized Collagen-GAG Scaffolds for In Vivo Implantation ...................................................................496D. W. Weisgerber, K. Erning, C. Flanagan, S. Hollister, B. A. Harley

Biodegradable Magnesium-Polymer Composite for Enhanced Corrosion Resistance and Mechanical Strength ..............................497D. Y. Shin, M. Kang, S. Kim, J. Song, H. Kim

Optimizing Mesenchymal Stem Cell Wound Healing Properties on Electrospun Silk with Selenium Nanoparticles........................498S. Chung, M. Stolzoff, P. Tran, B. Ercan, T. J. Webster

The Effect of Collagen Vitrigel Nanostructure on Stem Cell Derived Retinal Pigment Epithelial Maturation ..................................500X. Wang, J. Maruotti, J. Roman, H. Mao, D. J. Zack, J. H. Elisseeff

Microporous Biopolymer Cell Carriers Prepared by Microfluidic Device for Tissue Engineering .....................................................501J. Park, H. Lee, C. Han, H. Kim

Magnetite-doped Organic-inorganic Nanocomposite Scaffolds Stimulate Bone Cell Functions ..........................................................502J. Kim, K. Dashnyam, M. Kim, R. Perez, E. Lee, S. Seo, H. Kim

PEGylated Poly(Ester Amide) Elastomers with Tunable Physico-chemical, Mechanical and Degradation Properties ........................................................................................................................................................................................................503

Y. Xue, A. Patel, V. Sant, S. Sant

Feasibility of Novel Injectable Calcium Phosphate Cements Formulated with Bioactive Nanocomponent ........................................504S.-H. Shin, E.-F. Ahmed, R. Perez, D.-Y. Won, J.-H. Kim, S.-J. Seo, H.-W. Kim

Capturing Tissue Microenvironment on a Click-chemistry Based Biodegradable Polymer Membrane .............................................505C. Wang, J. Yang, W. P. Yau, Y. W. Lam, W. K. Yeung

Decellularized Lung Extracellular Matrix Electrospun with Poly-L-Lactic Acid for Tissue Engineering ..........................................506B. M. Young, R. A. Pouliot, B. A. Blakeney, B. P. Allen, G. E. Schreyak, R. L. Heise

Air-brushed Poly-DL-Lactic Acid Fiber Mats with Controllable Degradation for Tissue Engineering Applications .......................507W. Tutak, A. Behrens, J. E. Seppala, P. Kofinas, N. Hotaling

pH-Dependent Degradation of Poly(β-amino ester) Hydrogels ................................................................................................................508A. J. Chen, D. Puleo

BIOMATERIAL-TISSUE INTERACTION Modeling of Chronic Ventral Hernia in Rabbit ..........................................................................................................................................509

G. T. Hilas, M. S. Taylor, T. A. Pruitt, J. T. Corbett

PLLA Coated WE43 Magnesium with a Hydroxyapatite Interlayer for Enhanced Adhesion and Corrosion Resistance ........................................................................................................................................................................................................510

M. Kang, S. Kim, H. Kim, M. Diez

Clinical Biostability of Poly(Carbonate Urethane) Insulation in Neurostimulation Leads ...................................................................511G. Gallagher, C. Jenney

Medical Device Retrieval Programme : An Indian Initiative....................................................................................................................512J. Joseph, C. V. Muraleedharan, V. Ramanathan, A. Sabareeswaran, M. Mohanty

Bisphosphonate-Conjugated NIR Fluorophores for Bone-Specific Targeting and Imaging .................................................................513K. A. Nasr, S. L. Gibbs, H. S. Choi, K. Bao

Pore Formation Mediated by Polysaccharide Incorporation for 3D Skeletal Myotube Formation .....................................................514M. Rich, M. K. Lee, N. Marshall, J. Chen, Z. Mahmassani, M. Boppart, H. Kong

In Vivo Performance of Gellan Gum-based Structures: a Comparison Study Between Hydrogels and Spongy-like Scaffolds for Osteochondral Tissue Regeneration ......................................................................................................................................515

R. F. Canadas, D. R. Pereira, J. Silva-Correia, C. Viegas, A. Da Silva Morais, R. A. Sousa, A. P. Marques, R. L. Reis, J. M. Oliveira

Controlling Nano-Ferrofluid Permeability with Surface Engineering and Their Future Applications ...............................................516D. Shi, L. Sun, G. Mi, S. Bhattacharya, S. Nayar, T. Webster

Evaluation of Magnesium Alloys for Tracheal Stent Application ............................................................................................................517P. Saha, B. Lee, T. Yang, J. Waterman, T. Gilbert, P. Hebda, P. Kumta, J. Wu

Development of a Semi-Laparoscopic Cecal Abrasion Model for Peritoneal Adhesions in a Rat ........................................................518S. Mayes, S. Zawko, J. Ali, D. Peterson

Development of Tailored Bionanocomposites for Applications in Skin Tissue Regeneration ...............................................................519Y. S. Miranda Alarcón, A. M. Brown, I. A. Banerjee

Biocompatibility of the Intellirod System in an Ovine Posterior Lumbar Fusion Model ......................................................................520N. Russell, C. Christou, C. Tan, T. Wang, M. P. Pelletier, R. Eberle, W. R. Walsh

BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING Fluorenylmethyloxycarbonyl-based Peptide-Chitosan Hybrid Scaffolds for Potential Applications in Cartilage Tissue Regeneration .......................................................................................................................................................................................521

S. M. Romanelli, G. A. Knoll, I. A. Banerjee

ECM-mimic Coating of Biopolymer Scaffolds to Promote Bone Regeneration ......................................................................................522J.-E. Won, M.-H. Kim, H.-W. Kim

Biomimetic Collagen-Phosphorylcholine Hydrogels as Corneal Implants for High Risk Patients.......................................................523M. Islam, O. Buznyk, N. Pasyechnikova, M. Ljunggren, K. Meek, P. Lewis, S. Hayes, S. Iakymenko, J. Phopase, E. Alarcon, K. Merrett, W. Liu, P. Fagerholm, M. Griffith

Osteoblast Cellular Functions on Electron Beam Melting (EBM) Printed 3DTitanium Foam Structures as a Function of Porosity .......................................................................................................................................................................................524

K. Nune, D. Misra, L. Murr, S. Gaytan

Interpenetrating Collagen-Fibrin Hydrogels for Skeletal Muscle Regeneration ....................................................................................525S. Stagg, B. Pollot, C. R. Rathbone, A. Ong, T. Guda

BIOMIMETIC MATERIALS FOR TISSUE ENGINEERING 2 Poly(ε-Caprolactone)/Gelatin Composite Electrospun Scaffolds with Porous Crater-like Structures for Tissue Engineering .....................................................................................................................................................................................................526

P. T. J. Hwang, R. Huiszoon, J. Ng, K. Murdock, G. Alexander, D. Lim, H. Jun

Characterizing Natural Hydrogel for Reconstruction of Three-dimensional Lymphoid Stromal Network to Model T-cell Interactions...........................................................................................................................................................................................527

J. Kim, B. Wu, S. Niedzielski, M. Hill, R. Coleman, A. Ono, A. Shikanov

Modulating MMP-2 Expression in HUVECs using PEG-conjugated Biomolecules ..............................................................................528J. A. Hammer, R. M. Schweller, J. L. West

In Situ Forming Gelatin-Poly(Ethylene Glycol)-Tyramine Hydrogels via Dual Enzyme of Horseradish Peroxidase and Gluose Oxidase ........................................................................................................................................................................................529

B. Y. Kim, J. W. Bae, K. D. Park

A Biomimetic Hydrogel Matrix Facilitates Evaluation of Cancer-associated Fibroblast Contributions to Tumor Angiogenesis ....................................................................................................................................................................................................530

S. Ali, J. L. West

Adhesive Peptide Sequences Regulate Valve Interstitial Cell Phenotypes and Collagen Deposition ...................................................531Y. Wu, K. J. Grande-Allen, J. L. West

Perfusable Biomimetic Scaffolds within Microfluidic Devices ..................................................................................................................532N. K. Virdone, N. A. Vera-Gonzalez, M. P. Cuchiara, J. L. West

Biomimetically Enhanced Demineralized Bone Matrices ..........................................................................................................................533S. Ravindran

Synthesis and Characterization of Chitosan Based Composite Scaffolds for Bone Tissue Engineering ..............................................534U. Adhikari, N. Bhattarai, N. Rijal, D. Pai

Optimizing Decellularization Detergents for Meniscus-derived Injectable Hydrogel............................................................................535J. Wu, Q. Ding, A. Dutta, Y. Hong

Hydrogels with Gradient Niche Cues Enhance Cartilage Regeneration with Zonal Organization ......................................................536F. Yang, D. Zhu

Optimization of Skeletal Myocyte Expansion for Potential Use in Cell Therapy for Stress Urinary Incontinence............................537Y. Hu, Y. Zhang, D. Zhang, H. Yi, Z. Wang, Y. Zhao, J. Yoo, A. Atala

Nano-hybrid Gel Scaffold for Biopharmaceuticals Delivery and Soft Tissue Engineering ...................................................................538H. Tan, M. Fan

BIO-NANOMATERIALS FOR CANCER THERANOSTIC TREATMENT Enhanced Radiation Therapy with Gold Nanoparticle-Loaded Multilayer Microdisks........................................................................539

A. D. Paro, P. Zhang, Y. Qiao, J. Xia, J. Guan, L. Ma, M. Su

Synthesis of Cobalt Crosslinked Albumin Nanoparticles and In Vitro Evaluation of Macropinocytic Uptake in Gastric Carcinoma Cells................................................................................................................................................................................540

R. J. Cavazos Jr., C. Morrison, J. Lampe, D. Nguyen, A. Harris, B. McFarlin, R. Petros

Biodegradable Thermal-Responsive Dual-Imaging Enabled Nanoparticles ...........................................................................................541Z. Xie, P. Jadeja, J. U. Menon, D. Thakore, N. Pandey, J. Yang, K. T. Nguyen

Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy .....................................................................................................................................................................542

J. Chen, Y. Bi, H. Gao, A. Lan, Y. Hu

BIOSENSING AND COMPLEX TISSUE REGENERATION Chemical Synthesis of Amine and Carboxyl Functionalized Polypyrrole Nanoparticles and Covalent Attachment of Antibody for Biosensing ............................................................................................................................................................................543

J. Mao, Z. Zhang

Functionalization of Gold Nanostars Sensors through Engineered Peptides for Bacterial Detection ..................................................544H. Yazici, T. J. Webster

A New Method for Molecular Detection and Identification in a Metallic Nanopore..............................................................................545S. Bearden, G. Zhang

Active Microrheology of Magnetically-aligned Fibrin Gel to Measure Stiffness Anisotropy................................................................546M. Keating, S. Riemenschneider, E. Botvinick, R. Tranquillo

Biocompatibility Evaluation of Skin-wearable Silver Nanowire Based Hydration Sensors ..................................................................547M. G. McCord, H. Ma, Y. Zhu

CARBON NANOMATERIALS 3D-Printed High-Content Graphene Composites for Tissue Engineering...............................................................................................548

R. N. Shah, A. E. Jakus, A. L. Rutz, S. W. Jordan

ATP-Responsive Hybrid DNA/Graphene Nanoassemblies for Anticancer Drug Delivery....................................................................549W. Sun, R. Mo, T. Jiang, Z. Gu

CARDIOVASCULAR BIOMATERIALS Cellular Responses of Smooth Muscle Cell to Zinc Ion..............................................................................................................................550

J. Ma, N. Zhao, D. Zhu

The Effects of Extracellular Magnesium Ion on Smooth Muscle Cells ....................................................................................................551J. Ma, N. Zhao, D. Zhu

Recapitulation of Myocardial Infarction Coupled with Patient-Specific iPSC-Derived Cardiomyocytes for Characterization of Chromosomal Mutation 9p21.....................................................................................................................................552

A. Kumar, K. P. Tenerelli, W. Ferguson, V. Lo Sardo, K. K. Baldwin, E. J. Topol, A. J. Engler

Biodegradable Polymer-Coated Drug-Eluting Stents with Improved Coating Stability Using Biodegradable Nano-Brushes.............................................................................................................................................................................................................553

T. M. I. Bedair, Y. Cho, Y. K. Joung, D. K. Han

Impacts of Manufacturing Processes and Temperature on the Water Absorption of a Siloxane-Based Polyurethane .....................554G. Gallagher, C. Jenney

Performance of OptimTM Insulation in an Accelerated In Vitro Model of Environmental Stress Cracking.......................................555A. Padsalgikar, G. Gallagher, E. Tkatchouk, C. Iacob, J. Runt

Image Modalities to Visualize Polyester Fabric in Endovascular Stent Grafts.......................................................................................556T. Yao, K. Mathews, I. Robertson, D. S. Lalush, L. W. Tse, G. Soulez, M. W. King

Characterization and Preparation of Bio-Tubular Scaffolds for Fabricating Artificial Vascular by Combining Electrospinning and 3D Printing System .....................................................................................................................................................557

S. J. Lee, D. N. Heo, Su A Park, I. K. Kwon

Suppression of Abdominal Aortic Aneurysms Using Targeted Nanoparticles That Deliver an MMP Inhibitor ...............................558A. N. Chowdhury, N. Nosoudi, N. Vyavahare

Heparin-mimicking Reverse Thermal Gel for the Treatment of Myocardial Ischemia.........................................................................559M. Laughter, B. P. Castellanos, D. J. Lee, A. L. Nelson, J. R. Bardill, D. Park

Microporous Textured Exterior Biointerface Prevents Stenosis in Arteriovenous Grafts ....................................................................561A. J. Marshall, A. Oda, B. Scanlan, M. G. Maginness

CELLS AND THEIR MICROENVIRONMENT: TRANSLATIONAL SCIENCES Pulsed Electrical Stimulation Activates Fibroblast Migration, Collagen Contraction, A-smooth Muscle Actin Expression and Smad 2/3 Phosphorylation .................................................................................................................................................562

M. Rouabhia, Z. Zhang, Y. Wang

Anisotropy Increases Myogenic Regulatory Factors and Regenerates Skeletal Muscle ........................................................................563M. J. McClure, D. J. Cohen, Y. C. Huang, M. Sunwoo, B. D. Boyan, B. D. Boyan, Z. Schwartz, Z. Schwartz

CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY Effect of Crystal Lattice Modification of a-Cristobalite on Drug Adsorption and Release Kinetics ....................................................564

C. J. Trujillo, A. El-Ghannam

Development of Standardized Test Method for Evaluation of Nano-Crystalline Hydroxyapatite Forming Ability of Orthopedic, Dental and Craniofacial Device Materials .............................................................................................................................565

S. Brittain, P. Petrochenko, A. Kaiser, J. Johnson, L. Lo, J. Moreno, G. Kumar, A. Kaiser

Inkjet-printed Alumina Pattern for Improvement of the Activity of Periodontal Ligament Cells.......................................................566J. Kang, M. Lee, W. Seo, S. W. Lee, H. Choi

Effect of Coating and Pre-coating Techniques on the Compressive Strength of Fluorapatite Glass-ceramic Scaffolds...........................................................................................................................................................................................................567

O. Goudouri, J. Harless, I. Denry

Hydroxyapatite-PLGA-collagen Biomaterial for Bone Regeneration......................................................................................................568D. B. Bhuiyan, R. Tannenbaum, J. C. Middleton, T. Wick

MgO Nanoparticles Enhance Cell Functions and Reduce the Adhesion of Staphylococcus aureus on Hydroxyapatite-PLLA Nanocomposites for Orthopedic Tissue Engineering Applications ..................................................................569

D. J. Hickey, T. J. Webster

Fabrication and Characterization of Collagen/Apatite Scaffolds with Intrafibrillar Mineralized Collagen Fibers...........................570M. Wei, C. Hu

Cell Activity on the Alumina Microgroove Fabricated by Micro-molding Process................................................................................571J. Kang, S. Kim, M. Lee, W. Seo, S. W. Lee

CERAMICS AND COMPOSITES IN BONE TISSUE ENGINEERING AND DRUG DELIVERY Poly (Octanediol Citrate)/gallium-containing Bioglass Microcomposite Scaffolds.................................................................................572

E. Zeimaran, S. Pourshahrestani, I. Djordjevic, B. P. Murphy, N. A. Kadri, M. R. Towler

In-Vivo Performance of a Novel Bioabsorbable Suture Anchor in a Rabbit Femoral Model ...............................................................573O. Ortiz, K. Lahteenkorva

CHARACTERIZATION OF MICROENVIRONMENT OF IMMUNE CELLS IN WOUND HEALING M(IL-4) and M(IL-10) Induced Alterations in Gene and Protein Profiles of Rodent Wound Macrophages ......................................574

G. Bajpai, J. M. Durdik, J. Stenken

DELIVERY OF NUCLEIC ACIDS AND OTHER MOLECULES THAT MODULATE GENE EXPRESSION DNA Complex Release System by Injectable Auto-forming Alginate Gel Including Amorphous Calcium Phosphate .....................575

T. Ito, Y. Koyama

Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nano-Formulations...............................576T. A. Werfel, M. Miteva, C. Duvall

Surface Mediated Polymer Electrolyte and Nanostructured Calcium Phosphate Composite (NanoCaPs) Layers: Novel Approach to Non-Viral Gene Delivery ..............................................................................................................................................577

S. Shekhar, A. Roy, P. N. Kumta

Engineered RNA Nanorings for Efficient Delivery of siRNA....................................................................................................................578A. Koyfman, K. Afonin, A. Martins, E. Freed, W. Chiu, J. Rudra, B. Shapiro

The NanoAssemblrTM Platform - Microfluidic Manufacture of Nanomedicines for the Development of RNA Therapeutics....................................................................................................................................................................................................579

G. Heuck, C. L. Walsh, A. S. Ansari, A. White, K. Ou, A. Thomas, T. L. Leaver, E. C. Ramsay, P. R. Cullis, P. R. Cullis

One-pot Synthesis of Functional Poly(Amino Ester Sulfide)s and Utility in Delivering pDNA and siRNA ........................................580D. Siegwart, Y. Yan, L. Xue, J. Miller

DENTAL/CRANIOFACIAL Comparison of Electrospun and Lyophilized Gelatin + Chitin Whisker + Honey Membranes for Enhanced Periodontal Regeneration ..............................................................................................................................................................................581

A. E. Fetz, I. A. Rodriguez, B. W. Burger, G. L. Bowlin

Application of Stem Cells Derived from the Periodontal Ligament Or Gingival Tissue Sources for Tendon Tissue Regeneration ...................................................................................................................................................................................................582

S. Ansari, X. Xu, A. Moshaverinia, C. Chen, H. H. Zadeh, M. L. Snead, S. Shi

Composition Changes According to the Manufacturing Method of Dental Alloy Powder for Application of Selective Laser Melting System.....................................................................................................................................................................583

H. Lee, C. Lee, M. Kim, C. Lee, H. Kim

Observed of Change in the Hardness of Ni-Cr Alloy used to Dental Selective Laser Melting System .................................................584S. Choi, M. Hong, Y. K. Kim

Evaluation of the Effect of Early Bacterial Colonizers on the Surface of Retrieved Dental Healing Abutments ...............................585S. Sridhar, I. M. Gindri, P. Valderrama, T. G. Wilson Jr., D. C. Rodrigues

Cathepsin-K Targeting Nanotherapeutics for Regenerative Repair of Abdominal Aortic Aneurysms ...............................................586B. Jennewine, A. Ramamurthi

Preparation of Decellularized Mandible Bone with Periodontal Membrane for Periodontal Reconstruction ...................................587N. Nakamura, A. Ito, K. Nam, T. Kimura, T. Fujisato, T. Tsuji, A. Kishida

Correlation Between Rheological Behavior and Adhesion Properties of Denture Adhesives ...............................................................588N. Roohpour, S. Ghaderi

DRUG DELIVERY Nanogels of Hydrophobized Methylcellulose ..............................................................................................................................................589

M. Jamard, T. R. Hoare, H. Sheardown

Characterization of Crosslinked Gelatin Microspheres for Controlled Growth Factor Delivery ........................................................590P. A. Turner, J. P. Stegemann

Halloysite Nanotubes with Polyelectrolyte Nano-coatings Embedded with Rifampicin ........................................................................591W. R. Grimes Jr., D. K. Mills

Combinatorial Therapy of Rolipram and pNGF for Traumatic Brain Injury .......................................................................................592C. Macks, S.-J. Gwak, G. Temples, G. Korneva, J. Lee

Ricinoleic acid Encapsulation into Liposomal Matrix for Cutaneous Application.................................................................................593A. A. A. Nada, R. A. Abd El Azeem

DRUG DELIVERY 2 Incorporation of Protein-based Therapeutic Agents into Coaxial Electrosprayed Particles for Cardiac Regeneration ...................................................................................................................................................................................................594

M. Zamani, M. P. Prabhakaran, E. S. Thian, S. Ramakrishna

Combination of Cold Atmospheric Plasma and Nanoparticles Drug Delivery toward More Efficient Breast Cancer Therapy............................................................................................................................................................................................................595

W. Zhu, S. Lee, M. Keidar, L. G. Zhang

Controlled Release of Ophthalmic Therapeutics from Injectable, Resorbable Copolymer Scaffolds..................................................596G. Prosperi-Porta, B. Muirhead, H. Sheardown

Cell Membrane-mimetic Polymeric Micelles as Carriers for Drug Delivery ..........................................................................................597G. Liu, Y. Wang

Smart Hyperthermia Nanofiber Meshes With ‘On-Off’ Drug Release For Cancer Therapy ...............................................................598M. Ebara, E. Niiyama, K. Uto, C. M. Lee, T. Aoyagi

Hydroxyapatite-Calcium Sulfate Biphasic Microspheres As a Growth Factor Carrier for Sustainable Release ...............................599J. Baek, J. Song, H. Kim

Resorbable Bioactive Antimicrobial Implant for Bone Regeneration......................................................................................................600A. El-Ghannam, K. A. Aly Ahmed

PLGA/Chitosan based Composite Microspheres for Drug Delivery ........................................................................................................601S. Rahman, N. Bhattarai

An Accelerated Release Study to Evaluate Long-acting Levonorgestrel Contraception Dosage Forms..............................................602L. Wang, T. Lowe, S. Ananthula

The Effect of Induced Cell Alignment on the Endocytosis of Nanoparticles ...........................................................................................603P. Fattahi, P. J. Butler, J. L. Brown

Characterization of Pentagalloyl Glucose (PGG) loaded BSA Nanoparticles as Targeted Therapy for Abdominal Aortic Aneurysm (AAA) Regression ............................................................................................................................................................604

N. Nosoudi, A. Chowdhury, N. Vyavahare

Synthesis and Characteristics of PEI-based Copolymers and Nanoparticles for Potential Gene Delivery Applications.....................................................................................................................................................................................................605

C. Liu, M. Wang

DRUG DELIVERY FOR IMMUNOMODULATION Negatively Charged MRI Nanoprobes for Dendritic Cell Labeling and in Vivo Tracking ...................................................................606

H. Ai, C. Wu, L. Yang, Y. Xu, J. Wu, W. Zhu, C. Xia, Q. Gong, B. Song

Delivery of Indoleamine 2,3 Dioxygenase for the Induction of Immune Tolerance................................................................................607E. Bracho-Sanchez, A. Hassanzadeh, B. G. Keselowsky

In Vivo Macrophage Activation via Locally Delivered Dexamethasone ..................................................................................................608G. Keeler, J. Durdik, J. Stenken

Macrophage Response to Chitosan/poly-(γ-Glutamic Acid) Nanoparticles Carrying an Anti-inflammatory Drug...........................609R. M. Gonçalves, A. C. L. Pereira, I. O. Pereira, M. J. Oliveira, M. A. Barbosa

Less Phagocytosis of Biotinylated Polymeric Prodrug Micelles Using CD47-Streptavidin Fusion Protein.........................................610A. Sawdon, C. Peng

Tobramycin and Vancomycin Release from Local Delivery Devices .......................................................................................................611C. M. Wells, J. A. Jennings, W. O. Haggard, H. S. Courtney

ENGINEERING CELLS & THEIR MICROENVIRONMENTS Dynamically Stiffening Hydrogels Differentially Modulates Malignant Transformation of Mammary Epithelial Cells ..................................................................................................................................................................................................................612

S. Wei, J. Yang, A. Engler, M. Ondeck

Characterizing Effects of Microenvironments on Mechanical Properties of Cardiac Microtissues.....................................................613A. Desai, D. Dean

Heparin Cell Coating Effects on Cell Number During Mesenchymal Stem Cell Aggregate Culture with FGF-2..............................614J. Lei, E. Trevino, J. S. Temenoff

ENGINEERING TISSUE INTERFACES The Evaluation of Gold and Hydroxyapatite Nano-grafts in a Green Fluorescent Protein Porcine Model ........................................615

S. E. Smith, R. White, D. Grant, S. Grant

In Vitro Evaluation of Osteogenic Activity of Human Adipocyte Derived Stem Cells on Varied Scaffold Formulations ...................................................................................................................................................................................................616

A. V. Janorkar, P. Bierdeman, B. Gurumurthy

Tissue Regeneration of Tendon-Bone Junction: Evaluation of the Role of TgfbR2 Expressing Progenitor Cells on Multiphase Resorbable Braided Scaffolds...................................................................................................................................................617

H. Ramakrishna, T. He, T. Li, J. Temple, A. Spagnoli, M. King

Reconfigurable Substrate Topography for Tracking Cell Dynamics .......................................................................................................618P. Pholpabu, C. Bettinger, A. Balasubramanian, S. Kustra, H. Wu

HANDS-ON BIOMATERIALS RESEARCH Residual Volatiles Quantification for Novel Matrices ................................................................................................................................619

C. Culbreath, S. McCullen, C. Fitzwater, J. Corbett

Compositional Changes In Vitro for Two Glycolide Based Copolymers .................................................................................................620D. R. Ingram, J. T. Corbett, M. S. Taylor, S. D. McCullen

Building Scientific Confidence in BME Undergraduates via Inquiry-guided Biomaterials Laboratory .............................................621S. E. Stabenfeldt, C. Ankeny

Development of a 3-week Intensive Interdisciplinary Biomaterials Course for Non-engineering Majors...........................................622C. J. Wright, V. L. Turgeon

HARNESSING BIOMATERIALS TO ENGINEER THE ADAPTIVE RESPONSE FOR IMMUNITY OR TOLERANCE Immobilizing CD47 Polypeptide on Implantable Biomaterials.................................................................................................................623

C. M. Evaro, B. E. Mitchell, Z. Gu, M. W. King

HIGH-THROUGHPUT METHODS TO CONTROL CELL BEHAVIOR Microwell Arrays for High-throughput Investigation of Multi-species Biofilm Formation ..................................................................624

R. Hansen, C. Timm, S. Retterer

Engineering Hydrogels with Dual Gradients of Mechanical and Biochemical Cues to Decipher Stem Cell-Niche Interactions......................................................................................................................................................................................................625

X. Tong, J. Jiang, D. Zhu, F. Yang

Electrospun Photoclickble Thio-ene Poly(ethylene glycol) Hydrogel Microarrays for Stem Cell Fate Optimization........................626S. Sharma, M. Floren, W. Tan, S. Bryant

INJECTABLE BIOMATERIALS FOR TISSUE REGENERATION Composite Hydrogel Scaffold for Increased Fat Retention after Surgical Graft Procedure.................................................................627

C. M. Mahoney, D. Minteer, K. G. Marra, P. Rubin

Injectable Hydrogel based on Supramolecular Inclusion Complexes between Alginate-graft-Cyclodextrin and Polypropylene Glycol .....................................................................................................................................................................................628

T. Miao, S. L. Fenn, P. N. Charron, R. A. Oldinski

Degradation and Cell Survival in a Fast-Degrading Thio-Acrylate based Hydrogel .............................................................................629A. Emmakah, C. Lin, T-M. G. Chu

Injectable Enzymatically Crosslinked Hydrogels: A Unique Platform with Tunable Degradation Properties ..................................630S. V. Gohil, A. Padmanabhan, L. Nair

Development of a Novel Injectable Alginate-collagen-apatite Hydrogel for Bone Tissue Regeneration..............................................631S. Bendtsen, M. Wei

A Hydrogel for Local T Lymphocyte Delivery Towards Enhanced Cancer Immunotherapies............................................................632C. Ceccaldi, A. Monette, E. Assaad, R. Lapointe, S. Lerouge

Shear Strength of Thermogelling Scaffold for Intervertebral Disc (IVD) Tissue Engineering .............................................................633T. Mauriello, T. Christiani, P. Myers, D. Collins, A. Nitzl, E. England, C. Iftode, J. Kadlowec, A. J. Vernengo

Mechanically Enhanced Hyaluronic Acid-Based Hydrogels via Dual-Crosslinking Process ................................................................634J. Song, H. Kim, S. Jeong

Preparation of Poly(Ethylene Glycol)-B-Polyester Block Copolymers with Zwitterionic End Group for Thermo-Responsive Properties. ...................................................................................................................................................................................635

J. H. Park, D. Y. Kwon, B. K. Lee, C. H. Kim, M. S. Kim

In Vitro and in Vivo Evaluation of Chitosan-sotradecol Hydrogel, An Embolizing Sclerosing Agent for the Treatment of Endoleaks.................................................................................................................................................................................636

F. Zehtabi, A. Fatimi, A. Bertrand-Grenier, G. Soulez, S. Lerouge

Electrospinning of Alginate Micro-Beads ....................................................................................................................................................637N. Bhattarai, N. Rijal, R. Blount

Injectable Thermosensitive Chitosan Hydrogels with Enhanced Properties ..........................................................................................638E. Assaad, M. Maire, S. Lerouge

Extracellular Matrix Hydrogels from Decellularized Lung Tissue ..........................................................................................................639R. A. Pouliot, N. S. Mikhaiel, B. Wong, R. L. Heise

INNATE IMMUNITY AND INFLAMMATION IN BIOMATERIALS CONTEXTS Macrophage Polarization in Response to Self-Assembling Peptides ........................................................................................................640

R. De Loera, Y. Vigneswaran, J. Collier

Material-Modulated Polymorphonuclear Leukocyte Degranulation Affects Monocyte Adhesion on Endothelial Cells Under Shear Stress ...............................................................................................................................................................................641

T. J. Lieberthal, H. C. Cohen, J. Kao

In Vivo Effect of Locally-Delivered Modulators on Cytokine Production and Macrophage Activation .............................................642K. Alkhatib, G. D. Keeler, T. M. Poseno, J. M. Durdik, J. A. Stenken

Effects of Age-Related Changes in ECM Upon Macrophage Polarization ..............................................................................................643S. T. Lopresti, S. Patil, S. Dash, S. Bowers, L. Zhang, C. L. Dearth, B. N. Brown

LOCAL DELIVERY OF DRUGS AND GROWTH FACTORS FROM IMPLANT COATINGS Control of PLL/HA Multilayer Film Formation Via Crosslinkable Hyaluronic Acid Derivatives: The Differences Between Fast (Tyramine) and Slow (Aldehyde) Crosslinking Moieties ...................................................................................................644

H. Knopf-Marques, L. Wolfowa, S. Singh, V. Velebny, P. Schaaf, A. Ghaemmaghami, N. E. Vrana, P. Lavalle

Surface Modification of CoCr Alloy Using Vitamin-E for Cardiovascular Stents .................................................................................645E. Thiruppathi, J. Anderson, M. Larson, G. Mani

Model for Drug Partitioning in DAEMA Containing Poly(HEMA)-based Hydrogels using Coomassie Brilliant Blue ....................646R. Idziak, C. Kotanen, R. Sullivan, A. M. Wilson, D. R. Janagam, T. L. Lowe, A. Guiseppi-Elie

Biodegradable Antibiotic-releasing Implant Coatings to Prevent Orthopaedic Implant Infections ....................................................647A. A. Ashbaugh, J. Shahbazian, L. Miller, H. Mao, X. Jiang

In Situ Regeneration of Bioactive Coatings Using Evolved Staphylococcus Aureus Sortase A ............................................................648H. O. Ham, Z. Qu, E. Chaikof

MACROMOLECULAR DRUG DELIVERY Multifunctional SPIO Labeled Calcium Phosphate Microparticles for Localized Therapeutic Protein Delivery..............................649

A. E. B. Clements, C. S. Chamberlain, E. Aktas, R. Vanderby Jr., W. L. Murphy

Polymersomes: Towards Treatment of Neurodegenerative Disorders through Enzyme Replacement Therapy ...............................650J. Larsen, E. Pearce, D. Martin, M. Byrne

MATERIALS AND MATRICES FOR OSTEOCHONDRAL TISSUE ENGINEERING Cell-laden Nanofibrous Membrane Design for Osteochondral Repair ....................................................................................................651

J. Park, M. Kim, G. Jin, H. Kim

Analysis of Alkaline Phosphatase Expression and Tissue Mineralization in a Woven Tissue Engineering Test System ..............................................................................................................................................................................................................652

J. Gilmore, F. Yin, K. J. L. Burg

Fabrication of a TGF-β3 Encapsulated PLCL Scaffold by Supercritical CO2-HFIP Co-Solvent System ...........................................653S. H. Kim, S. H. Kim, Y. Jung

Collagen-Alginate-Hyaluronan Composite Hydrogels for Effective Culture and Maintenance of Chondrocytes..............................654H.-W. Kim, J. G. Zhen, C. Mahapatra

MECHANICAL CHARACTERIZATION OF BIOMATERIALS Finite Element Analysis of a Single Barbed Suture Using Beam Theory.................................................................................................655

M. Jeffries, J. S. Strenkowski, J. Cole, G. L. Ruff, M. W. King, H. Cong

Molecular Modulation of Long Lasting Absorbable Polymers for Compliance and Selective Degradation .......................................656J. A. Lilley, K. D. Gray, M. S. Taylor

The Stress-Relaxation Behaviors of Collagen-Depleted Heart Valve Tissues .........................................................................................657S. Huang, H.-Y. S. Huang

Biomechanical and Biochemical Study of Muscle-Tendon Junctions and Tendon-Bone Insertions ....................................................660B. Danley, X. Wu, M. Pankow, K. Peters, H.-Y. S. Huang

In Vivo Evaluation of Cervical Stiffness Evolution During Induced Ripening Using Shear Waves Elastography: Insight from an Animal Model......................................................................................................................................................................662

L. Peralta Pereira, E. Mourier, C. Richard, M. Tanter, G. Rus, P. Chavatte-Palmer, M. Muller

Multiple Length-Scale Spherical Indentation of PEG and Alginate-Based Hydrogels ..........................................................................663J. M. Shapiro, B. G. Bush, F. W. Delrio, R. F. Cook, C. A. Stratakis, M. L. Oyen

Tg and Fragility Determination of Glass-Forming Sugars using a Dynamic Mechanical Analyzer ....................................................664L. Weng, G. D. Elliott

MODULATING THE NEURAL MICROENVIRONMENT In Vitro Study of Astrocyte and Macrophage Response to Silicon Surface Modified with Cationic Microgels .................................665

E. Morin, S. Tang, K. Rogers, W. He

Magnesium Ferrite for Neural Applications ...............................................................................................................................................666Z. S. Thompson, N. Bhattarai

The Chronic FBR and Recording Performance in Aged Rat Cortex using High Density Silicon Recording Arrays ........................667M. B. Christensen, N. F. Nolta, P. A. Tresco

Markers of BBB Leakiness Correlate with Single Unit Recording Performance in High Density Penetrating Electrode Arrays Implanted Chronically in Rat Motor Cortex................................................................................................................668

N. F. Nolta, M. B. Christensen, P. A. Tresco

Controlling the Local Environment to Improve Schwann Cell Response ...............................................................................................669J. Stukel, W. Zhou, R. Willits

Transcranial Direct Current Stimulation (tDCS) Enhances Recovery From Motor Deficits Following Neonatal HIE Stroke.......................................................................................................................................................................................................670

C. L. Anderson, T. Demarse, M. Weiss, M. Douglas-Escobar, P. Carney, C. Rossignol

MOLECULAR MECHANISMS GOVERNING PROTEIN-SURFACE AND CELL-SURFACE INTERACTIONS The Role of Molecular Interaction Forces in Protein Adsorption Process on Materials Surfaces .......................................................671

S. Sakata, Y. Inoue, K. Ishihara

Crosstalk Between Integrin-β1 and BMPR1A Mediate Matrix Regulated MSC Osteogenesis ............................................................672R. Guo, S. Lu, J. M. Page, J. A. Sterling, S. A. Guelcher

The Effect of Network Properties on the Antifouling Properties of Amphiphilic Crosslinked Networks ...........................................673L. Villada, C. Kizilkaya, A. B. Brennan

MULTIFUNCTIONAL NANOMATERIALS FOR ENGINEERING COMPLEX TISSUES AND DRUG DELIVERY Targeted Drug Delivery Via Magnetic Nanoparticles: Novel Treatment for Canine Osteosarcoma ...................................................674

A. Kovach, T. Szasz, Z. Nelson, M. Cavalcanti, J. Gambino, L. Williams, J. Liao, R. Prabhu

High Surface Area Patterned Hydrogels for Drug Delivery or Tissue Engineering Applications ........................................................675M. Caldorera-Moore, L. Villermin

Polymeric Micelle as a Nucleic Acid Carrier for Axonal Regeneration in CNS .....................................................................................676S. Gwak, B. Green, C. Macks, K. Webb, J. S. Lee

Polymeric Micelle as a Drug and Gene Delivery Carrier for Brain Tumor ............................................................................................677B. Green, S. Gwak, G. Temples, J. S. Lee

Tumor-Targeting Upconversion–Nanoparticle-Based Unimolecular Micelles for Simultaneous Chemotherapy, Photodynamic Therapy, and Fluorescence Imaging ..................................................................................................................................678

G. Chen, L. Wang, S. Gong

MULTISCALE BIOMATERIAL DESIGN Encapsulating Hydrogels with Multi-Scale Porosity for Islet Transplantation to Treat Type 1 Diabetes...........................................679

P. Rios, X. Zhang, X. Luo, L. Shea

Effects of Processing on Glycoprene® 6829 Glycolide/Caprolactone/Trimethylene Carbonate Polyaxial Random Copolymer: A Preliminary Report ...............................................................................................................................................................680

C. Diruscio, G. Hilas, S. McCullen, M. S. Taylor

Mechanical Properties of Polypropylene-ePTFE Surgical Mesh Explanted After In Vivo Function...................................................681E. Casey, C. Hefner, K. Williams, A. Phillips, B. Heniford, A. Lincourt, M. Harman

Mechanically Tunable Hyaluronan-Based Hydrogels for Dental Pulp Stem Cell Growth....................................................................682S. Ananthula, K. B. Compton, D. R. Janagam, T. L. Lowe

MULTI-SCALE MATERIALS DESIGN FOR ABIOTIC-BIOTIC INTERFACES Anisotropic Supported Lipid Bilayers for Spatially Dynamic Surface Protein Presentation................................................................683

R. A. Meyer, M. P. Mathew, J. C. Sunshine, R. B. Shmueli, Q. Ren, K. J. Yarema, J. J. Green

NANOBIOMATERIAL AND DRUG DELIVERY STRATEGIES FOR DENTAL/CRANIOMAXILLOFACIAL REPAIR/REGENERATION Biosynthetic Materials Facilitate Effective Neurosurgical Closure ..........................................................................................................684

M. Macewan, T. Kovacs, W. Ray, M. Talcott

Random Acrylate Copolymer Surface Grafting to Poly(dimethyl siloxane) Elastomer Surfaces for Improved Anti-Biofouling ........................................................................................................................................................................................................685

C. Kuliasha, L. Villada, J. Royal, J. Finlay, M. Callow, J. Callow, A. Clare, A. Brennan, J. Chen

Evaluation of a Ciprofloxacin and Metronidazole Encapsulated Biomimetic Nanomatrix Gel on Enterococcus Faecalis and Treponema Denticola...............................................................................................................................................................686

S. Kaushik, T. Walker, J. Park, J. Scoffield, A. Andukuri, G. Alexander, B. Brott, P. Eleazer, H. Wu, N. Childers, H. Jun, K. Cheon

Controlled Release of Simvastatin from Anodized Ti Granules for Improving Its Antibacterial Effects ...........................................687Z. Gorgin Karaji, B. Houshmand, M. Jamadi Khiabani, S. S. Shafiei

Antimicrobial Effect of Calcium Phosphate Spheres Decorated with Ag nanodots on Periodontal Pathogens ..................................688T. B. Martin, D. A. V. Pulgarin, J. P. Babu, M. Shahbuddin, J. A. Jennings, J. D. Bumgardner, S. R. Mishra

NANOMATERIALS Surfactant Functionalization Induces Robust, Differential Adhesion of Tumor Cells and Blood Cells to Charged Nanotube-Coated Biomaterials Under Flow ...............................................................................................................................................689

M. J. Mitchell, C. Castellanos, M. King

Effect of Red Selenium Nanoparticles on Head and Neck Squamous Cell Carcinoma ..........................................................................690C. E. Hassan, T. Webster

Synthesis of Core/Shell Nanorod of Bismuth Doped Hydroxyapatite with Improved Antimicrobial Characteristics: a Facile Approach...........................................................................................................................................................................................692

M Selvakumar, S. K. Jaganathan, S. Chattopadhyay, G. B. Nando

Control of Clustered Iron Oxide Interparticle Spacing and Their Magnetic Properties .......................................................................693D. Wang, B. Lin, H. Ai

Synthesis and Characterization of CREKA-conjugated Iron Oxide Nanoparticles for Hyperthermia Applications ........................694A. K. Hauser, K. W. Anderson, Z. Hilt

Functional Clay Nanotube-Enzyme Biocomposites ....................................................................................................................................695J. Tully, R. Yendluri, Y. Lvov

Long Term Delivery of Nerve Growth Factor by Nano/microparticles for Enhancing Peripheral Nerve Regeneration ...................................................................................................................................................................................................696

A. D. Sharma, M. Uz, D. S. Sakaguchi, S. K. Mallapragada

Target-Specific Stimuli-Responsive Protoporphyrin IX Polysilsesquioxane Nanoparticles to Improve Photodynamic Therapy for Cancer Treatment...........................................................................................................................................697

J. L. Vivero-Escoto, Z. Lyles, D. L. Vega

Functionalized Polymersomes for Trapping the Ebola Virus ...................................................................................................................698C. Li, B. M. Geilich, T. J. Webster

Multifunctional Mesoporous Silica Nanoparticles for the Delivery of Cisplatin and Gemcitabine to Treat Cancer .........................699E. Fink, A. Hashemi, J. Pan, M. Alvarez-Berrios, J. Vivero-Escoto

Reducing Bacterial Adhesion on Surface Modified Titanium...................................................................................................................700H. Yazici, T. J. Webster, G. Bhardwaj

Shape and Surface Effects on the Cytotoxicity of Gold Nanospheres and Gold Nanostars...................................................................701P. M. Favi, M. Gao, L. J. S. Arango, S. P. O. Alvarez, M. M. Valencia, T. J. Webster

EDTA Loaded BSA Nanoparticles for Targeted Therapy to Reverse Vascular Calcification in Chronic Kidney Disease Animal Model ....................................................................................................................................................................................702

S. R. Karamched, N. Nosoudi, N. Vyavahare

Gellan-Gum Coated Gold Nanorods as Intracellular Drug Release System for Regenerative Medicine ............................................703S. Vial, S. Vieira, M. Carvalho, R. L. Reis, P. L. Granja, J. M. Oliveira

NANOTHERAPEUTICS FOR CARDIOVASCULAR APPLICATIONS Keratose as a Novel Drug Carrier for Drug Coated Balloons...................................................................................................................704

E. Turner, S. Tomblyn, L. Burnett, S. K. Yazdani

Multi-Functional Nanoparticle Development for Glycocalyx Heparan Sulfate Regeneration on Cultured Endothelial Cells .............................................................................................................................................................................................705

M. Cheng, H. Homayoni, R. Kumar, S. Sridhar, T. Webster, E. Ebong

Multifunctional Magnetic Nanoparticles to Restore Elastic Matrix Homeostasis in Abdominal Aortic Aneurysms .........................706B. Sivaraman, G. Swaminathan, L. Moore, M. Zborowski, A. Ramamurthi

NEXT GENERATION BIOMATERIAL AND DRUG DELIVERY TECHNOLOGIES FOR WOUND HEALING Microfluidic-based Generation of Protease-degradable PEG-MAL Microgels for Protein Delivery...................................................707

C. Gonzalez Garcia, D. Headen, M. Salmeron-Sanchez, A. J. Garcia

Nitric Oxide-Releasing Electrospun Polyurethane Wound Dressings......................................................................................................708B. V. Worley, R. J. Soto, M. H. Schoenfisch

Tunable Polyester Matrices Based On Sebacic Acid Using Crosslinking As A Strategy In Combinatorial Approach......................709Y. Chandorkar, G. Madras, B. Basu

High Moisture Vapor Transmission Rate and High Fluid Absorption Films for Wound Dressings....................................................710L. Miinea, P. Basone, A. Camardo, J. Baxter, E. Rohr, N. Marchant

Growth Factor Release from Poly(Ethylene Glycol) Diacrylate Hydrogels As a Treatment for Chronic Wound Healing .............................................................................................................................................................................................................711

P. Krzyszczyk, R. Olabisi

Effect of Polymer Architecture on Physical and Mechanical Properties of High Glycolide Content Polymers..................................712S. McCullen, C. Culbreath, J. E. Dixon, J. Corbett, M. S. Tayor

Biofunctionalized Hydrogels for Intestinal Epithelial Stem Cell Delivery...............................................................................................713R. Cruz-Acuna, A. E. Farkas, A. Nusrat, A. J. García

Bioresorbable Ureteral Stent Translation for in Vivo Model....................................................................................................................714A. A. A. Barros, C. Oliveira, E. Lima, R. A. C. Duarte, R. L. Reis

Delivery of Doxycycline from PLGA-Coated Hernia Meshes ...................................................................................................................715T. A. Q. Phan, D. A. Puleo, S. K. Ramineni, M. E. Brown, P. D. Fisher

Self-Assembling MMP-2 Cleavable Hydrogel Drug Delivery Systems; Neural Tissue Biocompatibility and Response ..........................................................................................................................................................................................................716

K. M. C. Koss, M. Churchward, K. Todd, L. D. Unsworth

Fabrication and Characterization of Hybrid Polymeric Scaffolds ...........................................................................................................717A. H. Najarzadeh, D. A. Puleo

Heparin-eluting Vascular Suture for Preventing Thrombosis and Stenosis ...........................................................................................719M. Dibalsi, S. Bae, J. S. Lee, G. Korneva, K. Kornev

Highly Elastic Nanofibrous Scaffolds for Skin Tissue Engineering Applications ...................................................................................720M. Mohiti-Asli, C. Molina, K. Rietzler, B. Pourdeyhimi, E. G. Loboa

In Vitro and In Vivo Degradation and Biocompatibility Evaluation of Chitosan Sponges and Paste..................................................721C. S. Rhodes, M. Whitaker, A. C. Parker, H. Doty, J. A. Jennings, W. O. Haggard

Arabinoxylan Sponges for Wound Healing Applications ..........................................................................................................................722D. C. Aduba Jr., A. Yeudall, H. Yang

OPHTHALMIC BIOMATERIALS Purification of an Acrylic IOL Dye Additive by a Solvent Washing Process – Effect of Precipitation Temperature ........................723

D. Urbaniak, M. D. Lowery, C. B. Hu

A Suspension of Porcine Cartilage Extra-cellular Matrix Exerts Anti-Angiogenic Effect in a Rabbit Corneal Model .....................724H.-W. Yun, S. Y. Kim, B. R. Song, T.-I. Kim, B. H. Choi, Y. J. Kim, S. R. Park, S.-H. Park, B.-H. Min

ORTHOPAEDIC BIOMATERIALS 2 Collagen Self-assembly on Orthopedic Magnesium Biomaterials Surface and Subsequent Bone Cell Attachment ..........................725

N. Zhao, J. Ma, D. Zhu

Effect of Poisson’s Ratio on the Intrinsic Mechanical Properties of Poly (Vinyl Alcohol) Hydrogels: Preliminary Results ..............................................................................................................................................................................................................726

M. A. Vaughn, K. J. L. Burg, J. T. Corbett

Structural Analysis of Gallium Based Glass Polyalkenoate Cements by Infrared Spectroscopy .........................................................727A. M. F. Alhalawani, D. Curran, M. Towler

Osteogenic and Antimicrobial Properties of Chitosan Treated Titanium Surface in a Co-Culture System of Peri-Operative Infection Model: An in Vitro Study ...........................................................................................................................................728

N. Ghimire, Y. Sun, Y. Deng

Microwave Processing of Amorphous Magnesium-Calcium Phosphate..................................................................................................729E. Babaie, Y. Ren, S. B. Bhaduri

Modularly Assembled Hyaluronic Acid Hydrogels with Tunable Stimuli Responsiveness ...................................................................730W. M. Gramlich

Patterning Bone Formation Using Proteins Derived from Seashell and Bone ........................................................................................731K. A. White, R. M. Olabisi

DC Stimulation for Spinal Fusion with a Piezoelectric Composite Material Interbody Implant: An Ovine Pilot Study ................................................................................................................................................................................................................732

L. Friis, N. Galvis, P. Arnold

Semi-resorbable Composite PMMA-Brushite Bone Cement for Spinal Augmentation ........................................................................733S. Aghyarian, E. Bentley, D. Rodrigues, J. Chari, I. Gindri, L. Rodriguez

Quantitative Assessment of Taper Damage and Head-Neck Moment Arm on Retrieved Total Hip Replacements with Modular Bore-Cone Taper Junctions..................................................................................................................................................734

C. M. Stamer, R. Taylor, P. Panigrahi, M. Harman

Role of Citric Acid on Apatite Nucleation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Aligned Nanofibers .........................................................................................................................................................................................735

D. Barati, S. R. Pajoum Shariati, S. Moeinzadeh, E. Jabbari

Effects of Heat Treatment on the Tensile Strength and Transition Temperature of Processed Collagen Devices .............................736M. Al-Rajhi, M. Diaz, A. Woodruff, G. Pomrink

Osteoblastic Stimulation Through Gene Silencing Approach Using Mesoporous Nanocarriers ..........................................................737J. Kim, M. Kang, T. Kim, S. Seo, H. Kim

PROTEINS & CELLS AT INTERFACES Extension, Locomotion, and Proliferation of Osteoblast-like Cells on Metals ........................................................................................738

P. Chen, Y. Tsutsumi, M. Ashida, H. Doi, T. Hanawa

Cellular and Gene Expression Responses in Osteoblast-like Cells to Metals ..........................................................................................739P. Chen, Y. Tsutsumi, M. Ashida, H. Doi, T. Hanawa

Bacterial Surface Display for Discovery and Study of Material Specific Peptides .................................................................................740B. L. Adams, M. Hurley, D. A. Sarkes, D. Stratis-Cullum

Nanotubular Composites Decorated on Titanium to Regulate Cell Responses.......................................................................................741H.-W. Kim, C. Mahapatra, J.-J. Kim, T.-H. Kim, K. D. Patel

RECENT ADVANCES IN SURFACE MODIFICATION OF BIOMATERIALS Methods and Reagents for Islet Surface Modification ............................................................................................................................... 742

R. R. Kane, C. Chang, J. M. Horton, M. A. Kanak, B. Naziruddin

Photoinduced and Self-initiated Grafting of 2-Methacryloyloxyethyl Phosphorylcholine to Poly(Ether-Ether-Ketone): Effects of Inorganic Salt for Shortening the Graft Polymerization Time ................................................................................743

K. Ishihara, T. Shiojima, M. Kyomoto

Surface Modification of CoCr Alloy Using Phosphoric and Phosphonoacetic Acids: Protein and Platelet Interactions......................................................................................................................................................................................................744

E. Thiruppathi, M. Larson, G. Mani

Surface Characterization and Corrosion Behavior of Silanized Magnesium Coated With Graphene for Biomedical Application ......................................................................................................................................................................................................745

M. P. Neupane, Y. K. Kim, J. H. Ji, I. S. Park, T. S. Bae, M. H. Lee

Biological Investigation of PEG-Containing Siloxane Materials by Metal-Free Click-Chemistry .......................................................746F. Lasowski, T. Rambarran, M. A. Brook, H. Sheardown

Hydroxyapatite Coating on PEEK: Material Processing, Analysis and Biocompatibility Study .........................................................747J. W. Durham III, A. Rabiei, M. J. Allen

Development of Nanoscale Hydrogel Coatings in High Speed Cell Sorting ............................................................................................748J. L. Lilly, B. J. Berron, G. Romero, W. Xu, H. Shin, V. Balasubramaniam

Light-sensitive Fluoropolymer Coated Surface for Control of Cell Adhesion Behavior........................................................................749M. Nakayama, T. Kanno, A. Kikuchi, T. Okano

Biological Tethering of N-Cadherin to Substrates Promotes Cell-Cell Adhesion ...................................................................................750J. C. M. Vega, M. K. Lee, D. E. Leckband, H. Kong

Effect of Micropattern Dimensions on Adhesion, and Nuclear Shape of Osteosarcoma Cells..............................................................751M. Ermis, D. Akkaynak, P. Chen, U. Demirci, V. Hasirci

SMALL MOLECULE DRUG DELIVERY Image-Guided Surgery for Pancreatic Neuroendocrine Tumors .............................................................................................................752

G. Park, J. H. Lee, H. S. Choi

Test Methodology of Characterizing the Behavior of Injectable Hydrogels: An In Vitro Model.........................................................753J. L. Isaacs, V. Binetti, K. Kita, A. Lowman, M. Marcolongo, G. W. Fussell

In Vivo Effects of Levonorgestrel Containing In Situ Gelling Drug Delivery Systems on Rat Pregnancy ..........................................754S. Ananthula, K. Chaudhry, D. R. Janagam, J. R. Johnson, T. Mandrell, T. L. Lowe

Conjugation of Bicyclol-Polymer Conjugates for Protecting Liver from Injury ....................................................................................755L. Wang, L. Wu, N. Li, K. Li, T. Lowe

STEM CELL AND BIOMATERIAL INTERACTIONS Assessing the Osteogenic Differentiation of Human Mesenchymal Stem Cells Co-Cultured with Human Vein Endothelial Cells on a Peptide Amphiphile Nanomatrix ...........................................................................................................................756

L. Deng, D. Patel, J. B. Vines, A. Javed, S. R. Gilbert, H. Jun

Hydrogel Microencapsulation Mimics Whole Body Response to Low Magnitude High Frequency Vibration ..................................757S. Mehta, R. M. R. Olabisi

Gold Nanoparticles Actuates Human Mesenchymal Stem Cell Differentiation Under Electric Field Stimulation ............................758G. Thrivikraman, G. Madras, B. Basu

Dynamic Extracellular Control of Mesenchymal Stem Cell Angiogenic Potential .................................................................................759A. Abdeen, J. Lee, K. Kilian

Matrix Rigidity-Modulated Cardiovascular Organoid Formation from Embryoid Bodies ..................................................................760A. Shkumatov, K. Baek, H. Kong

Susceptibility of Macroporous PHEMA Hydrogels for Growth of Mouse Embryonic Stem Cells ......................................................761O. Janouskova, M. Prádný, M. Dušková-Smrcková, K. Dušek, M. Šlouf, J. Michálek

Magnetic Field Triggered Osteogenic Differentiation of Human Mesenchymal Stem Cells on Ferromagnetic Substrates ........................................................................................................................................................................................................762

S. K. Boda, G. Thrivikraman, B. Basu

SURFACE CHARACTERIZATION & MODIFICATION Multi-Scale Surface Modification on Ti-6Al-4V Alloy by SPE process ...................................................................................................763

B. Moon, T. Jang, S. W. Kim, J. Song, H. Kim

Surface Response Model Characterizing and Predicting Selenium Nanoparticle Coatings on Medical Devices................................764M. Stolzoff, J. Bilsback, T. Webster

Comparative Study on Adsorbed and Grafted Fibronectin Coatings on Fluorocarbon Surfaces for Cardiovascular Applications.....................................................................................................................................................................................................765

V. Montaño-Machado, S. Díaz-Rodríguez, Jr., L. Hugoni, R. Tolouei, P. Chevallier, E. Pauthe, D. Mantovani

Evaluation of Protein Hydration by Vapor Sorption Methods .................................................................................................................766D. J. Burnett, M. Naderi, A. Kondor, M. Acharya

Mucoadhesive Surface Modification of PHEMA hydrogel for Ophthalmic Drug Delivery Application .............................................767L. Liu, H. D. Sheardown

A t-PA/Gold Nanoparticle Conjugate Based on Bio-affinity Ligation .....................................................................................................768Z. Tang, D. Li, H. Chen

Surface Characterization of Nanoparticles for Biomedical Applications ................................................................................................769Y. Wang, A. Rafati, D. G. Castner

Surface Modification using Polydopamine to adhere a novel anticoagulant Antithrombin-Heparin Complex to the surface of PDMS Oxygenators used as a Lung Assist Device for Neonates .............................................................................................770

D. Sandejas, J. Brash, C. Fusch, A. Chan, N. Rochow, G. Fusch, L. Berry, H. Atkinson, J. Leung, R. Cornelius, H. Matharoo, R. Selvaganapathy

TARGETED AND TARGET-ACTIVATED DRUG DELIVERY Selective Inhibition of MG-63 Osteosarcoma Cell Proliferation Induced By Curcumin-Loaded Self-assembled Arginine-Rich-RGD Nanospheres ................................................................................................................................................................771

R. Chang, L. Sun, T. J. Webster

Synthesis and In Vitro Assessment of Folate-targeted Polyamidoamine Dendrimer Gene Vector ......................................................772L. Xu, A. Yeudall, H. Yang

Folate-targeted Polyamidoamine Dendrimer for Head and Neck Cancer Gene Therapy .....................................................................773L. Xu, A. Yeudall, H. Yang

TECHNOLOGY DEVELOPMENT / NEW BIOMATERIALS FOR IMMUNE ENGINEERING Micro and Nano-patterned Surface Topographies for Control of Macrophage Form and Function ..................................................774

T. U. Luu, S. C. Gott, M. P. Rao, W. F. Liu

Self-assembled Glycopeptide Nanofibers As Synthetic Glycoprotein Mimetics to Modulate Lectin Bioactivity ................................775A. Restuccia Jr., G. A. Hudalla

THERANOSTIC NANOMATERIALS FOR IMAGE-GUIDED TREATMENTS Fibrin Glue Does Not Increase Drug Retention in the Spine.....................................................................................................................776

M. B. Giers, K. Cronk, Q. Lui, G. Ide, M. Preul, N. Theodore

Optimization of the Morphology of Multifunctional Mesoporous Silica Nanoparticles to Increase Therapeutic and Diagnostic Effects in Breast Cancer .............................................................................................................................................................777

A. L. Nelson, M. Intrator, D. Lee, J. Bardill, D. Park

Polymeric Nanoparticle-Based Enzymatically Activatable Near-Infrared Nanoprobes for Optical Detection of Cancer ..............................................................................................................................................................................................................779

T. Ozel, S. White, E. Nguyen, A. Moy, B. Choi, T. Betancourt

TISSUE ENGINEERING MC3T3 Cells Co-Cultured with Macrophages Demonstrate Enhanced Osteogenic Differentiation ...................................................780

F. Loi, R. Zhang, K. Barcay, H. Rogan, T. Lin, J. Pajarinen, C. Fan, T. Sato, J. Raphel, Z. Yao, S. Goodman

Multiple Layer Nerve Guide Using Carbon Nanotubes for Peripheral Nerve Regeneration................................................................781X. Lu, O. Yildiz, P. Bradford, M. W. King

New Bioactive Glass Fibers for Soft Tissue Regeneration .........................................................................................................................782M. T. Souza, O. Peitl, M. B. Puzzi, E. D. Zanotto

The Analysis of Residual Enzyme in the Cartilage Tissue After Partial Digestion ................................................................................783P. Lee, C. Chen, A. McNally, K. Sly, C. Chapman, S. Lin

Micro-Computed Tomography Technique to Study a Porouse Biphasic Scaffold .................................................................................784A. J. McNally, C. Chapman, K. Sly, L. Krengel, S. Lin

Microtopographical Effects on Differentiation of Embryonic Stem Cells into Cardiomyocytes ..........................................................785N. R. Patel, A. Whitehead, C. Tran, J. Newman, M. Caldorera-Moore

Protein Based Biocomposite Cryogels as Tissue Engineering Scaffolds ..................................................................................................786K. Kutuk, M. Ozmen, J. Patterson

New Blood Compatible Polymers for the Maintenance of Hepatocyte Functions to Develop Bioartificial Liver. ..............................787T. Hoshiba, T. Otaki, M. Tanaka

Effects of the Orientation of Anti-BMP2 Monoclonal Antibody Immobilized on Scaffold in Antibody Mediated Osseous Regeneration ....................................................................................................................................................................................788

H. Zadeh, S. Ansari, M. Freire, M. G. Choi, A. Tavari, A. Moshaverinia

Hybrid Nanofibers Designed to Deliver Oxygen Favorable for Cell Survival and Osteogenesis ..........................................................789H. Lee, J. Kim, S. Seo, H. Kim

Collagen Crosslinking Agent Injections to Reduce Soft Palate Vibrations in Equine Snoring .............................................................790S. Hunt, J. Kuo, T. Hedman

Strategic Design of Electrospun Fiber Scaffolds to Deliver Multiple Growth Factors for Bone Regeneration ..................................791M. S. Kang, J. J. Kim, H.-Y. Lee, J.-H. Kim, H.-W. Kim

Effect of Multi-layering of Endothelial Cell Seeded Electrospun Membranes for Vascularized Tissue Generation .........................792C. Hwang, S. Hong, H. Cho

Resveratrol Nanoparticle-incorporated Scaffolds to Modulate Inflammation and Promote Osteogenesis .........................................793K. E. Rutledge, E. Jabbarzadeh

Biomimetic Polymer Conduit for Nerve Guidance Following Peripheral Nerve Injury ........................................................................794D. J. Lee, P. Jenkins, M. R. Laughter, J. R. Bardill, A. L. Nelson, D. Park

Bioengineering Polycaprolactone Scaffolds for Growing Human Trabecular Meshwork Cells ...........................................................795J. R. Halman, K. Y. Torrejon, L. A. Beardslee, M. Bergkvist, S. T. Sharfstein, Y. Xie

VACCINE DELIVERY VEHICLES Hybrid Calcium Carbonate-Peptide Nanofiber Microparticles for Mucosal Antigen Delivery............................................................796

J. Snook, C. Chesson, A. Zloza, J. Rudra

Adjuvant Conjugated Microparticles for Vaccine Delivery: A Robust Method to Promote Immune Response ................................797K. Brink, M. V. Pishko

VASCULAR AND BLOOD CELLS RESPONSES TO NOVEL CARDIOVASCULAR BIOMATERIALS Effects of Magnesium on Endothelial Barrier Functions...........................................................................................................................799

N. Zhao, J. Ma, D. Zhu

Prohealing Multifunctional Endothelium Nanomatrix Coated Stents .....................................................................................................800G. Alexander, A. Andukuri, Y. Sohn, Y. Yoon, P. Anderson, J. Kim, B. Brott, H. Jun

Inhibition of Smooth Muscle Cell Growth by Paclitaxel Releasing Polyethylene Oxide films for Drug-Coated Balloons............................................................................................................................................................................................................801

J. Anderson, G. Mani

How Adsorbed Fibrinogen Conformation Affects Platelet Adhesion.......................................................................................................802B. J. Casey, L. Zhang, K. Vorvolakos, D. Galanakis, M. H. Rafailovich

An In Vitro Study on Early Inflammatory Response to Four Magnesium-Zinc-Strontium Alloys......................................................803A. F. Cipriano, A. Sallee, R. Guan, H. Liu

A Novel Metallic Scaffold that Promotes the Rapid Seeding of Endothelial Cells..................................................................................804M. Shayan, Y. Chun

Development of Biodegradable Elastomeric Polyurethanes with Low Initial Moduli ...........................................................................805Y. Hong, C. Xu

NaOH-etched PCLTA and mPEGA/PCLTA Networks for Regulating Smooth Muscle Cells .............................................................806X. Liu, J. Dou, S. Wang, T. Mickens

Albumin and Fibrinogen Adsorption, Platelet Adhesion and Activation on ePTFE and Electrospun PTFE .....................................807S. Lamichhane, T. Remund, M. Larson, P. Kelly, G. Mani

Hyaluronic Acid Modified Surfaces for the Reduction of the Inflammatory Response.........................................................................808J. E. Tengood, M. Reiss, J. Slee, B. Purcell, S. Caliari, R. J. Levy, J. Burdick, S. Stachelek

Fabrication and Characterization of Endothelialized Elastic Hollow Fiber Membranes As Small Diameter Vascular Grafts...............................................................................................................................................................................................809

A. E. Mercado Pagan, A. M. Stahl, M. Ramseier, A. Behn, Y. Yang

Fabrication of Human Serum Albumin Nano Films for Enhanced Hemocompatibility and Smooth Muscle Cell Response. .........................................................................................................................................................................................................810

A. Khanna, R. Burtovvy, M. Laberge, I. Luzinov, A. Simionescu

Author Index

Society for Biomaterials Annual Meeting and Exposition ...toc.proceedings.com/26876webtoc.pdf ·...

Documents

Transcript of Society for Biomaterials Annual Meeting and Exposition ...toc.proceedings.com/26876webtoc.pdf ·...