Do Aberration Changes with Accommodation Really...
Transcript of Do Aberration Changes with Accommodation Really...
Do Aberration Changes withAccommodation Really Matter?Austin Roorda, Han Cheng, Abhiram Vilupuru,
Justin Barnett, Jason Marsack, SanjeevKasthurirangan, Adrian Glasser, Ray Applegate
Visual Optics InstituteVisual Optics InstituteUniversity of Houston College of OptometryUniversity of Houston College of Optometry
Aberrations and Accommodation
• Koomen et al, 1949 (annular refraction)
• Ivanoff, 1956 (Scheiner principle)
• van den Brink, 1962 (localized subjective refraction)
• Jenkins, 1963 (localized retinoscopy)
• Howland and Buettner, 1989 (Howland aberroscope)
• Lu, Campbell, Munger, 1994 (Scheiner principle)
• Atchison et al, 1995 (Howland aberroscope)
• Lopez-Gil et al, 1998 (double pass PSF)
• He, Burns, Marcos, 2000 (Scheiner principle)
• Ninomiya et al, 2002 (Shack Hartmann)
• Artal, Fernandez, Manzanera, 2003 (Shack-Hartmann)
Summary of Previous Results
• Poll of results suggest that spherical aberrationbecomes more negative with accommodation
• Does this preclude a good wavefront correctionfor those who accommodate?
• Artal et al 2003 suggests that although newaberrations are generated by accommodation,the aberrations remain relatively low.
• We decided to test that theory with a populationstudy.
Current Study Methods
• 90 students enrolled
• 2.5 % Phenylephrine for dilation
• Measured wavefront for eyes accommodating at 3stimulus values, 0D, 3D & 6D (target adjusted foreye’s refractive error)
• Aberrations based on average of 3 repeated WFSmeasures
• For refractive errors >-2 D we had subject wearspectacles
• Selected the eyes who maintained > 5 mm pupil forevery stimulus (n=74)
Current Study Details
• Recorded the accommodative response as thebest fitting defocus for a 3 mm sub-pupil
• Full analysis for 5 mm pupils at allaccommodative states
• 6th order Zernike polynomial
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Z3
Z4
Z5
Z6
Zer
nike
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m
Avg Coeff RMS (mm)0 0.02 0.04 0.06 0.08 0.1-0.15 -0.05 0.05 0.150
Avg Coeff Value (mm)
6789101112131415161718192021222324252627
Results: Population Statistics of Eyes in theRelaxed State
very similar to population study by Porter et al. JOSA A, 2001
Average coeff value Average coeff magnitude
All Results - 27 Zernike Terms C
han
ge
in E
ach
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nik
e C
oef
fici
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3 – astigmatism (45 deg)5 – astigmatism (0 deg)7 – vertical coma8 – horizontal coma 12 – spherical aberration
-3-113
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Z3
Z4
Z5
Z6
Coefficient Value (mm)
Zer
nike
Ter
m
Average of the Change in Coeff Values-202
Z2
-0.4 -0.2 0 0.2 0.4
6789101112131415161718192021222324252627
345
0-1 D
95% conf limits
n=22
-3-113
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-5-3-1135
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Z3
Z4
Z5
Z6
Coefficient Value (mm)
Zer
nike
Ter
m
Average of the Change in Coeff Values-202
Z2
-0.4 -0.2 0 0.2 0.4
6789101112131415161718192021222324252627
345
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95% conf limits
n=36
-3-113
-4-2024
-5-3-1135
-6-4-20246
Z3
Z4
Z5
Z6
Coefficient Value (mm)
Zer
nike
Ter
m
Average of the Change in Coeff Values-202
Z2
-0.4 -0.2 0 0.2 0.4
6789101112131415161718192021222324252627
345
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95% conf limits
n=26
-3-113
-4-2024
-5-3-1135
-6-4-20246
Z3
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Z5
Z6
Coefficient Value (mm)
Zer
nike
Ter
m
Average of the Change in Coeff Values-202
Z2
-0.4 -0.2 0 0.2 0.4
6789101112131415161718192021222324252627
345
3-4 D
95% conf limits
n=24
-3-113
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-5-3-1135
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Z3
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Z5
Z6
Coefficient Value (mm)
Zer
nike
Ter
m
Average of the Change in Coeff Values-202
Z2
-0.4 -0.2 0 0.2 0.4
6789101112131415161718192021222324252627
345
4-5 D
95% conf limits
n=31
-3-113
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-5-3-1135
-6-4-20246
Z3
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Z5
Z6
Coefficient Value (mm)
Zer
nike
Ter
m
Average of the Change in Coeff Values-202
Z2
-0.4 -0.2 0 0.2 0.4
6789101112131415161718192021222324252627
345
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95% conf limits
n=19
Accommodation Change (D)
Cha
nge
in R
MS
abe
rrat
ion
(mm
)Which Aberrations Undergo the Largest
Changes in Magnitude?
Spherical Aberration (Z12): y = 0.043x - 0.0226
Coma (Z7&Z8): y = 0.0135x - 0.0126
Astigmatism (Z3&Z5): y = 0.0134x + 0.0005
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Accommodation Change (D)
Sph
eric
al A
berr
atio
n T
erm
(m
m)
6 D stim
3 D stim
0 D stim
Actual Change in Spherical Aberration
Aberrations of the Isolated Crystalline Lens
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Z[4,4]
Z[5,-5]
Z[5,-3]
Z[5,-1]
Z[5,1]
Z[5,3]
Z[5,5]
Zer
nik
e te
rm
Coefficient value (microns)
astigmatism
astigmatism
coma
coma
trefoil
trefoil
defocus
4th order SA
ACCOMMODATION
Isolated macaque lens in Glasser’s stretching apparatus
Roorda and Glasser, JOV, in press
Accommodative Lenticonus
Fincham, 1937
Variations in capsular thickness:ÿ Cause slight anterior central lenticonus during accommodationÿ Allow greater refractive change in the center than periphery of the lens
thereby causing increasing negative spherical aberration withaccommodation
Accommodating Mammals Non-accommodating Mammals
Accommodation Change (D)
RM
S W
ave
Abe
rrat
ion
(mm
)Change in RMS with Accommodation
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
resting state 0.0-1.0 1.0-2.0 2.0-3.0 3.0-4.0 4.0-5.0 5.0-6.0
all aberrations presentall aberrations corrected
-0.4
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
0.4
0 1 2 3 4 5 6
Accommodation Change (D)
Sph
eric
al A
berr
atio
n T
erm
(m
m)
6 D stim
3 D stim
0 D stim
Actual Change in Spherical Aberration
Accommodation Change (D)
RM
S W
ave
Abe
rrat
ion
(mm
)Change in RMS with Accommodation
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
resting state 0.0-1.0 1.0-2.0 2.0-3.0 3.0-4.0 4.0-5.0 5.0-6.0
all aberrations presentall aberrations corrected
all aberrations except SA corrected
So…
Do Aberration Changeswith Accommodation
Really Matter?There are significant changes, particularly forspherical aberration, which have importantimplications for image quality, DOF etc.YES!
The changes in aberration withaccommodation are not large enough topreclude a useful aberration-free correction (asquantified by RMS wave aberration)
NO!