Evidence Based Botanicals in the Treatment of Inflammation

Eugene R. Zampieron, ND,AHG

Sponsored by Restorative Formulations(Non-CME presentation)

DrZ teaching at the University of Bridgeport College of Naturopathic Medicine, CT

• Licensed Naturopathic physician– Connecticut since 1990

• Dr. Friedman’s mentor• Registered Professional,

Herbalist, AHG• Author/Radio host• Academic and clinical faculty

member and Founding Presidential advisors Board Member – University of Bridgeport College

of Naturopathic Medicine,Connecticut

• Caribbean Ethnobotany researcher– EcoToursforCures.com

Why do I choose/use Enfla-Mend Px & T-Cell balance Px & other RF products??

Our topic and objectives…• Inflammation is a primary factor in heart

disease, arthritic disease, digestive disorders, respiratory inflammation, diabetes, cancer and aging in general.

• Some botanical agents are shown to have broad acting anti-inflammatory effects for all these complaints

• I use the term INFLAM-aging with patients

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bVaM:

Boswellia serrata(Salai/Salai guggul)

• Boswellia serrata (Salai/Salai guggul), is a moderate to large sized branching tree of family Burseraceae (Genus Boswellia), grows in dry mountainous regions of India, Northern Africa and Middle East.

http://i.telegraph.co.uk/multimedia/archive/02433/Frankinsense1_2433367b.jpg

http://www.nature.com/nature/journal/v444/n7121/images/444529a-i1.0.jpg

Boswellia serrata(Salai/Salai guggul)

• The oleo gum-resins contain 30-60% resin, 5-10% essential oils, which are soluble in the organic solvents, and the rest is made up of polysaccharides.

Boswellia serrata(Salai/Salai guggul)

• The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes.

Penta{5} cyclic ringsSteroidal in nature

Fractions of Boswellic acid and inhibition of NFkB

Fractions of boswelliic acids

Effects of Boswellia triterpenoids

Boswellia is not inferior to

NSAID mesalazine

Some had complete remission with

Boswellia

Boswellia blocks

Smad7 and thus

restores Smad 3 &

TGFB, which

Acts to down

regulate the immune

system in colitis

Boswellia helps SMAD3

http://c431376.r76.cf2.rackcdn.com/18172/fimmu-03-00020-HTML/image_m/fimmu-03-00020-g003.jpg

IL17

Better for

autoimmunity

TgfBIL-2 Treg

IL-4Th2

Boswellia modulates

c3 into C3a & C3b

Stops NFkB

Your Cartilage & Collagen doesn't stand a chance when these pathways are activated!

B

Boswellia was as effective

as allopathic drugs for UC

and Crohn’s

AKBA from Boswellia Prevented Intestinal Polyposis better

than aspirin

Boswellia induces

apoptosis in the polyps

http://www.molecular-cancer.com/content/figures/1476-4598-2-41-3-l.jpg

Curcuma

prevents this

Boswellia may inhibit ulcers; this is critical in treating rheumatic dz,

as NSAIDS can cause ulcers & Leaky gut

Boswellia blocks

Leukotrienes and may

increase protective

prostaglandins

Eschscholzia is a fast acting herb in EnFlamend known to reduce pain and anxiety

• California Poppy (Eschscholziacalifornica) is the official state flower of California.

• The plant grows to 60 cm, has feathery foliage and velvety, golden-orange flower petals.

• It is a member of the Papaveraceae.

Ethnobotany of Eschscholzia

• Western coastal Indians used the seed as a general pain killer, especially as a toothache remedy

• Also used externally for its antimicrobial properties as a poultice for sores and other skin disorders, its extract has been shown to be a very effective antispasmodic aiding in muscle spasms, cramps, convulsions and chronic coughs, which are a type of spasm

History of Eschscholzia

• California Poppy was a commonly used herb in native American and Hispanic societies, and gained considerable interest from medical practitioners in the lat 1800’s, when it was added to the Park-Davis drug catalog as “an excellent soporific and analgesic, above all harmless.”

The Eclectics on California Poppy….

• Eschscholzia was stated to be an “…analgesic and soporific without the dangers attending opiates, quieting pain and producing (a) calm sleep” (1893).

• Externally, the various Poppies can be used to treat pain and arrest local inflammation, used as a lotion, liniment, or plaster

Eschscholzia Constituents• Like the Opium Poppy,

California Poppy contains a variety of isoquinolinealkaloids including very small amounts of morphine and codeine.

• Large varieties of other isoquinolines, including: californidine, californinechelerythrine, chelilutin chelirubine, coptisine,cryptocavine,cryptopine,escholidine, escholine, scholinine, eschscholtzidine, protopine and sanguinarine.

Clinical Studies

• California Poppy (CP) extract inhibits degradation of catecholamines and synthesis of epinephrine (adrenaline) in vitro.

• Preserving catecholamines may explain the Pain relieving and endorphin activity of CP.

• Alkaloids from CP enhance (GABA) binding to receptors, which may indicate a benzodiazapine-like activity.

Pain cycle broken by EnFlamend and its herb Eschscholzia….

Eschscholtia

Benzodiazepine receptors

Eschscholzia binds to GABA Receptors

Enfla-mend Px has 375 Mg of Eschscholtzia per 3 caps, in the range recommended by the worlds leading phytotherapists

• Dosage for pain:

• 1:2, 3-6 ml

(Mills and Bone 2005)

• 1:5, 1-4 ml, 25% ethanol (Hoffmann 2003)

• 200- 800 g dried equivalent, per day

Enfla-Mend Px has used the cutting edge technologies to provide practitioners with the best curcumin delivery

systems…..

Curcuma longa

• Curcumin (diferuloylmethane; 1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione)

• Curcumin is the major bioactive component of turmeric or Curcuma longa L., a widely used natural food product in curry powder and food coloring (mustard).

Curcuma and its multi-effects down-stream of NfKB

New mechanism of action of curcuma in Cardiovascular disease

Curcuma lowered

oxyLDL

Upregulated

ABCA1What the heck is this??

How does it work??

ATP binding

Cassette transporter?

Curcumin

causes efflux

ejection of

cholesterol from

foam cells which

is

picked up by

HDL & ApoA1ABCA1 is ATP-

Binding cassette

transporter A1

A deficiency in

ABCA1 may

cause

increased

atherosclerosis

Smooth muscle migration is

essential in the sequence &

pathogenesis of

atherosclerosis

MMP’s

Degrading

the

extracellular

matrix

STOP

Curcuma spp.

Stopped this

migration of smooth

muscle cells into the

plaque

Curcumin is Poorly Absorbed

• Traditionally people have prepared curcumin in fat – heating with butter or oil– creates “liposomes” of a sort: little spheres of fat that carry the curcumin across the intestinal wall.

Meriva TM

Phosphatidyl

Complex is a

Patented and

Evidence-based

Whole intact

Curcuma

Wholistic, balanced

with Meriva TM

Volatile oils intact

Bromelain acts

As another

Absorption

synergist, and is a

powerful botanical agent

By it’s own right…

Piperine for

ASSIMILATION

Quercetin & resveratrol, powerful anti-inflammatory

Agents by themselves….

synergizes absorption kinetics with Meriva

Bromelain,piperine & the volatile oils

Meriva

showing better

absorption of

curcuminoids

Adding Piperine…The science• Curcumin bioavailability has been improved by co-

administering it with piperine.• Piperine is a piperidine alkaloid found in the fruit of the

black pepper (Piper nigrum), and is responsible for the pungency of black pepper spice.

Piperine’s Effect on Curcumin

• Piperine improves Curcumin’s bioavailability by inhibiting Hepatic phase II glucuronidation

• Piperine also improves intestinal absorption by inhibiting P-glycoprotein-1, a broad-acting xenobiotic efflux transporter).

Piperine inhibits liver

degradation of the

curcuma, supporting

tissue saturation

Graph of curcuma plus synergists, not even taking into account EnFlamend uses Meriva, which is superior to

regular curcuma

Quercetin and Resveratrol also offer powerful anti-inflammatory effects

Quercetin

Quercetin stops

leaky gut

Resveratrol in Enfla-mend

Resveratrol has its own

effects on oxidative stress

by blocking TNF alpha

INHIBITION of

TNF alpha

BromelainProteolytic Enzyme From Pineapple

Bromelain

Bromelain modulates cytokines

Bromelain blocks bradykinin,VCAM-1 and Cox 2

Bromelain modulated

VCAM-1 and stops

atherosclerosis

Bromelain versus NSAIDS: an effective and healthier choicehttp://www.tbyil.com/BromelainT4.jpg

Osteoarthritis and Sports Medicine References for Bromelain