Muscle diseases
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Transcript of Muscle diseases
Supervised by:Dr.Eftekhar
Peresented by:Mohsen Koolivand
MSC Clinical of Biochemistry
Muscle Diseases
به نام خدا
OutlineIntroduction
Marker of muscle damage
Muscle dystrophies
Metabolic myopathies
Other myopathies
Introduction
Marker of muscle damage
CK
Tree forms M-B-MM
CK-MB : Use of management of chest pain
The highest activities in : necrosis , Duchenne
Serial plasma CK : for myopathic and response to treatment
Normal plasma CK
Other enzymes for marker
Aldolase , lactate dehydrogenase , myoglobin
In severe muscle damage, myoglobinuria can occur and cause a
brown colouration of the urine. Myoglobin can precipitate out in
the renal tubules and cause an obstructive nephropathy: the renal
failure associated with crush injuries is in part due to this.
Muscle dystrophiesMuscular dystrophy (MD) is a broad term that describes a genetic (inherited)
disorder of the muscles. Muscular dystrophy causes the muscles in the body to
become very weak.
Metabolic myopathies
Neuromuscular disorders in which the primary
symptom is muscle weakness due to dysfunction of
muscle fiber
Inflammatory Myopathies Polymyositis Dermatomyositis Inclusion body myositis Viral
Muscular dystrophies Duchenne muscular Limb-girdle Congenital Fasioscapulohumeral Oculopharyngeal Emery – Dreifuss Distal (Welander)
Myotonic Syndromes Myotonic dystrophy Inherited Schwarz-Jampel Drug-induced
Congenital myopathies Central core disease Nemaline myopathy Myotubular Fiber-type disproportion
Metabolic myopathies Glycogenoses Mitochondrial Periodic paralysis
Endocrine myopathies Thyroid Parathyroid Adrenal/steroid Pituitary
Drug-induced/toxic
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Other myopathies
Myotonia
Myasthenia gravis
Lambert–Eaton myasthenic syndrome
God is looking for clean hands and a pure heart