CASO CLÍNICO- PATOLÓGICO
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CASO CLÍNICO- PATOLÓGICO
Santiago Montes Moreno, Miguel Ángel Martínez González.Departamento de AP. H. U. 12 de Octubre, Madrid.
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CASO CLÍNICO- PATOLÓGICO
• Mujer de 50 años que desarrolla una clínica de 7 meses de evolución de insuficiencia respiratoria nasal, dolor e hipoacusia con sensación de taponamiento de oído derecho.
• EF: Adenopatías cervicales bilaterales y bultoma submandibular derecho no dolorosos.
• TAC: Adenopatía yugulodigástrica D, submandibular I y retrofaríngeas D con imágenes sugestivas de necrosis y captación en anillo.
Tumor en nasofaringe que afecta a rodete tubárico D
Con la sospecha clínica de proceso linfoproliferativo se realiza biopsia de cavum.
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kappa lambda
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DAP: Mucosa tubárica con infiltrado inflamatorio inespecífico, de probable naturaleza reactiva.
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S-100
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CD1a
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DAP: Ganglio linfático con Enfermedad de Rosai- Dorfman.
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Foucar E, Rosai J, Dorfman R. Sinus histicytosis with massive lymhadenopathy(Rosai- Dorfman disease). Review of the entity. Semin Diagn Pathol 1990, 7: 19.
ERD ganglionar- ERD extraganglionar
ERD en Cabeza y Cuello.
Wenig Bm, Abbondanzo SL, Childers EL, Kapadia SB, Heffner DR. Extranodalsinus histiocytosis with massive lymphadenopathy (Rosai- Dorfman disease) of the head and neck. Hum Pathol 1993; 24: 483.
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ERD en Cabeza y Cuello. DIAGNÓSTICO DIFERENCIAL:
-Infecciones fúngicas
-Rinoescleroma (células de Mikulicz)
-Sífilis secundaria
-Lepra
-Granulomatosis de Wegener
-Plasmocitosis de Membranas Mucosas
-Linfoma T/NK extranodal de tipo nasal.
-Linfoma de Hodgkin
-Histiocitosis de células de Langerhans
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Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymhadenopathy(Rosai- Dorfman disease). Review of the entity. Semin Diagn Pathol 1990, 7: 19.
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PAS
PAS-DIASTASA
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ERD y LINFOMA
Falk S, Stutte HJ, Frizzera G. Hodgkin´s disease and sinus histiocytosis with massive lymphadenopathy-like changes. Histopathology 1991; 19: 221.
Lu D, Estalilla OC, Manning JT, Medeiros LJ. Sinus histiocytosis with massive lymphadenopathy and malignant lymphoma involving the same lymph node: a report of four cases and review of the literature. Mod Pathol 2000; 13: 414.
ETIOLOGÍA?
Rosai J. Rosai- Dorfman disease (sinus histiocytosis with massive lymphadenopathy) in Rosai and Ackerman´s Surgical Pathology. Ninth Ed. Mosby 2004, volume 2: 1911.
Maric I, Pittaluga MD, Dale JK, et al. Histologic features of Sinus Histiocytosis with Massive Lymphadenopathy in patients with Autoimmune Lymphoproliferative Syndrome. Am J SurgPathol 2005; 7: 903.
Middel P, Hemmerlein B, Fayyazi A, Kaboth U, Radzun HJ. Sinus histicytosis with massive lymphadenopathy: evidence for its relationship to macrophages and for a cytokine-related disorder. Histopathology 2000; 35: 525.
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REFERENCIAS.
Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A pseudolymphomatous benign disorder. Analysis of 34 cases. Cancer 1972; 30: 1174.
Foucar E, Rosai J, Dorfman R. Sinus histicytosis with massive lymhadenopathy (Rosai- Dorfman disease). Review of then entity. Semin Diagn Pathol 1990, 7: 19.
Wenig Bm, Abbondanzo SL, Childers EL, Kapadia SB, Heffner DR. Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai- Dorfman disease) of the head and neck. Hum Pathol 1993; 24: 483.
Falk S, Stutte HJ, Frizzera G. Hodgkin s disease and sinus histiocytosis with massive lymphadenopathy-like changes. Histopathology 1991; 19: 221.
Lu D, Estalilla OC, Manning JT, Medeiros LJ. Sinus histiocytosis with massive lymphadenopathy and malignant lymphoma involving the same lymph node: a report of four cases and reviewof the literature. Mod Pathol 2000; 13: 414.
Rosai J. Rosai- Dorfman disease (sinus histiocytosis with massive lymphadenopathy) in Rosai and Ackerman´s Surgical Pathology. Ninth Ed. Mosby 2004, volume 2: 1911.
Maric I, Pittaluga MD, Dale JK, et al. Histologic features of Sinus Histiocytosis with Massive Lymphadenopathy in patients with Autoimmune Lymphoproliferative Syndrome. Am J Surg Pathol 2005; 7: 903.
Middel P, Hemmerlein B, Fayyazi A, Kaboth U, Radzun HJ. Sinus histicytosis with massive lymphadenopathy: evidence for its relationship to macrophages and for a cytokine-related disorder. Histopathology 2000; 35: 525.
Pulsoni A, Anghel G, Falcucci P, et al. Treatment of Sinus Histiocytosis With Massive Lymphadenopathy (Rosai- DorfmanDisease): Report of a case and literature review. Am J Hematol 2002; 69: 67.
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