1104/19/23

Parvo VirusesParvo Viruses

fackrel@Uwindsor.ca

2204/19/23

Parvo VirusesParvo Viruses

Structure Classification Multiplication Clinical manifestations Epidemiology Diagnosis Control

Baron’s Web SiteBaron’s Web Site

3304/19/23

Parvovirus Structure Small icosahedral non enveloped ssDNA + or - strand

Unable to grow Parvovirus in vitro cell culture

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Parvovirinae

Genus Parvovirus – Type Species mice minute virus

Genus Erythrovirus – Type Species B19 virus Web site

Genus Dependovirus– Type Species adeno-associated virus 2

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Classification Family Parvoviridae

–Subfamily Parvovirinae–Subfamily Densovirinae

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Densovirinae Genus Densovirus

– Type Species Junonia coenia densovirus Genus Iteravirus

– Type Species Bombyx mori densovirus Genus Contravirus

– Type Species Aedes aegypti densovirus

7704/19/23

Paroviridae Classification old

Parvovirus– Parvo Virus Like Agent– Serum Parvo Like Virus

Dependovirus– AKA Adeno Associated Virus

Insect virus

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B19 Genome

Parvovirus B19 Genome

VP1 Coding Region

VP2 Region2444

3125

4787

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Clinical manifestations Mild flu like illness Erythema infectosum Aplastic Crisis Stillbirth Web Site

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Mild flu like illness Fever Headache Chills Myalgia, Malaise Sore throat hemoglobin conc down

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Erythema infectosum

Fifth Disease Rash on face that spreads to

exposed skin eg arms and legs Subsides over 2 weeks Relapses frequent Arthritis of hands, wrists, knees

and ankles

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Typical facial exanthem of erythema infectiosum. Note the sparing of the perioral areas, resulting in the typical "slapped cheek” appearance.

Web Site

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Lacy, reticular exanthem of the extremity in a child with erythema infectiosum.Web site

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Aplastic Crisis patients with Sickle cell anemia

ie chronic hemolytic anemia Fever, malaise, myalgia, chills Maculopapular rash

– arthritis & joint swelling, itching Decreased RBC formation

–Life threatening

Web site

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Stillbirth Parvovirus can cross the placenta no congenital abnormalities

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Fifth Disease

Droplets inhaled into upper respiratory tract

local replication Viremia Replication in upper

respiratory tract Rash and arthalgia

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Aplastic Crisis Droplets inhaled into

upper respiratory tract virus replicates in bone

marrow Reticulocytosis

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Clinical manifestation of B19

Web site

191904/19/23 Web site

202004/19/23

Epidemiology Most infections before 40 years Erythema infectiosum 4-15 years 65% of adults have antibodies

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Spread by respiratory droplets less contagious than measles

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Diagnosis Virus detected in serum or throat

wash– Electron microscopy– EIA, RIA– DNA hybridization

Anti viral IgM in serum– easier

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Control No specific control patients with clinical erythema

infectiosm not infectious

–already transmitted the virus

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DONE!!!