(Microsoft PowerPoint - Bioq 2- Aminoacidos e prote\355nas.ppt)
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Aminoácido
Aminoácido em solução aquosa
a pH 7
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Estereoquímica de aminoácidos
Todos, menos a glicina, são quirais
Os L-aminoácidos predominam na natureza
A nomenclatura D/L baseia-se no D- e L-gliceraldeído
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Titulação da Glicina
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Alpha carboxyl group - pKa = 2
Alpha amino group - pKa = 9
(Estes numeros são aproximados)
Valores dos pKa dos Aminoácidos
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Titulação do Ácido Glutamico
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Os seis átomos da ligação peptidica estão dispostos num plano
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Unfavorable orbital overlap precludes some
combinations of phi and psi
•phi = 0, psi = 180 is unfavorable •phi = 180, psi = 0 is unfavorable •phi = 0, psi = 0 is unfavorable
Steric Constraints on phi & psi
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Estrutura Secundária das ProteínasHélice α
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Estrutura Secundária das ProteínasFolhas pregueadas β
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Estrutura Terciária das Proteínas
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Estrutura Quaternária das Proteínas
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Quaternary Structure of Hemoglobin
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