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Neurological Board Examination （I） 2007 09 15 A type: Select the most appropriate answer ( ) 1. Which drug is safe in the management of acute hepatic porphyria with

seizure? A. Gabapentin B. Carbamazepine C. Phenytoin D.Valproate E. Vigabatrin

解答：A 題目之出處：from Merritts neurology 11th ed ( ) 2. Which one of the followings is the most common type of reflex epilepsy?

A. Auditory B. Tactile C. Visual D. Vestibular E. Olfactory

解答：C 題目之出處：Adams and Victor’s Principles of Neurology. 7th edition. p.343 ( ) 3. A 25-year-old man awakened from sleep moaning, kicking his legs, and

rapidly turning his head from right to left. These spells last 15 seconds and repeat 3 times. What is the most likely diagnosis? A. Temporal lobe epilepsy B. Occipital lobe epilepsy C. Frontal lobe epilepsy D. Atonic seizure E. Generalized tonic-clonic seizure

解答：C 題目之出處：Merritt’s 11th edition. p. 994

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( ) 4. Which of the following statements about traumatic head injury is FALSE? A. Early posttraumatic seizures should be treated aggressively to avoid the

potential damaging effects of seizures on a traumatized brain. B. Long treatment of antiepileptic drugs ( > 6 months) is a must C. Penetrating head injury and depressed skull fracture are recognized risk

factors for posttraumatic epilepsy D. Coma lasting more than 24 hours is a risk factor for posttraumatic

epilepsy E. Intracranial hematoma is a risk factor for posttraumatic epilepsy

解答：B 題目之出處：Merritt’s 11th edition. p. 994-995 ( )5. Which of the following statements is CORRECT about the differential

diagnosis of nocturnal epileptic seizures (the former) and parasomnias (the latter)? A. The latter usually presents as stereotypic behavior. B. The latter is usually associated with dystonic or tonic posture. C. Patients with the former usually can remember the events. D. The former usually occurs in clusters. E. The duration of attack of the latter is usually brief but the former is much

longer.

解答：D 題目之出處：Merritt’s Neurology, 11th edition, P.1029 ( ) 6. If a patient has left sided peripheral facial palsy with impaired taste on

ipsilateral tongue and normal ipsilateral lacrimation, which of the following is the most probable lesion site? A. Facial nerve below the stylomastoid foramen. B. Chorda tympani. C. Facial nerve between chorda tympani and geniculate ganglion D. Facial nerve above geniculate ganglion. E. None of the above.

解答：C 題目之出處：Merritt’s neurology, 11th ed, p529

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( ) 7. The most important diagnostic study for motor neuron disease is: A. Nerve conduction study B. Needle EMG study C. Late response study D. Motor evoked potential study E. Somatosensory evoked potential study

解答：B 題目之出處：Kimura, Electrodiagnosis in Disease of Nerve and Muscle. 3rd Ed, p. 604 ( ) 8. Benzodiazepine overdose typically shows an EEG pattern of ?

A. Triphasic waves B. Widespread high amplitude beta activity C. Burst suppression pattern D. Alpha coma E. Spontaneous epileptiform spike and wave

解答：B 題目之出處 Neurology in clinical practice fourth edition ( ) 9. Which of the following statements concerning H reflex is WRONG?

A. The H reflex is a monosynaptic reflex with an afferent and efferent limb. B. The H reflex recording the soleus muscle is considered to be the electrical

equivalent of the ankle jerk. C. H reflex is recorded from multiple muscles in infants. D. The H reflex of the tibial nerve or soleus system is absent in 10% of

normal subjects. E. The H reflex occurs during supramaximal stimulation.

解答：E 題目之出處：Merritt’s Neurology,11th ed, 2005, p. 91

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( ) 10. Concerning about subacute combined degeneration, which of the followings is INCORRECT？ A. Lesions in posterior and lateral columns B. Mostly combined with optic atrophy, macrocytic anemia, and atrophic

glossitis C. Nerve conduction study may show decrease in both SNAP and

conduction velocity D. Diffuse hyperreflexia and sensory ataxia E. Absent ankle jerks

解答：C 題目之出處：Neurology in clinical practice, 2004 fourth edition, p.2376~2377 ( ) 11. Which of the following description of stiff person syndrome is CORRECT?

A. EMG examination is not useful for the diagnosis B. Antibody of GABA may be detected C. Symptom can be improved partially with diazepam D. Never associated with other autoimmune disorders E. The major clinical feature is myokemia of the hands and legs

解答：C 題目之出處：NICP 2165 ( ) 12. A 62-year-old man presents to outpatient clinic with a one-year history of

frequent falls. On examination he had axial rigidity, slow soft speech, a markedly diminished eye blinking rate with normal pursuit eye movement and mild motor perseveration. There is also slight tremulous of the right hand during the finger-to-nose test. Which of the following is the most likely diagnosis? A. Corticobasal degeneration. B. Parkinson disease C. Progressive supranuclear palsy D. Multiple system atrophy E. Dementia with Lewy bodies

解答：C 題目之出處：Adams & Victor’s Principles of Neurology, 8th edition, p926-928

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( ) 13. In Parkinson’s disease, the major component of Lewy bodies is A. Alpha-synuclein B. Parkin C. Lrrk2 D. PINK1 E. DJ1

解答：A 題目之出處：Movement Disorders, 2nd Ed, p. 197-207 ( ) 14. The following genetic cause is the most often found in the world wide

populations A. Alpha-synuclein gene B. Parkin gene C. PINK1 gene D. DJ-1 gene E. Lrrk2 gene

解答：B 題目之出處：Movement Disorders, 2nd Ed, p. 163-176 ( ) 15. A 50-year-old man is unable to stop blinking forcefully, and has frequently

grimacing movements of the face. Sometimes he protrudes his tongue against his will. He has never taken any medications. Please select the most likely condition. A. Meige syndrome B. Hemifacial spasm C. Tardive dyskinesia D. Spasmodic torticollis E. Dopa-responsive dystonia

解答：A 題目之出處：Principles of Neurology, 8th ed., P93-94

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( ) 16. In a Parkinsonian patient who has developed motor fluctuations, which of the following measures can be applied to decrease wear-offs? A. Avoiding L-dopa intake with meals, as well as diet protein restriction B. Adjusting L-dopa intervals between intakes C. Adding a COMT inhibitor D. Adding a dopamine agonist E. All of the above

Ans：E From Parkinson’s disease & movement disorder fifth edition, Joseph Jankovic & Tolosa 2007, Williams &Wilkines P.128 ( ) 17. Which of followings is NOT true about essential tremor?

A. The hallmark motor feature is a 7- to 12-Hz tremor that may involve several regions of the body

B. PET and MRS show metabolic abnormalities in the thalamus C. Many patients note that tremor is temporarily suppressed by drinking

alcoholic beverages D. Essential tremor is frequently misdiagnosed as parkinsonism, particularly

in the elderly E. The disorder is partly genetic. Many large kindreds show an

autosomal-dominant pattern 解答：B 題目之出處：Merrit’s Neurology 11th edition, p. 828 ( ) 18. Common carotid artery occlusion (CCAO) can be divided into two types:

type I (CCAO with internal carotid artery occlusion) and type II (CCAO with patent internal carotid artery). Which of the following disease having higher frequency of type II CCAO? A. Large artery atherosclerosis B. Cardioembolism C. Post-radiation vasculopathy D. Takayasu’s arteritis E. Post-trauma.

解答：D 題目之出處：Stroke: Pathophysiolody, Diagnosis, and Management,4th ed, 2004, p581

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( ) 19. Which one of the followings about arterial dissection is WRONG? A. A dissection is produced by subintimal penetration of blood in a vessel

with subsequent longitudinal extension of the intramural hematoma between its layers.

B. The mechanism of stroke may be due to hemodynamic change or embolism.

C. The most common artery of dissection is internal carotid artery. The dissection usually occurs 2 cm above the carotid bifurcation.

D. Surgical correction is recommended only for selected individuals without pseudoaneurysms or those who fail to respond to medical therapy.

E. The onset of ischemic symptoms is usually within a few days of dissection.

ANS：D From: Neurology in Clinical Practice, 4th edition, P.1214 ( ) 20. Which of the following about antiphospholid syndrome is NOT true ?

A. It has prolonged clotting time, anticoagulant cannot be used B. It may occur with SLE, cancer or some drug reactions C. It may present as headache, confusion, stroke or seizures D. It is known eponymously as Graham syndrome, or as an annexinopathy E. Patients have either or both the lupus anticoagulant or anticardiolipin

syndrome 解答：A 題目之出處：Merritt’s Neurology, 11th edition, p.309 ( ) 21. Which one of the following behavioral and psychotic symptoms is most

common in patients with vascular dementia? A. Delusions B. Depression C. Euphoria D. Hallucinations E. Obsessive-compulsive behavior

解答：B 題目之出處：Continnum 2007; 13:P. 171

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( ) 22. Which of the followings is NOT a typical finding in Kennedy disease? A. Fasciculation in the tongue and mentalis muscle B. Large-fiber sensory peripheral axonopathy C. Proximal limbs weakness D. Prominent upper motor neuron signs E. Gynecomastia

解答：D 題目之出處：Meritt’s Neurology, 2005 Eleventh edition, p.863 ( ) 23. Which of the following about autism is NOT true?

A. Impairment of both verbal and nonverbal communication B. Intelligence is a defining feature and influences prognosis C. Lack of insight into other people’s thinking D. Narrow range of interests and unusual preoccupations and activities E. Polygenic inheritance account for most cases with an unknown cause

解答：B 題目之出處：Merritt’s Neurology, 11th edition, p. 583-584 ( ) 24. Which one of the following is unusual for subcortical dementia ?

A. Slowed speed of cognition B. Personality change C. Broca aphasia D. Amnesia E. Lacunar infarct

解答：C 題目之出處：Manual of Neurologic Therapeutics 7th Edition (2004) p. 433-440

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( ) 25. Which of the following is effective in migraine prevention? A. Flunarizine B. Carbamazepine C. Ergotamine D. Opiates E. Phenytoin

解答：A 題目之出處、頁數及其版本章節或年卷：The Headache, 3/e, pp433-440 ( ) 26. A 46-year-old woman used to be a migraineur since adolescence. Since half

a year ago, she began to experience headaches with increasing frequency, which is now almost daily. She is now drinking 4 bottles of cough syrup (containing Acetaminophen and Caffeine) obtained over-the-counter every day to relieve her headaches in recent months. Upon presentation, neurological examination is normal. What do you suggest her to do FIRST? A. Arrange detailed neuroimaging studies to rule out intracranial lesions. B. Prescribe triptans for her headaches. C. Put her on migraine preventive agents D. Take off the cough syrup for the consideration of medication overuse

headache. E. Titrate analgesics to maximal tolerable dose.

解答：D 題目之出處：Olesen et al. The Headache. 3rd ed. p.613-7 ( ) 27. Which of the following is NOT true about the cluster headache ?

A. Men are affected about eight times than women. B. Propranolol and amitryptyline are effective in cluster headache . C. The major prophylactic drugs are predinisolone and lithium. D. Oxygen inhalation is effective in cluster headache. E. Alcohol provokes cluster headache attacks in about 70% of patients.

解答：B 題目之出處：Merritt’s Neurology, 11th edition, P 986-987

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( ) 28. Please compare the half-life of the following drugs: (1)valproate (2) lamotrigine (3) gabapentin. A. (3)>(2)>(1) B. (2)>(1)>(3) C. (3)>(1)>(2) D. (1)>(3)>(2) E. (1)>(2)>(3)

解答：B 題目之出處：Adams and Victor’s Principle of neurology P.292 ( ) 29. The following statements about benign childhood epilepsy with

centrotemporal spikes and benign childhood epilepsy with occipital spikes are correct EXCEPT? A. The former usually has clonic seizure over one side of face, developing

to generalized tonic-clonic seizure. B. The latter usually has visual and autonomic symptoms. C. The former has seizures mostly during wakefulness but the latter has

seizures mostly during sleep. D. Both seizures are readily controlled by a single anti-epileptic drug. E. Both have good prognosis.

解答：C 題目之出處：Adams and Victor’s Neurology, 8th edition, P.279-280 ( ) 30. Which of the followings is INCORRECT about the contraception issue in

women with epilepsy? A. The hormonal contraception failure maybe seen in epileptic women

using conventional antiepileptic drugs. B. Newer antiepileptic drugs have not been reported to result in failure of

hormonal contraception. C. Hormone implants are good alternatives for contraception in women with

epilepsy using enzyme-inducing antiepileptic drugs. D. Phenytoin, Phenobarbital, carbamazepine and primidome are inducers of

hepatic cytochrome P450. E. Breakthrough bleeding may occur in women with epilepsy using

enzyme-inducing antiepileptic drugs. 解答：C 出處：AAN guideline

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( ) 31. The findings of the repetitive stimulation study are NOT compatible with A. Lamber-Eaton myasthenic syndrome B Botulism C. Myasthenia gravis with thymoma D. Bungarotoxin intoxication E. None of the above

3Hz 20Hz Answer：C Form Kimura. Electrodiagnosis in disease of nerve and muscle ( ) 32. Which item of the followings regarding periodic epileptiform discharge

(PLED) is NOT correct? A. PLEDs ,a sign that usually indicates a focal pathology that is subacute or

chronic, almost always affect cerebral cortex, and more likely occur in the context of co-existing metabolic encephalopathy.

B. Cortical stroke is responsible for almost half of the incidence of PLEDs, and tumors and infections are each responsible for almost another 20%.

C. Among infectious disease, herpes simplex encephalitis is the most likely to produce PLEDs.

D. PLEDs are a useful sign to help distinguish Creutzfeldt-Jacob disease from other dementias or progressive encephalopathies.

E. Among stroke, embolism and watershed distribution are more likely to produce PLEDs than thrormbosis and small vessel occlusion.

解答：A 出處：Atlas of EEG patterns. 2005 by Lippincot Williams & Wilkins. P213-215.

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( ) 33. Which of the following electrophysiologic findings suggest poor outcome of Guillain-Barré syndrome? A. Severely slowed motor conduction velocities B. Severely prolonged motor distal latencies C. Absent F responses D. Appearance of multiple conduction blocks E. Compound muscle action potential amplitudes less than 20% of normal.

解答：E 題目之出處：Merritt’s Neurology,11th ed, 2005, p. 748 ( ) 34. Which of the following statement of spinal myoclonus is WRONG?

A. The myoclonic jerks may be bilateral or unilateral B. The myoclonic jerks are not sensitive to stimulus C. Most patients with propriospinal myoclonus have normal MRI findings D. Propriospinal myoclonus may be developed during the transition form

wake to sleep E. The frequency of spinal myoclonus may be rhythmic or semirhythmic

解答：B 題目之出處：NICP:2163 ( ) 35. What is WRONG about idiopathic paroxysmal kinesigenic dyskinesia?

A. Female predominance B. Mean age at onset is 11–12 years old C. Attacks are very brief, usually lasting seconds, and always less than 5

minutes D. Rising quickly from a chair to answer the telephone may provoke an

attack E. Good response to phenytoin or carbamazepine

解答：A 題目之出處：Merritt’s Neurology, 11th ed. P50

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( ) 36. The major pathophysiology of Parkinson’s disease are, EXCEPT A. Overall increased activity of the indirect pathway B. Hyperactivity of the subthalamic nucleus C. Decreased activity in the direct pathwa D. Increased activity of the thalamic related nucleus E. Increased activity of the globus pallidus

解答：D 題目之出處：Movement Disorders, 2nd Ed, p. 101-112 ( ) 37. A 74y/o male Idiopathic Parkinson’s Disease patient went to visit chest

clinic because of his chronic cough. Tuberculous infection was told. His parkinsonism deteriorated severely after he took the medicine from the chest clinic. This is because of the regimen containing A. Rifampicin B. Pyrazinamide C. Isoniazid D. Myambutol E. Streptomycin.

解答：C 題目之出處：Parkinson’s Disease & Movement disorders 4th ed. Joseph j.Jankovic.E.

Tolosa, P366 tab 25.1 ( ) 38. Which of the following feature has a better prognosis in Parkinson’s

disease? A. PARK2 B. Postural instability and gait disorder C. Parkinson’s disease with dementia D. Symmetry E. Depression

解答：A 題目之出處：Nisipeanu P et al. Parkin gene causing benign autosomal recessive

juvenile parkinsonism. Neurology 2001; 56:1573-1575.

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( ) 39. Which one of the following movement disorders is not responsive to dopamine agonists or levodopa? A. Dystonia in Segawa disease B. Parkinsonism in SCA2 C. Restlessness in RLS D. Ataxia in DRPLA E. Parkinsonism in young onset Parkinson’s disease

解答：D 題目之出處：Joseph Jankovic and Eduardo Tolosa. Parkinson’s Disease & Movement

Disorders 5th edition. p.338, 416. Lu CS et al. The parkinsonian phenotype of spinocerebellar ataxia type 2 Arch Neurol. 2004 ;61(1):35-8.

( ) 40. Which peripheral neuropathy could also result in tremor: A. Charcot-Marie-Tooth disease B. IgM gammopathy C. Chronic inflammatory demyelinating neuropathy D. HIV-associated neuropathy E. All of the above

解答：E 題目之出處：Joseph Jankovic and Eduardo Tolosa. Parkinson’s Disease & Movement

Disorders 5th edition. p.301 ( ) 41. Which one of the following statements is NOT true for cerebral venous

thrombosis (CVT)? A. CVT can cause venous infarct leading to variable clinical presentations. B. Because of tendency of hemorrhage, heparinization is contraindicative. C. Corkscrew appearance could sometimes be detected by angiogram. D. CVT may develop in relation to infections of adjacent ear and paranasal

sinus. E. Patients with coma and multiple cerebral hemorrhages are usually fatal.

解答：B 題目之出處：Adam’s Neurology, 8th edition, p.734-735

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( ) 42. A 25 year-old woman, pregnancy of 10 weeks gestational age, sustained transient hemiparesis and was found to have mitral stenosis. Which drug is better for her to use if she concerns about the teratogenic effect of the drugs? A. Aspirin B. Warfarin C. Low-molecular weight heparin D. Clopidogrel E. Conventional heparin

解答：C 題目之出處：Stroke: Pathophysiolody, Diagnosis, and Management, 4th ed, 2004 ( ) 43. Which of the following ultrasonographic parameters for diagnosis of

cervical internal carotid artery stenosis (ICA) >70% is the generally used criteria? A. The cross-sectional area reduction of the stenotic ICA >80% B. The peak systolic flow velocity of the stenotic ICA >250 cm/s C. The peak systolic flow velocity ratio of the stenotic ICA to the common

carotid artery (CCA) >2 D. The end-diastolic flow velocity of the stenotic ICA >140 cm/s E. The mean flow velocity of the stenotic ICA >150 cm/s.

解答：B 題目之出處：Stroke: Pathophysiolody, Diagnosis, and Management, 4th ed, 2004,

chap 21

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( ) 44. A 68-year-old hypertensive woman accepted angioplasty with stent placement for treatment of symptomatic 90% stenosis of the left internal carotid artery. Before stenting procedure, carotid sonography disclosed occlusion of her right internal carotid artery. Two hours after procedure, she had vomiting and then lost her consciousness. Emergent head CT showed a massive hematoma over the left hemisphere. Which of the following conditions most likely explains this postprocedural complication? A. Hypertensive encephalopathy. B. Postprocedural hypotension C. Rupture of undiagnosed intracranial aneurysm D. Hyperperfusion syndrome E. Cerebral amyloid angiopathy

解答：D 題目之出處：Adams & Victor’s Principles of Neurology, 8th edition, p698-699 ( ) 45. Multiple embolic strokes, which usually occur in young women patients

with ovarian cancers, is frequently referred to: A. Marantic endocarditis B. Rheumatic heart disease C. Cardiac myxoma D. Cardiomyopathy E. Cardiac arrhythmia

解答：A 題目之出處：Handbook of Clinical Neurology, vol. 53, vascular disease, part 1, p.156 ( ) 46. Agenesis of the corpus callosum may be one of the following syndromes

EXCEPT: A. Aicardi syndrome B. Septo-optic dysplasia (de Morsier syndrome) C. Smith-Lemli-Opitz syndrome D. Kallmann syndrome E. Arnold-Chiari malformation

解答：E 題目之出處：Swaiman, 4th ed., p.385

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( ) 47. Which of the following features can faithfully differentiate dementia with Lewy bodies (DLB) from Parkinson’s disease with dementia (PDD)? A. Exacerbated rigidity by antipsychotics B. Presence of Lewy bodies in limbic and neocortical regions C. Gait disturbance with repeated falls D. Recurrent, vivid visual hallucinations E. Presence of diffuse cortical atrophy on brain MRI

解答：B 題目之出處：Neurology in Clinical Practice, 4/e, p. 1924-1927 ( ) 48. What is the most frequently seen ocular motility disorder in patients with

Niemann-Pick disease type C? A. Vertical supranuclear gaze palsy B. Horizontal gaze palsy C. Pendular nystagmus D. Bilateral abducens palsy E. Unilateral 3rd nerve palsy

解答：A 題目之出處：Neurology in clinical practice, 3rd edition, Page 1645. ( ) 49. Which one of the following is NOT caused by a CAG (cytosine-adenine-

guanine) triplet expansion? A. Huntington’s disease B. Dentatorubropallidoluysian atrophy C. Friedreich’s ataxia D. Spinocerebellar ataxia type 1 E. Machado-Joseph disease

解答：C 題目之出處：Merritt’s Neurology, 11th ed. P784, 789, 804

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( ) 50. Frontotemporal dementia has been associated with mutations in the gene coding for which of the following? A. A-Synuclein B. Amyloid precursor protein C. Superoxide dismutase D. Tau protein E. Ubiquitin

解答：D 題目之出處：Continnum 2007; 13: P.95-97 ( ) 51. Which one of the descriptions for spinobulbar muscular atrophy (Kennedy

syndrome) is CORRECT? A. Beginning after 40 years old with bulbar dysfunction B. Limb weakness more severe distally C. Presence of both upper and lower motor neuron signs D. Demyelinating sensory neuropathy may be demonstrated by nerve

conduction study. E. Reproductive fitness prominently affected in most cases

解答：A 題目之出處：Merritte's Neurology 11th p.863 ( ) 52. which type of SCA (spinocerebellar atrophy) was associated with retinal

degeneration? A. SCA 2 B. SCA3 C. SCA6 D. SCA7 E. SCA12

解答：D 題目之出處：Merritt`s neurology 11th Edition P.794

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( ) 53. Which one of the followings is least related to Alzheimer's disease ? A. Over-production of beta-amyloid B. Hyperphosphoration of Tau protein C. Excessive apo-lipoprotein E3 D. Degeneration of acetylcholine neurons E. Synuclein anomaly

解答：C 題目之出處：Manual of Neurologic Therapeutics 7th Edition (2004) p. 429 ( ) 54. Which of the following is the treatment of choice for short-lasting unilateral

neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)? A. Lamotrigine B. Indomethacin C. Lithium D. Propranolol E. Steroid

解答：A 題目之出處：Merritt’s Neurology, 11/e, p987. ( ) 55. Which of the following is INCORRECT regarding spontaneous intracranial

hypotension (SIH)? A. The cardinal feature of SIH is orthostatic headache; only rarely are there

other neurological deficits such as diplopia or a self-audible bruit. B. Stupor consciousness or an upper cervical myelopathy may occur in

severe cases due to downward transtentorial displacement of diencephalon.

C. Tarlov cyst, a leaking meningeal diverticulum, may be the most common cause of SIH.

D. Subdural effusions or hematomas with mass effect are possible complications.

E. The image finding of pachymeningeal enhancement is typically restricted supratentorially.

解答：E 題目之出處：Adams and Victor’s Principles of Neurology, 8th edition, p. 542.

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( ) 56. Which of the following is an INCORRECT description of cluster headache? A. Lithium is effective for the cluster headache, especially for the chronic

form. B. Most patients are vulnerable to alcohol. C. The headache is one-sided while the autonomic symptoms tended to be

bilateral, with the headache side more prominently involved. D. Subcutaneous sumatriptan is effective in aborting the headache. E. Dorsal raphe nucleus is believed to be the site of pathogenesis.

解答：E 題目之出處：Merritt’s Neurology, 11th edition, p.986-7 ( ) 57. Concerning pharmacokinetics and pharmacogenomics of Carbamazepine

(CBZ): A. Bioavailability is similar among different generic formulations B. Intracerebral extracellular concentration of CBZ does not correlate to

concentration of free CBZ in blood C. Clearance is almost entirely by hepatic metabolism and is oxidized by

CYP3A4 isoform D. Although autoinduction may occur, co-administration of phenytoin does

not alter the half-life of CBZ E. CBZ-induced Steven-Johnson syndrome in Chinese/Taiwanese is

associated with HLA-A*1101 allele

Answer：C Ref: Engel J and Pedley TA. Epilepsy, 1998; vol 2, p 1492-3; Nature 2004; 428,486; Pharmacogenetics and Genomics 2006; 16: 297-306; Epilepsia 2007; 48(5):1015-8

( ) 58. Which of the following is NOT the electrodiagnostic abnormal feature of true thoracic outlet syndrome? A. Low amplitude of ulnar sensory nerve action potential B. Low amplitude of median sensory nerve action potential C. Low amplitude of ulnar compound muscle action potential recorded on

abductor digiti minimi D. Low amplitude of median compound muscle action potential recorded on

abductor pollicis brevis E. Delayed F-wave latency of ulnar nerve

解答：B 題目之出處：Merritt’s Neurology, 11th ed, 2005, p. 544

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( ) 59. Which of the following statements about posthypoxic myoclonus is WRONG? A. It is also called Lance-Adam syndrome B. The negative myoclonic component may cause fall of patients during

walking or standing C. CSF may show high levels of 5-hydroxyindole-acetic acid (5-HIAA) D. There is some tendency for improvement in myoclonus over time E. Valproic acid and clonazepam are usually used in the treatment of

posthypoxic myoclonus 解答：C 題目之出處：NICP:2163 ( ) 60. Which one of the following statements concerning dopa-responsive

dystonia is INCORRECT? A. Nigral cell loss with nigrostriatal dopamine deficiency B. Childhood onset dystonia with concurrent or subsequent development of

parkinsonism C. Female predominance D. A dramatic response to L-dopa, without long-term L-dopa induced motor

fluctuations E. Good long-term prognosis

解答：A 題目之出處：Merritt’s Neurology, 11th ed. P821–822 ( ) 61. Which of the following studies has been used with accuracy to follow

progression of Alzheimer's disease? A. FDG-PET scans for increasing areas of decreased parietal metabolism B. Genotyping for APOE4 status C. Serial lumbar punctures for A beta 1-42 protein levels D. Serial lumbar punctures for CSF tau levels E. Structural MRI for hippocampal and brain volume

解答：E 題目之出處：Continnum 2007; 13: P.53-54

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( ) 62. Which one of the neuropathy is not painful? A. Amyloid polyneuropathy. B. Diabetic polyneuropathy. C. Vitamin E deficiency. D. Porphyria E. Fabry disease.

解答：C 題目之出處：Diagnosis and Management of Peripheral Nerve Disorders, p. 131, 539 ( ) 63. Which of the following myopathies is inherited in an autosomal dominant

fashion? A. Miyoshi myopathy B. Oculopharymgeal muscular dystrophy C. Nonaka myopathy D. Acid maltase deficiency E. Limb girdle muscular dystrophy type 2B

解答：B 題目之出處：Muscle Diseases, edited by AHV Schapira and RC Griggs. Various chapetrs ( ) 64. About common clinical presentations of χ-linked bulbospinal neuronopathy,

which one is WRONG? A. Perioral fasciculation B. Tongue atrophy C. Proximal muscle weakness especially shoulder girdle muscles D. Prominent sensory impairment E. Testicular atrophy

解答：D 題目之出處：Arch Neurol 2002; 59: 1921-6; and Merritt’s Neurology 10th ed P.709-10

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( ) 65. Concerning about neonatal myasthenia gravis, which one is CORRECT A. About 80% of infants born to myasthenic mothers have a syndrome

characterized by impaired sucking, weak cry, limp limbs B. Symptoms begin in the first 48 hours and the children are still abnormal

in their elementary school C. The mothers are usually asymptomatic D. Acetylcholine receptors antibodies are demonstrable in child only (not in

mother) E. Respiratory support and nutrition are the key elements of treatment

解答：E 題目之出處、頁數及其版本章節或年卷：Merrit’s Neurology, 11th edition, Chapter

121, PP 878 ( ) 66. A 40-year-old man had acute onset of right wrist drop. The EMG study 3

weeks later showed normal findings in the biceps, triceps, and brachioradialis muscles, while fibrillation & positive sharp waves were noted in the extensor indicis proprius and extensor digitorum communis muscles. Based on the EMG findings, the lesion is most likely located… A. At the cervical root B. At the axilla C. At the spinal groove D. At the forearm E. Below the wrist

解答：D 題目之出處：Merritt’s Neurology, 11th ed., p536-7.

24

( ) 67. From the pathological findings of the sural nerve biopsy, which disease is the most appropriate diagnosis? A. IgM monoclonal gammopathy B. Amyloidosis C. DM neuropathy D. Cryoglobulinemia E. CMT

Ans. A From NICP: Chapter. Peripheral nerve disorder ( ) 68. About the description of lead neuropathy, which is NOT correct?

A. Most cases occur following chronic exposure to lead paint or fumes B. Predominantly affecting motor fibers in upper extremities C. Most frequently involving radial nerves D. Wrist and finger drop frequently seen E. Lead neuropathy most commonly seen in children

解答：E 題目之出處：Principles of Neurology, 8th edition, p. 1132

25

( ) 69. As comparing multifocal motor neuropathy (MMN) to CIDP, which of the following descriptions is NOT correct? A. Distal weakness is more profound than proximal weakness in MMN. B. Both proximal and distal weakness exist in CIDP. C. Upper motor neuron signs are absent in both MMN and CIDP D. CSF protein are usually elevated in both MMN and CIDP E. The sensory conduction velocity is reduced and the SNAPs are low in

CIDP

Ans：D 題目之出處：Neurology in Clinical Practice 3rd edition, P 2091

( ) 70. The most common single gene mutation causing Charcot-Marie-Tooth disease type 1A (CMT1A) is: A. Myelin protein zero (MPZ) B. Peripheral myelin protein (PMP22) C. Periaxin (PRX) D. Gap junction (GJB1) E. Calpain-3

Answer：B 題目之出處：Rowland LP (2005) Merritt’s Neurology. 11th ed. 738-745; Walsh RJ,

and Greenberg SA (2005) Molecular Diagnosis of Inherited Neuromuscular Disorders; Muscle & Nerve, Invited review, p432-434

( ) 71. Which of the following statements about the Lewy body is WRONG? A. It is an intra-neuronal, eosinophilic spherical body, measuring 8-30µm in

diameter B. In the classic well-formed Lewy body, ubiquitin tends to concentrate

within the central core, whereas α-synnuclein is located in the periphery C. All patients with Parkinson’s disease have Lewy bodies. D. Lewy body may be found in patients with subacute sclerosing

panencephalistis and progressive supranuclear palsy E. Lewy bodies in Parkinson’s disease are not restricted to the substantia

nigra

解答：C 題目之出處：Acta Neurol Taiwan 2005;14:40-47

26

( ) 72. The best empiric antibiotics regimen for CSF shunt or neurosurgery related bacterial meningitis is A. Cefotaxime + ampicillin B. Ceftriaxone + penicillin C. Vancomycin + ceftazidime D. Ciprofloxacin + ampicillin E. Vancomycin + ceftriaxone

解答：C 題目之出處：Infections of the nervous system and sacoidosis, Adams and Victor’s

Priciple of Neurology, 8th edition p599, table32-2 ( ) 73. Which one of the followings is NOT the common pathogen of adult

nonsurgical bacterial meningitis? A. Listeria monocytogenes B. Haemophilus Infleuenzae C. Staphylococcus aureus D. Streptococcus Pneumoniae E. Neisseria meningitides

解答：C 題目之出處：Infections of the nervous system and sacoidosis, Adams and Victor’s

Priciple of Neurology, 8th edition p594 ( ) 74. The most frequent causative microorganism of viral meningitis is

A. Enterovirus B. Herpes simplex virus C. EBV D. Adenovirus E. CMV

解答：A 題目之出處：Adams and Victors, 8th edition, p. 633

27

( ) 75. Which statement about periodic paralysis is CORRECT? A. In western countries, thyrotoxic periodic paralysis is more common than

familial periodic paralysis B. The incidence in female is greater than those in male C. Thyrotoxic periodic paralysis is related to human leukocyte antigen D. Periodic paralysisis only occurs in hypokalemic state E. The muscle weakness progresses from distal part to proximal part

解答：C 題目之出處：Principles of Neurology 6th edition, 1997, p1481-1485 ( ) 76. Which one is the deficient enzyme in acute intermittent porphyria?

A. Porphobilinogen deaminase. B. Coproporphyrinogen oxidase. C. Protoporphyrinogen oxidase. D. ALA (δ-aminolevulinic acid) dehydratase. E. ALA synthetase.

解答：A 題目之出處：Adams and Victor’s Principles of Neurology 8th edition, p.1154 ( ) 77. About tetrodotoxin poisoning, which one is NOT correct?

A. Tetrodotoxin is a potent sodium channel blocker B. Tetrodotoxin can cause numbness of the tongue and then rapidly

progressive polyneuropathy C. The electrophysiologyical studies show reduced amplitudes of compound

muscle action potentials without conduction block nor temporal dispersion

D. It is usually caused by cating tropical reef fish E. Treatment is symptomatic, no antidote is noted

解答：D 題目之出處：Merrtt’s Neurology, 10th Edition, p. 944-946

28

( ) 78. The diagnosis of NF1 (neurofibromatosis 1) is made on the basis of clinical features requiring the presence of at least two of the following major criteria EXCEPT: A. Café-au-lait spots B. Freckles at axillary or inguinal area C. Plexiform neurofibroma D. Bony defects E. Bilateral lower limb weakness

解答：E 題目之出處：Current Opinion in Neurology 2007;20:135-141 ( ) 79. The most common symptom in patient with surgically confirmed acoustic

neuroma is: A. Dysequilibrium B. Facial numbness C. Headache D. Hearing loss E. Tinnitus

解答：D 題目之出處：Merritt’s Neurology, 11th edition, p. 383 ( ) 80. Which of the following statements is CORRECT for circadian rhythm

disorders? A. Humans have a circadian rhythm shorter than 24 hours. B. Adaptation is slower after a westward flight than after an eastward flight. C. Patients with non-24-hour sleep-wake disorder suffer concomitant

insomnia and hypersomnia at the same period of time. D. Treatment with bright light and exercise in the evening may help patients

with delayed sleep phase syndrome. E. The delayed-sleep-phase syndrome is common in old people but the

advance-sleep-phase syndrome is common in young people.

解答：C 題目之出處：Merritt’s Neurology, 11th edition, P.1029

29

( ) 81. REM sleep behavior disorder can be found in A. Pontine infarction B. Multiple system atrophy C. Parkinson’s disease D. Dementia E. All of the above

解答：E 出處 Adams and Victor, 8th edition, p.343 ( ) 82. Which of the following disorders is NOT acute motor paralysis with

variable disturbance of sensory and autonomic function ? A. Guillian-Barré syndrome B. Prophyric polyneuropathy C. Critical illness polyneuropathy D. Tick paralysis E. Lyme disease

解答：E 題目之出處：Principles of Neurology 8th edition, p. 1120 ( ) 83. The following clinical featpure is INCORRECT in Myotonic dystrophy.

A. Autosomal dominant inheritance B. Would involve cranial muscles, like ptosis and ophthalmoparesis C. Cardiac conduction disorder D. Mental involvement in congenital type E. Predominant involve in proximal part of muscle group

解答：E 題目之出處：Merritt’s Neurology 11th Edition, pp 903-4

30

( ) 84. Which one of the following diseases develops cramps only during intense or ischemic exercise? A. Isaacs syndrome B. Myotonic disorders C. Stiff-man syndrome D. McArdle disease E. Tetany

解答：D 題目之出處：Merritt’s Neurology 11th Edition, pp: 925-8. ( ) 85. Cold-induced weakness and paralysis is most often seen in:

A. Hypokalemic periodic paralysis B. Myotonic dystrophy C. Paramyotonia congenita D. Myotonia congenita E. Limb girdle muscular dystrophy type 2B

解答：C 題目之出處：Muscle Diseases, edited by AHV Schapira and RC Griggs. P156-157. ( ) 86.Which one of the following statements is NOT true for spinal muscular

atrophy (SMA)? A. SMA is a motor neuron disease rather than muscular dystrophy. B. Most SMA cases have an autosomal recessive inheritance with a disease

related gene of SMN. C. SMN protein participates in forming protein-RNA complexes that are

essential for gene splicing. D. Muscle enzymes (ex. CK) in the serum are usually normal. E. Currently, muscle biopsy is the most important diagnostic tool.

解答：E 題目之出處：Adam’s Neurology, 8th edition, p.945-947

31

( ) 87. Which of the following statement is NOT true for critical illness polyneuropathy? A. Frequent development in critically ill and septic patients. B. Sensory symptoms are variable but tend to be mild. C. Cranial nerves are usually spared. D. EMG study usually shows evidences of conduction block and temporal

dispersion. E. CSF study usually reveals normal results.

解答：D 題目之出處：Adam’s Neurology, 8th edition, p.1128 ( ) 88. A 61-year-old man complained of hypesthesia over proximal regions of the

body, including face, oral mucosa and scalp. Proprioception is diminished in distal. Tendon reflexes are lost. Strength is entirely spared. Which statement about this patient is TRUE? A. The most likely diagnosis is neurosis because oral mucosa is rarely

involved in neuropathy. B. This is a patient with polyneuropathy C. Guillain-Barre syndrome is the most possible diagnosis D. This is a patient with ganglionopathy E. Except his hypesthesia, other neurological findings are compatible with

polyradiculopathy. 解答：D 題目之出處：Adams & Victor’s Principles of Neurology, 8th edition, p139 ( ) 89. Pinch sign is presented in:

A. Median neuropathy at the wrist B. Ulnar neuropathy at the elbow C. Radial neuropathy at the spiral groove D. Anterior interosseous nerve syndrome E. Cubital tunnel syndrome

解答：D 題目之出處：Kimura, Electrodiagnosis in Disease of Nerve and Muscle. 3rd Ed, p. 719

32

( ) 90. Concerning about myasthenia gravis (MG), which one is NOT correct? A. MG is caused by a defect of neuromuscular transmission owing to

antibody-mediated attack on muscarinic acetylcholine receptors (AchR) at neuromuscular junctions

B. MG is characterized by fluctuating weakness that is improved by inhibitors of cholinesterase

C. The pathogenesis of MG is related to the destructive effects of autoantibodies to AChR

D. The polyclonal IgG antibodies to AChR are produced by plasma cells in peripheral lymphoid organs, bone marrow, and thymus

E. These cells are derived from B cells that have been activated by antigen-specific T-helper (CD4+) cells

解答：A 題目之出處：Merrit’s Neurology, 11th edition, Chapter 121, PP 877-878 ( ) 91. Which of the following statements about myasthenic crisis is NOT correct ?

A. Crisis should be associated with profound weakness of limbs. B. Crisis may occur at any time after the diagnosis of myasthenia gravis, but

half of them are evident within 2 years. C. Anticholingeric drugs are best withdrawn during crisis. D. The use of plasma exchange appears to hasten improvement and weaning

from the ventilator. E. Measurement of vital capacity remains an important bedside test,

although it may not accurately reflect diaphragmatic function in myasthenic crisis.

解答：A 題目之出處：Principle of Neurology, 6th edition, 1997, p1469 ( ) 92. MRI findings strongly suggest multiple sclerosis (MS) EXCEPT?

A. 4 or more white matter lesions (each > 3mm) B. Ovoid lesions, oriented perpendicular to ventricles. C. Corpus callosum lesions. D. 3 white matter lesions, 1 periventricular E. Open ring appearance on FLAIR

解答：E 題目之出處：Neurology in clinical practice, fourth edition, p.1648

33

( ) 93. In multifocal motor neuropathy, the most frequently detected antigangliosides antibody is A. Anti-GM1 (IgG) B. Anti- GM1 (IgM) C. Anti-GQ1b D. Anti-GD1a E. Anti-GD1b

解答：B 題目之出處：Adams and Victor, 8th edition, p. 1149 ( ) 94. The asymmetric and bilateral slowly progressive weakness of wrists, ulnar

finger flexors, and knee extensors with normal facial muscles in a 55-year-old male is highly suggestive of A. Inclusion body myositis B. Acid maltase deficiency C. Myotonic dystrophy D. Nemaline myopathy E. Polymyositis

解答：A 題目之出處：Merritt’s Neurology p. 932-934 ( ) 95. Which of the following myopathies is related to a chloride channel defect?

A. Becker muscular dystrophy B. Myotonic dystrophy C. Paramyotonia congenita D. Hyperkalemic periodic paralysis E. Potassium-aggravated myopathy

解答：B 題目之出處：Merritt’s Neurology p.903-905

34

( ) 96. Apnea-testing performed in brain death are, EXCEPT A. Delivery 100% O2, 6L/min, into the trachea for 10 minutes before

disconnect the ventilator B. Look closely for respiratory movement C. Measure arterial PO2, PCO2 and pH after approximate 8 minutes and

reconnect the ventilator D. If respiratory movement are absent and arterial PCO2 is ≧60mmHg.

The apnea test result is positive E. If deoxygenation or cardiac arrhythmia require termination of apnea

testing before PaCO2 of 60mmHg is reached, the apnea test is still positive

解答：E 題目之出處：Merritt’s Neurology, 11th edition, p. 27 ( ) 97. Multifocal acquired demyelinating sensory and motor neuropathy is

characterized by A. Symmetric onset B. Conduction block C. Response to steroid D. High titer of anti-ganglioside GM1 antibody E. Unable to differentiate from chronic inflammatory demyelinating

neuropathy (CIDP) by its clinical, electrophysiological and pathological features

解答：B 題目之出處：Acta Neurologica Taiwanica 2004;13:24-28

35

( ) 98. Which of the following is NOT true about Huntington’s disease-like 2 (HDL-2)? A. It is an adult onset, progressive, neurodegenerative autosomal dominant

disorder. B. It is clinically characterized by abnormal movement, dementia, and

psychiatric syndrome. C. Neuropathology of HDL2 features prominent cortical and striatal atrophy

and intranuclear inclusion. D. The incidence is highest among individual of Hispanic ancestry E. It is caused by CTG/CAG expansion mutation on chromosome 16q24.3

解答：D 題目之出處：Acta Neurolo Taiwan 2005;14:1-8 ( ) 99. The phenomenon present in the patients with multiple sclerosis includes

A. Slowing of visual evoked response by hypoventilation B. Improvement of symptoms by smoking C. Absent association of histocompatibility locus antigens D. Temporal induction of visual blurring by heat E. Absent association of uveitis and sheathing of retinal veins

解答：D 題目之出處：Principles of Neurology (2005), p. 772-778

( ) 100. A 27 year-old female patient had subacute onset, rapid progression of dementia and myoclonus seizures. Fine tremor and goiter were found. Therefore, Hashimoto encephalopathy is highly suspected. About the Hashimoto encephalopathy, Which one is CORRECT? A. The patients often contain normal protein levels in CSF. B. High either antithyroid peroxidase or anithyroglobulin anti-body is

necessary for diagnosis. C. No response to steroid therapy. D. 14-3-3 protein in CSF could be used for differential diagnosis between

Hashimoto encephalopathy and Creutzfeldt-Jakob disease. E. Pathologic examination never shows spongiform changes.

解答：B 題目之出處：Merritt’s Textbook of Neurology, 11 ed, 2005, pp1120-1121

36

( ) 101. Which statement about Wilson’s disease is TRUE? A. It is caused by a deficiency of serum ceruloplasmin. B. Regression of Kayser-Fleischer ring after D-penicillamine treatment C. The pathophysiololgy is due to impairment of urine copper excretion D. The family screening of parents and kids is more important than that for

siblings in this inheritable disease E. Restriction of liver and shellfish in the diet is more important than the

administration of decoppering agents 解答：B 題目之出處：Merritt’s Neurology, 11th ed. P660-665 ( ) 102. Which brain lesions had been found commonly the hemorrhagic

complication? EXCEPT A. Oligodendrocytoma B. Melanoma C. Pituitary adenoma D. Herpes encephalitis E. Glioblastoma multiforms

解答：A 題目之出處：Merritt’s neurology 11th ed. ( ) 103. Which description concerning brain tumor is CORRECT?

A. Brain tumor is the most common malignancy in the pediatric population.

B. In children, high-grade astrocytoma and medulloblastoma predominate. C. Increased choline, decreased N-acetylaspartic acid, high lipid & lactate

levels in MR spectroscopy (MRS) suggest a high-grade neoplasm. D. Prophylactic anticonvulsants should be given routinely in all brain

tumor patients to prevent seizure attack. E. Modern dental x-rays and cellular phone usage increase the risk of brain

tumors.

解答：C 題目之出處：Merritt’s Neurology, 11th ed., p371-6.

37

( ) 104. Which one of the following structures is most vulnerable to anoxic damage? A. Granular layer of cerebral cortex B. Deep folia of cerebellum C. Pontine nuclei D. Purkinje layer of cerebellum E. Thalamus

ANS：B From: Adams & Victor’s Principles of neurology, 8th edition, P.960 ( ) 105. Which one of the following abnormalities commonly associated with

obstructive hydrocephalus？ A. Dandy-Walker malformation B. Chiari malformation C. Mega cisterna magna D. Posterior fossa arachnoid cyst E. Epidermoid cyst

解答：A 題目之出處：Diagnostic Neuroradiology，AG Osborn page 66 ( ) 106. The most characteristic neuropathological feature of HIV dementia is

A. Neurofibrillary tangles B. Periventricular demyelination C. Caudate atrophy D. Multinucleated giant cells E. Neuritic plaques

解答：D 題目之出處：Merritt’s Neurology p. 779

38

( ) 107. A damage to the frontal cortex results in all of the following EXCEPT: A. Loss of initiative B. Decrease spontaneity C. Sensory inattention D. Perservation E. Apathy

解答：C 題目之出處：Principle of neurology 5th version, P388-389 ( ) 108. Which of the following statement is NOT true for extramedullary cranial

nerve syndromes (site, cranial nerves involved, syndrome)? A. Lateral wall of cavernous sinus, II/III/IV/V/VI, Tolosa-Hunt syndrome. B. Apex of petrous bone, V/VI, Gradenigo syndrome. C. Jugular foramen, IX/X/XI, Vernet syndrome. D. Posterior retroparotid space, IX/X/XI/XII/Horner, Villaret syndrome. E. Sphenoidal fissure, VII/VIII, Foix syndrome.

解答：E 題目之出處：Adam’s Neurology, 8th edition, p.1180 ( ) 109. Which of following statement about narcolepsy with cataplexy is

CORRECT? A. In most patients, it is associated with HLA B8 B. Orexin/Hypocretin is produced by a group of neurons in the posterior

lateral hypothalamus C. CSF orexin/Hypocretin level are elevated in most patients with

narcolepsy D. Sleep paralysis is usually the first symptom in the patients with

narcolepsy and cataplexy E. Hypnagogic hallucinations are absent.

解答：B 題目之出處：Adams and Victor's Principle of Neurology, 8th ed., 2005, p. 344-348

39

( ) 110. About the descriptions of Kearns-Sayre Syndrome (KSS), choose the WRONG one: A. Kearns-Sayre Syndrome (KSS) is identified by an invariant triad: onset

before age 20, PEO, and pigmentary retinopathy. B. Heart block (usually needing a pacemaker), cerebellar syndrome, or

CSF protein content of 100 mg/dl or more can be found. C. A sporadic PEO (Progressive external ophthalmoplegia) with single

deletions of mtDNA D. Hypoparathyroidism, one of the several endocrine disorders sometimes

associated with KSS. E. A relatively benign condition, often compatible with a normal lifespan.

解答：E 題目之出處：Merritt's Neurology , 11th Edition, p. 698 ( ) 111. Which one of the following statements concerning about congenital

myopathy is NOT correct ? A. Severe form of myotubular myopathy and nemaline myopathy are

usually associated with neonatal death B. Ptosis is usually associated with myotubular myopathy C. Neonatal respiratory difficulties have not been the feature of central

core disease D. Extraocular muscular weakness is a prominent feature of congenital

fiber type disproportion E. The inheritance of congenital myopathy includes X-linked recessive,

autosomal dominant, autosomal recessive and sporadic cases 解答：D 題目之出處：Volpe, 4th ed., p.689

40

( ) 112. In patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the pathological finding in skin biopsy consistent with the diagnosis is ? A. Amyloid deposition in small vessels B. Calcification of blood vessels C. Eosinophilic vascular smooth muscle cell degeneration D. Large vessel atherosclerosis E. Microaneurysms

解答：C 題目之出處：Continnum 2007; 13: P.123 ( ) 113. Which one is the CORRECT statement for brain magnetic resonance

imaging in patients with amyotrophic lateral sclerosis? A. T2 hypointensity lesion in the precentral gyrus B. T2 hyperintyensity lesion in the precentral gyrus C. T2 hypointensity lesion in the subcortical white matter tract D. T1 hyperintensity lesion in the subcortical white matter tract E. T1 hyperintensity lesion in the precentral gyrus

解答：A 題目之出處：Imaging of the nervous system (Latchaw, Kucharczyk, Moseley) p.1126 ( ) 114. Positron emission tomography shows that the most severe reduction in

cerebral metabolism in case of Alzheimer’s disease is located in A. Temporal association cortex B. Frontal association cortex C. Motor cortex D. Parietal association cortex E. Basal ganglia

解答：D 題目之出處：Neurology in Clinical Practice p.1910

41

( ) 115. About persistent vegetative state (PVS) which description is CORRECT? A. The patients remain inattentive, and show no signs of awareness to

environment but responsive to inner drive B. There are significant changes of background activities in the EEG after

external stimulation C. The pathological evaluation revealing that the connection between

cerebellum and thalamus being disconnected D. PVS may be the terminal phase of progressive cortical degeneration

process such as Alzheimer disease E. PVS caused by traumatic lesion has a poor prognosis than those caused

by a non-traumatic lesion 解答：D 題目之出處：Adams and Victor’s : Principles of Neurology 8th eds page 30-4305