Amoxicillin
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Reactions 1264 - 8 Aug 2009 S Amoxicillin Biphasic anaphylaxis in an elderly patient: case report Biphasic anaphylaxis occurred in a 68-year-old man after amoxicillin administration. The man, who had a history of ischemic heart disease, hypertension and diabetes mellitus, took one amoxicillin tablet [dosage and therapeutic indication not stated], and developed itchy palms and soles, erythema on his thorax and conjunctival injection 15 minutes later. The man took a histamine H1 receptor antagonist, and his symptoms resolved. However, 3 hours after drug intake, he developed weakness and chest oppression, for which he took nitroglycerin [glyceryl trinitrate]; he experienced a feeling of tightness in his throat, and eventually lost consciousness and was admitted to an emergency department. On admission, he was hypotensive with a BP of 85/55; an acute cardiac event was excluded. After 9 hours of observation, his BP spontaneously normalised (120/80). Thoracic pain and allergic reaction were diagnosed, and he was discharged with prescriptions for a histamine H1 receptor antagonist and cortisone. The man underwent allergy testing 3 months later, in November 2008. Patch tests were negative for all tested antibacterials, including amoxicillin. However, intradermal skin tests showed an immediate-type reaction to amoxicillin 2 mg/mL, confirming the diagnosis of allergic biphasic anaphylaxis. Zisa G, et al. A case of protracted hypotension as unique symptom of a biphasic anaphylaxis to amoxicillin. European Annals of Allergy and Clinical Immunology 41: 60-61, No. 2, Apr 2009 - Italy 801146737 1 Reactions 8 Aug 2009 No. 1264 0114-9954/10/1264-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Amoxicillin
Reactions 1264 - 8 Aug 2009
SAmoxicillin
Biphasic anaphylaxis in an elderly patient: casereport
Biphasic anaphylaxis occurred in a 68-year-old man afteramoxicillin administration.
The man, who had a history of ischemic heart disease,hypertension and diabetes mellitus, took one amoxicillintablet [dosage and therapeutic indication not stated], anddeveloped itchy palms and soles, erythema on his thoraxand conjunctival injection 15 minutes later.
The man took a histamine H1 receptor antagonist, andhis symptoms resolved. However, 3 hours after drugintake, he developed weakness and chest oppression, forwhich he took nitroglycerin [glyceryl trinitrate]; heexperienced a feeling of tightness in his throat, andeventually lost consciousness and was admitted to anemergency department. On admission, he washypotensive with a BP of 85/55; an acute cardiac event wasexcluded. After 9 hours of observation, his BPspontaneously normalised (120/80). Thoracic pain andallergic reaction were diagnosed, and he was dischargedwith prescriptions for a histamine H1 receptor antagonistand cortisone.
The man underwent allergy testing 3 months later, inNovember 2008. Patch tests were negative for all testedantibacterials, including amoxicillin. However, intradermalskin tests showed an immediate-type reaction toamoxicillin 2 mg/mL, confirming the diagnosis of allergicbiphasic anaphylaxis.Zisa G, et al. A case of protracted hypotension as unique symptom of a biphasicanaphylaxis to amoxicillin. European Annals of Allergy and Clinical Immunology41: 60-61, No. 2, Apr 2009 - Italy 801146737
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Reactions 8 Aug 2009 No. 12640114-9954/10/1264-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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