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FOLLICULAR THYROID CARCINOMA

Referat

Oleh:Ratnawati 0410710117

Hans Peter H 0510710065

Pembimbing:

dr. P. C. Widyo Karsono, Sp.B, (K) KL

dr. Dwica Rahmawansa

LABORATORIUM ILMU BEDAH

FAKULTAS KEDOKTERAN UNIVERSITAS BRAWIJAYA

RUMAH SAKIT UMUM DR. SAIFUL ANWAR

MALANG

i

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2010

LEMBAR PERSETUJUAN

FOLLICULAR THYROID CARCINOMA

Disusun oleh:

Ratnawati 0410710117

Hans Peter H 0510710065

Disetujui untuk dibacakan pada

Hari : Kamis

Tanggal : 26 Agustus 2010

Pembimbing I Pembimbing II

( dr. P. C. Widyo Karsono, Sp.B, (K) KL ) ( dr. Dwica Rahmawansa )

ii

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DAFTAR ISI

HALAMAN JUDUL ........................................................................................ i

LEMBAR PERSETUJUAN ............................................................................ ii

DAFTAR ISI ................................................................................................... iii

DAFTAR GAMBAR ....................................................................................... iv

BAB I PENDAHULUAN ................................................................................. 1

1.1 Latar Belakang .................................................................................. 1

1.2 Rumusan Masalah ............................................................................ 2

1.3 Tujuan ................................................................................................ 2

BAB II TINJAUAN PUSTAKA ........................................................................ 3

2.1 Anatomi Kelenjar Tiroid ........................................................................... 3

2.2 Fisiologi Kelenjar Tiroid ........................................................................... 6

2.3 Patofisiologi Follicular Thyroid Carcinoma ............................................. 9

2.4 Klasifikasi Follicular Throid Carcinoma ................................................... 14

2.5 Diagnosis ................................................................................................. 15

2.6 Manajemen dan prognosis ...................................................................... 19

BAB III PENUTUP ......................................................................................... 22

DAFTAR PUSTAKA ...................................................................................... 24

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DAFTAR GAMBAR

Gambar 1. Kelenjar Tiroid, Tampak Anterior dan Lateral ........................... 3

Gambar 2. Histologi Kelenjar Tiroid Menunjukkan Unit Struktural Kelenjar 

dan Folikel, Terdiri dari Epitel Simplex yang Menutupi Ruang

Berisi Koloid ................................................................................ 3

Gambar 3. Distribusi Arteri Tiroid dalam Hubungannya dengan N.

Laryngeus, Tampak Anterior ...................................................... 4

Gambar 4. Distribusi Vena Tiroid .................................................................. 5

Gambar 5. Kelenjar Thyroid .......................................................................... 6

Gambar 6. Regulasi sintesis hormon tiroid (Fauci et al, 2008) .................... 8

Gambar 7. Jalur Pensinyalan Sel di Sel Folikular ........................................ 10

Gambar 8. Interaksi Sel-Sel dan Sel-Matrix pada Sel Ca Tiroid .................. 11

Gambar 9. Regulasi siklus sel di sel folikuler ............................................... 12

Gambar 10.Keterangan: GNAS 1, guanine nucleotide-binding α -subunit 1;

PPARG, peroxisome proliferation-activated receptor-ᵞ; TSHR,

thyroid-stimulating-hormone receptor ........................................ 13

iv