穿戴式計算在醫學的應用Wearable Computing in Medicine

詹曉龍

長庚大學電機系

醫學工程與電子電機資訊相關之研究微機電

類比積體電路系統晶片

嵌入式系統無線通訊無線網路

Wearable Computing Wearable Computing in Medicinein Medicine

訊號處理

Detect, Classify and Analyze Biomedical

Signals

系統分析與建模

Understand Physiological System

醫學影像

Display Anatomical Details and

Physiological Function

復建工程

Provide Therapeutics and Aids Devices for

the Disabled

醫療儀器

Monitor and Measure Physiological Event

醫學資訊

Build Medical Information and

Decision Support Systems

生物資訊

Solve Computational Problems in

Molecular Biology

醫學工程

心電圖量測技術

First Electrocardiograph (ECG) by William Einthoven in 1903

Patient Monitors

ECG Holter

Traditional Biomonitoring

ECG(心電圖) HolterEEG(腦電圖) HolterDisadvantages

缺乏與病患之醫療紀錄整合之功能

當偵測出異常，無立即的醫療處置

Medical Monitoring with Wearable Computing

即時回饋或傳送生理狀態給病人與訓練中運動員或醫護人員與教練

Mobile Health (M-Health)Mobile computing (行動計算)Medical sensors (生醫感測器)Communication technology (通訊技術)

What are Biomedical Signals?

EEG

EGG

EMG

ECG

Blood Pressure

HeartSound

Body Area Network (BAN)

E. Jovanov et al, IEEE EMBS, 2003

WISSE: wearable devices with sensors and BAN for physiological data collection

R.S. Istepanian et al, IEEE ITB, 2004

Smart Shirt (SensatexTM)

Smart Shirt (SensatexTM)

Detects when a baby stops breathing and sends an alarm

Smart Shirt (SensatexTM)

Memory GlassMassachusetts Institute of Technology

Wearable PhotoplethysmographicBiosensors

H.H. Asada et al, IEEE EMB, 2003

BodyMediaTM

Heart rate on the upper arm? Never say never

Heart Rate Monitor in MP3 PlayerSamsung yeppTM

Plethymography

Wearable Devices to Collect Patients’ Daily Information

ECG HolterCatch cardiac arrhythmiaHeart rate variability

EEG HolterCollect spikes’ information of seizure patients

Monitoring of Body Motion During Walking Poststroke Hemiplegic Patients

Healthy elder subject

Poststroke Hemiplegic Patients

M. Akay et al, IEEE EMB, 2003

Wearable Medicine on Electronics, Electrics and Information Technology

Sensor technologyMicromachine (微機電)Analog integrated circuit (類比積體電路)

Power-supply system (電源系統)Small-size, high-capacity batterySelf-provided power

System-on-chip (系統晶片) embedded system (嵌入式系統)

Compact microprocessor (微處理器)Power management (電源管理)Real-time operating system

Embedded computingDigital signal processing (數位訊號處理)

Medical information

Wireless TechnologyBluetoothWireless LAN Ad-hoc Network

System-on-Chip for Real-time Biotelemetry

Lei Wang et al, IEEE BME, 2005

University of Glasglow

System-on-Chip for Real-time Biotelemetry

8-bit MCU

2 Temperature

2 ISFET Ph

2 conductivity

2 dissolved oxygen sensors

ADC

SRAM

SPI

DS-SS

PN codeVCOOn-chip clock

RF transmission

Lei Wang et al, IEEE BME, 2005

Biomedical Signal Processing for Real-Time Monitoring

Heart rateCardiac arrhythmiaBrain states…

Continuous and On-Line Spectral Analysis of HRV

Labview圖形顯示介面

心電圖放大器

類比至數位轉換器

數位訊號處理器

ROM RAM

RS-232

串列傳輸埠

Real-Time Algorithm

ECG

[ ]dtd

[ ]2 ∑=

32

1321n

Template Match

Pan-Tompkins QRS Detection

QRSClassification

PartialMedian Filter

Heart PeriodResampling

SpectralAnalysis

HRV Index

Band-PassFilter

2~10Hz

Heart PeriodCalculation

Template update

Hybrid Heartbeat Detection

Cross Correlation

FDSI

VPCR

QRS

P T

Heart Period

TP VPC

Q S

ECG

Thres_HThres_L

1.0

-0.6

0.6

0.2

-0.2

-1.0

Lempel-Ziv Complexity (複雜度)

心室急速 (Ventricular Tachycardia)及心室纖維顫動 (Ventricular Fibrillation)

Ventricular Tachycardia

Ventricular fibrillation

Detecting Ventricular Tachycardia and Fibrillation by Complexity Measure (Xu-Sheng Zhang, et al, 1999)

window length 3 s

5 s

7 s

EEG Complexity under anesthesia in different states

awake state

intermediate state

asleep state

LZ complexity

Xu-Sheng Zhang et al, IEEE BME, 2001