CURRICULUM VITAE RAYMUND A.C. ROOS

Born in The Hague, The Netherlands on January 5th, 1954. He attended in Venlo and Delft the Gymnasium B and passed the examination in 1971. He started the study of Medicine at the State University of Leiden in 1971, where he passed his "doctoraal" examination cum laude in 1976. The Dutch Medical Licence examination was passed in November 1977. From November 1977 till May 1978 he worked as resident in internal medicine at the Diaconessenhuis, Leiden (Dr. R.Vink). The residency in neurology was started May 1st, 1978 at the Department of Neurology, State University Leiden (Prof. Dr. G.W.Bruyn). In his last year of training he was resident in Psychiatry at the Psychiatric Hospital "Endegeest", Oegstgeest (A.J.Lameyn). May 1st, 1982 he was entered in the specialist register. From that time he is staff neurologist at the academic Hospital Leiden (Prof. Dr. G.W.Bruyn). Thesis Leiden 1984; Roos RAC. Nuclear membrane indentations in Huntington's disease Child-neurologist. 01-05-1982 to 01-05-1986. Head of the out-patients department. 01-02-1986 to 01-12-1993 Visiting researcher University of Tsukuba, Japan. Biochemical and pathological studies on brains of Huntington's disease. 25-09-1988 to 01-12-1988: Associate professor University Hospital Leiden 01-05-1989 to 01-12-1993 Full Professor, Head and Chairman Department of Neurology. 01-12-1993-present Responsible for the training of Residents in Neurology 1993-2014 Consultant Psychiatric Hospital Endegeest (Rijngeest Groep) 1998-2003 Consultant Nursing Home Oostpoort Amsterdam (Huntington’s disease) 2013- Consultant Nursing Home Kloosterhoeve Geertruidenberg (Huntington’s disease) 2014- Management functions in LUMC: Member Management Team Division III LUMC, 01-05-1996 – 01-07-2008 Chairman Management Team Division III LUMC, 01-09-1996- 01-07-2008 Chairman Inter Divisioneel Overleg LUMC , 01-01-2000- 01-07-2008 Chairman ai Dept Huisarts- en verpleeghuisgeneeskunde 01-11-2002-15-01-2003 Member and chairman of several ‘Benoemingsadviescommissies’ of all chairman of div 3 Chairman project reorganisation metabolic laboratory 2004-2005 Member reorganisation ‘ in beweging’ LUMC 2001-2003 Member Boerhaave committee, treasurer. 1988-1994 Chairman Boerhaave Committee 01-07-2006 – 1-1-2011 Chairman Kwaliteitsraad (LKP/kwaliteitsraad: Safety and Quality)) 1-10-2010-present Chairman ad hoc committee scientific integrety 2012 Member Commission Scientific Integrety LUMC 2012-present Several of the external functions: -Member Raad van Toezicht St Duyn en Rhyn, Katwijk, 1992-2005 -Member Medical advisor Parkinson Patienten Vereniging 1984-2003, chairman 1998 -2003 -Member steering committee Expert Centr Huntington disease Leiden –Katwijk 01-09-2007-present -Medical advisor Vereniging van Huntington 1982-present -Chairman Foundation "Chorea van Huntington" 1984-2013 -Member Neurosurgical Study group The Netherlands 1990-present -Member Adviescommissie van de St.Wetenschapsfonds Dystonie 2010-present -Chairman Scientific Advisory Board Prinses Beatrix SpierFonds 30-03-2011-2015 - Lid stuurgroep Huntington Net zorg Nederland 2014- -Opname Kennisplein Huntington van Topaz, internet videoinformatie 2015 -Chairman WAR patientenvereniging Huntington 2015- -Member programcommittee training pecialists SO focus on HD 2015-2016 -Member NOW (ZON-MW) Division 3 Endocrine regulation and neurosciences 1992-1998. -Member Scientific Advisory Board Prinses Beatrix Fund 1995-2004 -Chairman Scientific Advisory Board International Society Alzheimer’s Disease, The Netherlands 1995-2000 -Member Advisory Board Brain bank Amsterdam -Member govermental commission "Gezondheidsraad" 1996-1998 -Lid begeleidingscommissie voor college van zorgverzekeringen. Neuromodulatie.van 2001-2003

-Member ‘Toetsingscommissie van St Fondsenwervingsacties Volksgezondheid’ 2003 -Member (Chairman 2002) stuurgroep Stroke service 1999-2003 -Member Board Van Alkemade fund. 1999-present -Member Research Committee on Huntington's disease of the World Federation of Neurology 1981-present -Member Research Committee on Huntington's disease of the WFN treasurer1999-2009 -Member Research Committee on Huntington's disease of the WFN secretary general 2009-present -Member excecutive Committee EURO-HD-Network 2004-2014 -Steering Committee Registry EURO-HD 2005-2014 -Steering Committee Track-HD 01-09-2006 – 2015 -EHDN Consultant 25-01-2013-2014 -Ad hoc reviewer: Neurology, J Neurology Neurosurg and Psychiatry, Lancet Neurology, J for Huntington disease, J Neurology, Clinical Neurology and Neurosurgery, Nederlands Tijdschrift voor Geneeskunde, Annals of Neurology, Movement Disorders, Archives of medical research Reviewer, Parkinson disease and related disorders, Hersenstichting, Neurology, Hersenstichting, Prinses Beatrix Fonds, Spaarne Ziekenhuis expertise voor een klacht -Member Editorial Board Movement Disorders 1999-2001 -Member Editorial Board Current opinion in Neurology 2001-2012 -Member Advisory Board Neuropraxis 1997-2012 -Member Editorial Board Pharmacotherapy on line 2001-2012 -External reviewer several research programmes University of Antwerp 2002 -Reviewer 6th framework EC grants, 14-17-may-2003 -Organisation several Boerhaave postgraduate courses -Organisation world congress on Huntington’s disease Scheveningen 1999 -Member organizing committee World Congres Huntington disease Rio de Janeiro2013 Nederlandse Vereniging voor Neurologie: (Dutch Society For Neurology) -Member plenaire visitatiecommissie 1992-2004 -Chairman CRON Ned Ver Neurologie, 1998-2004 -Member commissie Eindtermen NVN 2000-2003 -Member/chairman CWON Ned Ver Neurologie 1992-2013 -Member Consilium Neurologicum 1992-2004 -Member/chairman kernconsilium en plenair consilium2004-2012 -Member Commissie Visie Opleiding van Raad WOK van de orde 2009-2011 -Member Plenair Consilium 2004-2014 -ad hoc member Winkler medaille committee 2015

PUBLICATIONS Publicaties 1977 Buul PPW v, Roos RAC. The effect of exposure rate on translocation induction in somatic and germ cells of the mouse. Mutation Research 1977; 42: 99-108. Publicaties 1980 Roos RAC, Buruma OJS. De waarde van semi-quantitatieve glucosebepaling bij verdenking op nasale liquorroe. Ned Tijdschrift Geneesk, 1980; 124: 1265-1266. Bergh FAJTM vd, Roos RAC. Iso-electric focussing van de liquorcerebrospinalis. Boerhaave cursus, November 1980: 71-78. Voordrachten Roos RAC, Tiapride bij de chorea van Huntington. Nederlandse vereniging voor Huntington. 15-11-1980 Roos RAC, Tiapride bij de chorea van Huntington Nederlandse vereniging voor neurologie. 29-11-1980. Publicaties 1981 Roos RAC. Myoclonic epilepsy with Lafora bodies. Lafora Disease. In: Handbook of Clinical Neurology Vol. 42, Eds.: P.J.Vinken and G.W.Bruyn, Elsevier Science Publishers, Amsterdam, New York, 1981: 702-703. Roos RAC, Buruma OJS, Bruyn GW, Kemp B, Velde EA vd. Effect of Tiapride in Huntington's chorea. Clin Neurol and Neurosurg, 1981; 83: 41. Roos RAC, Buruma OJS, Bruyn GW. Tiapride bij de Chorea van Huntington. Kontaktblad van de vereniging van Huntington, 1981; 4: 10-12. Bergh FAJTM vd, Roos RAC. Gel isoelectric focussing and IgG index for demonstration of intrathecal IgG synthesis in neurological disorders. Ann Clin Biochem, 1981; 18: 153-157. Bots GTAM, Wattendorf AR, Buruma OJS, Roos RAC, Endtz LJ. Acute myelopathy caused by fibrocartilagi-nous emboli. Neurology, 1981; 31: 1250-1256. Endtz LJ, Wattendorf AR, Bots GTAM, Buruma OJS, Roos RAC. Acute myelopathy caused by fibrocartilagi-nous emboli. Human Pathol., 1981; 12:485. (letter). Wattendorf AR, Bots GTAM, Buruma OJS, Roos RAC, Endtz LJ. Acute myelopathy caused by fibrocartilagi-nous emboli (summ). Clin Neurol and Neurosurg, 1981; 83: 174. Buruma OJS, Kemp B, Roos RAC, Franzen JM. Quantification of involuntary movements by Doppler-Radartechnique.(Abstract 1256). International Congress Series (Exerpta Medica), 1981; 548: 402. Voordrachten Roos RAC, Tiapride bij de chorea van Huntington. Psychiatrisch ziekenhuis Bloemendaal. 29-05-1981, uitnodiging. Roos RAC, Tiapride in Huntington's chorea, Ixth Workshop on Huntington's chorea, Shizuoka, Japan. 28-09-1981, uitnodiging. Roos RAC, Nuclear membrane indentations in Huntington's disease, IXth workshop on Huntington's chorea, Shizuoka, Japan. 28-09-1981, uitnodiging. Roos RAC, Tiapride bij de chorea van Huntington. Psychiatrisch Ziekenhuis Sancta Maria. 14-12-1981, Uitnodiging. Publicaties 1982 Roos RAC, Buruma OJS, Bruyn GW, Kemp B, Velde EA vd. Tiapride in the treatment of Huntington's chorea. Acta Neurol Scand, 1982; 65: 45-50. Roos RAC, Buruma OJS, Bruyn GW, Kemp B, Velde EA vd, Zelvelder WG. Tiapride bij de chorea van Huntington en tardieve dyskinesie: een dubbelblind, placebo gecontroleerd cross-over onderzoek. TGO 1982; 7: 1234-1239. Roos RAC. Dyskinesia tarda. Ned. Tijdschrift Geneesk, 1982; 126: 2153-2158. Roos RAC, Bots GTAM, Bruyn GW. Nuclearmembrane indentation in Huntington's chorea (abstr.) IXth International Congress of Neuropathology, Vienna, 1982: 142. Buruma OJS, Roos RAC, Bruyn GW, Kemp B, Velde EA vd. Tiapride in the treatment of tardive dyskinesia. Acta Neurol Scand, 1982; 65: 38-44. Buruma OJS, Kemp B, Roos RAC, Franzen JM. Quantification of choreatic movements by Doppler-Radar. Acta Neurol Scand, 1982; 66: 363-368. Kemp B, Buruma OJS, Franzen JM, Roos RAC. Quantifications of choreatic movements by a Doppler Radar device. Med. and Biol. Engineering and Comp., 1982; 20: 539-544. Kemp B, Buruma OJS, Franzen JM, Roos RAC. Quantifications of random body movements by a Doppler-Radar device (abstr.). World congress in Medical Physics and Biomedical Engineering, Hamburg, 1982. Voordrachten

Roos RAC, Pathologische anatomie bij de chorea van Huntington. Psychiatrisch Ziekenhuis Endegeest. 25-03-1982, uitnodiging. Roos RAC, Kernmembraan indeukingen bij de chorea van Huntington. Pathologische Anatomie, Leiden. 31-08-1982. Roos RAC, Nuclear membrane indentations in Huntington's chorea. IXth International congress of Neuro-pathology, Vienna. 10-09-1982. Roos RAC, Objectieve meetmethoden bij tardieve dyskinesie. Psychiatrisch Ziekenhuis Vijverdal, Maastricht. 21-10-1982, uitnodiging. Roos RAC, Differentiële diagnose van tardieve dyskinesie. Psychiatrisch Ziekenhuis Vijverdal, Maastricht. 21-10-1982, uitnodiging. Roos RAC, Tiapride bij de behandeling van tardieve dyskinesie. Psychiatrisch Ziekenhuis Vijverdal, Maastricht. 21-10-1982, uitnodiging. Publicaties 1983 Roos RAC, Bots GThAM. Nuclear membrane indentations in Huntington's chorea. J Neurol Sciences 1983; 61: 37-47. Roos RAC. Dyskinesia tarda. Ned Tijdschrift Geneesk 1983; 127: 350-351. Roos RAC, Buruma OJS. Drug-induced dyskinesia In: Dyskinesias Eds: GW Bruyn, OJS Buruma, RAC Roos. Boerhaave Cursus 6-7 october 1983: 157-174. Roos RAC, Haas EJM d, Wolff FA d. Serumconcentrations of tiapride in dyskinesia, TGO 1983; 8: 1012-1013. Arts RJH, Bollen EL, Buruma OJS, Roos RAC. Evoked potentials in involuntary movement disorders In: Dyskinesias Eds: GW Bruyn, OJS Buruma, RAC Roos, Boerhaave Cursus 6-7 october 1983: 83-91. Buruma OJS, Roos RAC, Furnee EH, Antwerpen G v. Computer analysis of dyskinesia and its possibillities In: Dyskinesias Eds: GW Bruyn, OJS Buruma, RAC Roos, Boerhaave Cursus 6-7 october 1983: 61-66. Franzen JM, Kemp B, Roos RAC, Buruma OJS. Doppler-Radar in de medische wetenschap Electronica 1983; 13/14: 63-65. Wassenaar HA, Roos RAC, Spaander PJ, Oosterom AT v. Unusual pattern in testicular malignant teratoma, Med Pediatr Oncol 1983; 11: 8-11. Wolff FA d, Haas EJM d, Roos RAC. Kinetics of tiapride in patients with tardive dyskinesia, Pharmaceutisch weekblad scientific edition 1983; 5: 347. Voordrachten Roos RAC, Nuclear membrane indentations in Huntington's chorea, Xth Workshop on Huntington's chorea, Chicago, Ill. 21-24 april 1983, uitnodiging. Roos RAC, Morbus Parkinson. Psychiatrisch ziekenhuis Endegeest. 15-09-1983, uitnodiging. Roos RAC, Drug-induced dyskinesia, Boerhaave cursus: Dyskinesia, Leiden. 07-10-1983, internationaal. Roos RAC, Electronmicroscopical findings in Huntington's disease. Workshop on Dyskinesia, Leiden. 08-10-1983, intenationaal. Roos RAC, Farmacokinetiek van tiapride bij patienten met tardieve dyskinesie. Nederlandse vereniging voor klinische farmacologie en biofarmacie, Utrecht. 20-12-1983. Publicaties 1984 Roos RAC. Nuclear membrane indentations in Huntington's disease Thesis Leiden 1984. Roos RAC, Buruma OJS, Kemp B. Objectieve meetmethoden bij tardieve dyskinesie. Tijdschrift voor Psychiatrie 1984; 26: 53-56. Roos RAC, Buruma OJS. Extrapyramidal side-effects of neuroleptic drugs. J of drug Research 1984; 9: 82-85. Roos RAC, Buruma OJS. Drug-induced dyskinesia and tardive dyskinesia, In: Dyskinesias Eds: GW Bruyn, OJS Buruma, RAC Roos, Aktua Sandoz 1984; 7: 69-82. Roos RAC, Bots GTAM. Ultrastructural findings in Huntington's chorea, In: Dyskinesias Eds: GW Bruyn, OJS Buruma, RAC Roos, Aktua Sandoz 1984; 7: 95-102. Roos RAC, Wolff FA d, Haas EJM d. Pharmacokinetische parameters bij patiënten met tardieve dyskinesie Ned Tijdschrift Geneesk 1984; 128: 1550. Roos RAC. Loopstoornissen bij kinderen. Vorderingen en praktijk Boerhaave cursus 13-14 december 1984: 124-134. Arts RJHM, Bollen EL, Roos RAC, Buruma OJS. Somatosensory evoked potentials to tibial and median nerve stimulation in Huntington's chorea Muscle and Nerve 1984; 7: 582-583. Bruyn GW, Buruma OJS, Roos RAC. Dyskinesias Sandoz Aktua 7 1984. Buruma OJS, Roos RAC, Furnee EH, Antwerpen G v. Assessments of dyskinesia In: Dyskinesias Eds: GW -Bruyn, OJS Buruma, RAC Roos, Aktua Sandoz 1984; 7: 138-142 Buruma OJS, Barendswaard EC, Roos RAC. De behandeling van de ziekte van Parkinson op oudere leeftijd In: Geriatrie Boerhaave cursus 11-12 october 1984; 109-116. Endtz LJ, Wattendorf AR, Bots GTAM, Buruma OJS, Roos RAC. Acute central cervical cord injury due to disco-dancing (letter) Brit Med J 1984; 288: 408.

Peters ACB, Bots GTAM, Roos RAC, Gelderen HH v. Fukuyama type congenital muscular dystrophy two dutch siblings, Brain development 1984; 6: 406-416. Rossum J v, Roos RAC, Bots GTAM. Disulfiram neuropathy Clin Neurol and Neurosurg 1984; 86: 81-87. Voordrachten Roos RAC, Complications of longterm treatment in Parkinson's disease. Second European Workshop on Neuropharmacology, Budapest. 25-27 april 1984. Roos RAC, Kernmembraanindeukingen bij de chorea van Huntington. Stafcolloquium, Leiden. 01-05-1984. Roos RAC, Specificity of nuclear membrane indentations in Huntington's disease. European Workshop on Huntington's disease, Leiden. 22-24 juni 1984. Roos RAC, Nuclear membrane indentations in Huntington's disease. Rheinische Landesklinik Dusseldorf. 02-10-1984, uitnodiging. Roos RAC, Loopstoornissen bij kinderen. Boerhaavecursus Vorderingen en Praktijk. 14-12-1984. Publicaties 1985 Roos RAC, Pruyt JFM, Vries J d, Bots GTAM. Neuronal distribution in the putamen in Huntington's disease. J Neurol Neurosurg and Psychiat 1985; 48: 422-425. Roos RAC, Bots GTAM, Hermans J. Neuronal nuclear membrane indentations and astrocyte/neuron ratios in Huntington's disease. A quantitative electronmicroscopical study J fur Hirnforschung 1985; 26: 689-693. Roos RAC, Blij F vd. Pseudotumor cerebri and hyperthyroidism and hypovitaminosis A. Dev Med Child Neurol 1985; 27: 242-248. Bollen EL, Arts RJHM, Roos RAC, Velde EA vd, Buruma OJS. Somato sensory evoked potentials in Huntington's chorea. EEG and Clin Neurophysiol 1985; 62: 235-240. Bollen EL, Kamp W vd, Heyer JC d, Roos RAC, Buruma OJS. Oogbewegingsstoornissen bij extrapyramidale ziekten In: Neuroophthalmologie II. Oogbewegings stoornissen Boerhaave cursus 17-18 januari 1985; Buruma OJS, Barendswaard EC, Roos RAC. De medicamenteuze behandeling van de ziekte van ParkinsonModerne Geriatrie 1985; 3: 10-14. Bollen EL, Reulen JPH, Heyer JC d, Kamp W vd, Roos RAC, Buruma OJS. Saccadic eye movements in Huntington's chorea. World congress neurol Hamburg 1-6 september. J of Neurol 1985; 232 (supplement): 86. Voordrachten Roos RAC, Ongebruikelijke bewegingsstoornissen. Nascholing Neurologie. 03-05-1985, uitnodiging. Roos RAC, Nieuwe diagnostische mogelijkheden bij spina bifida occulta. Nederlandse vereniging voor Kinderneurologie en Nederlandse vereniging voor Kindergeneeskunde, Eindhoven. 11-05-1985, uitnodiging. Roos RAC, Klompvoeten en spitsvoeten. Heelkunde, Leiden. 21-05-1985. Roos RAC, Nuclear membrane indentations in Huntington's disease. XIth WFN Workshop on Huntington's disease, Lille. 08-09-1985. Publicaties 1986 Roos RAC, Velde EA vd, Buruma OJS, Wolff FA d. Assessment of the therapeutic range of tiapride in patients with tardive dyskinesia. J Neurol Neurosurg and Psychiatr 1986; 49: 1055-1058. Roos RAC, Haas EJM d, Buruma OJS, Wolff FA d. Pharmacokinetics of tiapride in patients with tardive dyskinesia and Huntington's disease. Europ J of Clin Pharmacology 1986; 31: 191-194. Roos RAC, Bots GTAM, Hermans J. Quantitative analysis of morphological features in Huntington's disease. Acta Neurol Scan 1986; 73: 131-135. Roos RAC. Neuropathology of Huntington's chorea In: Handbook of Clinical Neurology revised series 5, Vol 49. Extrapyramidal disorders Chapter 16. Eds: PJ Vinken, GW Bruyn, HL Klawans Elsevier Science Publishers Amsterdam, New York, 1986: 315-326. Roos RAC, Bruyn GW. Symptomatic dystonia, In: Handbook of clinical Neurology revised series 5 Vol 49. Extrapyramidal disorders Chapter 32. Eds: PJ Vinken, GW Bruyn, HL Klawans Elsevier Science Publishers, Amsterdam, New York 1986: 541-548. Roos RAC, Vielvoye JG, Voormolen JHC, Peters ACB. Magnetic resonance imaging in spinal dysraphism, Pediatr Radiology 1986; 16: 412-416. Roos RAC, Maat-Schieman MLC, Bots GTAM. Immunohistochemistry in Huntington's disease, Xth World Congress of Neuropathology Stockholm 1986: Abstr 424. Roos RAC. Sensibiliteit In: Praktische neurologie op vaste voet Boerhaave cursus 30-31 januari 1986: 35-37. Roos RAC. Klinische betekenis van liquoronderzoek In; Praktische neurologie op vaste voet Boerhaave cursus 30-31 januari 1986: 129-134. Roos RAC, Dijk JG v. Epileptic seizures induced by immersion in hot water. Clin Neurol and Neurosurg 1986; 88:321. Roos RAC, Vielvoye JG, Voormolen JHC, Peters ACB. Kernspinresonantietomografie (samenvatting) Ned Tijdschrift Geneesk 1986; 130: 2198. Bollen EL, Arts RJHM, Roos RAC, Velde EA vd, Buruma OJS. Brainstem reflexes and brainstem auditory evoked responses in Huntington's chorea, J Neurol Neurosurg and Psychiatr 1986; 49: 313-315.

Bollen EL, Reulen JPH, Heyer JC d, Kamp W vd, Roos RAC, Buruma OJS. Horizontal and vertical saccadic eye movement abnormalities in Huntington's chorea J Neurol Sci 1986; 74: 11-22. Bollen EL, Reulen JPH, Heyer JC d, Kamp W vd, Roos RAC, Buruma OJS. Saccadic eye movements in Huntington's chorea, J Neurol 1986; 232: 86. Bruyn GW, Roos RAC. Dystonia musculorum deformans, In: Handbook of Clinical Neurology revised series 5, Vol 49, Chapter 30 Eds: PJ Vinken, GW Bruyn, HL Klawans, Elsevier Science Publishers Amsterdam New York 1986: 519-528. Buruma OJS, Roos RAC. Benign paroxysmal Choreoathetosis, In: Handbook of Clinical Neurology Revised series 5, Vol 49, Chapter 19, Eds: PJ Vinken, GW Bruyn, HL Klawans Elsevier Science Publishers Amsterdam New York 1986: 349-358. Buruma OJS, Roos RAC. Lichaamsbeweging en de oudere patient met een neurologische of psychogeriatrische ziekteIn: Lichaamsbeweging op oudere leeftijd Eds:WJA Goedhard DL Knook Samson Stafleu Alphen aan den Rijn 1986: 82-91. Buruma OJS, Kremer HPH, Roos RAC. De behandeling van onwillekeurige bewegingen In: Cursusboek nascholing neurologie. Buruma OJS, Roos RAC. Herkennen van onwillekeurige bewegingen In: Vorderingen en praktijk Boerhaave cursus 11-12 december 1986 Eds: K Gill, P Lens, JD Mulder Dzn 1986: 29-31. Dijk JG v, Velde EA vd, Roos RAC, Bruyn GW. Juvenile Huntington's disease Human Genetics 1986; 73: 235-239. Voordrachten Roos RAC, Sensibiliteit. In: Praktische neurologie op vaste voet. Boerhaave cursus 30-31 januari 1986, Nationaal. Roos RAC, Klinische betekenis van liquoronderzoek. In; Praktische neurologie op vaste voet. Boerhaave cursus. 30-31 januari 1986, Nationaal. Roos RAC, Klinische aspecten van het tethered spinal cord. Leiden. 23-04-1986, Regionaal. Roos RAC, Vielvoye JG, Voormolen JHC, Peters ACB, NMR als diagnostische mogelijkheid bij spinale dysraphie (Kernspinresonantietomografie). Stichting samenwerkende Spina Bifida Werkgroepen in Nederland, Utrecht. 26-04-1986, Uitnodiging, nationaal. Roos RAC, Dijk JG v, Epileptic seizures induced by immersion in hot water. A case-report. Nederlandse vereniging voor kinderneurologie, Ede. 28-05-1986, Nationaal. Roos RAC, Aetiologie en de behandeling van de ziekte van Parkinson, Leiden. 29-05-1986, Regionaal. Roos RAC Immunohistochemistry in Huntington's disease. Xth International Congress of Neuropathology, Stockholm. 12-09-1986, Internationaal. Roos RAC, Buruma OJS, Herkennen van onwillekeurige bewegingen. Boerhaave cursus: Vordering en Praktijk. Leiden. 11-12-1986, Nationaal. Buruma OJS, Roos RAC, Lichaamsbeweging en de oudere patiënt met een neurologische of psychogeriatrische ziekte. Achtste gerontologie symposium, Utrecht. 23-04-1986. Publicaties 1987 Roos RAC, Minderaa RB, Cohen AP, Wetering BJM vd, Woerkom TCAM v. Treatment of Gilles de la Tourette Syndrome, Annals Neurol 1987; 22: 773. Roos RAC, Voormolen JHC, Rollema HJ, Vielvoye JG, Peters ACB. Spina bifida occulta, Een schoonheidsfoutje. Ned Tijdschrift Geneesk 1987; 131: 242-246. Roos RAC, Maaswinkel-Mooy PD, Loo EM vd, Kanhai HHH. Congenital microcephaly infantile spasms psychomotor retardation and nephrotic syndrome in two sibs. Europ Pediatr 1987; 146: 532-536. Roos RAC, Buruma OJS. Dementie en het syndroom van Down In: De ouderen hebben de toekomst Eds:MJG Cremers en MH Niermeijer Maatschappij en Gezondheid No 9. De Tijdstroom Lochem 1987: 38-50. Roos RAC. Spina Bifida Occulta, Een schoonheidsfoutje. Ned Tijdschrift Geneesk 1987; 131: 546-547. Roos RAC, Vink PJJV, Gerritsen EJA. Intracerebrale verkalkingen bij een patient met "late-onset" congenitale rubella. Ned Tijdschr Kindergeneesk 1987; 55: 100-103. Roos RAC. Sensibiliteit In: Praktische neurologie op vaste voet Boerhaave cursus 29-30 januari 1987: 35-38. Roos RAC. Klinische betekenis van liquoronderzoek. In: Praktische neurologie op vaste voet Boerhaave cursus 29-30 januari 1987: 129-134. Roos RAC, Buruma OJS. Loopstoornissen bij de oudere mens. Oefentherapie Mensendieck 1987; 48: 21-23. Roos RAC, Kremer HPH. Gilles de la Tourette Syndroom. Medisch diagnostisch informatie systeem 13 Boehringer Ingelheim 1987. Bollen ELEM, Buruma OJS, Roos RAC, Heyer J d, Reulen JPH, Arts RJHM, Velde EA vd. Lower brainstem dysfunction in Huntington's disease. Clinical Neurol Neurosurg 1987; 89: 121. Bollen EL, Kamp W vd, Heyer JC d, Dijk JG v, Roos RAC, Buruma OJS. Oculomotor disturbances in extrapyramidal disorders: a review of the literature In: Eye-movement disorders Eds: EACM Sanders, RJW de Keyzer, DS Zee, Kluwer Academic Publishers, Dordrecht The Netherlands 1987: 191-207.

Buruma OJS, Kamp W vd, Barendswaard E, Velde EA vd, Roos RAC. Environmental factors in Huntington's Disease. J Neurol Sci 1987; 80: 299-306. Ferrari MD, Vermey P, Wolff FA d, Veenema H, Peeters E, Roos RAC, Buruma OJS. Autosomal recessively inherited impairment of phenytoin hydroxylation A cytochrome P450 defect. Clin Neurol Neurosurg 1987; 89: 62. Haan J, Jansen ENH, Oostrom J, Roos RAC. Falling spells in normal pressure hydrocephalus: a favourable prognostic sign? European Neurology 1987; 27: 216-220. Hilten JJ v, Kerkhof GA, Roos RAC, Kamphuisen HAC. Disturbed circadian rhythmicity in association with insomnia. Chronobiologia 1987; 14. Voordrachten Roos RAC, Sensibiliteit. In: Praktische neurologie op vaste voet. Boerhaave cursus. 29-30 januari 1987, Nationaal. Roos RAC, Klinische betekenis van liquoronderzoek. In; Praktische neurologie op vaste voet. Boerhaave cursus. 29-30 januari 1987, Nationaal. Roos RAC, Gilles de la Tourette. Nascholing Boehringer Ingelheim, Valkenburg. 20-03-1987, uitnodiging. Roos RAC en OJS Buruma, Lichaamsbeweging door oudere patiënten met neurologische en psychogeriatrische stoornissen, Nederlandse Mensendieck Bond, Amsterdam, AMC. 21-3-1987, op uitnodiging. Roos RAC, Bots GTAM, Een patiënt met een Neuronale ceroïed Lipofuscinose. Ned. Vereniging Neuropathologie, Utrecht. 24-04-1987 Roos RAC, Panel Chorea van Huntington. Leiden. 30-05-1987, uitnodiging. Roos RAC, Workshop Gilles de la Tourette Syndrome, PAOG, Rotterdam, 21-11-1987, uitnodiging, nationaal. Publicaties 1988 Roos RAC, Voormolen JHC, Vielvoye GJ, Wintzen AR, Bots GTAM. Haemorrhagic necrosis of the grey matter of the spinal cord due to accidental injection of iopamidol in a patient with multiple neurofibromas; a clinico-pathological study. Neuroradiology 1988; 30: 178-183. Roos RAC, Dijk JG v. Reflex epilepsy induced by immersion in hot water A case report and review of the literature Europ Neurol 1988; 28: 6-10. Roos RAC, Buruma OJS, Wolff FA de. Treatment of tardive dyskinesia. Clin Neuropharmacol 1988; 11: 386. Roos RAC. Liquordiagnostiek bij metabole encephalopathie In: Metabole Encephalopathie Boerhaave Cursus 10-11 maart 1988: 37-46. Roos RAC. Behandeling van het syndroom van Gilles de la Tourette In: Grensgebieden van de kinderneurologie en kinderpsychiatrie Boerhaave cursus 28-29 april 1988: 131-144. Roos RAC. To Professor Narabayashi In Livre Jubilaire Ed Sato T et al 1988: 37-40. Roos RAC, Buruma OJS, Velde EA vd. Response fluctuations in Parkinson's disease In Parkinson's disease Kenes Jerusalem 1988: 137. Roos RAC. Transplantatie bij de ziekte van Parkinson. In: Vorderingen en Praktijk Boerhaave Cursus 15-16 december 1988: 1-4. Bakker HM d, Roos RAC, Vielvoye GJ, Voormolen JHC. Secundaire afwijkingen aan de wervelkolom bij spinale dysrafie. Ned Tijdschrift Geneesk 1988; 132: Bollen EL, Heyer JC d, Ponsioen C, Kramer C, Velden EA vd, Dijk JG v, Roos RAC, Kamphuisen HAC, Buruma OJS. Respiration during sleep in Huntington's chorea. J Neurol Sci 1988; 81: 63-68. Bollen EL, Roos RAC, Cohen AP, Minderaa RB, Reulen JPH, Wetering BJM vd, Woerkom TCAM v, Buruma OJS. Oculomotor control in Gilles de la Tourette Syndrome. J Neurol Neurosurg Psychiatry 1988; 51: 1081-1083. Caekebeke JFV, Jennekens-Schinkel A, Roos RAC, Buruma OJS. Aprosodia in Parkinson's disease In Parkinson's Disease. Kenes Jerusalem 1988: 16. Caekebeke JFV, Roos RAC, Buruma OJS. De medicamenteuze behandeling van de ziekte van Parkinson. TGO 1988; 13: 335-339. Dijk JG v, Bollen EL, Furnee EH, Demper EH, Velde EA vd, Roos RAC, Buruma OJS. Movement direction as well as laterality influence on peak velocity of fast hand movements. Funct Neurol 1988; 1: 69-78. Haan J, Roos RAC, Buruma OJS. Parkinson en dementie. Nederlands Tijdschrift Geneesk 1988; 132: 383-386. Haan J, Roos RAC, Buruma OJS. Dementie bij de ziekte van Parkinson. Nederlands Tijdschrift Geneesk 1988; 132: 787-788. Haan J, Roos RAC, Goekoop JG, Buruma OJS. Depressie en de ziekte van Parkinson. Nederlands Tijdschrift Geneesk 1988; 132: 1228-1231. Heyer JC d, Bollen EL, Reulen JPH, Dijk JG v, Kramer CGS, Roos RAC, Buruma OJS. Autonomic Nervous Function in Huntington's Disease. Arch Neurol 1988; 45: 309-314. Hoefnagels WAJ, Padberg GWAM, Roos RAC. Wegraking of niet? Het belang van een anamnese bij de differentiële diagnose van een tijdelijke bewustzijnsdaling. Ned Tijdschrift Geneesk 1988; 132: 145-148.

Hoefnagels WAJ, Padberg GWAM, Roos RAC. Wegraking of niet? Het belang van een anamnese bij de differentiële diagnose van een tijdelijke bewustzijnsdaling. Ned Tijschrift Geneesk 1988; 132: 1030. Vielvoye GJ, Roos RAC, Kessing PHL. MRI in occult spinal dysraphism. In:Essentials in MRI Ed: THM Falke Martinus Nijhoff Publishers 1988: 101-105. Wetering BJM vd, Cohen AP, Minderaa RB, Roos RAC, Woerkom TCAM v. Het syndroom van Gilles de la Tourette Klinische bevindingen. Ned Tijdschrift Geneesk 1988; 132: 21-25. Voordrachten Roos RAC, Liquordiagnostiek bij metabole encephalopathie. In: Metabole Encephalopathie, Boerhaave Cursus, 10-11 maart 1988 Roos RAC, Behandeling van het syndroom van Gilles de la Tourette. In: Grensgebieden van de kinderneurologie en kinderpsychiatrie, Boerhaave cursus, 28-29 april 1988 Roos RAC, De ziekte van Parkinson. Zin en onzin van paramedische behandeling, Utrecht, Tweede lustrum Parkinson Patiënten Vereniging, 17 september 1988. Roos RAC, Neuropathological changes in Huntington's disease. Department of Neurology, Institute of clinical medicine, University of Tsukuba, Tsukuba, Japan, 15 november 1988 Roos RAC, Transplantatie bij de ziekte van Parkinson, In: Vorderingen en Praktijk, Boerhaave Cursus, 16 december 1988 Publicaties 1989 Roos RAC, Vredevoogd CB. Pijn in spieren en gewrichten als eerste symptoom bij de ziekte van Parkinson. Ned. Tijdschrift Geneesk. 1989; 133: 961-962. Roos RAC. Sensibiliteit. In: Praktische neurologie op vaste voet. Boerhaave cursus 01-02 februari 1989; pp. 35-38. Roos RAC, Bruyn GW, Bots GThAM. Senile plaques in Huntington's disease. Aging of the brain and dementia: ten years later, Fidia Research Biomedical Information, Florence, 1989: 75. Roos RAC. Pijn in spieren en gewrichten als eerste symptoom van de ziekte van Parkinson. Ned. Tijdschrift Geneesk. 1989; 133: 1471. Roos RAC, Kremer HPH. Response fluctuations in Parkinson's disease, Focus on Parkinson's disease 1989;2:32-37 Roos RAC, Vegter van der Vlis M. Procedure en resultaten van diagnostiek bij de Chorea van Huntington. In: Boerhaave Cursus 1989: 27-35. Roos RAC. De wetenschappelijke bijeenkomst van de Research Group on Huntington's disease van de Wereld Federatie voor Neurologie in Vancouver, Kontaktblad van de Vereniging voor Huntington 1989; 13: 11-14. Begeer JH, Roos RAC. Spinale dysrafie en het tethered cord syndroom. Ned. Tijdschrift Kindergeneeskunde 1989; 57: 93-96. Haan J, Roos RAC, Duinen SG. Familial amyloidotic polyneuropathy. Trends in Neurosci 1989; 12: 256. Haan J, Lagaay AM, van Beek W, Bloem BR, Hymans W, Wintzen AR, Roos RAC. Neurological investigation of very old persons, with special reference to postural stability and gait. A community study. Aging of the brain and dementia: ten years later, Fidia Research Biomedical Information, Florence, 1989: 113. Haan J, Roos RAC, Briet PE, Herpers MJHM, Luyendijk W, Bots GThAM. Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Clin Neurol and Neurosurg 1989; 91: 285-291. Hoefnagels WAJ, Roos RAC, Padberg G. Diagnosis of first seizure. Neurology 1989; 39: 1644. Kamp JJP van de, Roos RAC, Rooymans HJM. Presymptomatische diagnostiek, Boerhaave Cursus boek. Keyser J de, Roos RAC, Ebinger G, Vauquelin G. Dopamine receptoren bij de chorea van Huntington. J Neurol Sci 1989; 92: 329-335. Kremer HPH, Roos RAC, Frölich M, Radder JK, Nieuwenhuijzen Kruseman AC, Radder JK, Velde EA vd, Buruma OJS. Endocrine functions in Huntington's disease; A two-and-a half years follow-up study. J Neurol Sci 1989; 90: 335-344. Lanser JBK, Haan J, Zijderveld I, Jennekens-Schinkel A, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): neuropsychological features. In: Wenen 1989. Lanser JBK, Velders G, Jennekens-Schinkel A, Roos RAC. Neuropsychologische bevindingen bij kinderen met het Syndroom van Gilles de la Tourette. Ned Tijdschr Geneesk 1989; 133: 2515-2517. Niermeijer MF, Vegter-van der Vlis M, Rooymans HGM, Kamp JJP van de, Roos RAC. Chorea van Hunting-ton. Med Contact 1989; 44: 1679. Skraastad MI, Verwest A, Bakker E, Rooy K de, Vegter-van der Vlis M, Roos RAC, Ommen GJB, Pearson PL. The presymptomatic diagnosis of Huntington's disease using molecular techniques, applications and nem developments. In: Genetics of neuropsychiatric diseases Vol 51. Ed. L Wetterberg, Stockton Press, Stockholm, 1989: 149-158. Wintzen AR, Bloem BR,Lagaay AM, van Beek W, Haan J, Hymans W, Roos RAC. Prevalence of subjective dysphagia in a non-selected population over 88 years of age. Aging of the brain and dementia: ten years later, Fidia Research Biomedical Information, Florence, 1989: 63.

Voordrachten Roos RAC, Sensibiliteit. In: Praktische neurologie op vaste voet. Boerhaave cursus 01-02 februari 1989, Nationaal. Roos RAC, De beginleeftijd van de ziekte van Huntington. Ned Ver Neurologie in Garderen. 08-12-1989, Nationaal Publicaties 1990 Roos RAC, Kanazawa I. Fine-distribution of gamma-aminobutyric-acid, aspartate and glutamate in the human dentate nucleus, Neuroscience J Neurol Sci 1990; 96: 41-48. Roos RAC, Vredevoogd CB, Velde EA van der. Response fluctuations in Parkinson's disease. Neurology 1990; 40: 1344-1347. Roos RAC, Vegter-van der Vlis M, Tibben A, Skraastad MI, Pearson PL. Procedure en eerste resultaten van presymptomatisch DNA-onderzoek bij de chorea van Huntington. Ned Tijdschr Geneesk 1990; 134: 704-707 en 1193. Roos RAC. Respons fluctuatie bij de ziekte van Parkinson, In Lakke JPWF, Roos RAC. Responsfluctuaties bij Morbus Parkinson. Medicom Europe BV, Spruijt Bussum 1990: 20-25. Roos RAC. Pharmacokinetics of levodopa in Parkinson's disease. Clin Neurol Neurosurg 1990; 92: 3 S. Roos RAC, Vegter-van der Vlis M, Hermans J, Bruyn GW. Age at onset in Huntington's disease in the Netherlands. Clin Neurol Neurosurg 1990; 92: 189. Roos RAC. Levensverwachting Parkinson patienten toegenomen door betere behandeling. De Vrouwelijke patient 1990; 3: 12-13. Roos RAC, Vielvoye-Kerkmeer APE. Wat is de incidentie van postherpetische neuralgie. Vademecum Permanente Nascholing Huisartsen. 1990; 8: 1-2. Roos RAC. Phantoom. Verandert het lichaamsbeeld na amputatie van een deel van het lichaam? In: Stoornissen in het lichaamsbeeld. Eds P Cohen-Kettenis, MW Hengeveld en RAC Roos Boerhaave cursus. 1990: 37-44. Roos RAC, Haan J, Lagaay AM, Beek W van, Wintzen AR, Hymans W. Inventarisation of gait and swallowing with the aid of a questionnaire in community residents over 87 years of age. In: From Gene to Man Gerontological research in the Netherlands. Eds.: Bezooyen CFA van, Ravid R, Verhofstad AAJ. Stichting Gerontologie en Geriatrie. Pasmans 's-Gravenhage 1990: 131-133. Roos RAC, Haan J, Maat-Schieman MLC, Duinen SG van, Bots GTAM. Neuropathological changes in Hereditary cerebral hemorrhage with amyloidosis-Dutch type. In: Sixth International symposium on amyloidosis. Ed Natvig JB. Oslo. 1990: 136. Roos RAC, Kremer HPH. De behandeling van de ziekte van Parkinson. In Practische neurologie, een stap verder. Eds IEC van Everdinck-van der Pols, JPM Hoogeveen, ME Solognier, AR Wintzen. 1990: 67-72. Roos RAC, Wintzen AR. Aging in relation to neurodegenerative and neuromuscular disorders. In: From Gene to Man Gerontological research in the Netherlands. Eds.: Bezooyen CFA van, Ravid R, Verhofstad AAJ. Stichting Gerontologie en Geriatrie. Pasmans 's-Gravenhage 1990: 130. Bakker HM d, Roos RAC, Voormolen JHC, Vielvoye GJ. Lumbar disk degeneration in spinal dysraphism. Am J Neuroradiol 1990; 11: 415. Bloem BR, Lagaay AM, Beek W van, Haan J, Roos RAC, Wintzen AR. Prevalence of subjective dysphagia in community residents over 87 years of age. Brit Med J 1990; 300: 721-722. Bloem BR, Irwin I, Buruma OJS, Haan J, Roos RAC, Tetrud JW, Langston JW. The MPTP model: versatile contributions to the treatment of Parkinsons's disease. J Neurol Sci 1990; 97: 273-293. Bloem BR, Beckley DJ, Tetrud JW, Dijk GJ van, Roos RAC, Remler MP, Langston JW. Postural reflexes in patients with MPTP-induced Parkinsonism. Movement Disorders 1990; 5 Suppl 1: 25. Bollen ELEM, Vielvoye GJ, Dijk GJ van, Roos RAC. Trigeminal neuralgia-like pain in an aged woman with fibrous dysplasia of the skull base. Headache 1990; 30: 277-279. Bruyn GW, Roos RAC. Senile plaques in Huntington's disease. Clin Neurol Neurosurg 1990; 92: 329-332. Broeckhoven C van, Haan J, Bakker E, Hardy J, Hul W van, Wehnert A, Roos RAC. Linkage of the beta-amyloid precursor-protein gene to hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D). Am J Hum Gen. 1990: 944. Broeckhoven C van, Haan J, Bakker E, Hardy J, Hul W van, Wehnert A, Roos RAC. The genetic defect in familial cerebral amyloid angiopathy of Dutch type is tightly linked to the beta-amyloid gene. Science 1990; 248: 1120-1122. Cohen-Kettenis P, Hengeveld MW, Roos RAC. Stoornissen in het lichaamsbeeld. Boerhaave Cursus 1990. Dijk JG van, Caekebeke JFV, Roos RAC, Kamphuisen HAC. Het restless legs syndrome. Ned Tijdschrift Geneesk 1990; 134: 121-124. Ferrari MD, Peeters EAJ, Haan J, Roos RAC, Vermey P, Wolff FA de, Buruma OJS. Cytochrome P450 and Parkinson's disease. J Neurol Sci 1990; 96: 153-157. Haak HR, Hilten JJ van, Roos RAC, Meinders EA. Functional hypothalamic derangement in a case of Wernicke's encephalopathy. Neth J Med 1990; 36: 291-296.

Haan J, Demmers R, Buruma OJS, Roos RAC. Lymphocyte concanavalin A capping in hereditary cerebral haemorrhage with amyloidosis-Dutch type. J Neurol 1990; 237: 117-119. Haan J, Van Kroonenburg MJPG, Algra RP, Buruma OJS, Pauwels EKJ, Bloem BR, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Tc-99m HM-PAO single emission computed tomography. Neuroradiology 1990; 32: 142-145. Haan J, Algra PR, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type: Clinical and computed tomographic analysis of 24 cases. Arch Neurol 1990; 47: 649-654. Haan J, Lanser JBK, Zijderveld I, Van der Does IFG, Roos RAC. Dementia in hereditaty cerebral hemorrhage with amyloidosis-Dutch type. Arch Neurol 1990; 47: 965-968. Haan J, Roos RAC. Coexistence of cystacin C and beta protein immunoreactivity. Stroke 1990; 21: 1510. Haan J, Roos RAC, Algra PR, Lanser JBK, Bots GTAM, Vegter van der Vlis M. Hereditary cerebral hemorrhage with amyloidosis-Dutch type: Magnetic Resonance Imaging Findings in seven cases. Brain 1990; 113: 1251-1267. Haan J, Roos RAC, Amyloid Research Group. Hereditary Cerebral Hemorrhage with amyloidosis, Dutch Type. Clin Neurol Neurosurg 1990; 92: 189. Haan J, Roos RAC. Dementia in Hereditary cerebral amyloidosis. In: Sixth International symposium on amyloidosis. Ed Natvig JB. Oslo. 1990: 137. Haan J, Roos RAC. Amyloid in central nervous system disease. Clin Neurol Neurosurg 1990; 92: 305-310. Haan J, Bollemeyer JG, Keizer RJW de, Roos RAC. Fluorescin angiography of the retina in hereditary cerebral amyloid angiopathy - Dutch type: a preliminary study. In.: From Gene to Man Gerontological research in the Netherlands. Eds.: Bezooyen CFA van, Ravid R, Verhofstad AAJ. Stichting Gerontologie en Geriatrie. Pasmans 's-Gravenhage 1990: 141-144. Hilten JJ van, Middelkoop HAM, Kerkhof GA, Roos RAC. An objective method for the assessment of motor fluctuations in Parkinson's disease. New Trends in Neuropharmacol 1990; 4: 123. Hilten JJ van, Roos RAC, Bakker HM de, Beer FC de. Hyperthermia in Rathke's cleft cyst. J Neurol Neurosurg Psychiatry 1990; 53: 553. Hoefnagels WAJ, Padberg GWAM, Overweg J, Roos RAC. Useful questions to separate an epileptic seizure from other causes of transient loss of consciousness. Clin Neurol Neurosurg 1990; 92: 184. Kremer HPH, Roos RAC, Dingjan G, Marani E, Bots GThAM. Atrophy in the hypothalamic lateral tuberal nucleus in Huntington's disease. J Neuropathol and Exp Neurol 1990; 49: 371-382. Kremer HPH, Roos RAC, Bots GTAM, Swaab DF. The hypothalamic lateral tuberal nucleus in Huntington's disease and Alzheimer's disease. In.: From Gene to Man Gerontological research in the Netherlands. Eds.: Bezooyen CFA van, Ravid R, Verhofstad AAJ. Stichting Gerontologie en Geriatrie. Pasmans 's-Gravenhage 1990: 137-140. Lakke JPWF, Roos RAC. Responsfluctuaties bij Morbus Parkinson. Medicom Europe BV, Spruijt Bussum 1990. Tibben A, Vegter-vd Vlis, Niermeyer MF, Kamp JJP vd, Roos RAC, Rooymans HGM, Frets PG, Verhage F. Testing for Huntington's disease with support for all parties. Lancet 1990; I: 553. Tibben A, Vegter-vd Vlis M, Roos RAC, Kamp JJP van de, Frets PG, Verhage F. Presymptomatische DNA-diagnostiek bij de chorea van Huntington: reacties op zekerheid niet-gendrager te zijn. Ned Tijdschr Geneesk 1990; 134: 701-704. Veltema AN, Roos RAC, Bruyn GW. Autosomal dominant adult amyotrophic lateral sclerosis. A six generation Dutch family. J Neurol Sci 1990; 97: 93-115. Woerkom TCAM van, Fortgens C, Cohen AP, Minderaa RB, Roos RAC, Wetering BJM van de. Auditory event related potentials in children with Gilles de la Tourette's syndrome in the oddball paradigm. In: Psychophysiological research. Eds.: CHM Brunia, AWK Gaillard, A Kok. Tilburg University Press, 1990: 243-247. Voordrachten Roos RAC Phantoom. Verandert het lichaamsbeeld na amputatie van een deel van het lichaam? Boerhaave Cursus, Nationaal, 30-11-1990. Roos RAC. Kwantificatie van onwillekeurige bewegingen. Voor de Amsterdamse Neurologen vereniging op 06-12-1990. Nationaal. Publicaties 1991 Roos RAC, Vegter van de Vlis M, Hermans J, Elshove HM, Moll AC, Kamp JJP van de, Bruyn GW. Age at onset in Huntington's disease: effect of lineage of of inheritance and patient's sex. J Med Genet 1991; 28: 515-519. Roos RAC, Vielvoye GJ, Wintzen AR, Polder TW. Paroxysmal kinesigenic choreoathetosis as presenting symptom of multiple sclerosis. J Neurol Neurosurg and Psychiatr 1991; 54: 657-658. Roos RAC, Haan J, Maat-Schieman MLC, Van Duinen SG, Bots GTAM. Pathological changes in hereditary cerebral hemorrhage with amyloidosis - Dutch type. In: Amyloid and amyloidosis. Eds.: Natvig JB, Forre O,

Husby G, Husebekk A, Skogen B, Sletten K, Westermark P, Kluwer Academic publishers, Dordrecht, Boston, London, 1991: 749-752. Roos RAC, Haan J, Van Broeckhoven Chr. Hereditary cerebral hemorrhage with amyloidosis - Dutch type. A congophilic angiopathy. An overview. Abstractbook 1991: 243-253. Roos RAC, Haan J, Van Broeckhoven Chr. Hereditary cerebral hemorrhage with amyloidosis - Dutch type. A congophilic angiopathy. An overview. Ann New York Acad Sci 1991; 640: 155-161. Roos RAC, Haan J, Maat-Schieman MLC. Hereditary cerebral hemorrhage with amyloiosis-Dutch: brief overview and description of recent developments. Bull Clin Neurosci 1991; 56: 34-39. Roos RAC, Kremer HPH. De behandeling van de ziekte van Parkinson. Boerhaave magazine 1991; 2: 38-39. Roos RAC. Herkenning van chorea. In de kliniek van bewegingsstoornissen, Nascholing neurologie. Garderen 26-27 april 1991; 28-32. Roos RAC, Hilten JJ van. Duizeligheid op hoge leeftijd. The Practitioner 1991; 8: 643-647. Roos RAC, Hermans J, Vegter- van der Vlis M, Ommen GJB van, Bruyn GW. Duration of illness in Huntington's disease. 14th International Workshop on Huntington's disease, Cardiff July 10-13 1991. pp 22. Roos RAC, Bruyn GW. Senile plaques in Huntington's disease. 14th International Workshop on Huntington's disease, Cardiff July 10-13 1991. pp 50. Roos RAC, Vredevoogd CB, Velde EA van der. Response fluctuations in Parkinson's disease. Parkinson/Alzheimer Digest 1991; 4: 11-13. Roos RAC, Hilten JJ van, Hoogland G, Velde EA van der, Kerkhof GA, Dijk JG van. Objective quantitative assessment of motor activity in Parkinson's disease. Tenth International congress on Parkinson's disease, Tokyo. 1991: 48. Roos RAC, van Hilten JJ, Hoogland G. Quantification of involuntary movements. Some preliminary results. Clin Neurol Neurosurg 1991; 93: 262. Roos RAC. Sociale en psychische aspecten van de ziekte van Parkinson. Ned Tijdschr Chron Ziekten. 1991; 1: 20-22. Roos RAC. Nieuwe inzichten in de behandeling van de ziekte van Parkinson. In Vorderingen en Praktijk. Ed Bolk J et al. 1991: 185-190. Roos RAC. Verslag Veertiende bijeenkomst van de onderzoeksgroep van de chorea van Huntington van de Wereld Federatie voor Neurologie. Kontaktblad van de Vereniging van Huntington. 1991; 15: 42-44. Bakker E, Broeckhoven C van, Haan J, Voorhoeve E, Hul W van, Lieberburg I, Carman MD, Ommen GJB, Frangione B, Roos RAC. DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch). Am J Hum Genet 1991; 49: 518-521. Beckley DJ, Bloem BR, Singh J, Remler MP, Wolfe NS, Roos RAC. Postural reflexes in patients on long-term neuroleptic medication. Clin Neurol Neurosurg 1991; 93: 119-123. Beckley DJ, Bloem BR, Dijk JG van, Roos RAC, Remler MP. Electrophysiological correlates of postural instability in Parkinson's disease. Electroencephalography and clinical Neurophysiology 1991; 81: 263-268. Beckley DJ, Bloem BR, Remler MP, Roos RAC, Dijk JG van. Long latency postural responses are functionally modified by cognitive set. Electroencephalography and clinical Neurophysiology 1991; 81: 353-358. Beckley DJ, Bloem BR, Singh J, Remler MP, Roos RAC. Scaling of long latency responses in patients on chronic neuroleptic medication. Neurology 1991; 41 (S1): 192. Bloem BR, Dijk GJ van, Beckley DJ, Zwinderman AH, Remler MP, Roos RAC. Are medium latency stretch reflexes enhanced in Parkinson's disease. Ann Neurol 1991; 30: 297. Bloem BR, Beckley DJ, Dijk JG van, Zwinderman AH, Remler MP, Roos RAC. Correction for the influence of background muscle activity on short- and medium-latency strtch reflexes in normal man. Muscle and Nerve 1991; 14: 874-875. Bloem BR, Roos RAC, Beckley DJ, Dijk JG van, Remler MP, Tetrud JW, Langston JW. Scaling of long-latency reflexes in the tibialis anterior muscle is impaired in patients with MPTP-induced parkinsonism. Tenth International congress on Parkinson's disease, Tokyo. 1991: 253. Caekebeke JFV, Jennekens-Schinkel A, Linden ME van der, Buruma OJS, Roos RAC. The interpretation of dysprosody in patients with Parkinson's disease. J Neurol Neurosurg Psychiatr 1991; 54: 145-148. Caekebeke JFV, Jennekens-Schinkel A, Linden ME van der, Buruma OJS, Roos RAC. The interpretation of dysprosody in patients with Parkinson's disease. Parkinson/Alzheimer Digest 1991; 7: 13-14. Dijk JG van, Haan J, Koenderink M, Roos RAC. Autonomic nervous function in progressive supranuclear palsy. Arch Neurol 1991; 48: 1083-1084. Haan J, Timmers-den Hollander L, Timmers WF, Timmers J, Roos RAC. Hereditaire cerebrale amyloid angiopathie en de ziekte van Alzheimer. Ned Tijdschr Geneesk 1991; 135: 83-87. Haan J, Timmers-den Hollander L, Timmers WF, Timmers J, Roos RAC. Hereditaire cerebrale amyloid angiopathie en de ziekte van Alzheimer. Parkinson/Alzheimer Digest 1991; 7: 20-21 Haan J, Roos RAC. Alzheimer A4 peptide, gamma trace, leukoencephalopathy, and hereditary cerebral hemorrhage with amyloidosis-Dutch type. Annal Neurol 1991; 29: 341.

Haan J, Roos RAC. Clinical aspects in HCHWA-D. In: Amyloid and amyloidosis. Eds.: Natvig JB, Forre O, Husby G, Husebekk A, Skogen B, Sletten K, Westermark P, Kluwer Academic publishers, Dordrecht, Boston, London, 1991: 753-756. Haan J, Hardy J, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type: its importance for Alzheimer research. Trends in Neurosci 1991; 14: 231-235. Haan J, Kleef JW van, Bloem BR, Zwartendijk J, Lanser JBK, Brand R, Does I van der, Krul EJ, Elshove HM, Moll AC, Buruma OJS, Roos RAC. Cognitive function after spinal or general anaesthesia for transurethral prostatectomy in elderly men. JAGS 1991; 39: 596-600. Hardy J, et al., Haan J, Roos RAC, et al. in the Alzheimer's disease research Group. Molecular classification of Alzheimer's disease. Lancet 1991; I: 1342-1343. Hilten JJ van, Middelkoop HAM, Kerkhof GA, Roos RAC. An objective method in the assessment of motoractivity in Parkinson's disease. Clin Neurol Neurosurg 1991; 93: 172. Hilten JJ van, Dijk JG van, Dunnewold RJW, Velde EA van der, Kemp B, Brummelen P van, Krogt JA van der, Roos RAC, Buruma OJS. Diurnal variation of essential and physiological tremor. J Neurol Neurosurg Psychiatry 1991; 54: 516-519. Hilten JJ van, Roos RAC. Posttraumatic hyperthermia: a possible result of frontodiencephalic dysfunction. Clin Neurol Neurosurg 1991; 93: 223-224. Hilten JJ van, Roos RAC. Misconceptions and inappropiate use of terms in hyperthermic syndromes. J Neurol Neurosurg Psychiatry 1991; 54: 941-942. Hilten JJ van, Roos RAC, Middelkoop HAM, Kerkhof GA. An objective assessment for motor fluctuations in Parkinson's disease. Tenth International congress on Parkinson's disease, Tokyo. 1991: 169. Hilten JJ van Middelkoop HAM, Kerkhof G, Roos RAC. A new approach in the assessment of motor activity in Parkinson's disease. J Neurol Neurosurg Psychiatry 1991; 54: 976-979. Hoefnagels WAJ, Vielvoye GJ, Jonge FAA d, Peetermans WEC, Wondergem JHM, Roos RAC. Sciatic neuritis as initial symptom of spontaneous clostridial myonecrosis. Clin Neurol Neurosurg 1991; 93: 149-151. Hoefnagels WAJ, Padberg GW, Overweg J, Velde EA van der, Roos RAC. Transient loss of consciousness: the value of the history for distinguishing seizure from syncope. J Neurology 1991; 238: 39-43. Hoefnagels WAJ, Roos RAC. Sinister tingling in the axilla. J Royal Soc Med 1991; 84: 372. Hoefnagels WAJ, Padberg GW, Overweg J, Roos RAC, Dijk JG van, Kamphuisen HAC. Syncope or seizure? The diagnostic value of the EEG and hyperventilation test in transient loss of consciousness. J Neurol Neurosurg Psychiatry 1991; 54: 953-956. Klop C, Roos RAC, Haan J. De ziekte van Parkinson en depressie. TGO 1991; 16: 241-243. Kremer HPH, Swaab D, Ravid R, Bots GTAM,Fisser B, Ravid R, Roos RAC. The hypothalamic lateral tuberal nucleus in Alzheimer's disease. Annal Neurol 1991; 29: 279-284. Kremer HPH, Roos RAC, Dingjan GM, Bots GTAM, Bruyn GW, Hofman MA. The hypoyhalamic lateral tuberal nucleus and the characteristics of neuronal loss in Huntington's disease. Neurosci Lett 1991; 132: 101-104. Kremer HPH, Roos RAC, Bruyn GW, Bots GTAM, Hofman MA, Albin RL. The hypothalamic lateral tuberal nucleus in Huntington's disease. 14th International Workshop on Huntington's disease, Cardiff July 10-13 1991. pp 46. Skraastad MI, Verwest A, Bakker E, Vegter-van der Vlis M, Leeuwen-Cornelisse I van, Roos RAC, Pearson PL, Ommen GJ van. Presymptomatic, prenatal, and exclusion testing for Huntington's disease using seven closely linked DNA-markers. Am J Hum Genet 1991; 38: 217-222. Tibben A, Vegter van der Vlis M, Skraastad MI, Frets PG, Kamp JJP van de, Niermeijer MF, Van Ommen GJB, Roos RAC, Rooijmans HGM, Verhage F. Presymptomatic DNA testing for Huntington's disease. International Congress of Human Genetics. 1991 Tibben A, Vegter van der Vlis M, Skraastad MI, Frets PG, Kamp JJP van de, Niermeijer MF, Van Ommen GJB, Roos RAC, Rooijmans HGM, Verhage F. Presymptomatic DNA testing for Huntington's disease in the Netherlands. Second World congress of Psychiatric Genetics. 1991 Tibben A, Vegter van der Vlis M, Roos RAC, Skraastad MI, Ommen GJB van, Kamp JJP van de, Niermeijer MF, Frets PG, Rooijmans HGM, Verhage F. Psychosocial impact of presymptomatic DNA-testing for Huntington's disease in the Netherlands. 14th International Workshop on Huntington's disease, Cardiff July 10-13 1991. pp 29. Wolters EC, Horstink MWIM, Roos RAC, Jansen ENH. Superior clinical efficacy of Sinemet CR 50/200 versus Sinemet 25/100 in patients with fluctuating Parkinson's disease. Tenth International congress on Parkinson's disease, Tokyo. 1991: 198. Voordrachten Roos RAC. Hereditary Cerebral Hemorrhage with Amyloidosis - Dutch Type. A congophilic angiopathy. An overview. Zurich. Uitnodiging, Internationaal, 17-02-1991. Roos RAC. Neurologische complicaties bij kunstklepimplantatie. Afd Thoraxchirurgie. Uitnodiging, locaal. 16-

03-1991 Roos RAC. Herkenning van chorea. Nascholing Nederlandse Neurologen. Uitnodiging nationaal, 26-03-1991. Roos RAC. Objective quantitative assessment of motor activity in Parkinson's disease. Tenth International congress on Parkinson's disease, Tokyo. 27-10-1991. Roos RAC. De ziekteduur bij de chorea van Huntington. Najaarsvergadering Garderen. 29-11-1991. Roos RAC. Nieuwe inzichten in de behandeling van de ziekte van Parkinson. Boerhaave Cursus: Vorderingen en Praktijk. 12/13-12-1991. (tweemaal) Publicaties 1992 Roos RAC, Haan J. Function of amyloid and amyloid protein precursor. Clin Neurol Neurosurg 1992; 94S: 1-4. Roos RAC. Behandeling van de ziekte van Parkinson. In: Praktische neurologie een stap verder. Eds.: Everdinck-van der Pols IEC, Hoogeveen JPM, Rotteveel-van der Geest CAM, Solognier ME, Wintzen AR. Boerhaave Proceedings. 1992: 173-179. Roos RAC. Klinische betekenis van liquoronderzoek en mogelijke complicaties. In: Praktische neurologie een stap verder. Eds.: Everdinck-van der Pols IEC, Hoogeveen JPM, Rotteveel-van der Geest CAM, Solognier ME, Wintzen AR. Boerhaave Proceedings. 1992: 145-153. Roos RAC. Dementie toch erfelijk? In: Ontwikkelingen in de geriatrie. Eds.: Cools HJM, Ligthart GJ, Roos RAC, Springer MP. Boerhaave Proceedings 1992: 105-107. Roos RAC, Hermans J, Vegter van de Vlis M, Ommen GJB van, Bruyn GW. Duration of illness in Huntington's disease. Movement disorders 1992; 7 S: 26. Roos RAC, Hermans J, Vegter van de Vlis M, Ommen GJB van, Bruyn GW. Duration of illness in Huntington's disease. Clin Neurol Neurosurg 1992; 94: 81. Roos RAC. Oorzaken en differentiele diagnostiek. In: Torticollis spasmodica. Eds.: JD Speelman, JWM Brans. Bakker Merkelbeek. 1991: 29-41. Roos RAC. Nieuwe inzichten in de behandeling van de ziekte van Parkinson. Boerhaave Magazin 1992; 3: 7-8. Roos RAC. Wat verstaat men onder myalgische encephalitis (ME) en waarop berust de diagnose? Vademecum 1992; 10: 11. Roos RAC. Wanneer kan de huisarts een beginnende multipele sclerose herkennen? Vademecum 1992; 10: Roos RAC, Vielvoye-Kerkmeer APE. Wat is de incidentie van postherpetische neuralgie. Respons 1992; 3(13): 3. Bloem BR, Beckley DJ, Dijk JG van, Zwinderman AH, Roos RAC. Are medium and long latency reflexes a screening tool for early Parkinson's disease? J Neurol Sci 1992; 113: 38-42. Bloem BR, Haan J, Lagaay AM, Beek W van, Wintzen AR, Roos RAC. Investigation of gait in elderly subjects over 88 years of age. J Geriatr Psychiatry Neurol 1992; 4: 78-94. Bloem BR, Beckley DJ, Dijk JG van, Remler MP, Roos RAC. Influence of age at onset of parkinson's disease on medium latency stretch reflexes. In: Woollacott M, Horak F. Posture and Gait: Control mechanisms. Vol II, University of Oregon Books, Portland, 1992: 12-15. Bloem BR, Beckley DJ, Zwinderman AH, Dijk JG van, Remler MP, Roos RAC. Enhanced medium latency stretch reflexes in Parkinson's disease are not influenced by dopaminergic medication. Movement disorders 1992; 7S: 110. Bloem BR, Dijk JG van, Beckley DJ, Roos RAC, Remler MP, Bruyn GW. Altered postural reflexes in Parkinson's disease: a reverse hypothesis. Med Hypoth 1992; Cath DC, Wetering BJM van de, Woerkom TCAM van, Hoogduin CAL, Roos RAC, Rooymans HGM. Mental play in Gilles de la Tourette syndrome and obsessive compulsive disorder. Brit J Psychiatr 1992; 161: 542-545. Cath DC, Hoogduin CAL, van de Wetering BJM, van Woerkom TCAM, Roos RAC, Rooymans HGM. Gilles de la Tourettte syndrome and obsessive compulsive disorder: an analysis of associated phenomena. In Advances of Neurology Vol 58. Eds.: TN Chase, AJ Friedhoff, DJ Cohen. Raven Press New York. 1992: 33-41. Cools HJM, Ligthart GJ, Roos RAC, Springer MP. Ontwikkelingen in de Geriatrie. Boerhaave Proceedings. 1992. Dijk JG van, Koenderink M, Kramer CGS, Heyer J den, Roos RAC. Non-invasive assessment of autonomic nervous function in Gilles de la Tourette syndrome. Clin Neurol Neurosurg 1992; 494: 157-161. Dijk JG van, Haan J, Zwinderman AH, Kremer HPH, Roos RAC. Autonomic nervous system dysfunction in Parkinson's disease in relation to age, medication, duration and severity. Clin Neurol Neurosurg 1992; 94: 85. Haan J, Kluft C, Leebeek FWG, Bart ACW de, Buruma OJS, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis Dutch type: a study of fybrinolysis. Thrombosis and hemostasis 1992; 67: 16-18. Haan J, Roos RAC. A comparison between the Icelandic and Dutch forms of hereditary cerebral amyloid angiopathy. Clin Neurol Neurosurg. Clin Neurol Neurosurg 1992; 94S: 82-84. Haan J, Bakker E, Jennekens-Schinkel A, Roos RAC. Progressive dementia, without cerebral hemorrhage in a patient with hereditary cerebral amyloid angiopathy. Clin Neurol Neurosurg 1992; 94: Hilten JJ van, Roos RAC. The continuum of hyperthermic syndromes with impaired dopaminergic activity. Arch Intern Med 1992; 152: 1727-1730.

Hilten JJ van, Hoogland G, Middelkoop HAM, Roos RAC. Diurnal effects of motor activity and fatigue in Parkinson's disease. Movement disorders 1992; 7S: 118. Hoefnagels WAJ, Padberg GW, Overweg J, Roos RAC. Syncope or seizure? A matter of opinion. Clin Neurol Neurosurg 1992; 94: 153-157. Kremer HPH, Roos RAC, Bots GTAM, Swaab DF, Hofman MA. The hypothalamic nucleus tuberis lateralis: a model for neuronal loss in Huntington's disease. Clin Neurol Neurosurg 1992; 94: 77. Kremer HPH, Roos RAC. Weight loss in Huntington's disease. Arch Neurol 1992; 49: 349. Laboyrie PM, Roos RAC, Verspaget HW. Copper zinc superoxide dismutase in cerebrospinal fluid: Implications for oxygen-radical stress in the central nervous system. Clin Neurol Neurosurg 1992; 94S: 106-108. Maat-Schieman MLC, Duinen SG van, Haan J, Roos RAC. Morphology of cerebral plaque-like lesions in hereditary cerebral hemorrhage with amyloidosis Dutch. Acta Neuropath 1992; 84: 674-679. Rozemuller JM, Bots GTAM, Roos RAC, Eikelenboom P. Acute phase proteins but not activated microglial cells are present in parenchymal beta/A4 deposits in brains of patients with Hereditary cerebral hemorrhage with amyloidosis Dutch type. Neuroscience Letters 1992; 140: 137-141. Rozemuller JM, Maat-Schieman MLC, Eikelenboom P, Roos RAC. Role of microglial cells in early plaque formation : absence of microglia cells in diffuse plaques in HCHWA-D. In Neurobiology of aging 1992; 13 S1: 89. Santen WHC, Roos RAC. Smoking: protection for Parkinson's disease or not? Review of he literature. Focus on Parkinson's disease 1992; 4: 33-36. Tibben A, Vegter van der Vlis M, Skraastad M, Frets PG, Kamp JJP van de, Niermeijer MF, Ommen GJB v, Roos RAC, Rooijmans HGM, Stronks D, Verhage F. DNA-testing for Huntington disease in the Netherlands: A retrospective study of psychosocial effects. Am J Med Genet 1992; 44: 94-99. Tibben A, Vegter van der Vlis M, Skraastad MI, Leeuwen Cornelisse ISJ, Frets PG, Kamp JJP van de, Niermeijer MF, Van Ommen GJB, Roos RAC, Rooijmans HGM, Verhage F. Presymptomatic DNA testing for Huntington's disease in the Netherlands. In Psychosocial aspects of genetic counselling. Eds.: Evers-Kieboom G, Fryns JP, Cassiman JJ, Berghe H van den. Birth defects: Original Article Series, Vol 28. Wiley-Liss New York, 1992: 127-131. Van Nostrand WE, Wagner SL, Haan J, Bakker E, Roos RAC. Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type share a decrease in cerebrospinal fluid levels of amyloid beta-precursor. Ann Neurol 1992; 32: 215-219. Van Nostrand WE, Farrow JS, Shankle WR, Rozemuller JM, Roos RAC, Wagner SL. Alzheimer's isease and hereditary cerebral hemorrhage with amyloidosis-Dutch type share decreased cerebrospinal fluid levels of amyloid beta-protein precursor. Neurobiology of aging 1992; 13 S1: 26. Wetering BJM vd, Cath DC, Roos RAC, Woerkom TCA, Hoogduin CAL, Minderaa RB. De tics bij het syndroom van Gilles de la Tourette. Ned Tijdschr Geneesk 1992; 136: 1644-1647. Wolters EC, Horstink MWIM, Roos RAC, Jansen ENH and the Dutch Sinemet-CR Study Group. Clinical efficacy of Sinemet CR 5-/200 versus Sinemet 25/100 in patients with fluctuating Parkinson's disease: an open and a double blind double dummy, multicenter treatment evaluation. Clin Neurol Neurosurg 1992; 94: 205-213. Voordrachten Roos RAC. New aspects on hereditary cerebral amyloid angiopathy, The French Foundation Los Angeles, Op Uitnodiging. 17-01-1992. Roos RAC. Nieuwe aspecten van de behandeling van de ziekte van Parkinson. Boerhaave cursus. 24-01-1992. Roos RAC. Klinische betekenis van liquoronderzoek enmogelijke complicaties. Boerhaave cursus. 24-01-1992. Roos RAC. Is dementie erfelijk? Boerhaave cursus 28-02-1992. Roos RAC. Functie van amyloid en zijn precursor protein. Boerhaave cursus. 13-03-1992. Roos RAC. De behandeling van epilepsie bij ouderen in het Verpleeghuis. Regionale Verpleeghuisartsen, Warmond, op uitnodiging 24-09-1992. Roos RAC. Amyloid angiopathie, nieuwe ontwikkelingen. Regionale huisartsen Katwijk, op uitnodiging, 19-10-1992.

Publicaties 1993 Roos RAC, Hermans J, Vegter van de Vlis M, Ommen GJB van, Bruyn GW. Duration of illness in Huntington's disease. J Neurol Neurosurg Psychiatry 1993; 56: 98-100. Roos RAC, Steenvoorden JMC, Mulder GJ, Kempen GMJ van. Aceaminophen sulfation in patients with Parkinson's disease and Huntington's disease is not impaired. Neurology 1993; 43: 1373-1376 Roos RAC, Tijssen MAJ, van der Velde EA, Breimer DD. The influence of a standard meal on Sinemet CR absorption in patients with Parkinson's disease. Clin Neurol Neurosurg 1993; 95: 215-221. Roos RAC. Dementie. Vorderingen en Praktijk. Eds.: Boerhaave Proceedings 1992: Bloem BR, Dijk JG van, Beckley DJ, Zwinderman AH, Remler MP, Roos RAC. Correction for the influence of background muscle activity on stretch reflex amplitudes. J Neurosci Meth 1993; 46: 167-174. Dijk JG van, Haan J, Zwinderman K, Kremer HPH, Hilten JJ van, Roos RAC. Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity. J Neurol Neurosurg Psychiatry 1993; 56: 1090-1095. Durlinger ETL, Haan J, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type. (Letter) Neurology 1993; 43:1626-1627. Hilten JJ van, Hoogland G, Velden EA van der, Dijk JG van, Kerkhof GA, Roos RAC. Quantitative assessment of parkinsonian patients by continuous wrist activity monitoring. Clin Neuropharmacology 1993; 16: 36-45. Hilten JJ van, Kabel JF, Middelkoop HAM, Kramer CGS, Kerkhof GA, Roos RAC. Assessment of response fluctuations in Parkinson's disease by ambulatory wrist activity monitoring. Acta Neurol Scand 1993; 87: 171- 177. Hilten JJ van, Weggeman M, Velde EA van der, Kerkhof GA, Dijk JG van, Roos RAC. Sleep, excessive daytime sleepiness and fatigue in Parkinson's disease. J Neurotransm (P-D sect) 1993; 5: 235-244. Hilten JJ van, Hoogland G, Velden EA van der, Middelkoop HAM, Kerkhof GA, Roos RAC. Diurnal effects of motor activity and fatique in Parkinson's disease. J Neurol Neurosurg Psychiatry 1993; 56: 874-877. Hilten JJ van, Middelkoop HAM, Kuiper SIR, Kramer CGS, Roos RAC. Where to record motor activity: an evaluation of commonly used sites of placement for activity monitors. Electroencephalography and Clin Neurophysiol 1993; 89: 359-362. Hilten JJ van, Hof JI, Roos RAC. Ambulatory activity monitoring: an evaluation of intra-subject variability in Parkinson's disease and healthy elderly. J Ambulat Mon 1993; 6: 219-223. Hoogeveen AT, Willemsen R, Meyer N, Rooij KE de, Roos RAC, Ommen GJB van, Galjaard H. Characterisation and localisation of the Huntington disease gene product. Hum Molec Genet 1993; 2: 2069 -2073. Laar T van, Jansen ENH, Essink AWG, Neef C, Oosterloo S, Roos RAC. A double-blind study of the efficacy of apomorphine and its assessment in 'off'-periods in Parkinson's disease. Clin Neurol Nerosurg 1993; 95: 231- 236. Lammers GJ, Roos RAC. Hyponatraemia due to amantadine hydrochloride and L-dopa/carbidopa. (letter) Lancet 1993; 342 II: 439. Lanser JBK, Santen WHC van, Jennekens-Schinkel A, Roos RAC. Neurospychological in Gilles de la Tourette. Brit J Psychiatr. 1993; 163: 116-118. Rooij KE de, Koning Gans PAM de, Skraastad MI, Belfroid RDM, Vegter van de Vlis M, Roos RAC, Bakker E, Ommen GJB van, Dunnen JT den, Losekoot M. Dynamic mutation in Huntington's disease patients: increased paternal repeat instability extending to within the normal size range. J Med Genet 1993; 30: 996-1002. Rooij KE de, Koning Gans PAM de, Losekoot M, Bakker E, Dunnen JT, Vegter van de Vlis M, Roos RAC, Ommen GJB van. Diagnostic dilemmas with borderline repeat expansion in Huntington's disease. (Letter) Lancet 1993; 342: 1491-1492. Rozemuller JM, Roos RAC, Bots GTAM, Kamphorst W, Eikelenboom P, VanNostrand WE. Distribution of /A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease. Am J Pathol 1993; 142: 1449-1457. Schmeier AH, Dahl LD, Rozemuller AJM, Roos RAC, Wagner SL, Chung R, VanNostrand WE. Protease Nexin-2/amyloidßProtein Precursor. J Clin Invest 1993; 92: 2540-2545. Storimans C, Roos RAC, Jennekens-Schinkel A, Oosterhuis JA. Hereditary retinal and cerebral vasculopathy. A new clinical syndrome. In Hereditary vascular retinipoathy. C Storimans. Thesis 1993. Tibben A, Frets PG, Van de Kamp JJP, Niermeijer MF, Vegter Van der Vlis M, Roos RAC, Rooymans HGM, Van Ommen GJB, Verhage F. On attituides and appreciation 6 months after predictive DNA testing for Huntington's disease in the Dutch program. Am J Med Genet 1993; 48: 103-111. Tibben A, Duivenvoorden HJ, Vegter Van der Vlis M, Niermeijer MF, Frets PG, Van de Kamp JJP, Roos RAC, Rooymans HGM, Verhage F. Presymptomatic DNA testing for Huntington's disease: identifying the need for psychological intervention. Am J Med Genet (Neuropsychiatric Gen) 1993; 48: 137-144. Tibben A, Frets PG, Kamp JJP vd, Niermeijer MF, Vegter-vd Vlis M, Roos RAC, Ommen GJB v, Duivenvoorden H, Verhage F. Presymptomatic DNA-testing for Huntington disease: Pre-test attitudes and

expectations of applicants and their partners in the Dutch program. Am J Med Genet 1993; 48: 10-16. Bruyn GW, Roos RAC. Senile plaques in Huntington's disease: a preliminary report. In Scritti in onore di Carlo Loeb. Universita di Genova 1993: 83-85. Haan J, Durlinger ETL, Vries MCS de, Roos RAC. Preliminary results of DNA testing program in persons at risk for hereditary cerebral hemorrhage with amyloidosis (Dutch) Abstract T15. VII International symposium on amyloidosis Ontario, Canada 1993: 115. Roos RAC. Dopaminomimetic psychosis: clinical manifestations, epidemiology and risk factors. In: Mental dysfunction in Parkinson's disease. Eds Wolters ECh, Scheltens P. Vrije Universiteit, Amsterdam. 1993: 281- 285. Roos RAC. Een patiënt met pijn. In Ferrari MD, Vecht ChJ, Bosch DA, Roos RAC (Eds), Pijn in de neurologie. Boerhaave Proceedings 1993: 127-129. Ferrari MD, Vecht ChJ, Bosch DA, Roos RAC (Eds). Pijn in de neurologie. Boerhaave Proceedings 1993 Wolters EC, Horstink MWIM, Roos RAC, Jansen ENH. Superior clinical efficacy of Sinemet CR 50/200 versus Sinemet 25/100 in patients with fluctuating Parkinson's disease: an open double blind doubble dummy multicenter treatment evaluation. In: Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y. Advances in Neurology Vol 60 Parkinson's disease. 1993: 648-653. Wolters ECh, Scheltens P, Kuiper MA, Roos RAC, Horstink MW. Mental dysfunction in Parkinson's disease. Vrije Universiteit. 1993. Brooks DJ, Lees A, Abbot R, Sagar H, Rascol O, Ebinger G, Roos RAC, Philcox, Nappi G, Murray G. Ropinorole: a double blind placebo controlled multicentre study of efficacy and safety in early Parkinson's disease (monotherapy). Can J Neurol Sci 1993; S4-S153. Jennekens-Schinkel A, Tol M van, Lanser JBK, Roos RAC. Set shifting disorder is not characteristic for cognition in Parkinson's disease. In: Mental dysfunction in Parkinson's disease. Eds Wolters ECh, Scheltens P, Kuiper MA, Roos RAC, Horstink MW. Vrije Universiteit. 1993: 14. Lanser JBK, Jennekens-Schinkel A, Roos RAC. Dementia in Alzheimer's disease, Huntington's disease and Parkinson's disease: a comparative neuropsychological study. Abstract in Proceedings Int Neuropsychological Soc 15th European Conference, Island of Madeira (Portugal), June 23-26, 1993. Lanser JBK, Jennekens-Schinkel A, Roos RAC. Dementia in patients with Parkinson's disease: not distinguishable from dementia in Alzheimer's disease. In: Mental dysfunction in Parkinson's disease. Eds Wolters ECh, Scheltens P, Kuiper MA, Roos RAC, Horstink MW. Vrije Universiteit. 1993: 15. Maat Schieman MLC, Haan J, Duinen SG van, Roos RAC. Variations in the morphology of plaque like lesions in hereditary cerebral hemorrhage with amyloidosis (Dutch). Clin Neurol Neurosurg 1993; 95: 75. Maat Schieman MLC, Duinen SG van, Haan J, Roos RAC. Plaque formation in hereditary cerebral hemorrhage with amyloidosis (Dutch). Clin Neurol Neurosurg 1993; . Roos RAC. Dopaminomimetic psychosis: clinical manifestations, epidemiology and risk factors. In: Mental dysfunction in Parkinson's disease. Eds Wolters ECh, Scheltens P, Kuiper MA, Roos RAC, Horstink MW. Vrije Universiteit. 1993: 31. Roos RAC, Haan J, Maat-Schieman MLC. Hereditaire cerebrale amyloid angiopathie als een model voor de ziekte van Alzheimer: nieuwe ontwikkelingen. Nederlandse Neurochirurgen Studieclub. Syllabus. Rooij KE de, Losekoot M, de Koning Gans PAM, Roos RAC, den Dunnen JR, van Ommen GJB. Analysis of the expanding (CAG)n repeat in Huntington's disease brains. Abstract nr. 3. In: Proceedings 15th Int. WFN workshop on Huntington's Chorea. Boston, August 31-Sept 3, 1993. Tibben A, Vegter VM, Duivenvoorden HJ, Niermeijer MF, Kamp JJP, Roos RAC, Ommen GJB van. Presymptomatic DNA-testing for Huntington disease: identifying the need for psychological intervention. Psychiatric Genetics 1993; 3: 145. Tibben, A, Trijsburg W, Niermeijer M, Vegter-vd VlisR, van de Kamp W, Roos RAC, Duivenvoorden H, van Ommen GJ. Psychological defense and presymptomatic DNA-testing (PDT) for Huntington disease. Abstract nr. 32. In; Proceedings 15th Int. WFN workshop on Huntington's Chorea. Boston, August 31-Sept 3, 1993. Tibben A, Vegter-vd Vlis R, Duivenvoorden H, Niermeijer M, van de Kamp J, Roos RAC, van Ommen GJ. Presymptomatic DNA-testing (PDT) for Huntington disease; identifying the need for psychological intervention. Abstract nr. 33. In: Proceedings 15th Int. WFN workshop on Huntington's Chorea. Boston, August 31-Sept 3, 1993. Hilten JJ van, Ferrari MD, Roos RAC. Migraine bij patiënten met de ziekte van Parkinson. Papaver 1993; 16: Roos RAC. Europees Botox Symposium Verslag. In Nederlandse vereniging van Dystonie patiënten. 1993; 10: 14-17. Roos RAC. Tardive Dyskinesia, WHO Expert Series on Biological Psychiatry, Vol 2, Haag H, Ruther E, Hippius H (eds), 1992, Hogrefe & Huber Publ, Kirkland, WA. In: Clin Neurol Neurosurg 1993; 95; 167. Voordrachten Roos RAC. Een patiënt met pijn. Boerhaave Cursus: Pijn in de Neurologie, 4 en 5 februari 1993 Roos RAC. Botulinum toxine. Klinische toepassing en toekomst. Eindhoven. 13-maart 1993

Roos RAC. Respons fluctuaties bij de Ziekte van Parkinson. Nascholing assistenten Neurologie Nederland. Wolfheze 27-03-1993. Roos RAC. Dopaminomimetic psychosis: clinical manifestations, epidemiology and risk factors. European Congres Mental dysfunction in Parkinson's disease. Amsterdam, 22-10-1993. Roos RAC. Welke overdraagbare neurodegenratieve ziekten zijn een contraindicatie voor weefsel- en orgaantransplantatie. Biotransplant. Leiden 05-11-1993. Roos RAC. Transplantatie als behandeling voor de ziekte van Parkinson. Eerste landelijke bijeenkomst van de YOPPERS. Bunnik, 06-11-1993. Roos RAC. Hereditaire cerebrale amyloid angiopathie als een model voor de ziekte van Alzheimer: nieuwe ontwikkelingen. Nederlandse Neurochirurgen Studieclub. Leiden 12-11-1993. Roos RAC. De klinische aspecten van de ziekte van Parkinson. Aesculapios, 108 ste verjaardag LPSV. Leiden 18-11-1993. Publicaties 1994 Roos RAC, Laar T van, Hilten JJ van. Beperkte waarde van de apomorfinetest bij de ziekte van Parkinson. Ned Tijdschr Geneesk 1994: 138: 1374-1377. Bloem BR, Beckley DJ, Dijk JG van, Zwinderman AH, Remler MP, Langston JW, Roos RAC. Medium latency stretch reflexes in young-onset Parkinson's disease and MPTP-induced parkinsonism. J Neurol Sci 1994; 123: 52-58. Collinge J, Palmer MS, Sidle KCI, Mahal SP, Campbell T, Brown J, Hardy J, Brun AE, Gustafson L, Bakker E, Roos RAC, Groen JJ. Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease. Letter J Neurol Neurosurg Psychiat 1994; 57: 762-768. Haan J, Maat-Schieman MLC, Roos RAC. Clinical aspects of cerebral amyloid angiopathy. Dementia 1994; 5: 210-213. Haan J, Maat-Schieman MLC, Van Duinen SG, Jensson O, Thorsteinsson L, Roos RAC. Co-localization of ß/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis. Acta Neurol Scand 1994; 89: 367-371. Haan J, Van Broeckhoven C, van Duijn CM, Voorhoeve E, van Harskamp F, van Swieten JC, Maat-Schieman MLC, Roos RAC, Bakker E. The apolipoprotein E 4 allele does not influence the clinical expression of the amyloid precursor protein-gene codon 693 or 692 mutations. Ann Neurol 1994; 36: 434-437. Hilten JJ van, Hoff JI, Middelkoop HAM, Velde EA van der, Kerkhof GA, Wauqier A, Kamphuisen HAC, Roos RAC. Sleep disruption in Parkinson's disease: assessment by continuous activity monitoring. Arch Neurol 1994; 51: 922-928. Hilten JJ van, Hoff JI, Middelkoop HAM, Roos RAC. The clinimetrics of hypokinesia in Parkinson's disease: subjective versus objective assessment. J Neural Trans [P-D Sect] 1994; 8: 117-121 Hilten JJ van, Weggeman M, Velde EA van der, Kerkhof GA, Dijk JG van, Roos RAC. Sleep, daytime sleepiness and fatigue in Parkinson's disease. J Neural transm Park Dis 1993; 5: 235-244. Hilten JJ van, Zwan AD van der, Zwinderman AH, Roos RAC. Rating impairment and disability in Parkinson's disease: Evaluation of the Unified Parkinson's disease rating scale. Movement disorders 1994; 9: 84-88. Kamp W van der, Zwinderman AH, Roos RAC, Ferrari MD, Kamphuisen HAC, Dijk JG van. Magnetic evoked potentials are larger inleft-handed subjects. Muscle and Nerve 1994; 17: 118-119. Maat-Schieman MLC, Rozemuller AJ, Duinen SG van, Haan J, Eikelenboom P, Roos RAC. Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch). An immunohistochemical study. J Neuropath and Exp Neurol 1994; 53: 483-491. Maat-Schieman MLC, Radder CM, Duinen SG, Haan J, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology. Act Neuropath 1994; 88: 371-378. Peeters EAJ, Bloem BR, Kuiper MA, Vermey P, Wolff FA de, Wolters EC, Roos RAC, Ferrari MD. Phenytoin parahydroxylation is not impaired in patients with young onset Parkinson's disease. Clin Neurol Neurosurg 1994; 96:: 296-299. Steenstraten IM vd, Tibben A, Roos RAC, KampJJP vd, Niermeijer MF, Predictive DNA testing for Huntington Disease: non participants compared with participants in the Dutch program. Am J Hum Geneti 1994; 55: 618-625. Tibben A, Duivenvoorden HJ, Niermeijer MF, Vegter-van de Vlis, Roos RAC, Verhage F, Psychological effects of presymptomatic DNA testing for Huntington's disease in the Dutch program. Psychosom Med 1994; 56: 526-532. Wintzen AR, Badrising UA, Roos RAC, Vielvoye GJ, Liaauw L, Pauwels EKJ. Dysphagia in ambulant patients with Parkinson's disease: common, not dangerous. Can J Neurol Sci 1994; 21: 53-56. Wintzen AR, Badrising UA, Roos RAC, Vielvoye GJ, Liaauw L. Influence of bolus volume on hyoid movements in normal individuals and patients with Parkinson's disease. Can J Neurol Sci 1994; 21: 57-59. Woerkom TCAM, Dijk JG van, Roos RAC. Altered attentional processing of background stimuli in Gilles de la Tourette syndrome: a study in auditory event-related potentials evoked in an oddball paradigm. Acta Neurol

Scand 1994; 90: 116-123. Roos RAC. Nieuwe therapieën bij epilepsie. In Vorderingen en praktijk. Eds MP Springer, JH Bolk, J de Bruine, WM Hoekstra. 1994: 133-138. Roos RAC. Neurodegeneratieve aandoeningen. In: Neurologie. Eds.: Hydra A, Koudstaal PJ, Roos RAC. 1994: 461-501. Roos RAC, Kortbeek LHTS, Mirandolle JF, Stam J. Codering systeem Neurologie. Serono, 1994. Roos RAC. Lage rugpijn bij de oudere mens. Geriatrie Boerhaave cursus. In Ontwikkelingen in de geriatrie. Eds GJ Ligthart, GN de Ruyter, RAC Roos, J Stolk, HJM Cools. 1994: 65-69. Roos RAC. Neurological complications of carbon monoxide intoxication. In Handbook of Clinical Neurology. Eds PJ Vinken, GW Bruyn. Elsevier Publi. Amsterdam 1994: 31-39. Bloem BR, Beckley DJ, Remler MP, Roos RAC, Dijk JG van. Adaptation of postural reflexes in Parkinson's disease during a resist or yield paradigm. In Vestibular and neural front, Eds K Taguchi, M Igarashi, S Mori. Elsevier Science BV, Amsterdam, 1994: 349-352. Hilten JJ van, Roos RAC. Neurologische afwijkingen. In: Reitsma WD, Elte JWF, Overbosch D. Differentiële diagnostiek in de interne geneeskunde. Bohn Stafleu Van Loghum, Houten/Zaventem, 1994; ch. 15: 285-309. Hoogenraad TU, Hijdra A, Roos RAC. De hersenzenuwen. In: Neurologie. Eds.: Hydra A, Koudstaal PJ, Roos RAC. 1994: 31-71. Hydra A, Koudstaal, Roos RAC. Behandeling van neurologische aandoeningen. In: Neurologie. Eds.: Hydra A, Koudstaal PJ, Roos RAC. 1994: 243-251. Hydra A, Koudstaal P, Roos RAC. Neurologie, Bunge Utrecht 1994 Ligthart GJ, Ruyter GN de, Roos RAC, Stolk J, Cools HJM. Geriatrie. Boerhaave cursus. 1994. Meché FGA van der, Roos RAC. Motoriek. In: Neurologie. Eds.: Hydra A, Koudstaal PJ, Roos RAC. 1994: 71-103. Roos RAC. Dystonia musculorum deformans. In Dystonie Eds Speelman JD, Brans J. Bakker, Merkelbeek. 1994: 19-29. VAKPUBLICATIES Roos RAC. Hoe behandelt men Horton's neuralgie. Vademecum 1994; 12: 3. Roos RAC. Wat is van belang inzake oorzaken en behandeling van de perifere facialisparese? Vademecum 1994; 12: 1. Roos RAC. The influence of a standard meal on Sinemet CR absorption in patients with Parkinson's disease. Clin Digest Series 1994; Roos RAC. Editorial Focus on Parkinson's disease. 1994; 6: 3. Roos RAC. Editorial Focus on Parkinson's disease. 1994; Roos RAC. Department of Neurology. Transfer News 1994: 4. Hilten van JJ, Hoogland G, Middelkoop HAM, Velde van der EA, Kerkhof GA, Roos RAC. Diurnal effects of motor activity and fatigue in Parkinson's disease. Focus on Parkinson's Disease. 1994; 6: 62-63. ABSTRACTS Roos RAC. Longer term strategy in Parkinson's disease. In European Parkinson's disease Conference. Glasgow, 1994: 13. Roos RAC, Jongen J, Velde EA vander. Survival of patients with idiopathic Parkinson's disease. Abstractbook Aviemore Scotland 1994: 96 Roos RAC, Jongen JCF, Velde EA van der, Survival of patients with idiopathic Parkinson's disease. Movement Disorders 1994; 9 (Suppl): 74. Roos RAC, Laar T van, Hilten JJ van, Apomorphine challenge in Parkinson's disease. Movement Disorders 1994; 9 (Suppl): 79. Bloem BR, Beckley DJ, Dijk JG van, Remler MP, Roos RAC, Influence of dopaminergic medication on postural reflexes and balance impairment in Parkinson's disease. Movement Disorders 1994; 9 (Suppl): 96. Haan J, Durlinger ETL, Bakker E, De Vries S, Zoetwey M, Roos RAC. Presymptomatic testing in persons at risk for HCHWA-D. Boek OSLO 1994 Hilten van JJ, Weggeman M, Velde van der EA, Dijk van JG, Kerkhof GA, Roos RAC. Sleep, daytime sleepiness and fatigue in Parkinson's disease. Focus on Parkinson's Disease 1994; 6: 63. Hilten JJ van, Hoff JI, Middelkoop HAM, Roos RAC, The clinimetrics of hypokinesia in Parkinson's disease: subjective versus objective assessment. Movement Disorders 1994; 9 (Suppl): 78. Hilten van JJ, Hof JI, Middelkoop HAM, Kamphuisen HAC, Roos RAC. Sleep disruption in Parkinson's disease: assessment by continuous activity monitoring. 11th International Symposium on Parkinson's disease, Rome, Italy - March 26-30, 1994, In: New Trends in clinical Neuropharmacology 1994; 8: 124. Hilten van JJ, Kabel H, Kramer C, Middelkoop HAM, Kerkhof GA, Roos RAC. Morbo di Parkinson: Valutazione dell'andmento oscillante nella risposta all terapia mediante

monitoraggio ambulatoriale dell' attivita del polso. Update on Parkinson's 1994; 3: 22-23. Hilten van JJ, Hoogland G, Velde van der EA, Kerkhof GA, Dijk van JG, Roos RAC. Valutazione quantitativa dei pazienti Parkinsoniani mediante monitoraggio continu o dell' attita del polso. Update on Parkinson's 1994;3:61-62. Laar T van, Geest R van der, Roos RAC, Danhof M, Pharmacokinetics and pharmacodynamics of intravenous apomorphine. Movement Disorders 1994; 9 (Suppl): 64. Laar T van, Geest R van der, Roos RAC, Danhof M. Pharmacokinetics and pharmacodynamics of intravenous apomorphine In:Measurement and kinetics of in vivo drug effects, 2nd International symposium 1994, Noordwijkerhout. Maat-Schieman MLC, Van Duinen SG, Haan J, Roos RAC. Plaque-formation in hereditary cerebral hemorrhage with amyloidosis (Dutch). Clin Neurol Neurosurg (abstract) 1994; 96:204 Maat-Schieman MLC, van Duinen SG, Haan J, Roos RAC. Plaque-like lesions and cerebral amyloid angiopathy (CAA) in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D). Brain Pathol 1994; 4:503. (Abstract). Neef C, Hofstee DJ, Van Laar T, Roos RAC, Danhof M. PK-PD modeling of apomorphine in Parkinson's disease. In: Measurement and kinetics of in vivo drug effects, 2nd International symposium 1994, Noordwijkerhout. Tijssen MAJ, Boerman R, Deutekom J van, Padberg G, Frants RR, Roos RAC, Dijk JG van. Hyperekplexia: clinical and genetic relationships Association of British Neurologists and Nederlandse Vereniging voor Neurologie. Aviemore 4-6 may 1994. J Neurol Neurosurg Psychiatry 1994; 57: 1290 Boekbespreking Roos RAC. Handbook of cerebrovascular diseases. Adams HP. Tijdschrift v Gerontologie en Geriatrie 1994; 25: 219. Publicaties 1995 Bloem BR, Beckley DJ, Dijk GJ van, Remler MP, Roos RAC. Stretch reflexes in Parkinson's disease. (letter) Acta Neurol Scand 1995; 91: 76-78. Bloem BR, Beckley DJ, Remler MP, Roos RAC, Dijk GJ van. Postural reflexes in Parkinson's disease during 'resist' and 'yield' tasks. J Neurol Sci 1995; 129: 109-119. Bloem BR, Dijk JG van, Roos RAC. Met behoud van evenwicht; experimenteel onderzoek naar de grenswaarden voor versnellingen die het menselijk lichaam kan ondergaan zonder het houdingsevenwicht te verliezen. Ned Tijdschr Geneesk 1995; 139: 905. Bohlega S, McLean DR, Omer S, Al-Kawi MZ, Roos RAC, Losekoot M, Bakker E. Huntington's disease in Saudie Arabia (393). J Med Genet 1995; 32: 325-328. Duinen SG van, Maat-Schiman MLC, Bruijn, Haan J, Roos RAC. Cortical tissue of patients with hereditary cerebral hemorrhage with amyloiosis (Dutch) contains various extracellular matrix deposits. Lab Invest 1995; 73: 183-189. Harder H, Lanser JBK, De Haan EHF, Roos RAC. De mini-mental state'-test ontoereikend als screeningstest voor cognitieve deterioratie op een afdeling neurologie. Ne Tijdschr Geneesk 1995; 139: 1742-1745. Hilten JJ van, Braat EAM, Velde EA van der, Middelkoop HAM, Dijk JG van, Ligthart GJ, Roos RAC. Hypokinesia in Parkinson's isease: influence of age, disease severity, and disease duration. Movement disorders 1995; 10: 424-432. Laar T van, Jansen ENH, Neef C, Danhof M, Roos RAC. Pharmacokinetics and clinical efficacy of rectal apomorphine in Patients with Parkinson's disease: a study of five different suppositories. Movement disorers 1995; 10: 433-439. Kempen GMJ van, Janjua R, Roos RAC. Effect of disease and drug treatment on blood serotonin and monoamine oxidase B activity in Parkinson's disease. Clin Neurol Neurosurg 1995; 97: 131-133. Rooij KE de, Konong-Gans PAM de, Roos RAC, Ommen GJB van, Dunnen JT den. Somatic expansion of the (CAG)n repeat in Huntington's disease brains. Hum Genet 1995; 95: 270-274. Tijssen MAJ, Dijk JG van, Roos RAC, Padberg GW. Startle Disease "Van schrik verstijven". Ned Tijdschr Geneesk 1995; 139: 1940-1943. Boeken Bloem BR, Roos RAC, Neurotoxicity of designer drugs and related compounds. Handbook ofClinical Neurology Intoxications of the nervous system Part II, Eds PJ Vinken, GW Bruyn, FA de Wolff, 1995: 363-414. Roos RAC. Statisch, Dynamisch. Neuron en neuroloog. Oratie. Roos RAC. Behandeling van de ziekte van Parkinson. In: Vorderingen in de verpleeghuisgeneeskundige praktijk. Eds.: HJM Cools, WJ e Graaff, MW Ribbe, PBM Went. 1995: 1-5. Roos RAC, Van Hilten JJ. Behandeling van patiënten met de ziekte van Parkinson. Wanneer en met welke medicatie beginnen? In: Therapeutische mogelijkheden in de neurologie. Boerhaave Cursus. Eds RAC Roos en AR Wintzen. 1995: 67-73. Roos RAC, AR Wintzen. Therapeutische mogelijkheden in de neurologie. Boerhaave Cursus. 1995.

Van Hilten JJ, Roos RAC. Dystonie, wanneer moet en kan er worden behandeld? In: Therapeutische mogelijkheden in de neurologie. Boerhaave Cursus. Eds RAC Roos en AR Wintzen. 1995: 75-86. Vakpublicaties Roos RAC. De ziekte van Parkinson. Ned Tijdschr Chron Ziekten 1995; 5: 10-13. Roos RAC. Wat kan de oorzaak zijn van een tremor van het hoofd op volwassen leeftijd. Vademecum 1995; 13: 2-3. Roos RAC. Samenvatting 16de bijeenkomst Research committee WFN in Leuven. Kontaktblad Vereniging van Huntington. 1995; 19: 18-21. Roos RAC. Eitorial Focus on Parkinson's disease 1995; 7: 51. Roos RAC. Eitorial Focus on Parkinson's disease 1995; 7: 27. Roos RAC. Eitorial Focus on Parkinson's disease 1995; 7: 3. Publicaties 1996 Bloem BR, Beckley DJ, Dijk JG van, Zwinderman AH, Remler MP, Roos RAC. Influence of dopaminergic medication on automatic postural responses and balance impairment in Parkinson's disease. Movement Disord 1996; 11: 509-521. Bohlega S, McLean D, Zuheir Al Kawi M, Omer S, Roos RAC, Losekoot M, Bakker E. Huntington's disease: report on four Saudi families. Saudi Med J 1996; 17: 456-460. Bornebroek M, Haan J, Maat-Schieman MLC, Duinen SG van, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D):I-A review of clinical, radiologic and genetic aspects. Brain Pathol 1996; 6: 111-114. Bornebroek M, Haan J, Van Buchem MA, Lanser JBK, De Vries-van de Weerd MACS, Zoeteweij M, Roos RAC. White matter lesions and cognitive deterioration in presymptomatic carriers of the amyloid precursor protein gene codon 693 mutation. Arch Neurol 1996; 53: 43-48. Bornebroek M, Van Buchem MA, Haan J, Brand R, Lanser JBK, De Bruine FT, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis - Dutch type: better correlation of cognitive deterioration with advancing age than with the number of focal lesions or white matter hyperintensities. Alz Dis Assoc Dis 1996; 10: 224-231. Bornebroek M, Verzijlbergen JF, Haan J, Scheyen EJ van, Verhoeff NPLG, Pauwels EJK, Roos RAC. Potential imaging of cerebral amyloid deposits using 123I-labeled amyloid P component and SPECT. Nucl Med Comm 1996; 17: 929-933. CVST Study Group: Lensing AWA, Tijssen JGP, Bossuyt PM, van Gijn J, Dippel DWJ, Koudstaal PJ, Hilten JJ van, Roos RAC, Sander JJ van der, Hamburger HL, Lodder J, Tijssen CC, Bertelsman FW, Koetsier JC, Sandercock P, Humphrey P, Mallo GN, Verlooy P, Van Walbeek HK, Soek JW. Thunderclap headache as first symptom of cerebral venous sinus thrombosis. Lancet 1996; 348: 1623-1624. Maat-Schieman MLC, Duinen SG van, Bornebroek M, Haan J, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D):II-A review of histopathological aspects. Brain Pathol 1996; 6: 1151-120. Reinders M, Hoogduin CAL, Speelman J, Horstink M, Roos RAC. Die Effecte von Hypnose und Verhaltenstherapie bei Torticollis Spasticus. Experimentelle und Klinische Hypnose 1996; 12: 113-121. Roos RAC, Jongen J, Velde EA van der. Survival of patients with idiopathic Parkinson's disease. Movement Disorders 1996; 11: 236-243. Roos RAC, Wintzen AR, Will RG, Ironside, Duinen SG van. Een patiënt met de ziekte van Creutzfeldt-Jakob na behandeling met humaan groeihormoon. Ned Tijdschr Geneesk 1996; Vinters HV, Roos RAC. Introduction to the amyloid symposium. Brain pathology 1996; 6: 109. Vugt JJP van, Hilten JJ van, Roos RAC. Hypokinesia in Huntington's disease. Movement Disorders 1996; 11: 384-389. Boeken Bijdrage Boerhaave cursus over de ziekte van Alzheimer, Vorderingen in de geriatrie -01-1996 Broeckhoven C van, Roos RAC. De ziekte van Alzheimer. Boerhaave cursus 22-11-1996. Cools HJM, Roos RAC. Boerhaave cursus: Vorderingen in de verpleeghuisartsgeneeskundige praktijk. Cools HJM, Ribbe MW, Went PBM, Bolder FA (eds) 1996: 91-98. Roos RAC. Tuberculose in het centrale zenuwstelsel. In Boerhaave cursus Tuberculosis anno 1996. Eds Broekmans JF, Dijkman JH, Kroon FP, Thompson J. 1996: 111-117 Roos RAC. Klinisch-genetische aspecten van de ziekte van Huntington. In: Tibben A, Beemer FA, Brunner HG, Frets PG, Klijn JGM, Maat-Kievit JA, Niermeijer MF, Roos RAC (eds). Presymptomatische DNA-diagnostiek voor erfelijke, later in het leven optredende, ziekten. Bureau PAOG, Rotterdam 1996; 21-22 maart: 4-6. Roos RAC. Erfelijkheid bij de ziekte van Huntington. In Bruijne J de, Gerschtanowitz RH, Jansen FAJ, Landheer T, Lisdonk EH van, Poortman YS, Prinsen JE, Roos RAC, Springer MP, Stolk J, Visser M de (eds). Boerhaave cursus: Zorg om neurologische aandoeningen; een cursus voor huisartsen, 1996: 63-65. Roos RAC. Het subdurale hematoom. In: Springer MP (ed). Boerhaave cursus: Vorderingen en Praktijk. 1996: 217-219.

Roos RAC. Genetische factor bij de ziekte van Alzheimer. In: Lagaay AM, Cools HJM, Roos RAC (eds). Boerhaave cursus Ontwikkelingen in de Geratrie, 1996: 153-156. Roos RAC. Clinical diagnosis and management of Alzheimer's disease. Gauthier S (ed). Dunitz M. Publ, London 1996, In: Clin Neurol Neurosurg 1996; 98: 266 Roos RAC. Clinical disorders of balance, posture and gait. Bronstein AM et al (eds). Arnold, 1996. In: Clin Neurol Neurosurg 1996; 98: 321. Woerkom TCAM van, Tavy-van Heeswijk LH, Roos RAC, Stam CJ. Non-linear dynamics of the EEG in Tourette syndrome. Movement Disorders 1996; 11S: 245 Bloem BR, Beckley DJ, Dijk JG van, Remler MP, Roos RAC. Are abnormal reflexes in patients with Parkinson's disease secondary to their stooped posture? Movement Disorders 1996; 11S: 170 Hilten JJ van, Wagemans EAH, Middelkoop HAM, Roos RAC. Bradykinesia and hypokinesia in Parkinson's disease: what's in a name? Movement Disorders 1996; 11S: 127 Laar T van, Geest R van der, Bodde HE, Danhof M, Roos RAC. Transdermal ionotophoretic delivery of apomorphine in patients with Parkinson's disease. Movement disorders 1996; 11S: 196 Vugt JJP van, Sieslinfg S, Vergeer M, Velde EA vd, Roos RAC. Clozapine versus placebo in Huntington's disease. Movement Disorders 1996; 11S: 54 Siesling S, Vugt JJP van, Hilten JJ van, Roos RAC. Hypokinesia: a promina\ent feature in Huntington's disease. Movement Disorders 1996; 11S: 55 } Bloem BR, Beckley DJ, Dijk JG van, Remler MP, Roos RAC. Are abnormal reflexes in patients with Parkinson's disease secondary to their stooped posture? Movement Disord 1996; 11S: 170 Hilten JJ van, Wagemans EAH, Middelkoop HAM, Roos RAC. Bradykinesia and hypokinesia in Parkinson's disease: what's in a name? Movement Disord 1996; 11S: 127 Laar T van, Geest R van der, Bodde HE, Danhof M, Roos RAC. Transdermal ionotophoretic delivery of apomorphine in patients with Parkinson's disease. Movement Disord 1996; 11S: 196 Laar T van, Geest R van der, Bodde HE, Danhof M, Roos RAC. Transdermal iontophoretic delivery of apomorphine in patients with Parkinson’s disease. Verslag wetenschappelijke vergadering Ned. Ver. Klin. farmacologie en Biofarmacie, najaar 1996 Maat-Schieman MLC, Rozemuller JM, Duinen SG van, Roos RAC. HLA-DR-positive cells of the monocy-te/phagocyte system (MPS) colocalize with arterial ß-amyloid. Neuropathol Appl Neurobiol 1996; 22 Suppl.1: C28. Maat-Schieman MLC, Rozemuller JM, Duinen SG van, Roos RAC. HLA-DR-positive cells of the monocyte/phagocyte (MPS) system colocalize with arterial ß-amyloid (Aß). Pathologendagen (NVVP) 1996, 73. Siesling S, Vugt JJP van, Hilten JJ van, Roos RAC. Hypokinesia: a prominent feature in Huntington's disease. Movement Disord 1996; 11S: 55. Vugt JJP van, Siesling S, Vergeer M, Velde EA vd, Roos RAC. Clozapine versus placebo in Huntington's disease. Movement Disord 1996; 11S: 54 Woerkom TCAM van, Tavy-van Heeswijk LH, Roos RAC, Stam CJ. Non-linear dynamics of the EEG in Tourette syndrome. Movement Disord 1996; 11S: 245 Roos RAC. Eitorial Focus on Parkinson's disease 1996; 8: 3 Roos RAC. Eitorial Focus on Parkinson's disease 1996; 8: 59 Roos RAC, Vugt JJP van. Clozapine bij de behandeling van de ziekte van Huntington. Kontaktblad voor de ziekte van Huntington. 1996; 20: 15-17. Roos RAC. Behandeling van patiënten met de ziekte van Parkinson. Wanneer beginnen en met welke medicatie beginnen? Recept 1996; 2: 18-20. Roos RAC. De ziekte van Parkinson. Optima Farma 1996; 10: 13-16. Publicaties 1997 Bloem BR, Boers I, Lagaay AM, Haan J, Wintzen AR, Roos RAC. Loopbeperkingen bij de alleroudsten. Tijdschr Gerontol Geriatr 1997; 28: 76-81. Bloem BR, Roon KI, Delleman NJ, Dijk JG van, Roos RAC. Prolonged duration of standing up is an early dopa-sensitive abnormality in Parkinson's disease. J Neurol Sci 1997; 146: 41-44. Boo GM de, Tibben A, Lanser JBK, Jennekens-Schinkel A, Hermans J, Vegter-van der Vlis M, Roos RAC. Intelligence indices in people with a high/low risk for developing Huntington's disease. J Med Genet 1997; 34: 564-568. Boo GM de, Tibben A, Lanser JBK, Jennekens-Schinkel A, Hermans J, Maat-Kievit A, Roos RAC. Early cognitive and motor symptoms in identified carriers of the gene for Huntington's disease. Arch Neurol 1997; 54: 1353-1357. Bornebroek M, Haan J, Duinen SG van, Maat-Schieman MLC, Buchem MA van, Bakker E, Broeckhoven C van, Roos RAC. Dutch hereditary cerebral amyloid angiopathy; structural lesions and Apoe genotype. Ann Neurol 1997; 33 : 695-698.

Bornebroek M, Haan J, Backhovens H, Deutz P, VanBuchem MA, VandenBroeck M, Bakker E, Roos RAC, Van Broeckhoven C. Pre-seneline-1 polymorphism and hereditary cerebral hemorrhage with amyloidosis, Dutch type. Ann Neurol 1997; 42: 108-110. Bornebroek M, Westendorp RGJ, Haan J, Bakker E, Timmers WF, Broeckhoven C van, Roos RAC. Mortality from hereditary cerebral hemorrhage with amyloidosis - Dutch type. The impact of sex, parental transmission and year of birth. Brain 1997; 120: 2243-2249. Hoff JI, Hilten JJ van, Middelkoop HAM, Roos RAC. Fatigue in Parkinson's disease is not associated with reduced pysical activity. Parkinsonism and related disorders 1997; 3: 51-54. Maat-Schieman MLC, Duinen SG van, Rozemuller AJM, Haan J, Roos RAC. Association of vascular amyloid beta and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease. J Neuropathol and Exp Neurol 1997; 56: 273-284. Siesling S, Zwinderman AH, Vugt JPP van, Kieburtz K, Roos RAC. A shortened version of the motor section of the unified Huntington's Disease Rating Scale. Movement Disord 1997; 12: 229-234. Siesling S, Vegter-van der Vlis M, Roos RAC. Juvenile Huntington's Disease in the Netherlands. Pediatric Neurology 1997; 17: 37-43 Siesling S, Vugt JJP van, Roos RAC. Hypokinesia: a prominent feature in Huntington's disease. Kinesis, Advances in neuroscience 1997; 2: 17-22. Tibben A, Roos RAC, Niermeijer MF. Psychological consequences of presymptomatic testing for Huntington's disease Lancet 1997; 349: 809. Tijssen MAJ, Schoemaker HC, Edelbroek PJ, Roos RAC, Cohen AF, Dijk JG van. The effects of clonazepam and vigabatrin in hyperekplexia. J Neurol Sci 1997; 149: 63-67. Vugt JJP van, Siesling S, Vergeer M, Velde EA van der, Roos RAC. Clozapine versus placebo in Huntington's disease: a double blind randomised comparative study. J Neurol Neurosurg Psy chiatry 1997; 63: 35-39. Boekhoofdstukken Roos RAC. Dementie. In: Everdinck-van der Pols IEC, Rotteveel-van der Geest CAM (eds). Neurologie in de verpleegkunde. Boerhaave Cie voor PAOG, Leiden 1997: 111-114. Roos RAC. Herkenning en behandeling van tardieve dyskinesie. In: JH Bolk, ed. Farmacotherapie voor huisarts en verpleeg huisarts Boerhaave Cie voor PAOG, Leiden 1997: 103-109. Roos RAC. Aandoeningen van het centraal zenuwstelsel. In Arbeid en belastbaarheid. In: JHBM Willems, NHTh Croon, JW Koten, eds. Bohn Stafleu Van Loghum. 1997. Roos RAC, Wintzen AR. Therapeutische mogelijkheden in de neurologie. Boerhaave Coe vor PAOG, Leiden, 14-11-97. Hemert Van der Poel JC en Roos RAC. Grote lijnen Neurologie 1986-1995. SIG zorginformatie. 1997 Abstracts DeBoo G, Tibben A, Lanser JBK, Jennekens-Schinkel A, Maat-Kievit A, Roos RAC. Early cognitive and motor symptoms in individuals with an identified high risk for Huntington's disease. WFNHD Research Meeting Sydney 1997: 48. Helderman-vandenEijnden ATJM, Vunderink F, Zoeteweij MW, Hilhorst-Hofstee Y, Belfroid RDM, Losekoot M, Roos RAC, VanHaeringen. Unexpected results in predictive testing for Huntington's disease; implications for predictive test applicants and their family, a case study. WFNHD Research Meeting Sydney 1997: 58. Laan J van der, Maat-Schieman MLC, Roos RAC, Duinen SG van. No extracerebral Aß in hereditary cerebral hemorrhage with amyloidosis-Dutch. Brain Pathol 1997; 7: 1107 Maat-Kievit JA, Vegter-vanderVlis M, Zoeteweij, Losekoot M, VanHaeringen A, Kanhai HHH, Roos RAC. Procedures and results of prenatal testing for Huntington's disease in Leiden, The Netherlands. (1987-1996) WFNHD Research Meeting Sydney 1997: 52. Roos RAC, Ottenkamp W. Clinical practice of drug prescription in Huntington's disease. WFNHD Research Meeting Sydney 1997: 60. Siesling S Van Vugt JJP, Ottenkamp W, Vos HMM, Roos RAC. Unified Huntington's disease rating scale, a follow-up. WFNHD Research Meeting Sydney 1997: 28. Siesling S, Vugt JPP van, Ottenkamp W, Vos H, Roos RAC. “Unified Huntington’s Disease Rating Scale: a follow-up”Movement Disorder Congres Sydney Australie augustus 1997 Siesling S, Hille ETM, Vegter-van der Vlis M. Rosendaal FR, Roos RAC. “The mortality in ten families with Huntington’s Disease from 1800-1997" IEA European Regional Meeting Epidemiology, Munster, Duitsland, september 1997 Siesling S, Vegter-vander Vlis M, Losekoot M, Kremer HPH, Maat-Kievit JA, Roos RAC. The genetic background of chorea ECI. WFNHD Research Meeting Sydney 1997: 41. Vugt JJP van, Siesling S, VanderVelde EA, Roos RAC. Clozapine versus placebo in Huntington's disease. WFNHD Research Meeting Sydney 1997: 33. Watson D, Maat-Schieman M, Saido T, Teplow D, Biere AL, Roos R, D Selkoe. N-terminal heterogeneity of Aß caused by the HCHWA-D mutation. Society for Neuroscience Abstracts 1997;23:821 (Abstract 321.9)

Vakpublicaties: Roos RAC. Editorial Focus on Parkinson's disease 1997; 9: 3. Roos RAC. Editorial Focus on Parkiinson's disease 1997; 9: 31 Roos RAC. Verslag 17de internationale bijeenkomst van de researchcommittee van de wereld federatie voor neurologie in Sydney, 1997. Kontaktblad van de vereniging van Huntington 1997; 21: 38-40. Roos RAC. Autorijden en de ziekte van Huntington. Kontaktblad van de vereniging van Huntington 1997; 21: 42-45. Roos RAC. Kan een huisarts een meralgia paresthetica zelf behandelen? Vademecum 1997; 15(40a): 2-3. 37 in totaal Congres bezoek 12th International congres on Parkinson's disease. 23-26/3/1997 Londen. Nascholing Neurologie: Bewegingsstoornissen 25-26/4/1997 Huntington's disease. World Federation of Neurology Sydney. 31/8-3/9/1997 Boerhaave cursus: Therapie in de Neurologie II, 14-11-1997 Najaarsvergadering Nederlandse Vereniging voor Neurologie, Zeist. 12-13/12/1997. Publicaties 1998 Originele artikelen Bloem BR, Van Vugt JJP, Beckley, DJ, Remler MP, Roos RAC. Habituation of lower leg responses in Parkinson's disease. Electroencephalography and Clin Neurophysiol 1998; 109: 73-77. Bloem BR, Beckley DJ, Hilten JJ van, Roos RAC. Clinimetrics of postural instability in Parkinson's disease. J Neurol 1998; 245: 669-673 de Boo G, Tibben A, Hermans J, Maat A, Roos RA. Subtle involuntary movements are not reliable indicators of incipient Huntington's disease. Mov Disord 1998;13:96-9. Bosboom-van der Hurk PR, Middelkoop HAM, Van Waalwijk-Van Doorn ESC, Roos RAC, Cools HJM. Long-term monitoring of urine leakage in the elderly: an evaluation of the validity and clinical applicability of thermistor signalling. J Med Eng Techn 1998; 22: 91-93. Laar T van, Geest R van der, Danhof M, Goossens PH, Roos RAC. Stepwise intravenous infusion of apomorphine to determine the therapeutic window of patients with Parkinson's disease. Clin Neuropharmacology 1998; 21: 152-158. Geest R van der, Laar T van, Kruger PP, Bodde HE, Roos RAC, Danhof M. Pharmacokinetics, enantiomer interconversion and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease. Clin Neuropharmacol 1998; 21: 159-168. Siesling S, Van Vugt JJP, Zwinderman KA, Kieburtz K, Roos RAC. Unified Huntington's disease Rating Scale: a follow-up. Mov Disorders 1998: 13: 915-919. Terwindt GM, Haan J, Ophoff RA, Groenen SMA, Storimans CWJM, Lanser JBK, Roos RAC, Bleeker-Wagemakers, Frants RR, Ferrari MD. Clinical and genetic analysis of a large dutch family with autosomal dominant vascular retinopathy, migraine and Raynaud's phenomenon. Brain 1998; 121: 303-316. Vinters HV, Natte R, Maat-Schieman MLC, Van Duinen SG, Hegeman-Klein I, Welling-Graafland C, Haan J, Roos RAC. Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). Acta neuropathologica 1998; 95 : 235-244. Natte R, Vinters HV, Maat-Schieman ML, Bornebroek M, Haan J, Roos RA, van Duinen SG. Microvasculopathy is associated with the number of cerebrovascular lesions in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Stroke 1998;29:1588-94 Boekhoofdstukken Hilten JJ van, Roos RAC. Neurologische afwijkingen. In Differentiele diagnostiek in de interne geneeskunde. Tweede druk. Eds: WD Reitsma, JWF Elte, D Overbosch. Bohn Stafleu en van Lochem Houten 1998: 341-355. Hydra A, Koudstaal P, Roos RAC. Neurologie. Tweede druk Elsevier/Bunge 1998 Roos RAC. Editorial. Focus on Parkinson's disease 1998; 10: 59. Roos RAC. Geneesmiddelen bij neurodegeneratieve aandoeningen. In Algemene Farmacotherapie. 7de druk. Eds Wesseling.Bohn Stafleu, van Loghum. 1999 Roos RAC. Hoe lopen ouderen? In: Ontwikkelingen in de geriatrie Eds HJM Cools, AM Lagaay, RAC Roos, J Stolk. Boerhaave cursus 1998: 143-144 Roos RAC. Huntington in de familie. Hoe verder? In Boerhaave cursus Zorg om neurologische aandoeningen. Eds J de Bruijne, RH Gerschtanowitz, T Landheer, JE prinsen, RAC Roos, MP Springer, J Stolk, M de Visser. 1998 13-18 J de Bruijne, RH Gerschtanowitz, T Landheer, JE prinsen, RAC Roos, MP Springer, J Stolk, M de Visser. Zorg om Neurologische aandoeningen. Boerhaave syllabus 1998 Cools HJM, Lagaay AM, Roos RAC, Stolk J. Ontwikkelingen in de geriatrie 1998 RAC Roos. Alzheimer's disease. Boerhaave cursus 20-11-1998 Abstracts

Bloem BR, Grimbergen YAM, Cramer M, Roos RAC. Prospective assessment of falls in Parkinson's disease. Movement disorders 1998; 13: 147. Siesling S, Vegter vd Vlis M, Losekoot M, Maat-Kievit JA, Kremer HPH, Roos RAC. Familiegeschiedenis en DNA bepaling in patiënten verdacht van de ziekte van Huntington: onderschatting van de prevalentie? WEON Maastricht 11-12 6-1998. Tijdschrift voor Gezondheidswetenschappen 1998; 4: 49 (A22.1) Siesling S, Hille ETM, Vegter-vd Vlis M, Rosendaal FR, Roos RAC. The mortality in ten families with Huntington's disease from 1800-1997. Movement disorders 1998; 13 suppl2: 156. Siesling S, VanVugt JJP, Zwinderman AH, Kieburtz K, Roos RAC. Unified Huntington's disease rating scale: a follow-up. Movement Disorders 1998; 13 suppl 2: 92 Siesling S, Vegter-vd Vlis M, Losekoot M, Kremer HPH, Maat-Kievit JA, Roos RAC. Family history and DNA analysis in patients suspect of Huntington's disease. Movement Disorders 1998; 13 suppl 2: 92. VanVugt JJP, Siesling S, Vink L, Roos RAC. Reaction time in Huntington's disease. Movement Disorders 1998; 13 suppl 2: 158. Ane MNW, Zoetwey MW, Vegter-vd Vlis M, VanVugt JJP, Lanser JBK, Van Ommen GJB, Roos RAC. Early changes in cognitive functioning in gene carriers of Huntington's disease. 5th European meeting on psychosocial aspects of genetics 1998. Vakpublicaties Roos RAC. Interview Cicero over de ziekte van Huntington. 1998, 3: 23 Roos RAC. Radio-intervieuw Evangelische Omroep: Ziekte van Huntington. Uitgezonden 09-05-1998, 9.00-10.00 Roos RAC. Interview Haagsche Courant 18-07-1998. Ziekte van Alzheimer. Roos RAC . Interview De Neuroloog. CRON. sept 1998 Roos RAC. Foetale celimplantatie als behandeling voor de ziekte van Huntington. Kontaktblad van de vereniging van Huntington 1998; 4: 27-29. Boo G de, Roos RAC. Onderzoek naar de eerste ziekteverschijnselen bij gendragers van de ziekte van Huntington.Kontaktblad van de vereniging van Huntington 1998; 4: 25-26. Publicaties 1999 Originele artikelen Berardelli A, Noth J, Thompson PD, Bollen ELEM, Curra A, Deuschl G, Van Dijk JG, Topper R, Schwarz M, Roos RAC. Pathophysiology of chorea and bradykinesia in Huntington's disease. Movement Disorders 1999; 14: 398-404. Boo GM de, Tibben A, hermans J, Jennekens-Svhinkel A, Maat-Kievit A, Roos RAC. Memory and learning are not impaired in presymptomatic individuals with an increased risk of Huntington's disease. Journ Clin Exp Neuropsychology 1999; 21: 831-836 Van Duinen SG, Lammers GJ, Maat-Schieman MLC, Roos RAC. Numerous an widespread alpha-synuclein-negative Lewy bodies in an asymptomatic patiënt. Acta Neuropathologica 1999; 97: 533-539. Dorsman JC, Smoor MA, Maat-Schieman MLC, Bout M, Siesling S, Van Duinen SG, Verschuuren JJGM, Den Dunnen JT, Roos RAC, Van Ommen GJB. Analysis of the cellular localisation of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington'sisease autopsy brain. Phil Trans Soc Lond B 1999; 354: 1061-1067. Hille ETM, Siesling, Vegter-van der Vlis M, Vandenbroucke JP, Roos RAC, Rosendaal FR. Two centuries of mortality in ten large families with Huntington disease: a rising impact of gene carriership. Epidemiology 1999; 10: 706-710. Van Hilten JJ, Roos RAC. Farmacotherapie bij de ziekte van Parkinson.Ned Tijdschr Geneesk 1999; 143: 234-240. Hoff JI, Van Hilten JJ, Roos RAC. Review of the assessment van dyskinesias. Movement Disorders 1999; 14: 737-744. Maat-Kievit A, et al.Predictive testing of 25 percent at-risk individuals for huntington disease (1987-1997). Am J Med Genet. 1999 Dec 15;88(6):662-8. Maat-Kievit A, et al. Experience in prenatal testing for Huntington's disease in The Netherlands: procedures, results and guidelines (1987-1997). Prenat Diagn. 1999;19:450-7. Maat-Schieman ML, et al. Distribution of inclusions in neuronal nuclei and dystrophic neurites in Huntington disease brain. J Neuropathol Exp Neurol. 1999 Feb;58(2):129-37. Natte R, De Boer WI, Maat-Schieman MLC, Baelde HJ, Vinters HV, Roos RAC, VanDuinen SG. Amyloid beta precursor protein-mRNA, is expressed throughout cerebral vessel walls. Brain res 1999; 828: 179-183. Natte R, Yamaguchi H, Maat-Schieman MLC, Prins FA, Neeskens P, Roos RAC, VanDuinen SG. Ultrastructural evidence of early non-fibrillar Abeta42 in the capillary basement membrane of patients wit hereditary cerebral hemaorrhage with amyloidosis, Dutch type. Acta neuropatholog 1999; 98: 577-582 Van de Vijver DAMC, Stricker BHC, Breteler MMB, Roos RAC, Porsius AJ, De Boer AJ,. A validity of

pharmacy records for identification of patients with Parkinson's disease. TSG 1999; 77: 20-21. Boekhoofdstukken Roos RAC. Geneesmiddelen bij neurodegeneratieve aandoeningen. In Algemene Farmacotherapie. 7de druk. Eds Wesseling.Bohn Stafleu, van Loghum. 1999 Dharmaperwira-Prins RII, Hengeveld MW, Roos RAC, Heeren TJ. Gerontopsychiatrische stoornissen.(caput 7) In: Inleiding gerontologie en geriatrie. Eds Eulderink F, Knook DL, Heeren TJ, Ligthart GJ. Bohn, Stafleu, van Loghum derde druk 1999. Baruch PJ, Dharmaperwira-Prins, Feenstra L, Roos RAC, Sterk CC, Knook DL. Zintuigen en communicatie.(caput 6) In: Inleiding gerontologie en geriatrie. Eds Eulderink F, Knook DL, Heeren TJ, Ligthart GJ. Bohn, Stafleu, van Loghum derde druk 1999. Breedveld FC, Dautzenberg PLJ, Duursma SA, Linden Sj vander, Lips PTAM, Postema K, Roos RAC, Eulderink F. Het bewegen: gaan , staan en doen wat men wil.(caput 5) In: Inleiding gerontologie en geriatrie. Eds Eulderink F, Knook DL, Heeren TJ, Ligthart GJ. Bohn, Stafleu, van Loghum derde druk 1999. Roos RAC, Siesling S. De differentiële diagnostiek bij chorea. In: Movement disorders: new developments. Boerhaave cursus 27-08-1999. pp 13-19. Roos RAC. Movement Disorders Boerhaave cursus syllabus 27-08-1999 Abstracts Nijssen PCG, Brusse E, Leyten ACM, Teepen JLJM, Roos RAC. Parkinsonism, myoclonus and dementia in afamily with adult neuronal ceroid lipofuscinosis (Kuf's disease). Second meeting of the Netherlands Society of Neurology and the Association of British Neurologists. Mei 14-15 1999 Nr 16 Bloem BR, Grimbergen YAM, Cramer M, Roos RAC. Prediction of falls in Parkinson's disease. Second meeting of the Netherlands Society of Neurology and the Association of British Neurologists. Mei 14-15 1999 Nr 22 Schillevoort IERM, Herings RMC, Kutikova L, Hugenholz GWK, Roos RAC, Leufkens HGM. Br J Clin Pharmacol 1999; 47: 476. Van Vugt JJP, Siesling S, Piet KKE, Zwinderman AH, Middelkoop HAM, Van Hilten JJ, Roos RAC. Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 15 Siesling S, Hille ETM, Vegter-van de Vlis M, Zwinderman AH, Rosendaal F, Roos RAC. Evidence for anticipation in Huntington diseas: a mortality study from 1800-1998.18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 27 Siesling S, Lodde BM, Van Vugt JJP, Losekoot M, Roos RAC. CAG repeat length and disease progression in Huntington disease. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 28. Siesling S, Van Vugt JJP, Roos RAC. Update: UHDRS forms by the european sites. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 33. Dorsman JC, Van Luenen HGAM, Smoor MA, Pepers B, Bremmer-Bout M, Den Dunnen JT, Plasterk RHA, Roos RAC, Van Ommen GJB. Analysis of C Elegans transgenic for HD gene constructs with an expanded repeat. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 41. Maat-Kievit A, Vegter-van de Vlis M, Zoeteweij M, Losekoot M, Van Haeringen A, Roos RAC. The paradox of a better test for Huntington disease. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 71. Maat-Kievit A, Vegter-van de Vlis M, Zoetweij M, Losekoot M, Kanhai HHH, Van Haeringen A, Roos RAC. Procedures, results and uptake of prenatal testing for Huntington disease. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 72. Ane MNW, Zoetewij MW, Vegter-van de Vlis M, Van Vugt JJP, Lanser JBK, Hermans J, Van Ommen GJB, Roos RAC. Early changes in cognitive functioning in gene carriers of Huntington disease. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 80-81. Helderman-van den Enden ATJM, Maat-Kievit JA, Siesling S, Vunderink F, Silberg S, Belfroid RDM, Losekoot M, Breuning MH, Roos RAC, Vegter-van de Vlis M. Examples of the sherman paradox in Dutch families with Huntington disease identified with the Leiden roster for Huntington's disease. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 90. Helder DI, Kaptein AA, Van Kempen GMJ, Roos RAC. Living with Huntington's disease: patients and partners. 18th International meeting of the world federation of Neurology research group on Huntington disease 28-31-1999, pp 98. Van de Vijver DAMC, Stricker BHC, Breteler MMB, Roos RAC, Porsius AJ, De Boer AJ,. A validity of pharmacy records for identification of patients with Parkinson's disease. Pharmacoepidemiol Drug Saf 1999; 8: 175.

Van de Vijver DAMC, De Boer AJ, Herings RMC, Roos RAC, Porsius AJ, .Pharmacoepidemiol Drug Saf 1999; 8: 173. Van de Vijver DAMC, De Boer AJ, Herings RMC, Roos RAC, Porsius AJ, .Pharmacoepidemiol Drug Saf 1999; 8:476. Vakpublicaties Siesling S, Roos RAC. De verandering van de ziekteverschijnselen in de tijd. Kontaktblad van de vereniging van Huntington. 1999: 23: 18-21. Ziekte van Huntington. Interview in de Telegraaf. 21-08-1999. Ziekte van Huntington. Interview in Mare 1999; 23: 11. Siesling S, Roos RAC. De ziekte van Huntington. Nederlands Tijdschrift voor Neurologie 1999; 4: 281. Siesling S en Roos RAC. Verstoord energiemetabolisme bij de ziekte van Huntington. Neurolgie actueel 1999; 2: 1-3. Roos RAC. Bookreview. Clin Neurol Neurosurg 1999: ] Congres en bijeenkomsten -Studiemiddag Raad van Toezichtleden. De open Ankh. 31-03-1999 -Second meeting of the Netherlands Society of Neurology and the Association of British Neurologists. Mei 14-15 1999 (20 ptn) -Boerhaave cursus Bewegingsziekten: Leiden 27-8-1999 (10 ptn) -Congres Huntington's disease Den Haag. 28-31 augustus 1999 (10 ptn)Organisator en voorzitter. -Alzheimer's disease, Maastricht 17 september 1999. Organisator en voorzitter. -Euroyapmeeting Parkinson Veldhoven 15-17 october 1999. Organisator en voorzitter op twee dagen. - Kinderneurologie: up(-to-)date, leiden. 19-11-1999, voorzitter van een sessie Voordrachten Roos RAC. Ziekte van Parkinson; klinische aspecten. GBG symposium, PAO-Farmacie, Utrecht 19-01-1999. Uitnodiging Roos RAC. Huntington's disease.Huntington Zentrum Symposium, Bochum. 3-12-1999. Uitnodiging Publicaties 2000 Cath DC, SPinhoven P, Wetering BJM van de, Hoogduin CAL, landman AD, Woerkom TCAM van, Roos RAC, Rooymans HGM. The relationship between types and severity of repetitive behaviors in Gilles de la Tourette dirsorder and obsessive-compulsive disorder. J Clin Psychiatry 2000; 61: 505-513 Maat-Kievit A, Vegter van der Vlis M, Zoetewey M, Losekoot M, Van Haeringen A, Roos RAC. The paradox of a better test for Huntington disease. J Neurol Neurosurg Psychiatry. 2000;69:579-83. Maat-Schieman MLC, Yamaguchi H, Van Duinen SG, Natte R, Roos RAC. Age related plaque morphology and C-terminal heterogeneity of amyloid beta in Dutch-type hereditary cerebral hemorrhage with amyloidosis. Acta Neuropatholog 2000; 99: 409-419. Siesling S, Vegter-van de Vlis M, Losekoot M, Belfroid RD, Maat-Kievit JA, Kremer HP, Roos RA. Family history and DNA analysis in patients with suspected Huntington's disease. J Neurol Neurosurg Psychiatry 2000;69:54-9. Yamaguchi H, Maat-Schieman MLC, Van Duinen SG, Prins F, Neeskens P, Natte R, Roos RAC. Amyloid beta starts to deposit as plasma membrane bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis Dutch type, Alzheimer disease, and non-demented aged subjects. J Neuropathol Exper Neurology 2000; 59: 723-732 Boekhoofdstukken Van Hilten JJ, Roos RAC. Neurologische afwijkingen. In Compendium differentiële diagnostiek in de interne geneekunde. Eds WD Reitsma, JWF Elte, D Overbosch. Bohn Stafleu Van Loghum. 2000: 188-193. Roos RAC De ziekte van Parkinson en andere syndromen. In: Voorwaarts bij CVA en ziekte van Parkinson Boerhaave cursus. 2000, pp 65-71. Mulder WJ, Roos RAC. Voorwaarts bij CVA en ziekte van Parkinson Boerhaave cursus 24-02-2000 Roos RAC, Cools HJM. Veranderende zorg bij het cerebrovasculaire accident. In Ontwikkelingen in de geriatrie. Boerhaave pp 65-73. Lagaay AM, Cools HJM, Roos RAC, Verhoeff JB Ontwikkelingen in de geriatrie. Boerhaave cursus 13-14 april 2000. Roos RAC, van Duinen SG, Maat-Schieman MLC. Ziekte van Alzheimer Boerhaave cursus 23-11-2000. Boekbespreking Roos RAC Neural transplantation methods Clin Neurol Neurosurgery 2000 Roos RAC. The human brain. Clin Neurol Neurosurg 2000; 102: 64. Roos RAC Parkinson's disease. Ned Tijschrift v Geneesk 2000; 144: 56 Roos RAC. Oefenboek Neurologie. Medisch Contact 2000; 55: 367 Voordrachten Roos RAC De ziekte van Parkinson en andere syndromen. In: Voorwaarts bij CVA en ziekte van Parkinson

Boerhaave cursus. 23-2-2000. Roos RAC. Veranderende zorg bij het cerebrovasculaire accident. In Ontwikkelingen in de geriatrie. Boerhaave cursus 13-04-2000. Roos RAC. Een diagnostische valkuil: casuistiek duizeligheid. Boerhaave cursus Diagnostische strategieen. 18-5-2000 Roos RAC. De plaats van de vereniging bij het onderzoek naar de ziekte van Huntington. Den Haag 24-8-2000. Roos RAC. De vele gezichten van de ziekte van Huntington. Patientenvereniging van Huntington Utrecht 28-9-2000 Roos RAC. De ziekte van Huntington. Goes 24-11-2000 Vakpublicaties Roos RAC. De behandeling van de ziekte van Parkinson. Modern medicine 2000; 24: 754-756. Congresbezoek De ziekte van Parkinson in het nieuwe milennium. 15-01-2000 Voorzitter en organisator, Maastricht (accredidatie: 5) Nascholingscursus Neurologie Consultatieve Neurologie 30-3-2000 (accr: 5) Movement Disorders Barcelona 11-16 juni 2000 GOC2000, Ned Ver Med Onderwijs, Veldhoven 30-11 tot 1-12-2000. Congresbezoek en scholing Leergang Hoger management Jan-maart 2000 Het Nationaal BPR congres 15-3-2000 Publicaties 2001 Maat-Kievit A, Helderman-van den Enden P, Losekoot M, de Knijff P, Belfroid R, Vegter-van der Vlis M, Roos RAC, Breuning M. Using a roster and haplotyping is useful in risk assessment for persons with intermediate and reduced penetrance alleles in Huntington disease. Am J Med Genet 2001;105:737-44 Maat-Kievit, Losekoot M, Roos RAC. Van gen naar ziekte; het HD-gen en de ziekte van Huntington. Ned Tijdschr Geneesk 2001;145: 2120-2123. Roos RAC Cruts M, Van gen naar ziekte: Presenilinen en de ziekte van Alzheimer. Ned Tijdsch Geneesk 2001; 145: 2027-2029. Cath DC, Spinhoven P, Hoogduin CAL, Landman AD, van Woerkom TCAM, Van de Wetering BJM, Roos RAC, Rooijmans HGM. Repetitive behaviors in Tourette’s syndrome and OCD with and without tics: what are the differences? Psychiatry research 2001; 101: 171-185. Cath DC, Spinhoven P, van Woerkom TCAM, Van de Wetering BJM, Hoogduin CAL, Landman AD, Roos RAC, Rooijmans HGM. Gilles de la Tourette’s syndrome with and without obsessive-compulsive disorder compared with obsessive-compulsive disorder without tics: which symptoms discriminate? J Nerv and Ment dis 2001; 189: 219-228. Cath DC, Spinhoven P, Hoogduin CAL, Landman AD, van Woerkom TCAM, Van de Wetering BJM, Roos RAC, Rooijmans HGM. Repetitive behaviors in Tourette’s syndrome and OCD with and without tics: what are the differences? Psychiatry research 2001; 101: 171-185. VanVugt JPP, Siesling S, Piet KKE, Zwinderman AH, Middelkoop HAM, VanHilten JJ, Roos RAC. Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington’s disease. Movement Disorders 2001; 16: 481-488. Haan J, Bakker E, Bornebroek M, Roos RAC. Van gen naar ziekte; het gen voor amyloid beta-precursorproteine betrokken bij erfelijke cerebrale amyloidangiopathie. Ned Tijdschr v geneesk 2001; 145: 1639-1641. Helder DI, Kaptein AA, Van Kempen GMJ, Van Houwelingen JC, Roos RAC. Impact of Huntington’s disease on quality of life. Movement Disorders 2001; 16: 325-330. Natte R, Maat-Schieman MLC, Haan J, Bornebroek M, Roos RAC Van duinen SG. Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles. Ann Neurol 2001; 50: 765-772. Vijver DAMC van de, Stricker BHC, Breteler MMB, Roos RAC, Porsius AJ, Boer A de. Evaluation of antiparkinsonian drugs in pharmacy records as a marker for Parkinson’s disease. Pharm World Sci 2001; 23: 148-152. Boekhoofdstukken Roos RAC. Richtlijnen voor de behandeling van patienen met de ziekte van Parkinson. In Zorg om neurologische aandoeningen. Eds J de Bruijne, RH Gerschtanowitz, RAC Roos, MP Springer, M de Visser. Boerhaave cursus 22-03-2001, pp 1-8. Bruijne J de, Gerschtanowitz RH, Roos RAC, Springer MP, Visser M de. Zorg om neurologische aandoeningen. Boerhaave cursus. 22-03-2001. Breuning MH, Maat-Kievit A, Losekoot M, Vegter-van de Vlis M, Maat-Schieman MLC, Roos RAC. Nieuwe ontwikkelingen bij de ziekte van Huntington. In: Zorg om neurologische aandoeningen. Eds J de Bruijne, RH gerschtanowitz, RAC Roos, MP Springer, M de Visser. Boerhaave cursus 22-03-2001, pp 65-72.

Maat-Kievit A, Losekoot M, Vegter-van de Vlis M, Maat-Schieman MLC, Roos RAC. Genetica voor de neuroloog. Bijscholing genetica Biemond Cursus Garderen 5-16. Roos RAC. De behandeling van de ziekte van Parkinson. In: Vorderingen in de verpleeghuisartsgeneeskunde. Eds HJM Cools, P Went. Boerhaave cursus 27-09-2001, pp 1-6. Vakpublicaties Roos RAC. Wat zijn de risico’s voor recidief na staminfarct (syndroom van Wallenberg) ten gevolge van een dissectie van de arteria vertebralis? Vademecum 2001; 19: 3-4 Roos RAC. Het Huntington congres in Kopenhagen. Kontaktblad 2001; 25: 9-11 Publicaties 2002 Bornebroek M, Haan J, Maat-Schieman MLC, Roos RAC. Erfelijke cerebrale amyloid angiopathie van het Nederlandse type: de stand van zaken. Ned Tijdschr Neurologie 2002; 1: 4-11. Dorsman JC, Pepers B, Langenberg D, Kerkdijk H, Ijszenga M, den Dunnen JT, Roos RA, van Ommen GJ. Strong aggregation and increased toxicity of polyleucine over polyglutamine stretches in mammalian cells. Hum Mol Genet. 2002;11:1487-96. Helder DI, Kaptein AA, Van Kempen GMJ, Weinman J, Van Houwelingen JC, Roos RAC. Living with Huntington´s disease: Illness perceptions, coping mechanisms, and spouses´quality of life. Int J Behavioral Med 2002;9:37-52. Helder DI, Kaptein AA, Van Kempen GM, Weinman J, Van Houwelingen HC, Roos RAC. Living with Huntington's disease: Illness perceptions, coping mechanisms, and patients' well-being. Br J Health Psychol. 2002;7:449-462. Maat-Schieman MLC Neurobiology of aging 2002; 23: 1764 Ozawa K, Tomiyama T, Maat-Schieman ML, Roos RA, Mori H. Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D). Ann N Y Acad Sci 2002 Nov;977:149-54 Maat-Kievit A, Losekoot M, Zwinderman K, Vegter-van der Vllis M, Belfroid R, Lopez F, van Ommen GJB, Breuning M, Roos RAC. Predictability of age at onset in Huntington disease in the Dutch population. Medicine 2002; 81: 251-259. Nijssen P, Brusse E, Leyten ACM, Martin JJ, Teepen JLJM, Roos RAC. Autosomal dominant adult neuronal ceroid lipofuscinosis: parkinsonism due to both striatal and nigral dysfunction. Mov Disorders 2002; 17: 482-487. Ozawa K, Tomiyama T, Maat-Schieman ML, Roos RAC, Mori H. Enhanced Abeta(40) Deposition Was Associated with Increased Abeta(42/43) in Cerebral Vasculature with Dutch-Type Hereditary Cerebral Hemorrhage with Amyloidosis (HCHWA-D). Ann N Y Acad Sci. 2002 ;977:149-54. Schillevoort I, de Boer A, van der Weide J, Steijns LS, Roos RAC, Jansen PA, Leufkens HG. Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case-control study. Pharmacogenetics. 2002;12:235-40. Schillevoort I, van Puijenbroek EP, de Boer A, Roos RAC, Jansen PA, Leufkens HG.Extrapyramidal syndromes associated with selective serotonin reuptake inhibitors: a case-control study using spontaneous reports. Int Clin Psychopharmacol. 2002;17:75-9. Schillevoort Ann Pharmacotherapy 2002: 35: 1517-1522 Vijver DAMC van de, Roos RAC, Jansen PAF, Porsius AJ, Boer A de. Antipsychotics and Parkinson´s disease: association with disease and drug choice during the first 5 years of antiparkinsonian drug treatment. Eur J Clin Pharmacol 2002 ;58:157-161. Vijver DAMC van de, Roos RAC, Jansen PAF, Porsius AJ, Boer A de. Start of a selective serotonin reuptake inhibitor (SSRI) and increase of antiparkinsonian drug treatment in patients on levodopa. Br J Clin Parmacol 2002; 54: 168-170. Vijver van de DA, Roos RAC, Jansen PA, Porsius AJ, de Boer A. Influence of benzodiazepines on antiparkinsonian drug treatment in levodopa users. Acta Neurol Scand. 2002;105:8-12. Vijver DAMC van de, Roos RAC, Jansen PAF, Porsius AJ, Boer A de. Antipsychotics and Parkinson´s disease: association with disease and drug choice during the first 5 years of antiparkinsonian drug treatment. Eur J Clin Pharmacol 2002 58 : 157-161. Vijver DAMC van de, Roos RAC, Jansen PAF, Porsius AJ, Boer A de. Brit J Clin Psycholog 2002; Witjes-Ane MN, Zwinderman AH, Tibben A, van Ommen GJB, Roos RA. Behavioural complaints in participants who underwent predictive testing for Huntington's disease. J Med Genet, 2002; 39, 857-862. Boek en boekhoofdstukken : Roos RAC, Tibben A, Kremer HPH. De ziekte van Huntington. Elsevier.2002 Roos RAC Ziekte van Huntington in: Bewegingsstoornissen. Ed EC Wolters en T van Laar. VU Uitgeverij, Amsterdam, pp 339-347 Roos RAC. Symptomatische chorea. In Bewegingsstoornissen. Ed EC Wolters en T van Laar. VU Uitgeverij Amsterdam, pp 333-339.

Vakpublicaties: Roos RAC. Progress in the field of Huntington´s disease and Parkinson´s disease. In While there is life, there is hope. PBF. 2002: 34-4. VanVugt JPP, Roos RAC. Bewegingstraagheid bij Huntington: een onderschat probleem. Kontaktblad 2002; 26: 20-23. Roos RAC, Wintzen AR. In memoriam GW Bruyn: Cicero; neuroloog’ Roos RAC. Reductio sigillum veri. In Liber amicorum AR Wintzen. 2002 Review Roos RAC. psychiatric and cognitive disorders in Parkinson's disease Ned Tijschr Geneesk 2002; 146: Interviews etc: Discussie over profielschets en eindtermen. In Neuroloog 2002; 9: 6-7 Balanceren met tijd. In Cicero: 2002 19-4-2002: 18 Congresbezoek en scholing Detectie en protectie bij de ziekte van Parkinson. Amsterdam 19-01-2002 voorzitter (8 uur) Nascholing Nederlandse Vereniging Neurologie Veldhoven 31-10-2002 Cerebral amyloid angiopathy. New Castle 4-6 december 2002 Publicaties 2003 Grimbergen YA, Roos RAC. Therapeutic options Huntington's disease. Curr Opin Investig Drugs 2003;4:51-4. Van Vugt JPP, Stijl M, Roos RAC, van Dijk JG. Impaired antagonist inhibition may contribute to akinesia and bradykinesia in Huntington's disease. Clin Neurophysiol. 2003;114:295-305. Witjes-Ane MN, Vegter-van der Vlis M, van Vugt JPP, Lanser JB, Hermans J, Zwinderman AH, van Ommen GJB, Roos RAC. Cognitive and motor functioning in gene carriers for Huntington's disease: a baseline study. J Neuropsychiatry Clin Neurosci. 2003;15:7-16. Schillevoort I, Heuvel E van den, Sturkenboom MCJM, Boer A de, Roos RAC , Jansen PAF, Leufkens HGM. Use of antiparkinsonian medication to identify patients with extrapyramidal syndromes in an outpatient setting. pharmacoepidemiology and drug safety 2003; Spliethoff-Kamminga NG, Zwinderman AH, Springer MP, Roos RAC. Psychosocial problems in Parkinson's disease: Evaluation of a disease-specific questionnaire. Mov Disord. 2003;18:503-9. Spliethoff-Kamminga NG, Zwinderman AH, Springer MP, Roos RA. A disease-specific psychosocial questionnaire for Parkinson's disease caregivers. J Neurol. 2003;250:1162-8. Timman R, Roos RAC, Tibben A. A non linear effects in behavioral changes in Huntington’s disease. Cognitive and behavioral Neurology 2003; 16: 82. Nijssen PC, Ceuterick C, van Diggelen OP, Elleder M, Martin JJ, Teepen JL,Tyynela J, Roos RA. Autosomal dominant adult neuronal ceroid lipofuscinosis: a novel form of NCL with granular osmiophilic deposits without palmitoyl protein thioesterase 1 deficiency. Brain Pathol. 2003;13:574-81. Hydra, P Koudstaal, RAC Roos. Neurologie derde druk, Elsevier 2003. Voordrachten Roos RAC. Acute neurologie voor huisartsen. 19-02-2003 en 11-03-2003 Roos RAC : The follow-up of presymptomatic cases with Huntington’s disease. A prospective study. Naarden 29-04-2003 Roos RAC: de ziekte van Parkinson. Faculty of Pharmaceutical Sciences Utrecht 02-04-2003 Intervieuw de neuroloog over de opleiding Intervieuw De neuroloog over de CWON Congresbezoek WFN-IHA Huntingtoncongres 14-19 augustus 2003 in Toronto Neurologietoets Cijfer voldoende: 8 Najaarsvergadering Nederlandse Vereniging Neurologie 28-11-2003 Publicaties 2004 Maat-Schieman ML, Yamaguchi H, Hegeman-Kleinn IM, Welling-Graafland C, Roos RA, Van Duineen SG. Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Acta Neuropathol (Berl) 2004; 107: 389-398. Munts AG, Roos RAC, Koehler PJ. Vergeet de corticobasale degeneratie niet. Tijdschrift voor neurologie en

neurochirurgie 2004; 105: 217-222. De Pril R, Fischer DF, Maat-Schieman ML, Hobo B, De Vos RA, Brunt ER, Hol, EM, Roos RA, Van Leeuwen FW. Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases. Hum Mol Genet. 2004;16: 1803-1813 Timman R, Roos RAC, Maat-Kievit JA, Tibben A. Adverse effects of predictive testing for Huntington’s disease underestimated effects 7-10 years after the test. Health Psychology 2004; 23: 189-197. VanVugt JPP, Piet KKE, Vink LJ, Siesling S, Zwinderman AH, Middelkoop HAM, Roos RAC. Objective assessment of motor slowness in Huntington’s disease: clinical correlates and 2-year follow-up. Movement disorders 2004; 19: 285-297. Vakpublicatie RAC Roos. EURO-HD: Ontwikkeling van een mooie europese samenwerking. Kontaktblad Vereniging Neurologie 2004; 28: 7-9. Roos RAC Wokke J. Capacitetsplanning in de neurologie. Neuroloog 2004; 11: 11-14. Boeken: Ontwikkelingen inde geriatrie. Chel VGM, Cools HJM, Iserief PB, Roos RAC, Vliet Vlieland CW, Westendorp RGJ, Zitman FG. Boerhaave cursus 2004. Neurologische stoornissen. Chel VGM, Vliet Vlieland CW, Roos RAC. Boerhaave cursus 2004 Breedveld FC, Dautzenberg PLJ, Duursma SA, Linden Sj vander, Postema K, Roos RAC. Het bewege: gaan, staan en doen wat men wil. Inleiding in de gerontologie en geriatrie. Eds Eulderink F, Heeren TJ, Knook DL, Ligthart GJ. Bohn Stafleu Van Loghum 2004 Houten. Pp 101-136 PJ Baruch, Dharmaperwira-Prins RII, Feenstra L, Roos RAC, Sterk CC. Zintuigen en communicatie. Inleiding in de gerontologie en geriatrie. Eds Eulderink F, Heeren TJ, Knook DL, Ligthart GJ. Bohn Stafleu Van Loghum 2004 Houten. Pp 137-148. Dharmaperwira-Prins RII, Hengeveld MW, Roos RAC. Gerontopsychiatrische stoornissen. Inleiding in de gerontologie en geriatrie. Eds Eulderink F, Heeren TJ, Knook DL, Ligthart GJ. Bohn Stafleu Van Loghum 2004 Houten. Pp 149-165 Congresbezoek: Boerhaavecursus Ontwikkelingen in de geriatrie. 22 en 23 jan 2004. (accr …) Nascholing Neurologie 11 en 12 maart 2004 Nijkerk. (accr 16 pnt) Movement Disorders 12-17 juni 2004 Rome (17 pnt) EURO-HD First European Congress on HD, Madrid 1 en 2 okt 2004 Boerhaave cursus Neurologische aandoeningen 11-11-2004 (accr..) Voordrachten: Roos RAC. Bewegingsstoornissen. Biemondcursus 12-03-2004 Nijkerk en 10-12-2004 Veldhoven, uitnodiging Roos RAC. Wetenschappelijk onderzoek bij HD, Wijk aan Zee 13-04-2004. uitnodiging Roos RAC. Motor abnormalities in Huntington disease Madrid, First EURO-HD meeting.uitnodiging 01-10-2004 Publicaties 2005 . Petersen A, Gil J, Maat-Schieman ML, Bjorkqvist M, Tanila H, Araujo IM, Smith R, Popovic N, Wierup N, Norlen P, Li JY, Roos RA, Sundler F, Mulder H, Brundin P. Orexin loss in Huntington's disease. Hum Mol Genet. 2005;14:39-47. Epub 2004 Nov 03. Cong SY, Pepers BA, Evert BO, Rubinsztein DC, Roos RA, van Ommen GJ, Dorsman JC. Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci. 2005 30:12-23 Cong SY, Pepers BA, Roos RA, Van Ommen GJ, Dorsman JC. pitope Mapping of Monoclonal Antibody 4C8 Recognizing the Protein Huntingtin. Hybridoma (Larchmt). 2005 Oct;24(5):231-5. PMID: 16225422 [PubMed - in process] Cong SY, Pepers BA, Evert BO, Rubinsztein DC, Roos RA, van Ommen GJ, Dorsman JC. Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci. 2005 ;30:560-71. van Duijn E, Roos RA, Smarius LJ, van der Mast RC. Electroconvulsieve therapie bij patienten met de ziekte van Huntington's en depressie. Ned Tijdschr Geneeskd. 2005;149:2141-4. Maat-Schieman M, Roos R, van Duinen S. Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Neuropathology. 2005;25:288-97.

Van Oostrom JC, Maguire RP, Verschuuren-Bemelmans CC, Veenma-vanderDuin L, Pruim J, Roos RA, Leenders KL. Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease. Neurology. 2005;65:941-3. Schillevoort I, Herings RM, Boer A, Leufkens HG, Hugenholtz GW, Nolen WA, Roos RA. Antipsychotic-induced Extrapyramidal Syndromes in Psychiatric Practice: A Case-control Study. Pharm World Sci. 2005;27:285-9. Timman R, Claus JH, Slingerland HM,van der Schalk M, De meulenare S, Roos RA, Tibben A. Nature and Development of Huntington Disease in a Nursing Home Population: The BOSH Rating Scale. Cognitive and Behavioral Neurology 2005; 18: 215-222. Roos RAC De behandeling van dementie Boerhaave cursusboek Vorderingen en PraktijkEd Assendelft WJJ et al. 2005: 199-203 Euro-HD Congres 8-9 sept 2005 Wereldcongres voor Huntington disease 10-13 sept 2005 Publicaties 2006 Cong SY, Pepers BA, Roos RA, van Ommen GJ, Dorsman JC. Small N-terminal mutant huntingtin fragments, but not wild type, are mainly present in monomeric form: Implications for pathogenesis. Exp Neurol. 2006 Jun;199:257-64. Kaptein AA, Helder DI, Scharloo M, Van Kemper GMJ, Weinman J, Van Houwelingen H, Roos RAC, Illness perception and coping explain well-being in patients with Huntington disease. Psychology & Health 2006, 21: 431-446. Montagne B, Kessels RPC, Kammers MPM, Kingma E, Haan EHF de, Roos RAC, Middelkoop HAM. Perception of emotional facial expressions at different intensities in early-symptomatic Huntington’s disease European Neurology 2006; 55: 151-154. DePril R, DF Fischer, Roos RAC, Van Leeuwen FW. Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. Molecular and Cellular Neuroscience Smith R, Chung H, Rundquist S, Maat-Schieman ML, Colgan L, Englund E, Liu YJ, Roos RA, Faull RL, Brundin P, Li JY. Cholinergic neuronal defect without cell loss in Huntington's disease. Hum Mol Genet. 2006 Sep 20; PMID: 16987871 Wintrebert CM, Zwinderman AH, Maat-Kievit A, Roos RA, van Houwelingen HC. Assessing genetic effects in survival data by correlating martingale residuals with an application to age at onset of Huntington disease. [Epub ahead of print] Stat Med. 2006 Sep 30;25(18):3190-200 Zhang-Nunes SX, Maat-Schieman ML, van Duinen SG, Roos RA, Frosch MP, Greenberg SM. The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol. 2006;16:30-9. Vakpublicaties Roos RAC. De behandeling van dementie. Modern Medicine 2006; 30: 133-136 Boek Roos RAC. Aandoeningen van het centrale zenuwstelsel. In Algemene ziekteleer voor tandartsen. Tweede druk 2006. Eds HS Brand DE van Diermen, PC Makkes Bohn Stafleu e van Loghum. 265-279. Voordracht 24-03-2006: afscheidssympsium Tans. Opleiden tot opleiden 21-11-2006 Verpleeghuis Duyn en Rhyn Katwijk Ziekte van Huntington Promoties Ommen GJB van, RAC Roos. Shu Yan-Cong 23-05-2006 Promotiecomissie SCA Stevens 31-05-2006 Van Heuven V, Roos RAC, Liang Ji Experiments on the modular nature of words and sentence phonology in Chinese Broca’s patients. 10-05-2006 Congres Najaarsvergadering NvN Congres Movement disorders Kyoto 26-10—3-11 2006

Publicaties 2007

Aziz NA, Swaab DF, Pijl H, Roos RAC. Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington’s disease: clinical consequences and therapeutic implications. Reviews in neurosciences 2007; 18: 223-251. Duyn E van, Mast R vd, Roos RAC. Behavioural problems in Huntington's disease using the Problem Behaviours Assessment. General Hospital Psychiatry 2007; de Pril R, Fischer DF, Roos RA, van Leeuwen FW. Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. Mol Cell Neurosci. 2007;34:10-9. Van der Hiele K, Jurgens CK, Vein AA, Reijntjes RHAM, Witjes-Ané MNW, RoosRAC, Van Dijk JG, Middelkoop HAM. Memory activation reveals abnormal EEG in preclinical Huntington’s disease. Mov Disord. 2007; 22: 690-695 Kaptein AA, Scharloo M, Helder DI, Snoei L, van Kempen GMJ, Weinman J, van Houwelingen JC, Roos RAC. Quality of life in couples living with Huntington's disease: The role of patients' and partners' illness perceptions". Quality of life research 2007; 16(5):793-801 Maat-Schieman MLC, Roos RAC, Losekoot M, Dorsman J Welling-Graafland C, Hegeman-Kleinn I, Broeyer F, Breuning M, VanDuinen SG. Neuronal intranuclear and neuropil inclusions for pathological assessment of Huntington Disease. Brain Pathology 2007;17: 31-37 Nishitsuji K, Tomiyama T, Ishibashi K, Kametani F, Ozawa K, Okada R, Maat-Schieman ML, Roos RA, Iwai K, Mori H. Cerebral vascular accumulation of Dutch-type Abeta42, but not wild-type Abeta42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type. J Neurosci Res. 2007 Jul 12; 85(13):2917-23 van Oostrom JC, Sijens PE, Roos RA, Leenders KL. H magnetic resonance spectroscopy in preclinical Huntington disease.Brain Res. 2007; 1168:67-71 Roos RAC, Aziz NA. Hypocretin-1 and secondary signs in Huntington’s disease. Parkinsonism and rel Disorders 2007; 13: S387-S390. Witjes-Ane MN, Mertens B, van Vugt JPP, Bachoud-Levi AC, van Ommen GJB, Roos RAC Longitudinal follow-up of presymptomatic carriers of Huntington’s disease. J Neuropsychology and Clinical Neuroscience 2007; 19: 310-317 Vakpublicatie Roos RAC, Aandoeningen van het centraal zenuwstelsel. Hoofdstuk 23. In Handboek Arbeid en Belasting Ed JHBM Willems, NHTh Croon, JW Koten. 2007 pp 1-39. (boekhoofdstuk) Roos RAC, Cats E. De neuroloog in op leiding. De Neuroloog 2007; 14: 1/19. Roos RAC. Chorea and Huntington’s disease. In Parkinsonism and related disorders Eds EC Wolters, T van Laar, HW Berendse. Vu University Press Amsterdam 2007: 393-401. Spliethoff-Kamminga NPA, Boerhaave cursus: PEPP 31-01-2007 Voordracht: 16-01-2007 regionale verpleeghuisartsen uitnodiging: De ziekte van Huntington 17-04-2007 Noorderbreedte Grou Verpleeghuisproject Ziekte van Huntington: organisatie van zorg. 12-12-2007 International Parkinson Congres Amsterdam. :Hypocretin-1 and secondary signs in Huntington’s disease. Congres Amyloid congres Reykjavik Aug 2007 (2,5 dag) European Huntington Disease Network Congres Dresden 6-9 september 2007 (3 dg) Wereldcongres voor de ziekte van Huntington Dresden 9-12 september 2007 (3 dg) XVII th congres parkinsonism and related disorders 9-13 dec 2007 Amsterdam Publicaties 2008

Aziz A, Fronczek R, Maat-Schieman M, Unmehopa U, Roelandse F, Overeem S, van Duinen S, Lammers GJ, Swaab D, Roos RA. Hypocretin and Melanin-Concentrating Hormone in Patients with Huntington Disease. Brain Pathol. 2008;18: 474-83 Aziz NA, Van der Marck MA, Pijl H, Olde Rikkert MGM, Bloem BR, Roos RAC. Gewichtsverlies bij neurodegeeratieve aandoeningen. Tijdschrift voor Neurologie en neurochirurgie 2008;109: 192-199.

Aziz NA, Roos RAC. I Intergenerational CAG repeat instability is highly heritable in Huntington's disease' J Med Genet. 2008 Nov;45(11):766.

Aziz NA, Van der Burg JMM, Landwehrmeyer GB, Brundin P, Stijnen T, EHDI Study Group, and Roos RAC. Weight loss in Huntington disease increases with higher CAG repeat number. Neurology 2008;71 1506-1513

Bacos K, Björkqvist M, Petersén A, Luts L, Maat-Schieman ML, Roos RA, Sundler F, Brundin P, Mulder H, Wierup N. Islet beta-cell area and hormone expression are unaltered in Huntington's disease. Histochem Cell Biol. 2008; 129(5):623-9 Grimbergen YA, Knol MJ, Bloem BR, Kremer BP, Roos RA, Munneke M. Falls and gait disturbances in Huntington's disease. Mov Disord. 2008; 23(7): 970-6 Kingma EM, Van Duijn E, Timman, R, Van der Mast RC, Roos RAC. Behavioural problems in Huntington’s disease using the problem behaviours assessment. Gen Hosp Psychiatry 2008; 30: 155-161.

van Duijn E, Kingma EM, Timman R, Zitman FG, Tibben A, Roos RA, van der Mast RC. Cross-Sectional Study on Prevalence of Psychiatric Disorders in Mutation Carriers of Huntington's Disease Compared With Mutation-Negative First-Degree Relatives. J Clin Psychiatry. 2008 Nov 24. pii: ej08m04155. [Epub ahead of print]

Jurgens CK, van de Wiel L, van Es AC, Grimbergen YM, Witjes-Ané MN, van der Grond J, Middelkoop HA, Roos RA. Basal ganglia volume and clinical correlates in 'preclinical' Huntington's disease. J Neurol. 2008;255:1785-91.

Roos RA, Aziz NA. Hypocretin-1 and secondary signs in Huntington's disease Parkinsonism Relat Disord. 2007;13 Suppl 3:S387-90.

Van den Hout WB, Peul WC, Koes BW, Brand R, Kievit J, Thomeer RT; Leiden-The Hague Spine Intervention Prognostic Study Group. Prolonged conservative care versus early surgery in patients with sciatica from lumbar disc herniation: cost utility analysis alongside a randomised controlled trial. BMJ. 2008;336(7657):1351-4

Peul WC, van den Hout WB, Brand R, Thomeer RT, Koes BW; Leiden-The Hague Spine Intervention Prognostic Study Group. Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation: two year results of a randomised controlled trial. BMJ. 2008;336(7657):1355-8 Vakpublicatie Roos RAC. Opleiding tot neuroloog. Interview De Neuroloog 2008: Roos RAC, Peeters R. Boerhaave cursus 50 jaar. Leids Dagblad June 3 2008 Boekhoofdstuk: Rivastigmine en memantine bij dementia. Boerhaave cursus Vorderingen in de verpleeghuisgeneeskunde. 25-09-2008 Voordracht: Information to HD patients. Meeting EuroHD Leuven 8 May 2008 The ten test in HD Motor working group Bern 30 May 2008 Rivastigmine en memantine bij dementie Boerhaave Cursus 25 sept 2008 Congres 50 jaar Boerhaave cursus voor huisartsen, 10-04-2008. Cursuscommissie Genetic couselling in HD. Leuven 8-9 May 2008 Motor working group Bern 30-31 May 2008 EHDN Lissabon 2-8 Sept 2008 Publicaties 2009

A'campo LE, Wekking EM, Spliethoff-Kamminga NG, Le Cessie S, Roos RA. The benefits of a standardized patient education program for patients with Parkinson's disease and their caregivers. Parkinsonism Relat Disord. 2009 Aug 10. [Epub ahead of print]

A'campo LE, Spliethoff-Kamminga NG, Macht M; The EduPark Consortium, Roos RA. Caregiver education in Parkinson's disease: formative evaluation of a standardized program in seven European countries. Qual Life Res. 2009 Nov 28.

Aziz NA, van der Marck MA, Pijl H, Olde Rikkert MG, Bloem BR, Roos RA. Weight loss in neurodegenerative disorders. J Neurol. 2008; 255:1872-80 (Epub 2009 Jan 22)

Aziz NA, Van der Burg JMM, Landwehrmeyer GB, Brundin P, Stijnen T, EHDI Study Group, and Roos RAC. Weight loss in Huntington disease increases with higher CAG repeat number. Reply. Neurology 2009;

Aziz NA, Pijl H, Frölich M, van der Graaf AW, Roelfsema F, Roos RA. Increased hypothalamic-pituitary-adrenal axis activity in Huntington's disease. J Clin Endocrinol Metab. 2009 Apr;94(4):1223-8. Epub 2009 Jan 27.

Aziz NA, Pijl H, Frölich M, van der Graaf AW, Roelfsema F, Roos RA. Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington's Disease. Endocrinology. 2009 ;150(3):1558.

Aziz NA, Roos RAC. Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD study. Mov Disord 2009; 15;24(8):1253.

Aziz NA, Roelfsema F, Frölich M, Roos RA, Pijl H. A strategy for finding the optimal deconvolution estimates for hormone secretory kinetics using AutoDecon. Anal Biochem. 2009 Aug 1;391(1):69-71. Epub 2009 May

Aziz NA, Pijl H, Frölich M, Schröder-van der Elst JP, van der Bent C, Roelfsema F, Roos RA. Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease. Eur J Neurol. 2009 Oct 21. [Epub ahead of print]

Aziz NA, Pijl H, Frölich M, Van der Graaf AW, Roelfsema F, Roos RA. Leptin secretion rate increases with higher CAG repeat number in Huntington's disease patients. Clin Endocrinol (Oxf). 2009 Jun 22. [Epub ahead of print]

Aziz NA, Jurgens CK, Landwehrmeyer GB, van Roon-Mom WM, van Ommen GJ, Stijnen T, Roos RA; EHDN Registry Study Group Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease. Neurology. 2009 Oct 20;73(16):1280-5. Epub 2009 Sep 23.

Aziz NA, Pijl H, Frölich M, Schröder-van der Elst JP, van der Bent C, Roelfsema F, Roos RA Delayed onset of the diurnal melatonin rise in patients with Huntington's disease. J Neurol. 2009 Jun 27. [Epub ahead of print]

Grimbergen YA, Langston JW, Roos RA, Bloem BR. Postural instability in Parkinson's disease: the adrenergic hypothesis and the locus coeruleus. Expert Rev Neurother. 2009 Feb;9(2):279-90.

Jurgens CK, Bos R, Luyendijk J, Witjes-Ané MN, van der Grond J, Middelkoop HA, Roos RA. Magnetization transfer imaging in 'premanifest' Huntington's disease. J Neurol. 2009 Oct 13. [Epub ahead of print] Nijssen PCG, Brekelmans GJF, Roos RAC. Electroencephalography in autosomal dominant adult neuronal ceroid lipofuscinosis. Clinical neurophysiology 2009

van Oostrom JC, Dekker M, Willemsen AT, de Jong BM, Roos RA, Leenders KL. Changes in striatal dopamine D2 receptor binding in pre-clinical Huntington's disease. Eur J Neurol. 2009;16:226-31.

de Pril R, Hobo B, van Tijn P, Roos RA, van Leeuwen FW, Fischer DF. Modest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model. Mol Cell Neurosci. 2009 Dec 17. Ritfeld GJ, Nandoe Tewarie RD, Rahiem ST, Hurtado A, Roos RA, Grotenhuis JA, Oudega M. Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. Neuroreport. 2009 Dec 30. [ Roos RAC. De patiënt met de ziekte van Parkinson aan het werk. Tijdschrift v bedrijfsgeneeskunde 2009; 17: 116-120 Roos RAC. Medicamenteuze behandeling van de ziekte van Huntington. Tijschr voor neuropsychiatrie en gedragsneurologie 2009; 8: 87-90

Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC; the TRACK-HD investigators. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol. 2009 Sep;8(9):791-801. [Epub ahead of print

Veerman SRT, Sno HN, Ravelli DP, Roos RAC. Een patient met laat ontsane schizofrenie en angst voor de Katwijkse ziekte. Tijdschrift voor Psychiatrie 2009; 51: 255-261. Boekhoofdstuk: Roos RAC. Inleiding en De ziekte verschijnselen van de ziekte van Huntington. In De ziekte van Huntington en verwante erfelijke neuropsychiatrische aandoeningen. Eds EL Vervoort en FJ van Zuuren.Van Gorcum 2009: 9-17 Roos RAC Tibben A. Juveniele ziekte van Huntington. In De ziekte van Huntington en verwante erfelijke neuropsychiatrische aandoeningen. Eds EL Vervoort en FJ van Zuuren.Van Gorcum 2009: 399-402

Roos RAC. EURO-HD.In De ziekte van Huntington en verwante erfelijke neuropsychiatrische aandoeningen. Eds EL Vervoort en FJ van Zuuren.Van Gorcum 2009: 445-448 Aziz NA, VanderBurg JM, Pijl H, Roos RAC Huntington’s disease and metabolic abnormalities: lessons fro mice and men. In Treatment strategies EASD 2009 review: 32-39. The Cambridge Research Centre LtD UK. Voordracht: MTI in Huntington disease Parijs 31-01-2009 Behandeling van de ziekte van Hunington 05-02-2009, Amersfoort Ziekte van Huntington Afd Neurologie UMCU 27-02-2009 Ziekte van Huntington masterclass Afd Neurologie UMCU. 27-02-2009 Europees onderzoek bij de ziekte van Huntington Klin Gen 18-05-2009 De ziekte van Huntingon. Pharmaciestudenten Apeldoorn. 22-05-2009 De ziekte van Huntington Verpleeghuis Overduin 25-05-2009 Vakpublicatie Interview: Leids Dagblad, Wat beweegt de neuroloog. 26-01-2009 AAN Nov 2009 Congres Bewegingsstoornissen Amersfoort 05-02-2009 Movement Disorders Parijs 7-11 juni 2009 Huntington wereld congres Vancouver 16-19 sept 2009 Wetenschappelijk congres NVN 05-11-2009 Nascholing Neurologie Veldhoven 17-18 dec 2009

Publicaties 2010

A'Campo LE, Spliethoff-Kamminga NG, Macht M; EduPark Consortium, Roos RA. Caregiver education in Parkinson's disease: formative evaluation of a standardized program in seven European countries. Qual Life Res. 2010 Feb;19(1):55-64. Epub 2009 Nov 28.

Aziz NA, Anguelova GV, Marinus J, Van Dijk, JG, Roos RA. Autonomic symptoms in patients and premanifest mutation carriers of Huntington’s disease. Eur J Neurol. 2010 ;17:1068-1074.

Aziz NA, Anguelova GV, Marinus J, Lammers GJ, Roos RA. Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease. Parkinsonism Relat Disord. 2010;16:345-350.

Aziz NA, Pijl H, Frölich M, Snel M, Streefland TC, Roelfsema F, Roos RA. Systemic energy homeostasis in Huntington's disease patients. J Neurol Neurosurg Psychiatry. 2010;81:1233-1237.

Aziz NA, Pijl H, Frölich M, Roelfsema F, Roos RA. Altered thyrotropic and lactotropic axes regulation in Huntington's disease. Clin Endocrinol (Oxf). 2010 Jun 9.

Aziz NA, Pijl H, Frölich M, Schröder-van der Elst JP, van der Bent C, Roelfsema F, Roos RA. Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease. Eur J Neurol. 2010 Feb;17(2):280-8. Epub 2009 Oct 21.

Bechtel N, Rachael I, Scahill H, Rosas D, Acharya T, Van den Bogaard SJA, Jauffret C, Say MJ, Sturrock A, Johnson H, Onorato CE, SalatDH, Durr A, Leavitt BR, Roos RAC, Landwehrmeyer GB, Langbehn DR, Stout JC, Tabrizi SJ, Reilmann R. Tapping linked to function and structure in premanifest & symptomatic Huntington's disease. Neurology 2010 14;75:2150-60.

Groen JL, De Bie RMA, Foncke EMJ, Roos RAC, Leenders KL, Tijssen MAJ. Late-onset Huntington disease with intermediate CAG repeats: true or false? J Neurol Neurosurg Psychiatry. 2010;81:228-30. Heemskerk AW, Roos RA. Dysphagia in Huntington's Disease: A Review. Dysphagia. 2010 Sep 14. Jurgens CK, Bos R, Luyendijk J, Witjes-Ané MN, van der Grond J, Middelkoop HA, Roos RA. Magnetization transfer imaging in 'premanifest' Huntington's disease. J Neurol. 2010 Mar;257(3):426-32. Jurgens CK, Jasinschi R, Ekin A, Witjes-Ané MN, Middelkoop H, van der Grond J, Roos RA. MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease. PLoS Curr. 2010 Sep 2;

Keus SH, Nijkrake MJ, Borm GF, Kwakkel G, Roos RA, Berendse HW, Adang EM, Overeem S, Bloem BR, Munneke M; ParkinsonNet Trial Study Group. The ParkinsonNet trial: design and baseline characteristics. Mov Disord. 2010 May 15;25(7):830-7. Munneke M, Nijkrake MJ, Keus SH, Kwakkel G, Berendse HW, Roos RA, Borm GF, Adang EM, Overeem S, Bloem BR. Efficacy of community-based physiotherapy networks for patients with Parkinson's disease: a cluster-randomised trial. Lancet Neurol 2010; 9: 46-54 Oosterveer DM, Overweg-Plandsoen WCT, Roos RAC. Sydenham's Chorea: A Practical Overview of the Current Literature. Pediatric Neurology 2010;(43)1:1-6

Orth M; European Huntington's Disease Network, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho A, Wild EJ, Tabrizi SJ. Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY. PLoS Curr. 2010 Sep 28;2. pii:

de Pril R, Hobo B, van Tijn P, Roos RA, van Leeuwen FW, Fischer DF. Modest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model. Mol Cell Neurosci. 2010;43281-6.

Reedeker N, Van Der Mast RC, Giltay EJ, Van Duijn E, Roos RA. Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning. Mov Disord. 2010 15;25:1612-1618.

Ritfeld GJ, Nandoe Tewarie RD, Rahiem ST, Hurtado A, Roos RA, Grotenhuis A, Oudega M. Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. Neuroreport. 2010:17;21:221-226.

Roos RAC, Bijlsma EK. Fenokopieen van de ziekte van Huntington. Tijdschr Neurol Neurochir 2010; 111: 142-145.

Roos RAC. Huntington's disease: a clinical review. Orphanet Journal of Rare Diseases 2010, 5:40.

Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC; the TRACK-HD investigators. Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol. 2010 Dec 1. [Epub ahead of print]

van den Bogaard SJ, Dumas EM, Acharya TP, Johnson H, Langbehn DR, Scahill RI, Tabrizi SJ, van Buchem MA, van der Grond J, Roos RA; TRACK-HD Investigator Group. Early atrophy of pallidum and accumbens nucleus in Huntington's disease. J Neurol. 2010 Oct 9. [Epub ahead of print]

van Duijn E, Giltay EJ, Zitman FG, Roos RA, van der Mast RC. Measurement of psychopathology in Huntington's disease: the critical role of caregivers. J Nerv Ment Dis. 2010 ;198:329-333.

van Duijn E, Reedeker N, Giltay EJ, Roos RA, van der Mast RC. Correlates of Apathy in Huntington's Disease. J Neuropsychiatry Clin Neurosci. 2010 Summer;22:287-294.

van Duijn E, Selis MA, Giltay EJ, Zitman FG, Roos RA, van Pelt H, van der Mast RC. Hypothalamic-pituitary-adrenal axis functioning in Huntington's disease mutation carriers compared with mutation-negative first-degree controls. Brain Res Bull. 2010 30;83:232-237.

Van Wamelen DJ, Shan L, Aziz NA, Anink JJ, Bao AM, Roos RA, Swaab DF

Functional Increase of Brain Histaminergic Signaling in Huntington's Disease. Brain Pathol. 2010 Nov 25.

Boekhoofdstuk

Roos RAC. De ziekte van Parkinson. In Parkinson: geen leven geen dood. door W Breedveld. Stavenuiter Publiciteit 2010 pp97-107. Roos RAC . Diagnostische strategieën bij de patiënt met een tremor. Boerhaave cursus In: Diagnostische strategieën, 2010: 39-44. Roos RAC, Neuron, Opleidingsplan Neurologie Nederland Neurologie druk 4 Hydra AH, Koudstaal P, Roos RAC 2010 Voordracht: Ziekte van Parkinson. Boerhaave cursus. 21-04-2010 Diagnostische strategieën bij de patiënt met een tremor. Boerhaave cursus. 22-04-2010 Premanifest diagnosis in HD. Leuven 06-05-2010 Boerhaave Cursus Neurologie 18-11-2010 PB Iserief, E de Lange en RAC Roos Biomarkers bij de ziekte van Huntington Boerhaave cursus Neurologie 18-11-2010

Boerhaave Cursus Ziekte van Huntington 19-11-2010 A Tibben RAC Roos Ontwikkelingen in Europa RAC Roos 19-11-2010 Interview Cicero Huntington 2010 maart Interview Lumens 2010 april: Boerhaave Cursus ICH-GCP profess dd 12-01-2010 in Oud Poelgeest

Publicaties 2011

A'Campo LE, Spliethoff-Kamminga NG, Roos RA. An evaluation of the patient education programme for Parkinson's disease in clinical practice. Int J Clin Pract. 2011 Nov;65(11):1173-9.

Aziz NA, van der Burg JM, Roos RA, Maison P, Saleh N, Bachoud-Lévi AC. High insulinlike growth factor I is associated with cognitive decline in Huntington disease. Neurology. 2011 Feb 15;76(7):675-6.

Aziz NA, Pijl H, Frölich M, Roelfsema F, Roos RA. Leptin, adiponectin, and resistin secretion and diurnal rhythmicity are unaltered in Parkinson's disease. Mov Disord. 2011 Mar;26(4):760-1

Aziz NA, Pijl H, Frölich M, Roelfsema F, Roos RA. Diurnal secretion profiles of growth hormone, thyrotropin and prolactin in Parkinson's disease. J Neuroendocrinol. 2011 Jun;23(6):519-24.

Aziz NA, van der Burg JM, Roos RA. High insulinlike growth factor I is associated with cognitive decline in Huntington disease. Neurology. 2011 Feb 15;76(7):675-6; author reply 675-6.

Aziz NA, van Belzen MJ, Coops ID, Belfroid RD, Roos RA. Parent-of-origin differences of mutant HTT CAG repeat instability in Huntington's disease. Eur J Med Genet. 2011 Jul-Aug;54(4):e413-8.

Aziz NA, van Roon-Mom WM, Roos RA. CAG repeat size in the normal HTT allele and age of onset in Huntington's disease. Mov Disord. 2011 Nov;26(13):2450-1.

Aziz NA, Pijl H, Roos RA. Weight loss and exercise in obese older adults. N Engl J Med. 2011 Jun 23;364(25):2467.

Hart E, Middelkoop H, Jurgens CK, Witjes-Ané MN, Roos RA. Seven-year clinical follow-up of premanifest carriers of Huntington's disease. PLoS Curr. 2011 Nov 30;3:RRN1288.

Heemskerk AW, Roos RA. Dysphagia in Huntington's Disease: A Review. Dysphagia. 2011 Mar;26(1):62-6. Epub 2010 Sep 14.

Hubers AA, Reedeker N, Giltay EJ, Roos RA, van Duijn E, van der Mast RC. Suicidality in Huntington's disease. J Affect Disord. 2011 Nov 23. [Epub ahead of print]

Jurgens CK, van der Hiele K, Reijntjes RH, van de Wiel L, Witjes-Ané MN, van der Grond J, Roos RA, Middelkoop HA, van Dijk JG. Basal ganglia volume is strongly related to P3 event-related potential in premanifest Huntington's disease. Eur J Neurol. 2011 Aug;18(8):1105-8

López-Sendón JL, Royuela A, Trigo P, Orth M, Lange H, Reilmann R, Keylock J, Rickards H, Piacentini S, Squitieri F, Landwehrmeyer B, Witjes-Ane MN, Jurgens CK, Roos RA, Abraira V, de Yébenes JG; and the European HD Network. What is the impact of education on Huntington's disease? Mov Disord. 2011 Jul;26(8):1489-95

Ritfeld GJ, Roos RA, Oudega M. Stem cells for central nervous system repair and rehabilitation. PM R. 2011 Jun;3(6 Suppl 1):S117-22. Review.

Saft C, Epplen JT, Wieczorek S, Landwehrmeyer GB, Roos RA, de Yebenes JG, Dose M, Tabrizi SJ, Craufurd D; REGISTRY Investigators of the European Huntington's Disease Network, Arning L. NMDA receptor gene variations as modifiers in Huntington disease: a replication study. PLoS Curr. 2011 Oct 4;3:RRN1247

Scahill RI, Hobbs NZ, Say MJ, Bechtel N, Henley SM, Hyare H, Langbehn DR, Jones R, Leavitt BR, Roos RA, Durr A, Johnson H, Lehéricy S, Craufurd D, Kennard C, Hicks SL, Stout JC, Reilmann R, Tabrizi SJ; the TRACK-HD investigators. Clinical impairment in premanifest and early Huntington's disease is associated with

regionally specific atrophy. Hum Brain Mapp. 2011 Nov 18.

Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC; the TRACK-HD investigators. Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol. 2011;10(1):31-42.

van den Bogaard SJ, Dumas EM, Acharya TP, Johnson H, Langbehn DR, Scahill RI, Tabrizi SJ, van Buchem MA, van der Grond J, Roos RA; TRACK-HD Investigator Group. Early atrophy of pallidum and accumbens nucleus in Huntington's disease. J Neurol. 2011 Mar;258(3):412-20.

van den Bogaard SJ, Dumas EM, Teeuwisse WM, Kan HE, Webb A, Roos RA, van der Grond J. Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington's disease provides in vivo evidence for impaired energy metabolism. J Neurol. 2011 Dec;258(12):2230-9. Epub 2011 May 26.

van den Bogaard SJ, Dumas EM, Ferrarini L, Milles J, van Buchem MA, van der Grond J, Roos RA. Shape analysis of subcortical nuclei in Huntington's disease, global versus local atrophy--results from the TRACK-HD study. J Neurol Sci. 2011 Aug 15;307(1-2):60-8.

van der Burg JM, Winqvist A, Aziz NA, Maat-Schieman ML, Roos RA, Bates GP, Brundin P, Björkqvist M, Wierup N. Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice. Neurobiol Dis. 2011 Oct;44(1):1-8. Epub 2011 May 23.

van Wamelen DJ, Shan L, Aziz NA, Anink JJ, Bao AM, Roos RA, Swaab DF. Functional Increase of Brain Histaminergic Signaling in Huntington's Disease. Brain Pathol. 2011 Jul;21(4):419-27.

Publicaties 2012

A'campo LE, Wekking EM, Spliethoff-Kamminga NG, Stijnen T, Roos RA. Treatment effect modifiers for the patient education programme for Parkinson's disease. Int J Clin Pract. 2012 ;66(1):77-83.

Aziz NA, Roos RA, Gusella JF, Lee JM, Macdonald ME. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology. 2012 Aug 28;79(9):952-3

Booij SJ, Engberts DP, Tibben A, Roos RA. Euthanasia and physician-assisted suicide in Huntington's disease in The Netherlands. Int Psychogeriatr. 2012; 10:1-2. [Epub ahead of print] Booij SJ, Engberts DP, Rödig V, Tibben A, Roos RA.A plea for end-of-life discussions with patients suffering from Huntington's disease: the role of the physician. J Med Ethics. 2012 Dec 22. [Epub ahead of print]

Cong SY, Pepers BA, Zhou TT, Kerkdijk H, Roos RA, van Ommen GJ, Dorsman JC. Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway. Neurobiol Dis. 2012 Jun;46(3):673-81.

Delmaire C, Dumas EM, Sharman MA, van den Bogaard SJ, Valabregue R, Jauffret C, Justo D, Reilmann R, Stout JC, Craufurd D, Tabrizi SJ, Roos RA, Durr A, Lehéricy S. The structural correlates of functional deficits in early huntington's disease. Hum Brain Mapp. 2012 Mar 22. doi: 10.1002/hbm.22055.

Dumas EM, van den Bogaard SJ, Ruber ME, Reilman RR, Stout JC, Craufurd D, Hicks SL, Kennard C, Tabrizi SJ, van Buchem MA, van der Grond J, Roos RA. Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease.. Hum Brain Mapp. 2012 Jan;33(1):203-12

Dumas EM, Versluis MJ, van den Bogaard SJ, van Osch MJ, Hart EP, van Roon-Mom WM, van Buchem MA, Webb AG, van der Grond J, Roos RA. Elevated brain iron is independent from atrophy in Huntington's Disease. Neuroimage. 2012 Jul 2;61(3):558-64

Hart EP, Dumas EM, Reijntjes RH, van der Hiele K, van den Bogaard SJ, Middelkoop HA, Roos RA, van Dijk JG. Deficient sustained attention to response task and P300 characteristics in early Huntington's disease. J Neurol. 2012 Jun;259(6):1191-8

Heemskerk AW, Roos RA. Aspiration pneumonia and death in Huntington's disease. PLoS Curr. 2012 Jan 30;3

Nicola Z Hobbs, PhD; James H Cole, PhD; Ruth E Farmer, MSc; Elin M Rees, MSc; Helen E Crawford; Ian B Malone, PhD; Raymund A C Roos, PhD; Reiner Sprengelmeyer, PhD; Alexandra Durr, PhD; Bernhard Landwehrmeyer, PhD; Rachael I Scahill, PhD; Sarah J Tabrizi, PhD. Evaluation of multi-modal, multi-site

neuroimaging measures in Huntington's Disease: baseline results from the PADDINGTON Study. Neuroimage 2012;

Hubers AA, Reedeker N, Giltay EJ, Roos RA, van Duijn E, van der Mast RC. Suicidality in Huntington's disease. J Affect Disord. 2012 Feb;136(3):550-7. Epub 2011 Nov 25.

Labuschagne I, Jones R, Callaghan J, Whitehead D, Dumas EM, Say MJ, Hart EP, Justo D, Coleman A, Dar Santos RC, Frost C, Craufurd D, Tabrizi SJ, Stout JC; The TRACK-HD Investigators. Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Res. 2012 Oct 7. pii: S0165-1781(12)00519-7.

Macleod R, Tibben A, Frontali M, Evers-Kiebooms G, Jones A, Martinez-Descales A, Roos R; editorial committee working group; ‘Genetic testing Counselling’ of the European Huntington Disease Network. Recommendations for the Predictive Genetic Test in Huntington's Disease. Clin Genet. 2012 May 29

Quarrell OW, Handley O, O'Donovan K, Dumoulin C, Ramos-Arroyo M, Biunno I, Bauer P, Kline M, Landwehrmeyer GB; European Huntington’s Disease Network. Discrepancies in reporting the CAG repeat lengths for Huntington's disease. Eur J Hum Genet. 2012 Jan;20(1):20-6. doi: 10.1038/ejhg.2011.136. Epub 2011 Aug 3.

Reedeker W, van der Mast RC, Giltay EJ, Kooistra TA, Roos RA, Duijn EV. Psychiatric Disorders in Huntington's Disease: A 2-Year Follow-up Study. Psychosomatics. 2012 Mar 27.

Reedeker N, Bouwens JA, Giltay EJ, Le Mair SE, Roos RA, van der Mast RC, van Duijn E. Irritability in Huntington's disease. Psychiatry Res. 2012;200(2-3):813-8.

Ritfeld GJ, Tewarie RN, Vajn K, Rahiem ST, Hurtado A, Wendell DF, Roos RA, Oudega M. Bone marrow stromal cell-mediated tissue sparing enhances functional repair after spinal cord contusion in adult rats. Cell Transplant. 2012 Apr

Stout J, Jones R, Labuschagne I, O'Regan AM, Say MJ, Dumas EM, Queller S, Justo D, Santos RD, Coleman A, Hart EP, Dürr A, Leavitt BR, Roos RA, Langbehn DR, Tabrizi SJ, Frost C. Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. J Neurol Neurosurg Psychiatry. 2012 Jul;83(7):687-94.

Tabrizi SJ, Reilmann R, Roos RA, Durr A, Leavitt B, Owen G, Jones R, Johnson H, Craufurd D, Hicks SL, Kennard C, Landwehrmeyer B, Stout JC, Borowsky B, Scahill RI, Frost C, Langbehn DR; the TRACK-HD investigators. Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data. Lancet Neurol. 2012 Jan;11(1):42-53

van den Bogaard SJ, Dumas EM, Milles J, Reilmann R, Stout JC, Craufurd D, van Buchem MA, van der Grond J, Roos RA. Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease AJNR Am J Neuroradiol. 2012. Epub

van den Bogaard S, Dumas E, van der Grond J, van Buchem M, Roos R. MRI biomarkers in Huntington's disease. Front Biosci (Elite Ed). 2012 Jan 1;4:1910-25. Review.

van Rij MC, de Die-Smulders CE, Bijlsma EK, de Wert GM, Geraedts JP, Roos RA, Tibben A. Evaluation of exclusion prenatal and exclusion preimplantation genetic diagnosis for Huntington's disease in the Netherlands. Clin Genet. 2012 Nov 8. doi: 10.1111/cge.12058. [Epub ahead of print]

van Wamelen DJ, Aziz NA, Anink JJ, Roos RA, Swaab DF. Paraventricular nucleus neuropeptide expression in Huntington's disease patients. Brain Pathol. 2012 Sep;22(5):654-61.

Zielonka D, Marinus J, Roos RA, De Michele G, Di Donato S, Putter H, Marcinkowski J, Squitieri F, Bentivoglio AR, Landwehrmeyer GB. The influence of gender on phenotype and disease progression in patients with Huntington's disease. Parkinsonism Relat Disord. 2012 Oct 25. doi:pii: S1353-8020

Vakpublicaties:

Roos RAC. Ziekte van Huntington. Tijdschrift voor ouderengeneeskunde 2012; 37: 221-224

Algemeen Interview in Neurology News nov 2012 nr6 p9-10

Boek:

RAC Roos. Aandoeningen van het centrale zenuwstelsel. In Algemene ziekteleer voor tandartsen. Red: HS Brand, DE van Diemen, PC Makkes. Bohn Stafleu, van Loghum. Houten 2012. Pp 279-293.

Voordracht:

Introduction to Huntington disease, Prosensa Leiden, 19-01-2012

Juveniele ziekte van Huntington Het Roessing Enschede 2-3-2012

Profilering in de neurologie LUMC. 4-4-2012

Veilig werken? 10-04-2012

Therapy for hyperkinesias Dubrovnik 5-5-2012

Ziekte van Huntington Maastricht MUMC, 21-08-2012

Europese ontwikkeling ziekte van Huntington Boerhaavecursus 16-11-2012

Ziekte van Huntington Verenso Rotterdam 30-11-2012

Behandelaarschap in het LUMC afd hoofdenlunch 6-12-2012

Ziekte van Huntington. Specialisten Ouderen Leiden 11-12-2012

Ziekte van Huntington Overduin 13-12-2012

Behandelaarschap in het LUMC Chefs de (poli)kliniek 18-12-2012

Publicaties 2013

el Barzouhi A, Vleggeert-Lankamp CL, Lycklama à Nijeholt GJ, Van der Kallen BF, van den Hout WB, Jacobs WC, Koes BW, Peul WC; Leiden-The Hague Spine Intervention Prognostic Study Group. Magnetic resonance imaging in follow-up assessment of sciatica. N Engl J Med. 2013 Mar 14;368(11):999-1007.

Booij SJ, Engberts DP, Tibben A, Roos RA. Euthanasia and physician-assisted suicide in Huntington's disease in The Netherlands. Int Psychogeriatr. 2013 Feb;25(2):339-40

Booij SJ, Engberts DP, Rödig V, Tibben A, Roos RA. A plea for end-of-life discussions with patients suffering from Huntington's disease: the role of the physician. J Med Ethics. 2013 Oct;39(10):621-4. doi

Borowsky B, Warner J, Leavitt BR, Tabrizi SJ, Roos RA, Durr A, Becker C, Sampaio C, Tobin AJ, Schulman H. 8OHdG is not a biomarker for Huntington disease state or progression. Neurology. 2013; 80: 1934-1941.

Chel VG, Ooms ME, van der Bent J, Veldkamp F, Roos RA, Achterberg WP, Lips P. High prevalence of vitamin D deficiency and insufficiency in patients with manifest Huntington disease: An explorative study. Dermatoendocrinol. 2013 Jun 1;5(3):348-51.

Helen E. Crawforda, Nicola Z. Hobbsa, Ruth Keoghb, Douglas R. Langbehnc, Chris Frostb, Hans Johnsond, Bernhard Landwehrmeyere, Ralf Reilmannf , David Craufurdg, Julie C. Stouth, Alexandra Durri, Blair R.

Leavittj, Raymund A.C. Roosk, Sarah J. Tabrizia and Rachael I. Scahilla, the TRACK-HD Investigators.

Corpus Callosal Atrophy in Premanifest and Early Huntington’s Disease. Journal of Huntington’s Disease 2 (2013) 517–526. Delmaire C, Dumas EM, Sharman MA, van den Bogaard SJ, Valabregue R, Jauffret C, Justo D, Reilmann R, Stout JC, Craufurd D, Tabrizi SJ, Roos RA, Durr A, Lehéricy S. The structural correlates of functional deficits in early huntington's disease. Hum Brain Mapp. 2013 Sep;34(9):2141-53

Doan NT, van den Bogaard SJ, Dumas EM, Webb AG, van Buchem MA, Roos RA, van der Grond J, Reiber JH, Milles J. Texture analysis of ultrahigh field T2 *-weighted MR images of the brain: Application to Huntington's disease. J Magn Reson Imaging. 2013 May 30

Dumas EM, van den Bogaard SJ, Middelkoop HA, Roos RA. A review of cognition in Huntington's disease . Front Biosci (Schol Ed). 2013 Jan 1;5:1-18.

Dumas EM, van den Bogaard SJ, Hart EP, Soeter RP, van Buchem MA, van der Grond J, Rombouts SA, Roos RA; TRACK-HD investigator group.Reduced functional brain connectivity prior to and after disease onset in Huntington's disease. Neuroimage (Amst). 2013 Mar 14;2:377-84. doi: 10.1016/j.nicl.2013.03.001. Hart EP, Marinus J, Burgunder JM, Bentivoglio AR, Craufurd D, Reilmann R, Saft C, Roos RA; the REGISTRY Investigators of the European Huntington's Disease Network. Better global and cognitive functioning in choreatic versus hypokinetic-rigid Huntington's disease. Mov Disord. 2013 Mar 14. doi: 10.1002/mds.25422. [Epub ahead of print]

Hart EP, Dumas EM, van Zwet EW, van der Hiele K, Jurgens CK, Middelkoop HA, van Dijk JG, Roos RA. Longitudinal pilot-study of Sustained attention to response task and P300 in manifest and pre-manifest Huntington's disease. J Neuropsychol. 2013 Oct 24

HORIZON Investigators of the Huntington Study Group and European Huntington's Disease Network* A Randomized, Double-blind, Placebo-Controlled Study of Latrepirdine in Patients With Mild to Moderate Huntington Disease JAMA Neurol. 2013;70(1):25-33. doi:10.1001/2013.jamaneurol.382.

Hubers AA, van Duijn E, Roos RA, Craufurd D, Rickards H, Bernhard Landwehrmeyer G, van der Mast RC, Giltay EJ; The REGISTRY investigators of the European Huntington's Disease Network. Suicidal ideation in a European Huntington's disease population. J Affect Disord. 2013 Oct;151(1):248

MacLeod R, Tibben A, Frontali M, Evers-Kiebooms G, Jones A, Martinez-Descales A, Roos RA; Editorial Committee and Working Group ‘Genetic Testing Counselling’ of the European Huntington Disease Network. Recommendations for the predictive genetic test in Huntington's disease. Clin Genet. 2013;83:221-31.

Metzger S, Walter C, Riess O, Roos RA, Nielsen JE, Craufurd D; REGISTRY Investigators of the European Huntington’s Disease Network, Nguyen HP. The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients. PLoS One. 2013 Jul 22;8(7):

Müller HP, Grön G, Sprengelmeyer R, Kassubek J, Ludolph AC, Hobbs N, Cole J, Roos RA, Duerr A, Tabrizi SJ, Landwehrmeyer GB, Süssmuth SD.Evaluating multicenter DTI data in Huntington's disease on site specific effects: An ex post facto approach. Neuroimage (Amst). 2013 Jan 3;2:161-7. doi: 10.1016/j.nicl.2012.12.005.

Quinn L, Khalil H, Dawes H, Fritz NE, Kegelmeyer D, Kloos AD, Gillard JW, Busse M; Outcome Measures Subgroup of the European Huntington's Disease Network. Reliability and minimal detectable change of physical performance measures in individuals with pre-manifest and manifest Huntington disease. Phys Ther. 2013 Jul;93(7):942-56. doi: 10.2522/ptj.20130032. Epub 2013 Mar 21.

Roos RA. Genetic diagnosis of hyperkinetic movement disorders. Expert Opin Med Diagn. 2012 Sep;6(5):439-47. doi: 10.1517/17530059.2012.704017. Epub 2012 Jul 13.

Roos RAC, Engberts DP, Tamsma J. Regievoerend arts biedt houvast. Medisch Contact 2013; 68: 151-=1513

Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc Natl Acad Sci U S A. 2013 Jan 22.

Tabrizi SJ, Scahill RI, Owen G, Durr A, Leavitt BR, Roos RA, Borowsky B, Landwehrmeyer B, Frost C, Johnson H, Craufurd D, Reilmann R, Stout JC, Langbehn DR; the TRACK-HD Investigators.Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol. 2013; 12: 637-649

van den Bogaard SJ, Dumas EM, Hart EP, Milles J, Reilmann R, Stout JC, Craufurd D, Gibbard CR, Tabrizi SJ, van Buchem MA, van der Grond J, Roos RA. Magnetization transfer imaging in premanifest and manifest huntington disease: a 2-year follow-up. AJNR Am J Neuroradiol. 2013 Feb;34(2):317-22.

van den Bogaard SJ, Dumas EM, Roos RA. The Role of Iron Imaging in Huntington's Disease. Int Rev Neurobiol. 2013;110:241-50. doi: 10.1016/B978-0-12-410502-7.00011-9.

van den Bogaard SJ, Kruit MC, Dumas EM, Roos RA. Eye-of-the-tiger-sign in a 48year healthy adult. J Neurol Sci. 2013 Oct 9.

van Duijn E, Reedeker N, Giltay EJ, Eindhoven D, Roos RA, van der Mast RC. Course of Irritability, Depression and Apathy in Huntington's Disease in Relation to Motor Symptoms during a Two-Year Follow-Up Period. Neurodegener Dis. 2013 Aug 16.

van Rij MC, de Koning Gans PA, van Belzen MJ, Roos RA, Geraedts JP, Rademaeker MD, Bijlsma EK, de Die-Smulders CE. The uptake and outcome of prenatal and preimplantation genetic diagnosis for Huntington's disease in the Netherlands (1998-2008). Clin Genet. 2013 Jan 25

van Rij M, de Die-Smulders C, Bijlsma E, de Wert G, Geraedts J, Roos R, Tibben A. Evaluation of exclusion prenatal and exclusion preimplantation genetic diagnosis for Huntington's disease in the Netherlands. Clin Genet. 2013 Feb;83(2):118-124. doi: 10.1111/cge.12058. Epub 2012 Dec 14.

van Rij MC, de Koning Gans PA, Aalfs CM, Elting M, Ippel PF, Maat-Kievit JA, Vermeer S, Verschuuren-Bemelmans CC, van Belzen MJ, Belfroid RD, Losekoot M, Geraedts JP, Roos RA, Tibben A, de Die-Smulders CE, Bijlsma EK. Prenatal testing for Huntington's disease in The Netherlands from 1998 to 2008. Clin Genet. 2013 Jan 25

Sprengelmeyer R, Orth M, Müller HP, Wolf RC, Grön G, Depping MS, Kassubek J, Justo D, Rees EM, Haider S, Cole JH, Hobbs NZ, Roos RA, Dürr A, Tabrizi SJ, Süssmuth SD, Landwehrmeyer GB. The neuroanatomy of subthreshold depressive symptoms in Huntington's disease: a combined diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) study. Psychol Med. 2013 Oct 7:1-12. van Wamelen DJ, Aziz NA, Anink JJ, van Steenhoven R, Angeloni D, Fraschini F, Jockers R, Roos RA, Swaab DF. Suprachiasmatic Nucleus Neuropeptide Expression in Patients with Huntington's Disease. Sleep. 2013;36:117-25.

van Wamelen DJ, Ahmad Aziz N, Anink JJ, Roos RA, Swaab DF. Neuropeptide alterations in the infundibular nucleus of Huntington's disease patients. J Neuroendocrinol. 2013; 25:198-205.

Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; REGISTRY investigators of the European Huntington’s Disease Network. β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease. J Huntingtons Dis. 2013 Mar 27;2(1):107-124.

Youssov K, Dolbeau G, Maison P, Boissé MF, de Langavant LC, Roos RA, Bachoud-Lévi AC. The unified huntington's disease rating scale for advanced patients: Validation and follow-up study. Mov Disord. 2013; 201;28(12):1717-23 and 2013 Dec;28(14):1995-2001

van Wamelen DJ, Aziz NA, Zhao J, Balesar R, Unmehopa U, Roos RA, Swaab DF. Decreased hypothalamic prohormone convertase expression in huntington disease patients. J Neuropathol Exp Neurol. 2013 Dec;72(12):1126-34.

Zielonka D, Marinus J, Roos RA, De Michele G, Di Donato S, Putter H, Marcinkowski J, Squitieri F, Bentivoglio AR, Landwehrmeyer GB. The influence of gender on phenotype and disease progression in patients with Huntington's disease. Parkinsonism Relat Disord. 2013 Feb;19(2):192-7

Boekhoofdstuk

Van den Bogaard SJA, Dumas EM, Roos RAC. The Role of Iron Imaging in Huntington’s Disease. In International review of neurobiology vol 110; Metal Related Neurodegenerative Disease. Ed Kailash.P Bhatia and SA Schneider.pp 241-251.

Voordracht

RAC Roos Masterclass Huntington Disease In Topics in de ouderengeneeskunde en ouderenzorg 2013, 6 maart Maastricht, uitnodiging

RAC Roos Leuven Universiteit. Uitnodiging W VandenBerghen

Publicaties 2014

Booij SJ, Tibben A, Engberts DP, Roos RA. Wishes for the end of life in Huntington's Disease - the perspective of European physicians. J Huntingtons Dis. 2014;3(3):229-32.

Booij SJ, Tibben A, Engberts DP, Marinus J, Roos RA. Thinking about the end of life: a common issue for patients with Huntington's disease. J Neurol. 2014 Nov; 261(11):2184-91

Bouwens JA, Hubers AA, van Duijn E, Cobbaert CM, Roos RA, van der Mast RC, Giltay EJ. Acute-phase proteins in relation to neuropsychiatric symptoms and use of psychotropic medication in Huntington׳s disease. Eur Neuropsychopharmacol. 2014 Aug;24(8):1248-56. doi: 10.1016/j.euroneuro.2014.05.004. Epub 2014 May 20.

Chel VG, Ooms ME, van der Bent J, Veldkamp F, Roos RA, Achterberg WP, Lips P. High prevalence of vitamin D deficiency and insufficiency in patients with manifest Huntington disease: An explorative study.Dermatoendocrinol. 2013 Jun 1;5(3):348-51.

Craufurd D, MacLeod R, Frontali M, Quarrell O, Bijlsma EK, Davis M, Hjermind LE, Lahiri N, Mandich P, Martinez A, Tibben A, Roos RA; on behalf of the Working Group on Genetic Counselling and Testing of the European Huntington's Disease Network (EHDN). Diagnostic genetic testing for Huntington's disease. Pract Neurol. 2014 Aug 28. pii: practneurol-2013-000790. doi: 10.1136/practneurol-2013-000790.

Doan NT, van den Bogaard SJ, Dumas EM, Webb AG, van Buchem MA, Roos RA, van der Grond J, Reiber JH, Milles J. Texture analysis of ultrahigh field T2*-weighted MR images of the brain: application to Huntington's disease. J Magn Reson Imaging. 2014 Mar;39(3):633-40. doi: 10.1002/jmri.24199. Epub 2013 May 30.

Herben-Dekker M, van Oostrom JC, Roos RA, Jurgens CK, Witjes-Ané MN, Kremer HP, Leenders KL, Spikman JM. Striatal metabolism and psychomotor speed as predictors of motor onset in Huntington's disease. J Neurol. 2014 Jul;261(7):1387-97 Hart EP, Dumas EM, Schoonderbeek A, Wolthuis SC, van Zwet EW, Roos RA. Motor dysfunction influence on executive functioning in manifest and premanifest Huntington's disease. Mov Disord. 2014;29(3):320-6 Heemskerk AW, Verbist BM, Marinus J, Heijnen B, Sjögren EV, Roos RA. The Huntington's disease dysphagia scale. Mov Disord. 2014;29(10):1312-6

el Barzouhi A, Vleggeert-Lankamp CL, van der Kallen BF, Lycklama à Nijeholt GJ, van den Hout WB, Koes BW, Peul WC; Leiden–The Hague Spine Intervention Prognostic Study Group. Back pain's association with vertebral end-plate signal changes in sciatica. Spine J. 2014 Feb 1;14(2):225-33

el Barzouhi A, Vleggeert-Lankamp CL, Lycklama à Nijeholt GJ, Van der Kallen BF, van den Hout WB, Koes BW, Peul WC; Leiden–The Hague Spine Intervention Prognostic Study Group. Influence of low back pain and prognostic value of MRI in sciatica patients in relation to back pain. PLoS One. 2014 Mar 17;9(3):e90800

Jankovic J, Roos RA. Chorea associated with Huntington's disease: To treat or not to treat? Mov Disord. 2014; 29: 1414-1418

Jones R, Stout JC, Labuschagne I, Say M, Justo D, Coleman A, Dumas EM, Hart E, Owen G, Durr A,Leavitt BR, Roos R, O'Regan A, Langbehn D, Tabrizi SJ, Frost C. The Potential of Composite Cognitive Scores for Tracking Progression in Huntington's Disease. J Huntingtons Dis. 2014 Jan 1;3(2):197-207. Kostro D, Abdulkadir A, Durr A, Roos RAC, Leavitt BR., Johnson H, Cash D, Tabrizi S J, Scahill R I, Ronneberger O, Kloeppel S. Correction of inter-scanner and within-subject variance in structural MRI based automated diagnosing. NeuroImage 2014; 98: 405-415.

Hans-Peter Müller, Jan Kassubek, Georg Grön, Reiner Sprengelmeyer, Albert C Ludolph, Stefan Klöppel, Nicola Z Hobbs, Raymund AC Roos, Alexandra Duerr, Sarah J Tabrizi, Michael Orth, Sigurd D Süssmuth, G Bernhard Landwehrmeyer.Impact of the control for corrupted diffusion tensor imaging data in comparisons at the group level: an application in Huntington disease. BioMedical Engineering Biomed Eng 2014 Sep 1;13:128

Ritfeld GJ, Rauck BM, Novosat TL, Park D, Patel P, Roos RA, Wang Y, Oudega M. The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair. Biomaterials. 2014 Feb;35(6):1924-31 Sprengelmeyer R, Orth M, Müller HP, Wolf RC, Grön G, Depping MS, Kassubek J, Justo D, Rees EM, Haider S, Cole JH, Hobbs NZ, Roos RA, Dürr A, Tabrizi SJ, Süssmuth SD, Landwehrmeyer GB. The neuroanatomy of subthreshold depressive symptoms in Huntington's disease: a combined diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) study. Psychol Med. 2014 Jul;44(9):1867-78. doi: 10.1017/S003329171300247X. Epub 2013 Oct 7 van den Bogaard SJA, Dumas EM, Webb AG, van Buchem MA., Roos RAC, van der Grond J, Reiber JHC, Milles J (2014): Texture analysis of ultrahigh field T-2*-weighted MR images of the brain: Application to Huntington's disease. Journal of magnetic resonance imaging 2014; 39 (3),:. 633-640. van den Bogaard SJ, Kruit MC, Dumas EM, Roos RA. Eye-of-the-tiger-sign in a 48year healthy adult. J Neurol Sci. 2014 Jan 15;336(1-2):254-6.

van Duijn E, Reedeker N, Giltay EJ, Eindhoven D, Roos RA, van der Mast RC. Course of irritability, depression and apathy in Huntington's disease in relation to motor symptoms during a two-year follow-up period. Neurodegener Dis. 2014;13(1):9-16.

van Rij MC, de Koning Gans PA, van Belzen MJ, Roos RA, Geraedts JP, De Rademaeker M, Bijlsma EK, de Die-Smulders CE. The uptake and outcome of prenatal and pre-implantation genetic diagnosis for Huntington's disease in the Netherlands (1998-2008). Clin Genet. 2014 Jan;85(1):87-95. doi: 10.1111/cge.12089. Epub 2013 Mar 21.

van Rij MC, de Koning Gans PA, Aalfs CM, Elting M, Ippel PF, Maat-Kievit JA, Vermeer S, Verschuuren-Bemelmans CC, van Belzen MJ, Belfroid RD, Losekoot M, Geraedts JP, Roos RA, Tibben A, de Die-Smulders CE, Bijlsma EK. Prenatal testing for Huntington's disease in the Netherlands from 1998 to 2008. Clin Genet. 2014 Jan;85(1):78-86. doi: 10.1111/cge.12090. Epub 2013 Mar 27. van Wamelen DJ, Ahmad Aziz N, Roos RA, Swaab DF. Hypothalamic alterations in Huntington's disease

patients: comparison with genetic rodent models. J Neuroendocrinol. 2014 ;26(11):761-75

Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; the REGISTRY investigators of the European Huntington's Disease Network. Copy number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease. Hum Mol Genet. 2014 15;23(12):3129-37 Publications 2015

Aziz NA, Onkenhout W, Kerstens HJ, Roos RA. Cystathionine Levels in Patients With Huntington Disease.

PLoS Curr. 2015 Sep 16;7.

Bouwens JA, van Duijn E, van der Mast RC, Roos RA, Giltay EJ. Irritability in a Prospective Cohort of Huntington's Disease Mutation Carriers. J Neuropsychiatry Clin Neurosci. 2015 Summer;27(3):206-12.

Burg van der JM, Pijl H, Campman YJ, Roos RA, Aziz NA. Does midlife obesity really lower dementia risk?

Lancet Diabetes Endocrinol. 2015 Jul;3(7

Callaghan J, Stopford C, Arran N, Boisse MF, Coleman A, Santos RD, Dumas EM, Hart EP, Justo D, Owen G, Read J, Say MJ, Durr A, Leavitt BR, Roos RA, Tabrizi SJ, Bachoud-Levi AC, Bourdet C, van Duijn E, Craufurd D. Reliability and Factor Structure of the Short Problem Behaviors Assessment for Huntington's Disease (PBA-s) in the TRACK-HD and REGISTRY studies. J Neuropsychiatry Clin Neurosci. 2015 Winter;27(1):59-64.

Craufurd D, MacLeod R, Frontali M, Quarrell O, Bijlsma EK, Davis M, Hjermind LE, Lahiri N, Mandich P,

Martinez A, Tibben A, Roos RA; Working Group on Genetic Counselling and Testing of the European

Huntington's Disease Network (EHDN). Diagnostic genetic testing for Huntington's disease. Pract Neurol. 2015

Feb;15(1):80-4. doi:

Evers MM, Schut MH, Pepers BA, Atalar M, van Belzen MJ, Faull RL, Roos RA, van Roon-Mom WM. Making (anti-) sense out of huntingtin levels in Huntington disease. Mol Neurodegener. 2015 Apr 28;10:21. Gregory S, Scahill RI, Seunarine KK, Stopford C, Zhang H, Zhang J, Orth M, Durr A, Roos RA, Langbehn DR, Long JD, Johnson H, Rees G, Tabrizi SJ, Craufurd D. Neuropsychiatry and White Matter Microstructure in Huntington's Disease.J Huntingtons Dis. 2015 Sep 29;4(3):239-49. doi: 10.3233/JHD-150160.

Hobbs NZ, Farmer RE, Rees EM, Cole JH, Haider S, Malone IB, Sprengelmeyer R, Johnson H, Mueller HP, Sussmuth SD, Roos RA, Durr A, Frost C, Scahill RI, Landwehrmeyer B, Tabrizi SJ. Short-interval observational data to inform clinical trial design in Huntington's disease. J Neurol Neurosurg Psychiatry. 2015 86: 1291-1298; Feb 10. pii: jnnp-2014-309768. doi: 10.1136/jnnp-2014-309768. [Epub ahead of print]

Hubers AA, van der Mast RC, Pereira AM, Roos RA, Veen LJ, Cobbaert CM, van Duijn E, Giltay EJ. Hypothalamic-pituitary-adrenal axis functioning in Huntington's disease and its association with depressive symptoms and suicidality. J Neuroendocrinol. 2015 Mar;27(3):234-44 Johnson EB, Rees EM, Labuschagne I, Durr A, Leavitt BR, Roos RA, Reilmann R, Johnson H, Hobbs NZ, Langbehn DR, Stout JC, Tabrizi SJ, Scahill RI; TRACK-HD investigators. The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease. Neuropsychologia. 2015 Dec;79(Pt A):138-46. doi: 10.1016/j.neuropsychologia.2015.10.033. Epub 2015 Oct 28. Klöppel S, Gregory S, Scheller E, Minkova L, Razi A, Durr A, Roos RA, Leavitt BR, Papoutsi M, Landwehrmeyer GB, Reilmann R, Borowsky B, Johnson H, Mills JA, Owen G, Stout J, Scahill RI, Long JD, Rees G, Tabrizi SJ; Track-On investigators. Compensation in Preclinical Huntington's Disease: Evidence From

the Track-On HD Study. EBioMedicine. 2015 Aug 4;2(10):1420-9. doi: 10.1016/j.ebiom.2015.08.002. eCollection 2015 Oct

Mastrokolias A, Ariyurek Y, Goeman JJ, van Duijn E, Roos RA, van der Mast RC, van Ommen GB, den

Dunnen JT, 't Hoen PA, van Roon-Mom WM. Huntington's disease biomarker progression profile identified by

transcriptome sequencing in peripheral blood. Eur J Hum Genet. 2015 Oct;23(10):1349-56. doi:

10.1038/ejhg.2014.281. Epub 2015 Jan 28. McColgan P, Seunarine KK, Razi A, Cole JH, Gregory S, Durr A, Roos RA, Stout JC, Landwehrmeyer B, Scahill RI, Clark CA, Rees G, Tabrizi SJ; Track-HD Investigators. Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease. Brain. 2015 Nov;138(Pt 11):3327-44. doi: 10.1093/brain/awv259. Epub 2015 Sep

Minkova L, Eickhoff SB, Abdulkadir A, Kaller CP, Peter J, Scheller E, Lahr J, Roos RA, Durr A, Leavitt BR,

Tabrizi SJ, Klöppel S; TRACK-HD Investigators. Large-scale brain network abnormalities in Huntington's

disease revealed by structural covariance. Hum Brain Mapp. 2015 Oct 10. doi: 10.1002/hbm.23014. [Epub

ahead of print]

Minkova L, Scheller E, Peter J, Abdulkadir A, Kaller CP, Roos RA, Durr A, Leavitt BR, Tabrizi SJ, Klöppel S;

TrackOn-HD Investigators. Detection of Motor Changes in Huntington's Disease Using Dynamic Causal

Modeling. Front Hum Neurosci. 2015 Nov 25;9:634. doi: 10.3389/fnhum.2015.00634. eCollection 2015.

Odish OF, van den Berg-Huysmans AA, van den Bogaard SJ, Dumas EM, Hart EP, Rombouts SA, van der Grond J, Roos RA; on behalf of the TRACK-HD Investigator Group. Longitudinal resting state fMRI analysis in healthy controls and premanifest Huntington's disease gene carriers: A three-year follow-up study. Hum Brain Mapp. 2015; 36: 110-119 (2014 Aug19. doi: 10.1002/hbm.22616 Odish OF, Leemans A, Reijntjes RH, van den Bogaard SJ, Dumas EM, Wolterbeek R, Tax CM, Kuijf HJ, Vincken KL, van der Grond J, Roos RA. Microstructural brain abnormalities in Huntington's disease: A two-year follow-up.. Hum Brain Mapp. 2015 Jun;36(6):2061-74.

Odish OF, Caeyenberghs K, Hosseini H, van den Bogaard SJ, Roos RA, Leemans A. Dynamics of the connectome in Huntington's disease: A longitudinal diffusion MRI study. Neuroimage Clin. 2015 Jul 31;9:32-43

Oosterloo M, Van Belzen MJ, Bijlsma EK, Roos RA.Is There Convincing Evidence that Intermediate Repeats in the HTT Gene Cause Huntington's Disease? J Huntingtons Dis. 2015 Jul 1;4(2):141-8. doi: 10.3233/JHD-140120.

Ritfeld GJ, Patel A, Chou A, Novosat TL, Castillo DG, Roos RA, Oudega M. The role of brain-derived neurotrophic factor in bone marrow stromal cell-mediated spinal cord repair. Cell Transplant. 2015;24(11):2209-20. doi

Gregory S, Scahill RI, Seunarine KK, Stopford C, Zhang H, Zhang J, Orth M, Durr A, Roos RA, Langbehn DR,

Long JD, Johnson H, Rees G, Tabrizi SJ, Craufurd D. Neuropsychiatry and White Matter Microstructure in Huntington's Disease.

J Huntingtons Dis. 2015 Sep 23

Valcárcel-Ocete L, Alkorta-Aranburu G, Iriondo M, Fullaondo A, García-Barcina M, Fernández-García JM,

Lezcano-García E, Losada-Domingo JM, Ruiz-Ojeda J, Álvarez de Arcaya A, Pérez-Ramos JM, Roos RA,

Nielsen JE, Saft C; REGISTRY investigators of the European Huntington's Disease Network, Zubiaga AM,

Aguirre A. Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential

Modifier Gene. PLoS One. 2015 Jul 6;10(7)

van der Burg JM, Pijl H, Campman YJ, Roos RA, Aziz NA. Does midlife obesity really lower dementia risk? Lancet Diabetes Endocrinol. 2015 Jul;3(7):499-500. van Wamelen DJ, Roos RA, Aziz NA. Therapeutic strategies for circadian rhythm and sleep disturbances in Huntington disease. Neurodegener Dis Manag. 2015 Dec;5(6):549-59. doi: 10.2217/nmt.15.45. Epub 2015 Dec 1 Presentattions: Roos RAC Waarom een Netwerk? Huntington Netwerk Nederland, Amsterdam 5-2-2015 26 maart verhaal Maastricht State of the art in HD (uitnodiging) 17 april verhaal Weert Juveniele Huntington (uitnodiging) 16 okt Huntington disease cure and a better care Publications 2016 Baake V, Hart EP, Bos R, Roos RA. Participants at the Leiden Site of the REGISTRY Study: A Demographic Approach. J Huntingtons Dis. 2016 Mar 15. [Epub ahead of print] Frank MJ, thomas_wiecki, chrystalina.antoniades, alexstevenson, chris.kennard, beth.borowsky, g.owen, bleavitt, r.a.c.roos, alexandra.durr, s.tabrizi A computational cognitive biomarker for early-stage Huntington’s disease Plos Keogh R, Frost C, Owen G, Daniel RM, Langbehn DR, Leavitt B, Durr A, Roos RA, Landwehrmeyer GB, Reilmann R, Borowsky B, Stout J, Craufurd D, Tabrizi SJ. Medication Use in Early-HD Participants in Track-HD: an Investigation of its Effects on Clinical Performance. PLoS Curr. 2016 Jan 11; Presentations 2016 Archipel in Eindhoven algemene aspecten van de ziekte van Huntington 14 jan 2016-01-15 26 mei: Werken met een beroerte 15 september Recent developments in treating HD Participation promotions University Leiden (PhD thesis) (Numbered italics are own PhD students) 1990 Roos RAC Co-promotor J Haan, Hereditary cerebral hemorrhage with amyloidosis Dutch type. 11-10-1990. 1991 Roos RAC. Oppositie Proefschrift E Goudsmit. Neural activation during aging and in Alzheimer's disease. Universiteit van Amsterdam. Uitnodiging, locaal, 16-02-1991. 1992 Roos RAC. Co-promotor HPH Kremer, The lateral tuberal nucleus in Huntington's disease, Parkinson's disease and Alzheimer's disease. 24-09-1992. Roos RAC. Co-promotor JG van Dijk, Autonomic nervous system disturbance in neurodegenerative disorders. 02-12-1992. Roos RAC. Lid Promotie commissie MI Skraastad, Genetic mapping and predictive DNA diagnosis of Huntington disease 22-10-1992. Roos RAC. Lid Oppositie commissie J Lyklema a Nyeholt, 09-12-1992.

1993 Roos RAC. Lid Promotiecommissie C Storimans. 24-02-1993. Roos RAC. Lid Oppositie commissie A Tibben Rotterdam 30-03-1993 Roos RAC. Co-promotor JJ van Hilten 24-06-1993. Roos RAC. Lid promotiecommissie FW Vreeling Maastricht 07-10-1993. 1994 01 Roos RAC. Promotor BR Bloem 22-11-1994. Roos RAC. Lid promotiecommissie CEH Hoffmann 28-04-1994. Roos RAC. Lid oppositiecommissie RQ Hintzen, Amsterdam, VU 29-04-1994. Roos RAC. Lid promotiecommissie, Maastricht ENH Jansen 2-6-1994. Roos RAC. Lid promotiecommissie HAM Middelkoop, 7-6-1994. Roos RAC. Lid promotiecommissie Amsterdam VU RJ Vermeulen 15-06-1994. Roos RAC. Lid promotieommissie MJ de Vries. 06-10-94 Roos RAC. Lid promotiecommissie JG van der Hoeven. 08-11-94 1995 02 Roos RAC. Promotor WAJ Hoefnagels 10-10-1995 Roos RAC. Lid promotiecommissie N Rots. 08-06-1995 1996 03 Roos RAC. Promotor T van Laar 17-01-1996. 04 Roos RAC. Promotor H Visser 09-05-1996. Roos RAC. Lid oppositiecommissie A Kneusting Neven. 20-02-1996. Roos RAC. Lid promotiecommissie M Reinders, Nijmegen. 19-03-1996 Roos RAC. Lid promotiecommissie AAM Berkhout. 08-05-1996. Roos RAC. Lid oppositiecommissie I Dawson. 30-05-1996 Roos RAC. Lid oppositiecommissie M Zijlmans. Nijmegen 27-06-1996 Roos RAC. Lid promotiecommissie OC Meijer Leiden 28-11-1996 Roos RAC. Lid promotiecommissie J van Deutekom. Leiden 28-11-1996 1997 05 Bruyn GW en Roos RAC. Promotor C Zwetsloot 15-01-1997 06 Roos RAC.Pomotor MLC Maat-Schieman 05-02-1997 07 Roos RAC en G Padberg. Promotor M de Koning-Tijssen 23-04-1997 08 Roos RAC. Promotor W van de Kamp 04-06-1997 09 Frants RR en Roos RAC. Promotor R Ophoff 22-10-1997 10 Roos RAC. Promotor M Bornebroek 29-10-1997 Roos RAC. Lid Promotiecommissie. E Lakke 05-1997 Roos RAC. Lid Promotiecommissie. Rotterdam, M de Rijk 10-09-1997 Roos RAC. Lid promotiecommissie. Rotterdam, Dudok-de Wit 08-10-97 Roos RAC. Lid promotiecommissie. Groningen. 15-10-1997 1998 11 Roos RAC en RR Frants. Promotor G Terwindt 15-12-1998 Roos RAC Lid promotiecommissie Utrecht, R van Harten 06-02-1998 Roos RAC Lid promotie commissie R van de Geest, Leiden 25-03-1998 Roos RAC Lid promotiecommissie K van Rijn, Leiden, 03-06-1998 Roos RAC Lid promotiecommissie Rotterdam, M Stevens 24-06-1998 1999 12 Roos RAC en Rosendaal F. Promotor Siesling 30-06-1999 13 Roos RAC. Promotor LAEM Laan 06-10-1999 14 Roos RAC en HAC Kamphuisen. Promotor GJ Lammers 20-10-1999 15 Roos RAC en A Tibben. Promotor G de Boo 10-11-1999 Roos RAC. Lid oppositiecommissie MB Hesselink 10-06-1999 Roos RAC. Lid promotiecommissie Schaafsma 22-06-1999 2000 16 Roos RAC. Promotor K Roon. 24-05-2000 Roos RAC. Lid Promotiecommissie J Gussekloo 13-01-2000 Roos RAC. Lid promotiecommissie J Rood 5-12-2000 Roos RAC. Lid oppositiecommissie. B Harhangi 12-04-1999 Rotterdam Roos RAC. Lid promotiecommissie. D Cath 24-05-2000 2001 17 Roos RAC. Promotor. WJ van de Beek. 07-11-2001 18 Roos RAC en MH Breuning. Promotor. A Maat-Kievit. 31-10-2001

Roos RAC. Lid promotiecommissie J Grootendorst. 13-01-2001 Roos RAC. Lid promotiecommissie. M Kuiper 21-03-2001 Amsterdam VU Roos RAC. Lid promotiecommissie J van Dorpe. 10-05-2001 KULeuven 2002 19 Porsius AJ, Roos RAC en de Boer A. Promotor. DAMC vd Vijver 30-01-2002 Utrecht 20 Roos RAC.Promotor. L Verhagen Metman. 21-02-2002 21 Leufkens E en Roos RAC. Promotor. I Schillevoort28-02-2002 Utrecht 22 Roos RAC. PromotorR Natte20-03-2002 23 Roos RAC en GMJ van Kempen. Promotor D Helder11-04-2002 24 Roos RAC JJP en JG van Dijk. Promotor JPP van Vugt 26-11-2002 Roos RAC. Lid Promotiecommissie Y Kamsma. 13-02-2002 Groningen Roos RAC. Lid promotiecommissie DP Shackleton. 24-04-2002 Roos RAC lid promotiecommissie. Van Exel 2003 25 Roos RAC. Promotor H Marinus, 11-06-2003 26 Roos RAC, Frants R, Brouwer OF Promotor P Tiijnk-Callenbach 08-10-2003 27 Roos RAC en GJB van Ommen. Promotor MN Witjes Ane Cognition in Huntington's disease : the influence of motor behaviour and time 30-10-2003 Roos RAC oppositiecommissie P Mouveroux, 06-02-2003 Roos RAC Referent CAJ Holtzer 19-03-2003 Roos RAC promotiecommissie S Overeem 28-05-2003 Roos RAC promotiecommissie M van Dijk 02-10-2003 Roos RAC lid promotiecommissie C Tissingh VU MC Amsterdam 31-10-2003 Roos RAC Lid promotiecommissie S Lesnik-Oberstein 17-12-2003 2004 28 Roos RAC. Promotor N Spliethoff-Kamminga 22-04-2004 Roos RAC. Promotiecommissie WM van der Flier. 24-03-2004 Roos RAC. Oppositiecommissie. JA van Vliet. 05-11-2004 Roos RAC. Oppositiecommissie E Kors. 07-12-2004 2005 29 Tibben A, Roos RAC Promotor R Timman Huntington's disease: psychological aspects of predictive testing 06-04-2005 30 Roos RAC Promotor H Visser 16-11-2005 31 Roos RAC Promotor JI Hoff 30-11- 2005 Roos RAC Promotiecommissie A Poortman Groningen 2-11-2005 Roos RAC Promotiecommissie Vis Nijmegen 2-11-2005 Roos RAC Oppositiecommissie Pwirtz 7-11-2005 Roos RAC promotiecommissie A Campi 17-11-2005 2006 32 Van Ommen Roos RAC promotor SY Cong 05-2006 33 Van Heuven V, Roos RAC, Liang Ji Experiments on the modular nature of words and sentence phonology in Chinese Broca’s patients. 10-05-2006 Roos RAC Oppositiecommisssie SCA Stevens 31-05-2006 2008 Roos RAC oppositiecommissie N Wiendels, 20-02-2008 Roos RAC oppositiecommissie H Mey Roos RAC oppositiecommissie G Schoonman 11-09-2008 Roos RAC oppositiecommissie R Thys 24-09-2008 2009 34 Middelkoop HAM, Roos RAC promotor Bemelmans 02-04-2009 Roos RAC. Promotiecommissie D Verbaan 11-03-2009 2010 35 Roos RAC: F Zitman 19-01-2010 36 Van de Mast RC, Roos RAC, F Zitman: E van Duijn Psychopathology in Huntington’s disease 02-02-2010 37 Roos RAC Pijl H: NA Aziz: Huntington's disease hypothalamic, endocrine and metabolic aspectsCum Laude 31-03- 2010 38 Roos RAC Bloem BR: S Keus 29-04-2010 39 Verschuuren JJGM, Roos RAC: M Titulaer: Cum Laude

Beoordelings- en Oppositiecommissie M Arbouw 29-06-2010 Oppositiecommissie M Houtlosser 30-06-2010 M van Rijn -10-2010 M Nijkrake 29-11-2010Nijmegen 2011 40 Roos RAC: P Nijssen19-01-2011 41Roos RAC, Middelkoop HAM: CK Jurgens Premanifest Huntington's Disease Geneeskunde 1-2-2011 42Roos RAC: R de Pril The Ubiquitin Proteasome System in Huntington Disease23-02-2011 Oppositiecommissie M Sons 1-11-20111 A Munts 2-11-2011 Roos RAC promotiecommissie 20-01-2011 Roos RAC promotie- en oppositiecommissie AM Meppelink Groningen 13-04-2011 Roos RAC promotie- en oppositiecommissie R Helmich Nijmegen 24-05-2011 Roos RAC promotiecommissie 30-06-2011 Roos RAC promotiecommissie M Sons, Leiden 01-11-2011 Roos RAC promotiecommissie A Munts Leiden 02-11-2011 Roos RAC Oppositiecommissie JG Kalf Nijmegen 22-12-2011 2012 43Roos RAC L A’CampoA Patient and Caregiver Education Program: In Parkinson's disease, Huntington's disease and other chronic diseases 5 juni 2012 44 Roos RAC, Bloem BR: YAM Grimbergen Falls in Parkinson’s disease and Huntington’s disease

23 oktober 2012 45 Roos RAC , van Buchem M EM Dumas Huntington’s disease functional and structural biomarkers

14 november 2012 46 Roos RAC, van Buchem M, SJA van den Bogaard. Huntington's disease : quantifying structural brain changes 14 november 2012 2013 47 De Die, , Roos RAC, J Geraerds: M van Rij Reproductive options for couples at risk of Huntington’s disease 13-06-2013 48 Roos RAC EP’t Hart Cognition in Huntington’s disease.. 14-11-2013 Roos RAC Promotie en oppositiecommissie van Waarden Roos RAC Promotie en oppositiecommissie ND van Burgel 29-05-2013 Roos RAC Yu Sun: Identification of disease genes by exome sequencing.: 26-03-2013 2014 49 Roos RAC Swaab DF: D van Wamelen Hypothalamus in HD 4 feb 2014 50 Roos RAC JG Ritfeld Bone marrow stromal cell mediated neuroprotection for spinal cord repair 27 feb 2014 51 Roos RAC Engberts DP: SJ BooijWishes for the end of life in Huntington’s disease 12 nov 2014 Member promotie commissie A Stam leiden -6-2014 CSM Straathof 28 oktober 2014 F Cox 25 nov 2014 Member oppositiecommissie Groningen 12 maart 2014 Bank april 2014 Leiden

2015 52 Roos RAC: AW Heemskerk Dysphagia in Huntington Disease Dysphagia in Huntington’s disease 15 april 2015 53 KN Leenders Roos RAC: J van Oostrom Biomarkers in premanifest Huntington's disease

14-10-2015 2016 54 Mast R vd, Roos RAC ; AAM Hubers Suicidality in Huntington’s disease 21-01-2016 55 Mast R vd, Roos RAC: N Reedekers Neuropsychiatric phenomena in Huntington’s disease 12-05-2016