Colágeno, elastina y fibronectinas
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Transcript of Colágeno, elastina y fibronectinas
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Forma parte
de la matriz
extracelular
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Colágeno
Estiramiento
FortalezaComprensibilidad
matriz
Resistencia
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• Fibroblastos: tamaño y organización de fibrillas.
• Tejido conjuntivo
• Células epiteliales
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Estructura helicoidal
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Homotrímero Heterotrímero
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Colágeno fibrilar
• Tipo I, II, III
Colágeno no fibrilar
• Tipo IV, VI
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Colágeno V
Colágeno I
Colágeno III
Colágeno
IX, X , XI
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EnfermedadesSINDROME DE EHLERS DANLOS DERMATOSPARAXIS
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ELASTINAFUNCIONES Y ESTRUCTURA
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ELAST “Dúctil”
IN “Sustancia”
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La elastina:
moléculas de
tropoelastina
tiene lisina y
carece de
desmosina
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1ª componente
de las fibras
elásticas
Alto contenido de
aminoácidos: como
prolina,valina y a.a no
cargados
a.a
exclusivos
como:
desmosin
a e
isodesmo
cina
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Microfibrillasfibrilina, rica en
a.a
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1-
Sustanci
a central
de
elastina
amorfa,
2-fibrillas
colágen
as,
3-
microfibr
illas de
fibrilina,
4-
prolonga
ciones
de
fibroblast
os.
x 32.000.
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FIBRONECTINA
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DOMINIO NOMBRE DEL DOMINIO ADHESIÓN A
N 1 Dominio de adhesión a la fibrina Fibrina, heparina,
S.aureus, F XII
N 2 Dominio de adhesión al colágeno
Y a la Celatina
Celatina, colágeno,
Clq S.pyogúnes
N3 Dominio de adhesión al ADN ADN
N 5 No se conoce
N 6 Dominio (le adhesión celular) Células, treponemas
N 8 Dominio de adhesión a la fibrina FRIBRINA
N 9 Carboxitenninus ¿ adhesión a
S.ourcus ?
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Glicoproteína
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