Sistem Imun Di Kulit
Transcript of Sistem Imun Di Kulit
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Sistem imun dikulit
dr. Muhammad In’am Ilmiawan,M.Biomed
fungsi kulit• Barier mekanis lingkungan eksternal
• Zat tanduk & stratum korneum: menjaga air hilang
• Keratinosit: defensins & kathelicidins (antibiotik)
• Sel Langerhans: respon imun
• Melanin: pelindung UV
• Pembuluh darah, keringat: mengatur suhu• Bau badan (pheromones)
• Kelenjar sebasea (sebum): pelumas, tahan air
• Lemak sub kutan: cadangan kalori
• Kuku: pelindung jari, memungut benda
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Histologi
Epidermis (Epi )Dermis (Derm)Stratum corneum (SC)Stratum granulosum (SGr)Stratum spinosum (SS)Stratum basale (SB)Duct of a sweat gland (D)Papillary layer (PL)Reticular layer (RL)
intercellular bridges
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Sel di epidermis
Epidermal SkinAppendages• Folikel rambut
• Kelenjar Sebasea
• Kelenjar Keringat ekrin
• Kelenjar Keringat apokrin
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Mengapa manusia perlusistem imun?
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Sistem imun
1. Innate immunity
2. Adaptive (acquired or specific) immunity
Komponen sistem imun
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Innate immunity• Sel epitel kulit, sal. gastrointestinal, sal. respirasi
• Leukosit fagosit (netrofil dan makrofag)
• Natural killer (NK) cell
• Protein-protein plasma (sistem komplemen)
Innate immunity di kulit• >20 peptida antimikroba (jamur, bakteri, virus):
Cathelicidins, B-defensins, substansi P, RANTES,RNase 2,3,7 dan S100A7.
• Sebaceous lipids (anti bakteri)
• Glikofosfolipid dan asam lemak bebas str. Korneum(bakteriostatik)
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Sel Langerhans’• Fagositosis
• Antigen processing,
• Antigen presentation
• Berinteraksi dengan limfosit
• Melepas sitokin
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Komponenimun didermis:• Limfosit T,• Makrofag,• Sel dendritik•
Sel mast
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Sel mast• Menghasilkan: Histamine, serotonin, protease,
leukotrien, prostaglandin, sitokin dan kemokin
Adaptive (acquired/specific)immunity
• Humoral : antibodi, dihasilkan limfosit B
• Seluler: Limfosit T
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Apa komponen sistemimun innate di kulit?
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Apa komponen sistemimun spesifik di kulit?
Inflamasi/radang
Mekanisme pertahanan tubuh
terhadap jejas
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Jejas• Mikroorganiasme: virus, bakteri, parasit, jamur
• Zat kimia: asam, basa, toksin bakteri
• Fisik: trauma, radiasi, panas, dingin, listrik
• Reaksi imunologi: hipersensitivitas, kompleks imun,reaksi autoimun
• Nekrosis jaringan
Istilah• Nama organ yang radang + “itis”
• Radang appendiks: appendisitis
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Pengaruh radang• Menguntungkan
o Pengenceran toksin
o Zat anti kuman
o Transportasi obat
o Pembentukan fibrin
o Transportasi nutrien dan oksigen
o Stimulasi respon imun
• Merugikan
o Kerusakan jaringan normal
o Pembengkakan
o Reaksi radang tidak tepat (hipersensitivitas)
Tanda cardinal radang(Aulus Cornelius Celsus (ca 30 BC–38 AD))• Rubor= merah (pembuluh darah melebar)
• Kalor= panas (pembuluh darah bertambah)
• Tumor= bengkak atau tonjolan(edema/cairan+sel sel radang keekstravaskuler)
• Dolor= sakit (penekanan jaringan, bradikinin,prostaglandin)
• Functio laesa (gangguan fungsi)
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Jenis Inflamasi
1. Akut: menit-hari, eksudasi cairan danprotein plasma, emigrasi netrofil
2. Kronik: lama, hari-tahun, limfosit danmakrofag
Komponen inflamasi
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Perubahan vasuler
pada radang akut:
vasokonstriksi vasodilatasialirandarah lambatmarginasi lekosit
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Reaksi seluler• 24-48 jam pertama: netrofil atau lekosit
polimorfonukleus (pmn)
Lekosit:
• Penepian ke tepi pembuluh (margination)
• Pelekatan di dinding pembuluh ( sticking)
• Diapedesis, keluar dari pembuluh darah(emigration)
• Fagositosis, menelan bakteri dan debris jaringan
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Reaksi radang di miokardium setelah nekrosis iskemik (infark).A, Early (neutrophilic) infiltrates and congested blood vessels.B, Later (mononuclear) cellular infiltrates.
Aktivasi lekosit
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Fagositosis
Outcome
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Radang reda
Terima kasih