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¹Ò¹ÒªÒμÔ Ñ§μ‹Íä»¹Õé

Journal of the American Chemical Society / Chemical Communications

/ Australian Journal of Chemistry / New Journal of Chemistry /

Supramolecular Chemistry / Journal of Inclusion Phenomena and

Molecular Recognition in Chemistry / Inorganic Chemistry / Journal

of Organometallic Chemistry / Journal of Coordination Chemistry /

CrystEngComm / Applied Organometallic Chemistry / Journal of Organic

Chemistry / Organic and Biomolecular Chemistry / Organic Letters /

Tetrahedron / Tetrahedron Letters / Analytica Chimica Acta / Biosensors

and Bioelectronics / Electroanalysis / Sensors and Actuators B: Chemical

/ Talanta / Journal of Molecular Structure

¾.È. 2550-»¨¨ØºÑ¹ ¡ÃÃÁ¡ÒÃÃÐ Ñº¹Ò¹ÒªÒμÔ ¡ÒÃ»ÃÐªØÁ Asian Conference on Coordination

Chemistry (ACCC)

¾.È. 2551-»¨¨ØºÑ¹ ¡ÃÃÁ¡ÒÃ½†ÒÂÇÔªÒ¡ÒÃ ¡ÒÃ»ÃÐªØÁ Pure and Applied Chemistry International

Conference (PACCON)


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Curriculum VitaeProfessor Dr. Thawatchai Tuntulani

DATE OF BIRTH December 18, 1967

PLACE OF BIRTH Bangkok, Thailand

MARITAL STATUS Single

OFFICE ADDRESS Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand Tel: 66-2-218-7643 Fax: 66-2-218-7598

PRESENT POSITION Professor of Chemistry and Head of Supramolecular Chemistry Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University

EDUCATION 1989 B.Eng. (Mining Engineering), Chiang Mai University, Chiang Mai, Thailand 1995 Ph.D. (Chemistry), Texas A&M University, College Station, Texas, USA 1996 Postdoctoral Training, Universit Louis Pasteur, Strasbourg, FrancePROFESSIONAL 1989 Lecturer, Department of Mining Engineering, Faculty of EXPERIENCE Engineering, Chiang Mai University, Chiang Mai, Thailand 1990 Transferred to the Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand 1990-1995 Pursued a Ph.D. in Chemistry at Texas A&M University, College Station, Texas, USA 1995 Resumed the position at the Department of Chemistry, Chulalongkorn University 1997-2004 Assistant Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University 2004-2008 Associate Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University


2008-present Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University

HONORS AND 1998 Professor Foundation Awards (Faculty of Science,AWARDS Chulalongkorn University) 1998 Young Scientist Awards (Foundation for the Promotion

Science and Technology under the Patronage of His Majesty the King)

2001 Science and Technology Award to Supramolecular Chemistry Laboratory (Thailand Toray Science Foundation)

2006 Highly-Cited Researcher Award (Faculty of Science, Chulalongkorn University)

2007 National Distinguished Researcher Award in Chemical and Pharmaceutical Sciences (National Research Council of Thailand)

2007 TRF Senior Research Scholar (The Thailand Research Fund) 2008 Distinguished Alumni, Faculty of Engineering, Chiang Mai

University 2009 CST Award (Chemical Society of High Impact Chemist

Thailand) 2009 Highly-Cited Researcher Award (Chulalongkorn University) 2010 TRF Senior Research Scholar (The Thailand Research Fund) 2010 Asian Core Program Lectureship Award (Asian CORE

Program) 2013 Outstanding Teaching Awards (Faculty of Science, Chulalongkorn

University) 2013 Outstanding Teaching Awards (Chulalongkorn University)


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2005-present Academic Committee, 32nd-40th Congress on Science and Technology of Thailand

2010-2013 Technical Committee, National Nanotechnology Center 2012-present Scientific Committee, Chemical and Pharmaceutical Sciences Division, National Research Council of Thailand

2000-present Reviewers for international journals: Journal of the American Chemical Society / Chemical Communications / Australian Journal of Chemistry / New Journal of Chemistry / Supramolecular Chemistry / Journal of Inclusion Phenomena and Molecular Recognition in Chemistry / Inorganic Chemistry / Journal of Organometallic Chemistry / Journal of Coordination Chemistry / CrystEngComm / Applied Organometallic Chemistry / Journal of Organic Chemistry / Organic and Biomolecular Chemistry / Organic Letters / Tetrahedron / Tetrahedron Letters / Analytica Chimica Acta / Biosensors and Bioelectronics / Electroanalysis / Sensors and Actuators B: Chemical / Talanta / Journal of Molecular Structure 2007-present International Committee, Asian Conference on Coordination Chemistry (ACCC) 2008-present Academic Committee, Pure and Applied Chemistry International Conference (PACCON)

MEMBERSHIPS/COMMITTEE MEMBERS - THAILAND

MEMBERSHIPS/COMMITTEE MEMBERS - INTERNATIONAL


LIST OF PUBLICATIONS

Professor Dr. Thawatchai Tuntulani

1. Rojsajjakul, T.; Veravong, S.; Tumcharern, G; Seangprasertkij-Magee, R.; Tuntulani, T. “Synthesis and Characterization of Polyaza Crown Ether Derivatives of Calix[4]arene and Their Role as Anion Receptors” Tetrahedron 1997, 53, 4669-4680.

2. Pothsree, T.; Seangprasertkij-Magee, R.; Tuntulani, T. “Anion and Cavity Effects on the Complexation Behavior of Di-Aza-Benzo-Crown-Ether Calix[4]arene towards Zn(II) Ions” J. Inclu. Phenom. 1997, 29, 99-107.

3. Tuntulani, T.; Ruangpornvisuti, V.; Tantikunwatthana, N.; Ngampaiboonsombut, O.; Seangprasertkij-Magee, R.; Asfari, Z.; Vicens, J. “Synthesis of the Tripodal-Amine Capped Benzo Crown p-tert-Butylcalix[4]arene and Its Host-Guest Chemistry” Tetrahedron Lett. 1997, 38, 3985-3988.

4. Tuntulani, T.; Volkmer, D.; Fenske, D.; Lehn, J.-M. “The Novel N-Donor Heterocyclic Ligands and Their Coordination Chemistry Towards a Cu(II) Salt” J. Sci. Soc. Thailand 1997, 23, 185-198.

5. Tomapatanaget, B.; Pulpoka, P.; Tuntulani, T. “Preparation of Diaza Dioxa Dithia Crown p-tert-Butylcalix[4]arene by S-Alkylation Reactions: Use of Metallo-Calix[4]arene Complexes as Reaction Templates” Chem. Lett. 1998, 1037-1038.

6. Suwattanamala, E.; Tuntulani, T.; Ruangpornvisuti, V. “QuantumChemical Investigations on Stabilities of Protonated Species of 25, 27-{2,2 -(2,2 -((2,5,8-triaza)nonyl)diphenoxy)diethyl}-p-tert-butylcalix[4]arene” ScienceAsia 1999, 25, 207-210.

7. Chantarasiri, N.; Tuntulani, T.; Tongraung, P; Wannarong, W.; Seangprasertkij-Magee, R. “New Metal-Containing Epoxy Polymers from Diglycidyl Ether of Bisphenol A and Tetradentate Schiff Base Metal Complexes” Eur. Polym. J. 2000, 36, 695-702.

8. Chantarasiri, N.; Tuntulani, T.; Chanma, N. “Application of Hexadentate Schiff Base Metal Complexes as Crosslinking Agents for Diglycidyl Ether of Bisphenol A” Eur. Polym. J. 2000, 36, 889-894.

ORIGINAL RESEARCH

ARTICLES


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9. Navakun, K.; Tuntulani, T.; Ruangpornvisuti, V. “p-tert-Butylcalix[4]arene Derivatives Containing Azathiol Recepting Units and Their Recognition towards Hg(II)” J. Inclu. Phenom. 2000, 38, 113-122.

10. Veravong, S.; Ruangpornvisuti, V.; Pipoosananakaton, B.; Sukwattanasinitt, M.; Tuntulani, T. “Synthesis of Tetraalkylated Calix[4]arenes and Studies of Their Conformational Behaviors” ScienceAsia 2000, 26, 163-170.

11. Pipoosananakaton, B.; Sukwattanasinitt, M.; Jaiboon, N.; Chaichit, N.; Tuntulani, T. “New Azobenzene Crown p-tert-Butylcalix[4]arenes as Switchable Receptors for Na+ and K+ ions: Synthesis and Isomerization Studies” Bull. Kor. Chem. Soc. 2000, 21, 867-874.

12. Pipoosananakaton, B.; Sukwattanasinitt, M.; Jaiboon, N.; Chaichit, N.; Tuntulani, T. “Preparation of New Azobenzene Crown Ether p-tert-Butylcalix[4]arenes and Their Roles as Switchable Ionophores for Na+ and K+ Ions” Tetrahedron Lett. 2000, 41, 9095-9100.

13. Pulpoka, B.; Jamkrotoke, M.; Tuntulani, T.; Ruangpornvisuti, V. “Synthesis of 1,3-Alternate Calix[4]-Cyclen-Benzo-Crown-6 as a Hard-Soft Receptor” Tetrahedron Lett. 2000, 41, 9167-9171.

14. Tuntulani, T.; Tumcharern, G.; Volkmer, D. “S- and NH-Bridging Pyridine- and Pyrimidine-Based Ligands for 2x2, 3x3 and 4x4 Molecular grids: Evidence of [2x2]Zn(II) Grids” Bull. Kor. Chem. Soc. 2000, 21, 1245-1248.

15. Jaiboon, N.; Chaichit, C.; Pipoosananakaton, B.; Tuntulani, T.; Sukwattanasinitt, M. “Crystal Structure of Diethoxynitrobenzene-p-tert-Butylcalix[4]arene•2(CH

3)2C=O: Evidence of Intra- and Intermolecular

CH/p Interactions Forced by Crystal Packing” J. Chem. Cryst. 2000, 30, 717-720.

16. Tuntulani, T.; Tumcharern, G.; Ruangpornvisuti, V. “Recognition Studies of a Pyridine-Pendant Calix[4]arene with Neutral Molecules: Effects of Non-Covalent Interactions on Supramolecular Structures and Stabilities” J. Inclu. Phenom. 2001, 39, 47-53.

17. Sukwattanasinitt, M.; Rojanathanes, R.; Tuntulani, T.; Sritana-Anant, Y.; Ruangpornvisuti, V. “Synthesis of Stilbene Crown Ether p-tert-Butylcalix[4]arenes” Tetrahedron Lett. 2001, 42, 5291-5293.

18. Tuntulani, T.; Poompradub, S.; Thavornyutikarn, P.; Jaiboon, N.; Ruangpornvisuti, V.; Chaichit, N.; Asfari, Z.; Vicens, J. “Aza Crown Ether Calix[4]arenas Containing Cation and Anion Binding Sites: Effects of Cations towards Anion Binding Ability” Tetrahedron Lett. 2001, 42, 5541-5544.


19. Tomapatanaget, B.; Tuntulani, T. “Lower Rim Tetra-Substituted and Upper Rim Ferrocene Amide Calix[4]Arenes: Synthesis, Conformation and Anion Binding Properties” Tetrahedron Lett. 2001, 42, 8105-8109.

20. Sukwattanasinitt, M.; Rojanathanes, R.; Jiwapanich, S.; Tuntulani, T.; Ruangpornvisuti, V. “Selective Oxidation of 25,27-Bis-(3-formylphenoxylethoxy)-p-tert-butylcalix[4]arene” ScienceAsia 2002, 28, 25-28.

21. Ruangpornvisuiti, V.; Pulpoka, B.; Tuntulani, T.; Thipyapong, K.; Suksai, C. “Conformational Investigations of HMPAO Isomers and Their Zinc(II) Complexes” Bull. Kor. Chem. Soc. 2002, 23, 555-562.

22. Tuntulani, T.; Thavornyutikarn, P.; Poompradub, S.; Jaiboon, N.; Ruangpornvisuti, V.; Chaichit, N.; Asfari, Z.; Vicens, J. “Synthesis of Tripodal Aza Crown Ether Calix[4]arenes and Their Supramolecular Chemistry with Transition-, Alkali Metal Ions and Anions” Tetrahedron 2002, 58, 10277-10285.

23. Tongraung, P; Chantarasiri, N.; Tuntulani, T. “Calix[4]arenes Containing Urea and Crown/Urea Moieties: Effects of the Crown Ether Unit and Na+ towards Anion Binding Ability” Tetrahedron Lett. 2003, 44, 29-32.

24. Tantrakarn, K.; Ratanatawanate, C.; Pinsuk, T.; Chailapakul, O.; Tuntulani, T. “Synthesis of Redox-Active Biscalix[4]quinones and Their Electrochemical Properties” Tetrahedron Lett. 2003, 44, 33-36.

25. Tomapatanaget, B.; Tuntulani, T.; Chailapakul, O. “Calix[4]arenes Containing Ferrocene Amide as Carboxylate Anion Receptors and Sensors” Org. Lett. 2003, 5, 1539-1542.

26. Wanno, B.; Sang-aroon, W.; Tuntulani T.; Polpoka, B.; Ruangpornvisuti, V. “Conformational and Energetical Structures of Sulfonylcalix[4]arene, p-tert-Butylsulfonylcalix[4]arene and Their Zinc Complexes” J. Mol. Struc.-Theochem. 2003, 629, 137-150.

27. Sukwattanasinitt, M.; Nantalaksakul, A.; Potisatityuenyong, A.; Tuntulani, T.; Chailapakul, O.; Praphairakait, N. “An Electrochemical Sensor from a Soluble Polymeric Ni-salen Complex” Chem. Mater. 2003, 15, 4337-4339.

28. Tumcharern, G.; Tuntulani, T.; Coles, S. J.; Hursthouse, M. B.; Kilburn, J. D. “A Novel Ditopic Receptor and Reversal of Anion Binding Selectivity in the Presence and Absence of Bound Cation” Org. Lett. 2003, 5, 4971-4974.


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29. Tomapatanaget, B.; Tuntulani, T.; Wisner, J. A.; Beer, P. D. “New Interlocked Molecules Generating from a Podand Containing Urea Units and Imidazolium Salts Using an Anion Template” Tetrahedron Lett. 2004, 45, 663-666.

30. Rojanathanes, R.; Pipoosananakaton, B.; Tuntulani, T.; Bhanthumnavin, W.; Orton, J. B.; Cole, S. J.; Hursthouse, M. B.; Grossel, M. C.; Sukwattanasinitt, M. “Comparative Study of Azobenzene and Stilbene Bridged Crown Ether p-tert-Butylcalix[4]arene” Tetrahedron 2005, 61, 1317-1324.

31. Suksai, C.; Leeladee, P.; Jainuknan, D.; Tuntulani, T.; Muangsin, N.; Chailapakul, O.; Kongsaeree, P.; Pakavatchai, C. “A New Heteroditopic Receptor and Sensor Highly Selective for Bromide in the Presence of A Bound Cation” Tetrahedron Lett. 2005, 46, 2765-2769.

32. Harding, D. J.; Adams, H.; Tuntulani, T. “B-N Bond Cleavage by Cobalt(II) in Acetato(3,5-diphenylpyrazole)[tris(3,5-diphenylpyrazolyl)borato]Cobalt(II)” Acta Cryst. 2005, C61, m301-m303.

33. Kerdpaiboon, N.; Tomapatanaget, B.; Chailapakul, O.; Tuntulani, T. “Calix[4]quinones Derived from Double Calix[4]arenes: Synthesis, Complexation and Electrochemical Properties towards Alkali Metal Ions” J. Org. Chem. 2005, 70, 4797-4804.

34. Rojanathanes, R.; Tuntulani, T.; Bhanthumnavin, W.; Sukwattanasinitt, M. “Stilbene-Bridged tert-Butylcalix[4]arene as Photoswitchable Molecular Receptors” Org. Lett. 2005, 7, 3401-3404.

35. Morakot, N.; Tomapatanaget, B.; Ngeontae, W.; Aeungmaitripirom, W.; Tuntulani, T. “Synthesis and Fluorescence Sensing Properties of Calix[4]arenes Containing Fluorophores” Supramol. Chem. 2005, 17, 655-659.

36. Suksai, C.; G mez, S. F.; Chhabra, A.; Liu, J: Skepper, J. N.; Tuntulani, T.; Otto, S. “Controlling the Morphology of Aggregates of an Amphiphilic Synthetic Receptor through Host-Guest Interactions” Langmuir 2006, 22, 5994-5997.

37. Ngeontae, W.; Aeungmaitrepirom, W.; Tuntulani, T. “Chemically Modifi ed Silica Gel with Aminothioamidoanthraquinone for Solid Phase Extraction and Preconcentration of Pb(II), Cu(II), Ni(II), Co(II) and Cd(II)” Talanta 2007, 71, 1075-1082.

38. Kaewwangchai, S.; Tuntulani, T.; Ruangpornvisuti, V. “Molecular Structure of 3,6-Di(hexylthioureido)acridine Conformers, Their Protonation, 1H NMR and IR Analyses: Theoretical and Experimental Studies” J. Mol. Struc. 2007, 832, 16-25.


39. Harding, D. J.; Harding, P.; Adams, H.; Tuntulani, T. “Synthesis and Characterization of Sterically Hindered Tris(pyrazolyl)borate Ni Complexes” Inorg. Chim. Acta 2007, 360, 3335-3340.

40. Ngeontae, W.; Xu, C.; Ye, N.; Wygladacz, K.; Aeungmaitrepirom, W.; Tuntulani, T.; Bakker, E. “Polymerized Nile Blue Derivatives for Plasticizer-Free Fluorescent Ion Optode Microsphere Sensors” Anal. Chim. Acta 2007, 599, 124-133.

41. Ngeontae, W.; Xu, Y.; Xu, C.; Aeungmaitrepirom, W.; Tuntulani, T.; Pretsch, E.; Bakker, E. “Sensitivity and Working Range of Backside Calibration Potentiometry” Anal. Chem. 2007, 79, 8705-8711.

42. Fuangswasdi, S.; Kaveevivitchai, N.; Tuntulani, T.; Savage, P. B. “Complexing Properties of Phenolic Diazacrown Ethers with Transition and Heavy Metal Ions” J. Sol. Chem. 2008, 37, 45-58.

43. Morakot, N.; Ngeontae, W.; Aeungmaitrepirom, W; Tuntulani, T. “Synthesis of Novel Calix[4]arenes Having Benzothiazolylacetamidoalkoxy Pendants and Their Potential Application as Ag+-Selective Electrodes” Bull. Kor. Chem. Soc. 2008, 29, 221-224.

44. Suksai, C.; Leeladee, P.; Jennings, C.; Tuntulani, T.; Kongsaeree, P. “Synthesis and Characterization of Monomeric and Dimeric Structures of Calix[4]arenes Containing Amidoferrocene” J. Chem. Cryst. 2008, 38, 363-368.

45. N geontae, W.; Janrungroatsakul, W.; Morakot, N.; Aeungmaitrepirom, W.; Tuntulani, T. “New Silver Selective Electrode Fabricated From Benzothiazole Calix[4]arene: Speciation Analysis of Silver Nanoparticles” Sens. Actuat. B-Chem. 2008, 134, 377-385.

46. S uksai, C.; Watchasit, S.; Tuntulani, T.; Pakawatchai, C. “Diaqua{2,6-bis[N-(2-pyridinylmethyl)carbamoyl]phenolato-K2O1,O2}zinc(II)” Acta Cryst. E 2008, E64, m884-885.

47. Wannalerse, B.; Tomapatanaget, B.; Tuntulani, T. “Synthesis, Optical and Electrochemical Properties of New Anion Receptors and Sensors Containing Anthraquinone and Benzimidazole Units” Tetrahedron 2008, 64, 10619-10624.

48. Ngeontae, W.; Janrungroatsakul, W.; Maneewattanapinyo, P.; Egkasit, S.; Aeungmaitrepirom, W.; Tuntulani, T. “Novel Potentiometric Approach in Glucose Biosensor Using Silver Nanoparticles as Redox Marker” Sens. Actuat. B-Chem. 2009 137, 320-326.


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49. Ngeontae, W.; Aeungmaitrepirom, W.; Tuntulani, T.; Imyim, A. “Highly Selective Preconcentration of Cu(II) from Seawater and Water Samples Using Amidoamidoxime Silica” Talanta 2009, 78, 1004-1010.

50. Suksai, C.; Pakawatchai, C.; Tuntulani, T. “Synthesis and Crystal Structure Analysis of Thiourea-Pendant Pyridines” J. Chem. Cryst. 2009, 39, 348-352.

51. Jamkratoke, M.; Ruangpornvisuti, V.; Tumcharern, G.; Tuntulani, T.; Tomapatanaget, B. “A-D-A Sensors Based on Naphthoimidazoledione and Boronic Acid as Turn-On Cyanide Probes in Water” J. Org. Chem. 2009, 74, 3919-3922.

52. Sirikulkajorn, A.; Duanglaor, P.; Ruangpornvisuti, V.: Tomapatanaget, B.; Tuntulani, T. “Tryptophan Receptors Containing Acridine-Based Thiourea” Supramol. Chem. 2009, 21, 486-494.

53. Suksai, C.; Leeladee, P.; Tuntulani, T.; Ruangpornvisuti, V.; Chaichit, N. “Structural and Conformational Investigations of Chiral Bis(phenylamido)ferrocenes by X-ray Crystallography and Density Functional Calculations” J. Mol. Struc. 2009, 938, 117-124.

54. Aeungmaitrepirom, W; Ngeontae, W.; Tuntulani, T. “Silica Gel Chemically Modifi ed with Ethyl-2-Benzothiazolylacetate for Selective Extraction of Pb(II) and Cu(II) from Real Water Samples” Anal. Sci. 2009, 25, 1477-1482.

55. Watchasit, S.; Kaowliew, A.; Suksai, C.; Tuntulani, T.; Ngeontae, W.; Pakawatchai, C. “Selective Detection of Pyrophosphate by New Tripodal Amine Calix[4]arene-Based Cu(II) Complexes Using Indicator Displacement Strategy” Tetrahedron Lett. 2010, 51, 3398-3402.

56. Kaewtong, C.; Noiseephum, J.; Morakot, N.; Morakot, M.; Wanno, B.; Tuntulani, T.; Pulpoka, B. “A Reversible E

m-FRET Rhodamine-Based

Chemosensor for Carboxylate Anions Using a Ditopic Receptor Strategy” New J. Chem. 2010, 34, 1104-1108.

57. Baulom, C.; Ngeontae, W.; Nitiyanotakit, S.; Ngamukot, P.; Tuntulani, T.; Aeungmaitrepirom, W. “Bulk Optode Sensors for Batch and Flow-through Determinations of Lead Ion in Water Samples” Talanta 2010, 82, 660-667.

58. Chaicham, A.; Kulchat, S.; Tumcharern, G.; Tuntulani, T.; Tomapatanaget, B. “Synthesis, Photophysical Properties and Cyanide Detection in Aqueous Solutions of BF

2-Curcumin Dyes”

Tetrahedron 2010, 66, 6217-6223.


59. Sirikulkajorn, A.; Tuntulani, T.; Ruangpornvisuti, V.; Tomapatanaget, B.; Davis, A. P. “Enantioselective Receptor Based on Steroidal Urea and Azobenzene for L-Tryptophan” Tetrahedron 2010, 66, 7423-7428.

60. Sooksawad, D.; Aeungmaitrepirom, W.; Ngeontae, W.; Tuntulani, T. “Logic Gates from Ion Selective Bulk Optodes” New J. Chem. 2011, 35, 345-352.

61. Noipa, T.; Srijaranai, S.; Tuntulani, T.; Ngeontae, W. “New Approach for Evaluation of the Antioxidant Capacity Based on Scavenging DPPH Free Radical in Micelle Systems” Food Res. Int. 2011, 44, 798-806.

62. Nerngchamnong, N.; Chailap, B.; Leeladee, P.; Chailapakul, O.; Suksai, C.; Tuntulani, T. “Topological and Metal Ion Effects on the Anion Binding Abilities of New Heteroditopic Receptors Derived from p-tert-Butylcalix[4]arene” Tetrahedron Lett. 2011, 52, 2914-2917.

63. Jamkratoke, M.; Tumcharern, G.; Tuntulani, T.; Tomapatanaget, B. “A Selective Spectrofl uorometric Determination of Micromolar Level of Cyanide in Water Using Naphthoquinone Imidazole Boronic-Based Sensors and a Surfactant Cationic CTAB Micellar System” J. Fluoresc. 2011, 21, 1179-1187.

64. Noipa, T.; Martwiset, S.; Tuntulani, T.; Ngeontae, W. “Enhancement of Fluorescence Quenching Ability of DPPH• by Colloidal Nanocrystalline Quantum Dots in Aqueous Micelle” J. Fluoresc. 2011, 21, 1941–1949.

65. Khamjumphol, U.; Watchasit, S.; Suksai, C.; Janrungroatsakul, W.; Boonchiangma, S.; Tuntulani, T.; Ngeontae, W. “New Polymeric Membrane Cadmium(II)-Selective Electrodes Using Tripodal Amine Based Ionophores” Anal. Chim. Acta 2011, 704, 73-86.

66. Thongkum, D.; Tuntulani, T. “Fluoride-Induced Intermolecular Excimer Formation of Bispyrenyl Thioureas Linked by Polyethylene Glycol Chains” Tetrahedron 2011, 67, 8102-8109.

67. Ngamdee, K; Noipa, T.; Martwiset, S.; Tuntulani, T.; Ngeontae, W. “Enhancement of Sensitivity of Glucose Sensors from Alizarin-Boronic Acid Adducts in Aqueous Micelles” Sens. Actuat. B-Chem. 2011, 160, 129-128.

68. Kaewtong, C.; Uppa, Y.; Wanno, B.; Morakot, N.; Pulpoka, B.; Tuntulani, T. “Facile Synthesis of Rhodamine-Based Highly Sensitive and Fast Responsive Colorimetric and Off-On Fluorescent Reversible Chemosensors for Hg2+: Preparation of a Fluorescent Thin Film Sensor” Dalton Trans. 2011, 40, 12578-12583.


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69. Kulchat, S.; Chaicham, A.; Ekgasit, S.; Tumcharern, G.; Tuntulani, T.; Tomapatanaget, B. “Self-Assembled Coordination Nanoparticles from Nuleotides and Lanthanide Ions with Dope-Boronic Acid-Fluorescein for Detection of Cyanide in the Presence of Cu2+ in Water” Talanta 2012, 89, 264-269.

70. Chailap, B.; Tuntulani, T. “Optical and Electrochemical Properties of Heteroditopic Ion Receptors Derived from Crown Ether-Based Calix[4]arene with Amido-Anthraquinone Pendants” Org. Biomol. Chem. 2012, 10, 3617-3625.

71. Marbumrung, S.; Wongravee, K.; Ruangpornvisuti, V.; Tumcharern, G.; Tuntulani, T.; Tomapatanaget, B. “Discrimination of Nucleotides by Single Fluorescence Sensor under Solvent-Dependent Recognition Patterns” Sens. Actuat. B-Chem. 2012, 171-172, 969-975.

72. Ngamdee, K.; Martwiset, S.; Tuntulani, T.; Ngeontae, W. “Selective Fluorescence Sensors for p-Phenylenediamine Using Formyl Boronate Ester with an Assistance of Micelles” Sens. Actuat. B-Chem. 2012, 173, 682-691.

73. Wannajak, K.; Jamkratoke, M.; Tuntulani, T.; Tomapatanaget, B. “Highly Specifi c Glucose Fluorescence Sensing Based on Boronic Anthraquinone Derivatives via the GOx Enzymatic Reaction” Tetrahedron 2012, 68, 8899-8904.

74. Janrungroatsakul, W.; Vilaivan, T.; Vilaivan, C.; Watchasit, S.; Suksai, C.; Ngeontae, W.; Aeungmaitrepirom, W.; Tuntulani, T. “New Calix[4]arene Derivatives as Ionophores in Polymeric Membrane Electrodes for Ag(I): Comparative Selectivity Studies and Detection of DNA Hybridization” Talanta 2013, 105, 1-7.

75. Noipa, T.; Tuntulani, T.; Ngeontae, W. “Cu2+-Modulated Cysteamine-Capped CdS Quantum Dots as a Turn-on Fluorescence Sensor for Cyanide Recognition” Talanta 2013, 105, 320-326.

76. Khanasa, T.; Prachumrak, N.; Rattanawan, R.; Jungsuttiwong,S.; Keawin, T.; Sudyoadsuk, T.; Tuntulani, T.; Promarak, V. “Effi cient Solution Processed Non-doped Red Emitter Based on Carbazole-Triphenylamine End-Capped Di(thiophen-2-yl)benzothiadiazole for Pure Red Organic Light-Emitting Diodes” Chem. Commun. 2013, 49, 3401-3403.

77. Wannalerse, B.; Pannil, P.; Loriang, J.; Tuntulani, T.; Duangthongyou, T. “2-Methyoxy-1-(2-methoxy-4-nitronaphthalene-1-yl)-6-nitronaphthalene” Acta Cryst. E 2013, E69, o682.


78. Anekthirakun, P.; Sukwattanasinitt, M.; Tuntulani, T.; Imyim, A. “Naked Eye Screening of 11 Phenolic Compounds and Colorimetric Determination Using Polydiacetylene Vesicles with -Cyclodextrin” Spectrochim. Acta A 2013, 111, 91-96.

79. Niamsa, N.; Kaewtong, C.; Srinonmuang, W.; Wanno, B.; Pulpoka, B.; Tuntulani, T. “Hybrid Organic-Inorganic Nanomaterial Sensors for Selective Detection of Au3+ Using Rhodamine-Based Modifi ed Polyacrylic Acid (PAA)-Coated FeNPs” Polym. Chem. 2013, 4, 3039-3046.

80. Thesana, W.; Tuntulani, T.; Ngeontae, W. “A Selective Turn-On ATP Fluorescence Sensor Based on Unmodifi ed Cysteamine Capped CdS Quantum Dots” Anal. Chim. Acta 2013, 783, 65-73.

81. Khanasa, T.; Prachumrak, N.; Rattanawan, R.; Jungsuttiwong, S.; Keawin, T.; Sudyodsuk, T.; Tuntulani, T.; Promarak, V. “Bis(carbalzol-9-ylphenyl)aniline End-Capped Oligoarylenes as Solution-Processed Nondoped Emitters for Full Emission Color Tuning Organic Light-Emitting Diodes” J. Org. Chem. 2013, 78, 6702-6713.

82. Khantaw, T.; Boonmee, C.; Tuntulani, T.; Ngeontae, W. “Selective Turn-On Fluorescence Sensors for Ag+ Using Cysteamine-Capped CdS Quantum Dots: Determination of Free Ag+ in Silver Nanoparticles Solution” Talanta 2013, 115, 849-856.

83. Wongsan, W.; Aeungmaitrepirom, W.; Chailapakul, O.; Ngeontae, W.; Tuntulani, T. “Bifunctional Polymeric Membrane Ion Selective Electrodes Using Phenylboronic Acid as a Precursor of Anionic Sites and Fluoride as an Effector: A Potentiometric Sensor for Sodium Ion and an Impedimetric Sensor for Fluoride Ion” Electrochim. Acta 2013, 111, 234-241.

84. Chaicham, A.; Shasithiwat, S.; Tuntulani, T.; Tomapatanaget, B. “Highly Effective Discrimination of Catecholamine Derivatives via FRET-On/Off Processes Induced by the Intermolecular Assembly with Two Fluorescence Sensors” Chem. Commun. 2013, 49, 9287-9289.

85. Janrungroatsakul, W.; Lertvachirapaiboon, C.; Ngeontae, W.; Aeungmaitrepirom, W.; Chailapakul, O.; Egkasit, S.; Tuntulani, T. “Development of Coated-Wire Silver Ion Selective Electrodes on Paper Using Conductive Films of Silver Nanoparticles” Analyst 2013, 138, 6786-6792.


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86. Kunthadee, P.; Watchasit, S.; Kaowliew, A.; Suksai, C.; Wongsan, W.; Ngeontae, W.; Chailapakul, O.; Aeungmaitrepirom, W.; Tuntulani, T. “Intriguing Sensing Properties of a Di-tripodal Amine Calix[4]arene Ionophore towards Anions from Donnan Failure in Ion Selective Membranes Induced by Cu2+” New J. Chem. 2013, 37, 4010-4017.

87. Noipa, T.; Boonmee, C.; Tuntulani, T.; Ngeontae, W. “Cysteamine CdS Quantum Dots Decorated with Fe3+ as a Fluorescence Sensor for the Detection of PPi” Spectrochim. Acta A 2014, 118, 17-23.

88. Khaodee, W.; Aeungmaitrepirom, W.; Tuntulani, T. “Effectively Simultaneous Naked-Eye Detection of Cu(II), Pb(II), Al(III) and Fe(III) Using Cyanidin Extracted from Red Cabbage as Chelating Agent” Spectrochim. Acta A 2014, 126, 98-104.

89. Waluvanaruk, J.; Aeungmaitrepirom, W.; Tuntulani, T.; Ngamukot., P. “Preconcentration of Trace Silver Ion Using Modifi ed Silica and Determination by Flow Injection FLAME Atomic Absorption Spectrometry” Anal. Sci. 2014, 30, 389-395.

90. Boonchiangma, S.; Srijaranai, S.; Tuntulani, T.; Ngeontae, W. “A Highly Selective Electrochemical Sensor for L-Tryptophan Based on a Screen Printed Carbon Electrode Modifi ed with Polyphenylene Diamine and CdS Quantum Dots” J. Appl. Polym. Sci. 2014 DOI: 10.1002/APP.40356 (1-8).

91. Kaewtong, C.; Niamsa, N.; Wanno, B.; Pulpoka, B.; Tuntulani, T. “Optical Chemosensors for Hg2+ from Terthiophene Appended Rhodamine Derivatives: FRET Based Molecular and in Situ Hybrid Gold Nanoparticles Sensors” New J. Chem. 2014 DOI: 10.1039/C4NJ00412D (1-8).

1. Suksai, C.; Tuntulani, T. “Chromogenic Anion Sensors” Chem. Soc. Rev. 2003, 32, 192-202.

2. Suksai, C.; Tuntulani, T. “Chromogenic Anion Sensors” Top. Curr. Chem. 2005, 255, 163-198.

REVIEW ARTICLES


Professor Dr. Thawatchai Tuntulani

THEACHIEVEMENTS

OF

Professor Dr. Thawatchai Tuntulani is interested in research in Supramolecular Chemistry or Host-Guest Chemistry which studies the interactions of molecules that act as host or receptor and guest (ions or molecules). He is one of the pioneers in supramolecular chemistry research in Thailand. He starts his research by synthesizing a number of receptors that can interact selectively with certain ions or molecules. The ultimate objective is to apply the synthetic receptors in ion sensing since ion sensors are an important tool in medicine and environments, such as the measurement of the amount of sodium ion in the blood and the amount of nitrate contamination


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in water used in agriculture. In principle, a chemical sensor consists of two parts: receptor unit and signalling unit or transducer. The performance of a sensor can be evaluated by its selectivity and sensitivity towards analytes as well as its proper stability. Professor Dr. Thawatchai Tuntulani and his colleagues have carried out their research and development in the following areas.

1. The synthesis of compounds that act as host molecules and their host-guest chemistry

The initial research of Professor Dr. Thawatchai Tuntulani is the synthesis of derivatives of p-tert-butylcalix[4]arene which is an oligomer of phenol connected by methylene bridges. Its cup-like structure can support various atoms or molecules inside the cavity. Calix[4]arene is one of the most popular and useful building blocks in supramolecular chemistry. It can be modifi ed into various derivatives by substitution reactions at the phenoxy groups or at the aromatic rings, changing the structure and functional groups to selectively bind a certain ion whose size is compatible with the host molecule. Furthermore, one needs to consider interactions that occur between the host and the guest: electrostatic interactions, ion-dipole interactions and hydrogen bonding interactions. When combined this knowledge together with knowledge in organic synthesis, Professor Dr. Thawatchai successfully synthesizes compounds that selectively bind to specifi c ions or molecules with appropriate molecular interactions for further applications in molecular sensors.

2. Bringing the synthetic molecular receptors to use in isolation or extraction of heavy metal ions

From the knowledge described above, Professor Dr. Thawatchai Tuntulani can synthesize a molecule that can specifi cally bind a certain heavy metal ion and can attach such a molecule on the surface of silica gel and fabricate materials that can absorb or extract a heavy metal ion selectively. With detail studies on the best condition for the extraction and understanding of the extraction mechanism, Professor Dr. Thawatchai can apply the synthetic materials in the fl ow system to extract heavy metal ions in water sample practically (in collaboration with Assistant Professor Dr. Wanlapa Aeungmaitrepirom and Assistant Professor Dr. Apichat Imyim of Chulalongkorn University).



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3. Synthetic compounds with optical and electrochemical signalling units and their applications in sensors

Professor Dr. Thawatchai Tuntulani has extended the scope of his research to molecular sensors by connecting receptor molecules which are derivatives of calix[4]arene or other building blocks with molecules that can give either spectroscopic signals, such as UV-visible or fl uorescence signals, or electrochemical signals, based on the principle that when an ion or molecule binds to a host connecting to the signaling unit will cause changes in electronic properties and resulting in changes of the signal from its origin. This principle can be applied to fabricate ion or molecule sensors. For example, derivatives of calix[4]arene linked to ion receptors and ferrocene can be used as sensor by measuring changes in the redox signal of ferrocene. Some compounds such as anthraquinone can give both fl uorescence and redox signals. It can be used as a dual mode signalling system that may prevent errors in the measurement of ions.

Collaboration with Assistant Professor Dr. Chatthai Kaewtong of Mahasarakham University reveals that the ring opening/closing of rhodamine derivatives containing ion receptors upon interacting with certain ions will cause distinctive changes in color and fl uorescence spectrum. A collaborative work with Assistant Professor Dr. Boosayarat Tomapatanaget of Chulalongkorn University has led to the discovery that naphthoquinone connecting to the boronic acid unit selectively binds cyanide ion and gives a negative charge compound resulting in the imbalance of the electrons to the boronic acid site and causing a signifi cant shift in the fl uorescence spectrum of the naphthoquinone unit.

Besides sensors using the receptors connecting directly to the sensory units, Professsor Dr. Thawatchai Tuntulani in collaboration with Assistant Professor Dr. Chomchai Suksai of Burapha University have pioneered ion sensors using indicator displacement assays (IDA) in Thailand. IDA employs transition metal complexes that fi rst interact with dyes. Upon adding a certain ion or molecule, it can replace the dye and the color of the solution changes. The IDA technique can thus be used to detect many analytes with only one receptor, by changing appropriate indicators. Furthermore, nanoparticles such as cadmium sulfi de quantum dots showed distinct color changes upon disturbing the surface properties of these particles by particular ions or molecules (under collaboration with Associate Professor Dr. Wittaya Ngeontae of Khon Kaen University).


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4. Membrane electrodes and their applications

To make ion sensing and detecting an easier task, Professor Dr. Thawatchai Tuntulani has taken molecular hosts such as derivatives of calix[4]arene, which can selectively interact with metal ions such as silver or cadmium and mixed with polyvinyl chloride (PVC) and the proper amount of the ion exchanger to make ion selective electrodes, which can selectively recognize heavy metal ions such as silver and cadmium. The measurement can be done by measuring the electrical potential of the membrane electrode with respect to standard reference electrode. Then, the concentration of the metal ion in the solution can be measured from the graph displaying the linear relation between the membrane potential and the concentration of metal ions.

The fabricated silver ion selective electrode (Ag-ISE) can be used to measure the amount of sugar by using silver nanoparticles as marker. When sugar or glucose reacts with the

enzyme glucose oxidase, the reaction produces gluconic acid and hydrogen peroxide. Hydrogen peroxide can oxidize silver nanoparticles to

silver ions which can be detected by the Ag-ISE. The fabricated Ag-ISE can also be used to detect the hybridization of DNA. Professor Dr. Thawatchai uses peptide nucleic acid (PNA from the collaboration with Professor Dr. Tirayut Vilaivan of Chulalongkorn University) as a probe for DNA with a particular sequence of oligonucleotides. Then, using silver nanoparticles modifi ed with cationic surfactant to interact with the negatively charged DNA. Oxidizing silver nanoparticles with hydrogen peroxide gives silver ions which are proportional to the amount of silver ions binding to the target DNA.

To construct an ion selective electrode mentioned above, one needs a fi lling solution in the electrode body to assist the change in ion to electron signal. Professor Dr. Thawatchai Tuntulani found that if the wire used in the traditional ion selective electrode was replaced by metal nanoparticles in the form of nanosilver ink and screened on poster paper (under collaboration with Associate Professor Dr. Sanong Ekgasit of Chulalongkorn University), he can make a membrane electrode on the paper without a fi lling solution since silver nanoparticles can act as ion to electron transducer, enabling an easy but effective measurement.


For ion selective electrodes, the amount of the ion exchanger in the membrane plays a crucial role in ion sensing by reducing the membrane resistance. The presence of a certain analyte can affect the concentration of an ion exchanger in the membrane. Professor Dr. Thawatchai Tuntulani has found that the amount of such analyte can be measured from the resistance of the membrane by using a technique called impedimetry. Furthermore, Professor Dr. Thawatchai discovered that a membrane with a specifi c metal ion receptor containing 2 receptor units which can form very stable complexes with metal ions can induce a particular anion through the membrane and cause the potential of the membrane to become more negative. This electrode can then be used as an anion selective electrode.

From the past research, Professor Dr. Thawatchai Tuntulani has endured the research and development in molecular interactions between host and guest as well as on/off signal transducers upon binding of guests. He has also put efforts in the fi eld of membrane selective electrodes for ion and molecule sensing. All understanding from the research can be used to develop more effective and easy-to-use ion and molecule sensors in the future.


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»ÃÐÇÑμÔ¡ÒÃä ŒÃÑºÃÒ§ÇÑÅËÃ×Í»ÃÐ¡ÒÈà¡ÕÂÃμÔ¤Ø³¾.È. 2543 ÃÒ§ÇÑÅ¹Ñ¡ÇÔ·ÂÒÈÒÊμÃ�ÃØ‹¹ãËÁ‹ Ò¡ÁÙÅ¹Ô¸ÔÊ‹§àÊÃÔÁÇÔ·ÂÒÈÒÊμÃ�áÅÐà·¤â¹âÅÂÕã¹¾ÃÐºÃÁ

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Prize for Young Scientist Award) ¾.È. 2552 ÃÒ§ÇÑÅ¹Ñ¡ÇÔ¨ÑÂ Õà´‹¹ ¡Í§·Ø¹ÃÑª´ÒÀÔàÉ¡ÊÁâÀª ¨ØÌÒÅ§¡Ã³ �ÁËÒÇÔ·ÂÒÅÑÂ ¾.È. 2552 ÃÒ§ÇÑÅ¹Ñ¡à¤ÁÕÃØ‹¹ãËÁ‹ Õà ‹¹ ¨Ò¡ÊÁÒ¤Áà¤ÁÕáË‹§»ÃÐà·Èä·Â ã¹¾ÃÐÍØ»¶ÑÁÀ�¢Í§ÈÒÊμÃÒ¨ÒÃÂ�

´Ã. ÊÁà´ç¨¾ÃÐà¨ŒÒÅÙ¡à¸Í à¨ŒÒ¿‡Ò¨ØÌÒÀÃ³ÇÅÑÂÅÑ¡É³ � ÍÑ¤ÃÃÒª¡ØÁÒÃÕ¾.È. 2552-2554 Alexander von Humboldt Research Fellow ³ Institute for Organic Chemistry,

University of Regensburg (ÈÒÊμÃÒ¨ÒÃÂ � Oliver Reiser áÅÐ ÈÒÊμÃÒ¨ÒÃÂ � Hans-Achim Wagenknecht)

¾.È. 2552-2555 àÁ ÕÇÔ¨ÑÂÍÒÇØâÊ Ê¡Ç. ¨Ò¡ÊíÒ¹Ñ¡§Ò¹¡Í§·Ø¹Ê¹ÑºÊ¹Ø¹¡ÒÃÇÔ¨ÑÂ (Ê¡Ç.)¾.È. 2553 ÃÒ§ÇÑÅ¼Å§Ò¹ÇÔ ÑÂ·Õèä ŒÃÑº¡ÒÃÍŒÒ§ÍÔ§ÊÙ§ÊØ ¨Ò¡ÊÁÒ¤Áà¤ÁÕáË‹§»ÃÐà·Èä·ÂÏ ¾.È. 2554 ÃÒ§ÇÑÅ¹Ñ¡ÇÔ¨ÑÂ´Õà´‹¹áË‹§ªÒμ Ô ÊÒ¢ÒÇÔ·ÂÒÈÒÊμÃ �à¤ÁÕáÅÐàÀÊÑª ¨Ò¡ÊíÒ¹Ñ¡§Ò¹

¤³Ð¡ÃÃÁ¡ÒÃÇÔ¨ÑÂáË‹§ªÒμÔ¾.È. 2557 ÃÒ§ÇÑÅ High Impact Chemist Award ¨Ò¡ÊÁÒ¤Áà¤ÁÕáË‹§»ÃÐà·Èä·ÂÏ ¾.È. 2557-2560 ÈÒÊμÃÒ¨ÒÃÂ �ÇÔ¨ÑÂ Õà´‹¹ Ê¡Ç. ¨Ò¡ÊíÒ¹Ñ¡§Ò¹¡Í§·Ø¹Ê¹ÑºÊ¹Ø¹¡ÒÃÇÔ¨ÑÂ (Ê¡Ç.)

Ë¹ŒÒ·ÕèáÅÐ¡Ô¨¡ÃÃÁã¹Í§¤�¡ÃÃÐ Ñº»ÃÐà·È ¾.È. 2543-»¨¨ØºÑ¹ ¼ÙŒ·Ã§¤Ø³ÇØ²ÔáÅÐ¡ÃÃÁ¡ÒÃ»ÃÐàÁÔ¹¼Å§Ò¹ÇÔªÒ¡ÒÃáÅÐ¢ŒÍàÊ¹Íâ¤Ã§¡ÒÃÇÔ¨ÑÂ¢Í§Ë¹‹ÇÂ

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¾.È. 2552-»¨¨ØºÑ¹ ÊÁÒªÔ¡ÊÒÁÑÞ ºÑ³±ÔμÂÊÀÒÇÔ·ÂÒÈÒÊμÃ�áÅÐà·¤â¹âÅÂÕáË‹§»ÃÐà·Èä·Â (ºÇ·.)¾.È. 2553-»¨¨ØºÑ¹ ÃÍ§»ÃÐ¸Ò¹½†ÒÂÇÔªÒ¡ÒÃ ¡ÒÃ»ÃÐªØÁÇÔ·ÂÒÈÒÊμÃ�áÅÐà·¤â¹âÅÂÕáË‹§»ÃÐà·Èä·Â (Ç··.)

¤ÃÑé§·Õè 36-40¾.È. 2555-»¨¨ØºÑ¹ ¡ÃÃÁ¡ÒÃÊÀÒÇÔ¨ÑÂáË‹§ªÒμÔ ÊÒ¢ÒÇÔ·ÂÒÈÒÊμÃ�à¤ÁÕáÅÐàÀÊÑª¾.È. 2557-»¨¨ØºÑ¹ ºÃÃ³Ò¸Ô¡ÒÃÃ‹ÇÁ Songklanakarin Journal of Science and Technology

Ë¹ŒÒ·ÕèáÅÐ¡Ô¨¡ÃÃÁã¹Í§¤�¡ÃÃÐ Ñº¹Ò¹ÒªÒμÔ ¾.È. 2543-»¨¨ØºÑ¹ ä ŒÃÑºàªÔÞà»š¹¼ÙŒ·Ã§¤Ø³ÇØ²Ô¾Ô ÒÃ³Òâ¤Ã§¡ÒÃà¾×èÍÃÑº·Ø¹ÃÐ Ñº¹Ò¹ÒªÒμÔ (National Science

Foundation, USA) áÅÐ¼ÙŒ·Ã§¤Ø³ÇØ²Ô¾Ô¨ÒÃ³Òº·¤ÇÒÁà¾×èÍμ Õ¾ÔÁ¾ �ã¹ÇÒÃÊÒÃÇÔªÒ¡ÒÃÃÐ´Ñº¹Ò¹ÒªÒμÔ àª‹¹ Amino Acids / Biosensors & Bioelectronics / Chemical Reviews / Journal of the American Chemical Society / Journal of Organic Chemistry / Organic Letters

¾.È. 2553-»¨¨ØºÑ¹ International Editorial Advisory Board Member of Chemistry - An Asian Journal

¾.È. 2553-»¨¨ØºÑ¹ National Representative of IUPAC - Organic and Biomolecular Chemistry Division

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Curriculum VitaeProfessor Dr. Tirayut Vilaivan

DATE OF BIRTH July 6, 1971

PLACE OF BIRTH Bangkok, Thailand

MARITAL STATUS Married to Mrs. Chotima Vilaivan

OFFICE ADDRESS Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand

PRESENT POSITION Professor of Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University

EDUCATION 1992 B.Sc. (First Class Honors) (Chemistry), Chulalongkorn University, Bangkok, Thailand (Development and Promotion of Science and Technology Talents Scholarship) 1996 D.Phil. (Organic Chemistry), University of Oxford, U.K. (Development and Promotion of Science and Technology Talents Scholarship). Thesis Title : Synthesis and Properties of Novel Nucleopeptides. Supervisor : Professor Gordon Lowe, FRS

PROFESSIONAL 1996 Lecturer, Department of Chemistry, Faculty of Science,EXPERIENCE Chulalongkorn University, Bangkok 1999 Assistant Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University 2004 Associate Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University 2013 Professor of Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University


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HONORS AND 2000 Young Scientist Award (Foundation for the Promotion AWARDS of Science and Technology under the Patronage of His Majesty the King) 2007 Chulalongkorn University Distinguished Lecturer Award 2006 2007 Third World Academy of Science (TWAS) Prize for Young Scientists in Thailand 2009 Chulalongkorn University Distinguished Researcher Award 2009 CST Award for Distinguished Young Chemist (Chemical Society of Thailand) 2009-2011 Alexander von Humboldt Fellowship for Experienced Researchers at Institute for Organic Chemistry, University of Regensburg (Hosts: Professor Dr. Oliver Reiser, Professor Dr. Hans-Achim Wagenknecht) 2009-2012 TRF Senior Research Scholar (The Thailand Research Fund) 2010 CST Citation Award (Chemical Society of Thailand) 2011 National Distinguished Researcher Award in Chemical and Pharmaceutical Sciences (National Research Council of Thailand) 2014 CST High Impact Chemist Award (Chemical Society of Thailand) 2014-2017 TRF Distinguished Professor (The Thailand Research Fund)

MEMBERSHIP/ 2009-present Elected Member, Thai Academy of Science and COMMITTEE Technology (TAST) MEMBER-THAILAND 2010-present Deputy Chairman of the Scientifi c Committee, 36th-40th Congress on Science and Technology of Thailand (STT36-STT40) 2012-present Scientifi c Committee, Chemical and Pharmaceutical Sciences Division, National Research Council of Thailand 2014-present Associate Editor: Songklanakarin Journal of Science and Technology


2000-present Reviewer for international granting agencies as well as international journals including Amino Acids / Biosensors & Bioelectronics / Chemical Reviews / Journal of the American Chemical Society / Journal of Organic Chem istry / Organic Letters, etc. 2010-present International Editorial Advisory Board Member of Chemistry - An Asian Journal 2012-present National Representative of IUPAC - Organic and Biomolecular Chemistry Division

MEMBERSHIP/COMMITTEE MEMBER - INTERNATIONAL


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LIST OF PUBLICATIONSProfessor Dr. Tirayut Vilaivan

1. Lowe G, McCloskey JA, Ni J, Vilaivan T. 1996. A mass spectrometric investigation of the reaction between 4,4 -vinylidenedipyridine bis[2,2 :6 ,2 -terpyridineplatinum(II)] and the self-complementary oligonucleotide d(CpGpTpApCpG). Bioorg Med Chem. 4:1007-1013.2. Lowe G, Vilaivan T. 1996. Reaction of 4-picoline(2,2 :6 ,2 -terpyridine) platinum(II) with nucleosides. J Chem Soc Perkin Trans 1. 1499-1503.3. Lowe G, Vilaivan T. 1996. An improved method for the synthesis of (2,2 :6 ,2 -terpyridine)platinum(II) complexes. J Chem Res (S). 386-387.4. Charnega A, Droz AS, Prout K, Vilaivan T, Weaver GW, Lowe G. 1996. Structural evidence for the reactivity of 4-picoline(22 :6 2 - terpyridine)platinum(II) complexes and evidence for -stacking in the crystal lattice. J Chem Res (S). 402-403.5. Lowe G, Vilaivan T. 1997. Amino acids bearing nucleobases for synthesis of novel peptide nucleic acids. J Chem Soc Perkin Trans 1. 539-546.6. Lowe G, Vilaivan T. 1997. Dipeptides bearing nucleobases for synthesis of novel peptide nucleic acids. J Chem Soc Perkin Trans 1. 547-554.7. Lowe G, Vilaivan T. 1997. Solid phase synthesis of novel peptide nucleic acids. J Chem Soc Perkin Trans 1. 555-560.8. Lowe G, Vilaivan T, Westwell MS. 1997. Hybridization studies with chiral peptide nucleic acids. Bioorg Chem. 25:321-329.9. Roengsumran S, Achayindee S, Petsom A, Pudhom K, Singtothong P, Surachetapan C, Vilaivan T. 1998. Two new cembranoids from Croton oblongifolius. J Nat Prod. 61:652-654.10. Roengsumran S, Petsom A, Sommit D, Vilaivan T. 1999. New labdane diterpenoids from Croton oblongifolius. Phytochemistry. 50:449-453.

ORIGINAL RESEARCH ARTICLES


11. Lowe G, Droz AS, Vilaivan T, Weaver GW, Tweedale L, Pratt JM, Rock P, Yardley V, Croft SL. 1999. Cytotoxicity of (2,2 :6 ,2-terpyridine) platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. J Med Chem. 42:999-1006.12. Pudhom K, Vilaivan T. 1999. Synthesis of aryl esters of protected amino acids from aryl sulfonates. Tetrahedron Lett. 40:5939-5942.13. Lowe G, Droz AS, Vilaivan T, Weaver GW, Park JJ, Pratt JM Tweedale L, Kelland LR. 1999. Cytotoxicity of (2,2 :6 ,2 -terpyridine) platinum(II) complexes against human ovarian carcinoma. J Med Chem. 42:3167-3174.14. Sithigorngul P, Panchan N, Vilaivan T, Sithigorngul W, Petsom A. 1999. Immunochemical analysis and immunocytochemical localization of crustacean hyperglycemic hormone from the eyestalk of Macrobrachium rosenbergii. Comp Biochem Phys B. 124:73-80.15. Rastelli G, Sirawaraporn W, Sompornpisut P, Vilaivan T, Kamchonwongpaisan S, Quarrell R, Lowe G, Thebtaranonth Y, Yuthavong Y. 2000. Interaction of pyrimethamine cycloguanil WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance Bioorg Med Chem. 8:1117-1128.16. Yuthavong Y, Vilaivan T, Chareonsethakul N, Kamchonwongpaisan S, Sirawaraporn W, Quarrell R, Lowe G. 2000. Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil resistant strain (T9/94) of Plasmodium falciparum. J Med Chem. 43:2738-2744.17. Vilaivan T, Khongdeesameor C, Harnyuttanakorn P, Westwell MS, Lowe G. 2000. Synthesis and properties of chiral peptide nucleic acids with a N-aminoethyl-D-proline backbone. Bioorg Med Chem Lett. 10:2541-2545.18. Roengsumran S, Petsom A, Kuptiyanuwat N, Vilaivan T, Ngamrojnavanich N, Chaichantipyuth C, Phuthong S. 2001. Cytotoxic labdane diterpenoids from Croton oblongifolius. Phytochemistry. 56:103-107.19. Pudhom K, Vilaivan T. 2001. Pentafl uorophenyl 4-nitrobenzenesulfonate as a peptide coupling reagent. Synth Commun. 31:61-70.20. Vilaivan T, Khongdeesameor C, Wiriyawaree W, Mansawat W, Westwell MS, Lowe G. 2001. Synthesis and properties of novel peptide nucleic acids with hydrophilic serine spacers ScienceAsia. 27:113-120.


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21. Vilaivan T, Suparpprom C, Harnyuttanakorn P, Lowe G. 2001. Synthesis and properties of novel pyrrolidinyl PNA carrying -amino acid spacers. Tetrahedron Lett. 42:5533-5536.22. Suparpprom C, Vilaivan T. 2001. Synthesis of 2-[4 -(ethylcarbamoyl) phenyl]-N-acetylglycine the proposed structure for giganticine. J Nat Prod. 64:1114-1116.23. Vilaivan T, Winotapan C, Shinada T, Ohfune Y. 2001. Indium mediated Barbier-type allylation of aldimines in alcoholic solvents. Tetrahedron Lett. 42:9073-9076.24. Roengsumran S, Musikul K, Petsom A, Vilaivan T, Sangvanich P, Pornpakakul S, Puthong S, Chaichantipyuth C, Jaiboon N, Chaichit N. 2002. Croblongifolin a new anticancer clerodane from Croton oblongifolius. Planta Med. 68:274-277.25. Saesaengseerung N, Vilaivan T, Thebtaranonth Y. 2002. An effi cient synthesis of 1-aryl-4,6-diamino-1,2-dihydro-135-triazines. Synth Commun. 32:2089-2100.26. Vilaivan T, Lowe G. 2002. A novel pyrrolidinyl PNA showing high sequence specifi city and preferential binding to DNA over RNA. J Am Chem Soc. 124:9326-9327.27. Vilaivan T, Saesaengseerung N, Jarprung D; Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y. 2003. Synthesis of solution- phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identifi cation of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum. Bioorg Med Chem. 11:217-224.28. Vilaivan T, Suparpprom C, Duanglaor P, Harnyuttanakorn P, Lowe G. 2003. Synthesis and nucleic acid binding studies of novel pyrrolidinyl PNA carrying an N-amino-N-methylglycine spacer. Tetrahedron Lett. 44:1663-1666.29. Mansawat W, Bhanthumnavin W, Vilaivan T. 2003. N-Salicyl- - aminoalcohols as a new class of ligand for catalytic asymmetric Strecker reactions. Tetrahedron Lett. 44:3805-3808.30. Janwitayanuchit W; Suwanborirux K, Patarapanich C, Pummangura S, Lipipun V, Vilaivan T. 2003. Synthesis and anti-herpes simplex viral activity of monoglycosyl diglycerides. Phytochemistry. 64:1253-1264.31. Kamchonwongpaisan S, Quarrell R, Charoensethakul N, Ponsinet R, Vilaivan T, Vanichtanankul J, Tarnchompoo B, Sirawaraporn W, Lowe G, Yutavong Y. 2004. Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities. J Med Chem. 47:673-680.


32. Banphavichit V, Chaleawlertumpon S, Bhanthumnavin W, Vilaivan T. 2004. A convenient synthesis of N-Boc-protected -aminonitriles from -amidosulfones. Synth Commun. 34:3147-3160.33. Banphavichit V, Mansawat W, Bhanthumnavin W, Vilaivan T. 2004. A highly enantioselective Strecker reaction catalyzed by titanium- N-salicyl- -aminoalcohol complexes. Tetrahedron. 60:10559-10568.34. Suparpprom C, Srisuwannaket C, Sangvanich P, Vilaivan T. 2005. Synthesis and oligodeoxynucleotide binding properties of pyrrolidinyl peptide nucleic acids bearing prolyl-2-aminocyclopentanecarboxylic acid (ACPC) backbones. Tetrahedron Lett. 46:2833-2837.35. Vilaivan T, Winotapan C, Banphavichit V, Shinada T, Ohfune Y. 2005. Indium-mediated asymmetric Barbier-type allylation of aldimines in alcoholic solvents: Synthesis of optically active homoallylic amines. J Org Chem. 70:3464-3471.36. Vilaivan T, Srisuwannaket C. 2006. Hybridization of pyrrolidinyl peptide nucleic acids and DNA: Selectivity base-pairing specifi city and direction of binding. Org Lett. 8:1897-1900.37. Ananthanawat C, Banphavichit V, Vilaivan T. 2006. Convenient procedure for synthesis of N-protected -aminomalonates and -amino acids from -amidosulfones. Synth Commun. 36:1845-1855.38. Vilaivan T. 2006. A rate enhancement of tert-butoxycarbonylation of aromatic amines with Boc

2O in alcoholic solvents. Tetrahedron

Lett. 47:6739-6742.39. Pudhom K, Vilaivan T, Ngamrojanavanich N, Dechangvipart S, Sommit D, Petsom A, Roengsumran S. 2007. Furanocembranoids from the stem bark of Croton oblongifolius. J Nat Prod. 70:659-661.40. Mansawat W, Saengswang I, U-prasitwong P, Bhanthumnavin W, Vilaivan T. 2007. Novel thiolated amino-alcohols as chiral ligands for copper-catalyzed asymmetric nitro-aldol reactions. Tetrahedron Lett. 48:4235-4238.41. Banphavichit V, Bhanthumnavin W, Vilaivan T. 2007. Synthesis of new tridentate chiral aminoalcohols by a multicomponent reaction and their evaluation as ligands for catalytic asymmetric Strecker reaction. Tetrahedron. 63:8727-8734.42. Sathapornvajana S, Vilaivan T. 2007. Prolinamides derived from zaminophenols as organocatalysts for asymmetric direct aldol reactions. Tetrahedron. 63:10253-10259.


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43. Siriwong K, Chuichay P, Saen-oon S, Suparpprom C, Vilaivan T, Hannongbua S. 2008. Insight into why pyrrolidinyl peptide nucleic acid binding to DNA is more stable than the DNA•DNA duplex. Biochem Biophys Res Commun. 372:765-771.44. Boontha B, Nakkuntod J, Hirankarn N, Chaumpluk P, Vilaivan T. 2008. Multiplex mass spectrometric genotyping of single nucleotide polymorphisms employing pyrrolidinyl peptide nucleic acid in combination with ion-exchange capture. Anal Chem. 80:8178-8186.45. Ananthanawat C, Vilaivan T, Hoven VP. 2009. Synthesis and immobilization of thiolated pyrrolidinyl peptide nucleic acids on gold-coated piezoelectric quartz crystals for the detection of DNA hybridization. Sens Actuators B. 137:215-221.46. Maitarad P, Kamchonwongpaisan S, Vanichtanankul J, Vilaivan T, Yuthavong Y, Hannongbua S. 2009. Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases. J Comput Aided Mol Des. 23:241-252.47. Banphavichit V, Mansawat W, Bhanthumnavin W, Vilaivan T. 2009. A practical synthesis of optically active arylglycines via catalytic asymmetric Strecker reaction. Tetrahedron. 65:5849-5854. 48. Ananthanawat C, Vilaivan T, Mekboonsonglarp W, Hoven VP. 2009. Thiolated pyrrolidinyl peptide nucleic acids for the detection of DNA hybridization using surface plasmon resonance. Biosens Bioelectron. 24:3544-3549.49. Chitnumsub P, YuvaniyamaJ, Chahomchuen T, Vilaivan T, Yuthavong Y. 2009. Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi the Chagas disease pathogen. Acta Cryst. F65:1175-1178.50. Ananthanawat C, Vilaivan T, Hoven VP, Su X. 2010. Comparison of DNA aminoethylglycyl PNA and pyrrolidinyl PNA as probes for detection of DNA hybridization using surface plasmon resonance technique. Biosens Bioelectron. 25:1064-1069 51. Nuanyai T, Chokpaiboon S, Vilaivan T, Pudhom K. 2010. Cytotoxic 3,4-seco-cycloartane triterpenes from the exudate of Gardenia tubifera. J Nat Prod. 73:51-54.


52. Taechalertpaisarn J, Sriwarom P, Boonlua C, Yotapan N, Vilaivan C, Vilaivan T. 2010. DNA- RNA- and self-pairing properties of a pyrrolidinyl peptide nucleic acid with a (2 R,4 S)-prolyl-(1S,2S)- 2-aminocyclopentanecarboxylic acid backbone. Tetrahedron Lett. 51:5822-5826.53. Ananthanawat C, Hoven VP, Vilaivan T, Su X. 2011. Surface plasmon resonance study of PNA interactions with double-stranded DNA. Biosens Bioelectron. 26:1918-1923.54. Ngamwiriyawong P, Vilaivan T. 2011. Synthesis and nucleic acids binding properties of diastereomeric aminoethylprolyl peptide nucleic acids (aepPNA). Nucleosides, Nucleotides Nucleic Acids. 30:97-112.55. Nuanyai T, Sappapan R, Vilaivan T, Pudhom K. 2011. Gardenoins E-H Cycloartane triterpenes from the apical buds of Gardenia obtusifolia. Chem Pharm Bull. 59:385-387.56. Nuanyai T, Sappapan R, Vilaivan T, Pudhom K. 2011. Cycloartane triterpenes from the exudate of Gardenia thailandica. Phytochemistry Lett. 4:26-29.57. Nuanyai T, Sappapan R, Vilaivan T, Pudhom K. 2011. Dammarane triterpenes from the apical buds of Gardenia collinsae. Phytochemistry Lett. 4:183-186.58. Vilaivan C, Srisuwannaket C, Ananthanawat C, Suparpprom C, Kawakami J, Yamaguchi Y, Tanaka Y, Vilaivan T. 2011. Pyrrolidinyl peptide nucleic acid with / -peptide backbone: A conformationally constrained PNA with unusual hybridization properties. Artifi cial DNA: PNA & XNA. 2:50-59. 59. Sangthong S, Krusong K, Ngamrojanavanich N, Vilaivan T, Puthong S, Chandchawan S, Muangsin N. 2011. Synthesis of rotenoid derivatives with cytotoxic and topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 21:4813-4818. 60. Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y. 2011. Trypanosomal dihydrofolate reductase reveals natural antifolate resistance. ACS Chem Biol. 6:905-911.61. Reenabthue N, Boonlua C, Vilaivan C, Vilaivan T, Suparpprom C. 2011. 3-Aminopyrrolidine-4-carboxylic acid as versatile handle for internal labeling of pyrrolidinyl PNA. Bioorg Med Chem Lett. 21:6465-6469.62. Boonlua C, Vilaivan C, Wagenknecht H-A, Vilaivan T. 2011. 5-(Pyren- 1-yl)uracil as a base-discriminating fl uorescent nucleobase in pyrrolidinyl peptide nucleic acids. Chem-Asian J. 6:3251-3259.


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63. Rutnakornpituk B, Wichai U, Vilaivan T, Rutnakornpituk M. 2011. Surface-initiated atom transfer radical polymerization of poly (4-vinylpyridine) from magnetite nanoparticle. J Nanopart Res. 13:6847-6857.64. Pudhom K, Nuanyai T, Matsubara K, Vilaivan T. 2011. Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp and their semi-synthetic analogs. Bioorg Med Chem Lett. 22:512-517.65. Rashatasakhon P, Vongnam K, Siripornnoppakhun W, Vilaivan T, Sukwattanasinitt M. 2012. FRET detection of DNA sequence via electrostatic interaction of polycationic phenyleneethynylene dendrimer with DNA/PNA hybrid. Talanta. 88:593-598.66. Yuanboonlim W, Siripornnoppakhun W, Niamnont N, Rashatasakhon P, Vilaivan T, Sukwattanasinitt M. 2012. Phenylene-ethynylene trication as an effi cient fl uorescent signal transducer in an aptasensor for potassium ion. Biosens Bioelectron. 33:1918-1923.67. Virakul S, Kupatawintu P, Nakkuntod J, Kangwanshiratada O, Vilaivan T, Hirankarn N. 2012. A nested sequence-specifi c primer-polymerase chain reaction for the detection of HLA-B*15:02. Tissue Antigens. 79:295-301.68. Mansawat W, Vilaivan C, Bal zs , Aitken D, Vilaivan T. 2012. Pyrrolidinyl peptide nucleic acid homologues: Effect of ring size on hybridization properties. Org Lett. 14:1440-1443.69. Mansawat W, Boonlua C, Siriwong K, Vilaivan T. 2012. Clicked polycyclic aromatic hydrocarbon as a hybridization-responsive fl uorescent artifi cial nucleobase in pyrrolidinyl peptide nucleic acids. Tetrahedron. 68:3988-3995. 70. Vanichtanankul J, Taweechai S, Uttamapinant C, Chitnumsub P, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S. 2012. Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil. Antimicrob Agents Chemother. 56:3928-3935. 71. Thipmanee O, Samanman S, Sankoh S, Numnuam A, Limbut W, Kanatharana P, Vilaivan T, Thavarungkul P. 2012. Label-free capacitive DNA sensor using immobilized pyrrolidinyl PNA probe: Effect of the length and terminating head group of the blocking thiols. Biosens Bioelectron. 38:430-435.


72. Sezi S, Varghese R, Vilaivan T, Wagenknecht H-A. 2012. Conformational control of dual emission by pyrrolidinyl PNA-DNA hybrids. ChemistryOpen. 1:173-176.73. Siripornnoppakhun W, Niamnont N, Krumsri A, Tumcharern G, Vilaivan T, Rashatasakhon P, Thayumanavan S, Sukwattanasinitt M. 2012. Inclusion complexes between amphiphilic phenyleneethynylene fl uorophores and cyclodextrins in aqueous media. J Phys Chem B. 116:12268-12274 .74. Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, Fantauzzi P, Yuvaniyama J, Charman WN, Matthews D. 2012. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci USA. 109:16823-16828.75. Sopitthummakhun K, Thongpanchang C, Vilaivan T, Yuthavong Y, Chaiyen P, Leartsakulpanich U. 2012. Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay. Malaria J. 11:194.76. Laopa PS, Vilaivan T, Hoven VP. 2013. Positively charged polymer brushes-functionalized fi lter paper for DNA sequence determination following Dot Blot hybridization employing pyrrolidinyl peptide nucleic acid probe. Analyst. 138:269-277. 77. Janrungroatsakul W, Vilaivan T, Vilaivan C, Watchasit S, Suksai C, Ngeontae W, Aeungmaitrepirom W, Tuntulani T. 2013. New calix[4] arene derivatives as ionophores in polymeric membrane electrodes for Ag(I): Comparative selectivity studies and detection of DNA hybridization. Talanta. 105:1-7.78. Sankoh S, Samanman S, Thipmanee O, Numnuam A, Limbut W, Kanatharana P, Vilaivan T, Thavarungkul P. 2013. A comparative study of a label-free DNA capacitive sensor using a pyrrolidinyl peptide nucleic acid probe immobilized through polyphenylenediamine and polytyramine non-conducting polymers. Sens Actuators B. 177:543-554.79. Vilaivan C, Srinarang W, Yotapan N, Mansawat W, Boonlua C,Kawakami J, Yamaguchi Y, Tanaka Y, Vilaivan T. 2013. Specifi c recognition of cytosine by hypoxanthine in pyrrolidinyl peptide nucleic acid. Org Biomol Chem. 11:2310-2317.


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80. Ditmangklo B, Boonlua C, Suparpprom C, Vilaivan T. 2013. Reductive alkylation and sequential reductive alkylation-click chemistry for on-solid-support modifi cation of pyrrolidinyl peptide nucleic acid. Bioconjugate Chem. 24:614-625. 81. Ulbrich K, Kreitmeier P, Vilaivan T, Reiser O. 2013. Enantioselective Synthesis of 4-heterosubstituted cyclopentenones. J Org Chem. 78:4202-4206.82. Theppaleak T, Rutnakornpituk B, Wichai U, Vilaivan T, Rutnakornpituk M. 2013. Magnetite nanoparticle with positively charged surface for immobilization of peptide nucleic acid and deoxyribonucleic acid. J Biomed Nanotechnol. 9:1509-1520.83. Yotapan N, Paptchikhine A, Bera M, Avula S K, Vilaivan T, Andersson PG. 2013. Simple proline-derived phosphine-thiazole iridium complexes for asymmetric hydrogenation of trisubstituted olefi ns. Asian J Org Chem. 2:674-680. 84. Theppaleak T, Rutnakornpituk M, Wichai U, Vilaivan T, Rutnakornpituk B. 2013. Anion-exchanged nanosolid support of magnetic nanoparticle in combination with PNA probes for DNA sequence analysis. J Nanopart Res. 15:2106.85. Maneelun N, Vilaivan T. 2013. Dual pyrene-labeled pyrrolidinyl peptide nucleic acid as an excimer-to-monomer switching probe for DNA sequence detection. Tetrahedron. 69:10805-10810. 86. Jampasa S, Wonsawat W, Rodthongkum N, Siangproh W, Yanatatsaneejit P, Vilaivan T, Chailapakul O. 2014. Electrochemical detection of human papillomavirus DNA type 16 using a pyrrolidinyl peptide nucleic acid probe immobilized on screen printed carbon electrodes. Biosens Bioelectron. 54:428-434.87. Boonlua C, Ditmangklo B, Reenabthue N, Suparpprom C, Poomsuk N, Siriwong K, Vilaivan T. 2014. Pyrene-labeled pyrrolidinyl peptide nucleic acid as a hybridization-responsive DNA probe: comparison between internal and terminal labeling. RSC Adv. 4:8817-8827.88. Vongnam K, Vilaivan T, Sukwattanasinitt M, Rashatasakhon P. 2014. New water soluble terphenylene diethynylene fl uorophores. J Fluoresc. 24:197-202.89. Sangthong S, Sangphech N, Palaga T, Ngamrojanavanich N, Puthong S, Vilaivan T, Muangsin N. Anthracene-910-dione derivatives induced apoptosis in human cervical cancer cell line (CaSki) by interfering with HPV E6 expression. Eur J Med Chem. 77:334-342.


90. Pray-in Y, Rutnakornpituk B, Wichai U, Vilaivan T, Rutnakornpituk M. 2014. Hydrophilic azlactone-functionalized magnetite nanoparticle for conjugation with folic acid. J Nanopart Res. 16:2357.91. Stubinitzky C, Vilaivan T, Wagenknecht H-A. 2014. The base discriminating potential of pyrrolidinyl PNA demonstrated by magnetic Fe

xO

y particles. Org Biomol Chem. 12:3586-3589.

1. Chavasiri W, Vilaivan T, Rashatasakhon P. 2008. Thiiranes and thiirenes: Fused-ring derivatives. In Comprehensive Heterocyclic Chemistry III, Katritzky AR, Ramsden CA, Scriven EF, Taylor RJK, Eds; Elsevier: Oxford, 1:391-432.

1. Lowe G, Vilaivan T. 2004. Chiral peptide nucleic acids with a N-aminoethyl-D-proline backbone. United States Patent US6716961 B2 date: April 6, 2004 (correction: June 15, 2004).2. Lowe G, Vilaivan T. 2006. Homologous peptide nucleic acids. United States Patent US7098321 B2 date: August 29, 2006.3. Lowe G, Vilaivan T. 2008. European Patent EP1513871 B1 date: October 29, 2008.4. Yuthavong Y, Vilaivan T, Kamchonwongpaisan S, Tarnchompoo B, Thongpanchang C, Chitnumsub P, Yuvaniyama J, Matthews D, Charman W, Charman S, Vivas L, Katiyar SB. 2013. Antimalarial compounds with fl exible side-chains. United States Patent US8530491 B2 date: September 10, 2013.

BOOK CHAPTERS

PATENTS


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Professor Dr. Tirayut Vilaivan

Professor Dr. Tirayut Vilaivan research involves synthetic methodology development and its applications in creating new molecules with interesting properties. Professor Dr. Tirayut’s selected research and achievements can be summarized as follows:

1. Synthesis, properties and applications of pyrrolidinyl peptide nucleic acids

The simple but elegant Watson-Crick rules of complementary base pairing in DNA and RNA are the basis for the storage, transfer and expression of genetic information. The high fi delity of the base pairing rules, together with the relative ease of preparation of DNA

THEACHIEVEMENTS

OF



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and RNA in virtually any sequences and lengths inspired scientists to explore other possible uses of nucleic acids. Recently, there are attempts to design analogues of nucleic acids that exhibit improved base pairing properties and chemical/biologically stability. Examples of promising nucleic acid analogues include phosphorothioates, morpholino, locked nucleic acids (LNA) and peptide nucleic acid (PNA). Among these, PNA is rather unique because of its non-sugar-phosphate-derived structure. Despite of this major difference, the Watson-Crick base pairing rules are still fully obeyed in PNA, both in self-recognition and cross-pairing with single-stranded natural nucleic acids. Most importantly, the base pairings in PNA-PNA and PNA-DNA/PNA-RNA are stronger and, quite surprisingly, more specifi c than the pairings observed in DNA or RNA. In addition, this structural difference also brings about several other unique properties of PNA, including the complete resistant to nucleases, the relative insensitivity of the hybridization to ionic strength and the ability to bind to double-stranded DNA to form unconventional ternary complexes.

Professor Dr. Tirayut has engaged in PNA research since the very beginning of his research career. Under the guidance of the late Professor Gordon Lowe, FRS at Oxford, he had developed robust synthetic methods to obtain new pyrrolidinyl PNA analogues deriving from a cyclic amino acid called D-proline. The idea was to constrain the fl exibility of the original PNA by introducing the cyclic structures into the PNA backbone with the aim to improve its binding affi nity to DNA. The challenge was to develop a chemistry that allows full control of stereochemistry so that one can explore which conformation is the most appropriate. Although the DNA binding studies of the originally designed pyrrolidinyl PNA system failed to support the hypothesis, they provided a strong basis and created inspiration for designing of further generations of pyrrolidinyl PNA, which was the main research theme of Professor Dr. Tirayut in the subsequent two decades. After returning to Thailand, Professor Dr. Tirayut continued to design and synthesize a number of new pyrrolidinyl PNA systems with support from various funding


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sources including The Royal Society (London), NSTDA, NRCT and, most importantly, TRF. Major breakthrough emerged around the year 2000–2002 when it was discovered that incorporation of cyclic beta-amino acids into pyrrolidinyl PNA backbone gave rise to very high affi nity and unprecedented selectivity in pairing to DNA over RNA. Shortly after that, the most successful and best-known member of the pyrrolidinyl PNA family (“acpcPNA”) was developed. AcpcPNA consists of an alternating sequence of nucleobase-modifi ed D-proline

and (1S,2S)-2-aminocyclopentane carboxylic acid (ACPC) which is a fi ve-membered cyclic beta-amino acid. This PNA system exhibits an exceptionally strong and specifi c binding to DNA, and to a lesser extent, RNA. The pairing was directional specifi c, i.e. it can take place only in antiparallel direction. AcpcPNA also exhibits other unusual properties including the relative insensitivity of the stability to base composition and sequence, and the inability to form self-hybrids. Several additional discoveries had been made during the past few years, for example, the self-pairing properties of acpcPNA could be modulated by changing the stereochemistry of the pyrrolidine ring, decreasing the ring size of the ACPC part of acpcPNA resulted in a stronger pairing to both DNA and RNA, and that the ACPC part can be modifi ed with a nitrogen atom to provide a handle for backbone modifi cation without affecting the base-pairing properties.

In addition to the basic studies on designing, synthesis and investigating properties of new pyrrolidinyl PNA, the excellent DNA recognition properties of acpcPNA prompted Professor Dr. Tirayut to explore its potential applications. Several DNA sensing systems based on surface-immobilized acpcPNA had been successfully developed. Another active research area is the development of self-reporting PNA probes that could change their fl uorescence in response to the binding to the correct DNA targets. These had demonstrated the potential applications of acpcPNA in various areas such as clinical diagnostics and agriculture & food sciences. They also encourage the exploration of possible diagnostic and therapeutic applications of acpcPNA and related


pyrrolidinyl PNA in living cells. The research on PNA had accounted for almost half of total publications of Professor Dr. Tirayut. The technology was patented in Europe and the USA under agreement between Chulalongkorn University, The Thailand Research Fund, and Oxford University (represented by ISIS Innovations) and was recently licensed to a USA-based diagnostic company specialized in PNA technology. In addition, a strong research team was created at both national and international levels.

2. Development of Antimalarial Compounds

Professor Dr. Tirayut is also active in the fi eld of medicinal chemistry, especially in the area of antimalarial drug development. The research on antimalarial began shortly after Professor Dr. Tirayut had returned to Thailand and joined the team at the National Center for Genetic Engineering and Biotechnology (BIOTEC)

led by Professor Dr. Yongyuth Yuthavong and Professor Dr. Yodhathai Thebtaranonth in 1996. The drug target of interest was an enzyme called dihydrofolate reductase (DHFR) that was responsible for thymidine biosynthesis in the malarial parasite (Plasmodium falciparum). Although it is one of the more well-established targets for antimalarial drugs, classical DHFR inhibitors developed during the World War II such as pyrimethamine and cycloguanil (or its prodrug, proguanil) became ineffective due to the problem of widespread resistance. The team at BIOTEC had revealed the mechanism of the resistance, which involves mutations of several amino acids in the DHFR active site. At the beginning, the design of new inhibitors aimed to be effective for both wild-type and mutant DHFRs were carried out mostly by trials and errors. Nevertheless, large libraries of pyrimidine and triazine derivatives had


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been made in collaboration with the BIOTEC chemistry team and some empirical relationships between structure and activities were built up. The recent success of the structural biology team at BIOTEC in solving three dimensional structures of malarial DHFR and its complexes with various inhibitors allows a more rational design of the inhibitors. However, the next major obstacle was the disconnection between the strength of the enzyme-inhibitor binding (expressed in terms of inhibition constant, K

i)

and the antimalarial activities in vitro. Under the support from Medicines for Malaria Venture (MMV), a close collaboration between BIOTEC, Professor Dr. Tirayut, and an international team of biologists and pharmacologists led to another major breakthrough in recognizing the key structural feature that was responsible for good cell permeability and thus enhanced antimalarial activities both in vitro and in vivo. This discovery had led to a series of antifolates based on 2,4-diaminopyrimidine core that not only bound tightly to both wild-type and mutant enzymes, but also showed extremely high in vitro antimalarial activities. One compound (P218) also showed highly promising pharmacokinetics properties and exhibited good potency and low toxicity in animal models, and was recently chosen by MMV as a candidate for preclinical studies. If successful, this could lead to the fi rst drug that is developed entirely in Thailand.

3. Development of new synthetic methodologies

Another main research area of Professor Dr. Tirayut is the development of new synthetic methodologies– especially in the area of catalytic asymmetric synthesis. Many compounds have “chiral” properties, which can exist in two different forms that are related to each other as mirror images (like our left and right hands) called enantiomers. Enantiomers are identical in all aspects except for two properties. Firstly, they rotate the plane of polarized light in equal mount but in opposite directions. Secondly, they interact differently with other chiral molecules- this aspect has a very signifi cant implication to biological systems since most biological molecules are chiral. As a result, enantiomers of most biologically active molecules including drugs generally exhibit unequal potency or even different biological activities. Accordingly, it is important to be able to produce chiral compounds in enantiomerically pure forms. However, synthesis of chiral molecules would normally lead to an inseparable 1:1 mixture of both enantiomers. It is more desirable to have reactions that selectively produce just the desired enantiomer (commonly known as asymmetric synthesis), which can be accomplished under infl uences of one or more pre-existing chirality in the


substrate, reagent or catalyst. The use of chiral catalysts should in principle be most effi cient because the pre-existing chirality was required in only a catalytic amount. The challenge is to fi nd a catalyst that is effective enough to give a complete control of selectivity (leading to product with high enantiomeric purity) and can work as many times as possible before it becomes inactive (leading to a low catalyst loading).

With these principles in mind, Professor Dr. Tirayut’s research team had successfully developed a very simple yet effi cient asymmetric cyanation of imines (Strecker reaction) catalyzed by tridentate chiral amino alcohol-titanium complexes (supported by the Thailand Toray Science Foundation). Several other catalytic asymmetric reactions had also been developed including nitroaldol, aldol, allylic alkylation and hydrogenation reactions. The enantiomerically pure or enriched products from these reactions are useful building blocks for more complex structures.


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Assistant Professor Dr. Songyot Nakariyakul

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»˜¨¨ØºÑ¹ ´Ã. ·Ã§ÂÈ ¹Ò¤ÍÃÔÂ¡ØÅ ÁÕ¼Å§Ò¹μ Õ¾ÔÁ¾ �ã¹ÇÒÃÊÒÃÇÔªÒ¡ÒÃÃÐ´Ñº¹Ò¹ÒªÒμ Ô â´Âà»š¹ corresponding author ÁÒ¡¡Ç‹Ò 10 àÃ×èÍ§ áÅÐÁÕ¼Å§Ò¹·ÕèμÕ¾ÔÁ¾ �à»š¹Ë¹Ñ§Ê×ÍáÅÐà»š¹º·Ë¹Öè§ã¹Ë¹Ñ§Ê×ÍÃÐ´Ñº¹Ò¹ÒªÒμÔ ´Ã. ·Ã§ÂÈ ä ŒÃÑºÃÒ§ÇÑÅ¨Ò¡§Ò¹ÇÔ¨ÑÂËÅÒÂÃÒ§ÇÑÅ àª‹¹ ÃÒ§ÇÑÅ¹Ñ¡ÇÔ¨ÑÂÃØ‹¹ãËÁ‹ÃÐ´Ñº¤³Ð ÁËÒÇÔ·ÂÒÅÑÂ¸ÃÃÁÈÒÊμÃ� »ÃÐ¨íÒ»‚ ¾.È. 2551 áÅÐÃÒ§ÇÑÅ«ÔÇ ¡ÒÞ¨¹¨ÒÃÕà¾×èÍÇÔÈÇ¡ÃÃÁä¿¿‡Ò »ÃÐàÀ·¼Å§Ò¹ÇÔ¨ÑÂÊíÒËÃÑº¹Ñ¡ÇÔ¨ÑÂÃØ‹¹àÂÒÇ � »ÃÐ¨íÒ»‚ ¾.È. 2554 à»š¹μŒ¹ ¹Í¡¨Ò¡¹ÕéÂÑ§ä ŒÃÑºà¡ÕÂÃμÔãËŒà»š¹ Senior Member ¢Í§ÊÁÒ¤Á The Institute of Electrical and Electronics Engineers (IEEE), ÊÁÒ¤Á The Association for Computing Machinery (ACM) áÅÐÊÁÒ¤Á TheSociety of Photo-optical Instrumentation Engineers(SPIE) ÍÕ¡ ŒÇÂ â´ÂμÅÍ´¡ÒÃ·íÒ§Ò¹ÇÔ ÑÂ·Ñé§ËÁ´·Õè¼‹Ò¹ÁÒ´Ã. ·Ã§ÂÈ ¹Ò¤ÍÃÔÂ¡ØÅä ŒÃÑº¡ÒÃÊÑè§ÊÍ¹áÅÐ¤íÒá¹Ð¹íÒ·Õè´ÕÂÔ è§¨Ò¡ Professor David Casasent áÅÐ Professor Luonan Chen áÅÐÂÑ§ä´ŒÃÑº¡íÒÅÑ§ã¨¨Ò¡¤ÃÍº¤ÃÑÇáÅÐ¡ÒÃÊ¹ÑºÊ¹Ø¹¨Ò¡¤³Ò¨ÒÃÂ �¤³ÐÇÔÈÇ¡ÃÃÁÈÒÊμÃ� áÅÐ¼ÙŒºÃÔËÒÃÁËÒÇÔ·ÂÒÅÑÂ¸ÃÃÁÈÒÊμÃ� ·ÕèàÅç§àËç¹¤ÇÒÁÊíÒ¤ÑÞ¢Í§¡ÒÃ·íÒÇÔ¨ÑÂàÊÁÍÁÒ


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Assistant Professor Dr. Songyot Nakariyakul was born on February 27, 1980 in Nakhon Sawan, Thailand. He is the youngest of the four children born to Mr. Somsak and Mrs. Kate-sara Nakariyakul. After completing his high school education from Nakhon Sawan School in 1996, he received a full scholarship from the Ministry of Science and Technology of Thailand for Higher Education to pursue his college degrees in Electrical Engineering in USA. He received a bachelor’s degree (with Summa Cum Laude) in Electrical Engineering from Columbia University in 2001 and completed his M.S. and Ph.D. degrees in Electrical and Computer Engineering from Carnegie Mellon University in 2003 and 2007, respectively. Under the supervision of Professor David Casasent, his doctoral dissertation is entitled “Hyperspectral Feature Selection for Detection of Chicken Skin Tumors”. He later won a good doctoral dissertation award from the National Research Council of Thailand in 2010 for his dissertation. Upon graduation in 2007, Dr. Songyot joined the Department of Electrical and Computer Engineering, Faculty of Engineering, Thammasat University, Thailand, and was later promoted to Assistant Professor of Electrical Engineering in 2009.

Dr. Songyot’s research has been supported by grants from many research funding organizations; in 2009, he received a New Researcher Scholarship of CSTS from the National Science and Technology Development Agency. In 2010, he was a recipient of the Fellowship for Young International Scientists from Chinese Academy of Sciences to conduct research in Bioinformatics under the supervision of Professor Luonan Chen at Shanghai Institutes for Biological Sciences, China, for one year. In 2012, he received a Research Grant for New Scholars, which was co-funded by The Thailand Research Fund, Offi ce of the Higher Education Commission, and Thammasat University. The mentors of this research project were Professor Luonan Chen and Associate Professor Dr. Paiboon Nakmahachalasint.



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Dr. Songyot’s research in the fi eld of Computer Sciences focuses on inventing new feature selection algorithms for classifi cation. Feature selection refers to algorithms that select a small subset of features from an original large set of features. Since many features in high-dimensional data sets are often redundant and irrelevant, feature selection is thus essential in machine learning. Not only does feature selection improve the classifi cation accuracy, but it also makes the learning task more effi cient and faster. Dr. Songyot proposes many novel feature selection techniques that are shown to perform better than prior algorithms. These techniques have been applied for use in various fi elds of study such as non-invasive food quality inspection, protein-ligand interaction prediction, and remote sensing based detection of military vehicles. These fi ndings were published in many

international journals, for example, Information Sciences, Pattern Recognition, Journal of Food Engineering, and Amino Acids.

At present, Dr. Songyot has published as the corresponding author of more than 10 international journals and a book and book chapter. He has received many awards from his research work including Outstanding Young Researcher Award from Thammasat University (2008) and Siew Karnchanachari Young Researcher Award for Electrical Engineering (2012). He is a senior member of the IEEE, ACM, and SPIE. These accomplishments would not be possible without the guidance of Professor David Casasent and Professor Luonan Chen, the encouragement from his family, and the support from his colleagues at Faculty of Engineering and the administrators at Thammasat University.


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»¨ ØºÑ¹ ¼ÙŒª‹ÇÂÈÒÊμÃÒ¨ÒÃÂ� ´Ã. ¸§ä·Â ÇÔ±ÙÃÂ� ÁÕ¼Å§Ò¹ÇÔ ÑÂ·Õèä ŒÃÑº¡ÒÃμÕ¾ÔÁ¾�ã¹ÇÒÃÊÒÃÃÐ Ñº¹Ò¹ÒªÒμÔ (ISI) ¨íÒ¹Ç¹ 18 àÃ×èÍ§ àª‹¹ Applied Energy, Bioresource Technology, Chemical Engineering Journal, Fuel Processing Technology áÅÐ Materials Chemistry and Physics áÅÐä´ŒÃÑºàªÔÞà»š¹¼ÙŒ·Ã§¤Ø³ÇØ²Ô¾Ô ÒÃ³Ò¼Å§Ò¹ÇÔ ÑÂ (reviewer) ãËŒ¡ÑºÇÒÃÊÒÃÇÔªÒ¡ÒÃ¹Ò¹ÒªÒμÔ¡Ç‹Ò 14 àÃ×èÍ§ ä Œá¡‹ Applied Surface Science, Ceramics International, Chemical Engineering Journal, Chemical Engineering Science, Colloid and Surface A, Energy & Fuel, Environmental Science & Technology, Industrial & Engineering Chemistry Research, International Journal of Hydrogen Energy, Journal of Industrial and Engineering Chemistry, Journal of Materials Science, Journal of Porous Materials, Separation Science and Technology áÅÐ The Journal of Supercritical Fluids áÅÐ ä´ŒÃÑºÃÒ§ÇÑÅàªÔ´ªÙà¡ÕÂÃμ Ô àª‹¹ ÃÒ§ÇÑÅ¹Ñ¡ÇÔ¨ÑÂ´ÒÇÃØ‹§¼ÙŒÊÃŒÒ§ÊÃÃ¤ �¼Å§Ò¹μÕ¾ÔÁ¾�áÅÐ¤Ø³ÀÒ¾ÊÙ§ÊØ »ÃÐ íÒ»‚ ¾.È. 2554 ÃÒ§ÇÑÅ¹íÒàÊ¹Í¼Å§Ò¹ÇÔ¨ÑÂ ÕàÂÕèÂÁáººâ»ÊàμÍÃ �ã¹¡ÒÃ»ÃÐªØÁÇÔªÒ¡ÒÃ¹Ñ¡ÇÔ¨ÑÂÃØ‹¹ãËÁ‹¾ºàÁ¸ÕÇÔ¨ÑÂÍÒÇØâÊ Ê¡Ç. ã¹»‚ ¾.È. 2556 áÅÐÃÒ§ÇÑÅºØ¤ÅÒ¡Ã´Õà´‹¹ÊÒÂÇÔªÒ¡ÒÃ ´ŒÒ¹ÇÔ¨ÑÂáÅÐ¹ÇÑμ¡ÃÃÁ áË‹§ÁËÒÇÔ·ÂÒÅÑÂà¡ÉμÃÈÒÊμÃ� »ÃÐ¨íÒ»‚ ¾.È. 2556 ¼Å§Ò¹ÇÔ¨ÑÂ·ÕèÁÕÍÍ¡ÁÒÍÂ‹Ò§μ‹Íà¹×èÍ§¢Í§ ¼ÙŒª‹ÇÂÈÒÊμÃÒ¨ÒÃÂ� ´Ã. ¸§ä·Â ÇÔ±ÙÃÂ � à»š¹¼ÅÊ×ºà¹×èÍ§ÁÒ¨Ò¡¡ÒÃä´ŒÃÑº¡ÒÃÊ¹ÑºÊ¹Ø¹·Õè´Õ¨Ò¡ ÃÍ§ÈÒÊμÃÒ¨ÒÃÂ � ´Ã. àÁμμÒ à¨ÃÔÞ¾Ò¹Ôª ÈÒÊμÃÒ¨ÒÃÂ� ´Ã. íÒÃÑÊ ÅÔéÁμÃÐ¡ÙÅ áÅÐ¤³Ò¨ÒÃÂ�ã¹ÀÒ¤ÇÔªÒÇÔÈÇ¡ÃÃÁà¤ÁÕ·Ø¡·‹Ò¹ μÅÍ´¨¹¤ÇÒÁÍØμÊÒËÐáÅÐ¤ÇÒÁ¾ÂÒÂÒÁ¢Í§¹ÔÊÔμ·Ø¡æ ¤¹ã¹¡ÅØ‹ÁÇÔ¨ÑÂ

Assistant Professor Dr. Thongthai Witoon was born on May 25, 1983 in Chachoengsao province. He is the youngest son of Mr. Sutas and Mrs. Kaesorn Witoon. Dr. Thongthai completed his secondary school from Benchamaratrangsarit School, Chachoengsao. After that, he enrolled for undergraduate study in the Faculty of Engineering, Kasetsart University and received his bachelor’s degree in chemical engineering with fi rst class honors in 2005. He received the scholarship from the Royal Golden Jubilee Ph.D. Program for his graduate study at the Department of Chemical Engineering, Kasetsart University and completed his study in 2010 under the supervision of Associate Professor Dr. Metta Chareonpanich. His thesis involved the synthesis and development of silica materials with the pore sizes in two different scales including 2-20 nanometers and 100-300 nanometers. The obtained silica materials were used as a cobalt support for the conversion of syngas to clean fuel. His Ph.D. work was awarded outstanding thesis by the Graduate School Kasetsart University in 2010 and the National Research Council of Thailand in 2011. After graduation, he became a faculty member at the Chemical Engineering Department, Faculty of Engineering, Kasetsart University in 2010 and was promoted to be an assistant professor in 2012.



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The research work of Dr. Thongthai has been supported from many research funding organizations such as The Thailand Research Fund, Offi ce of the Higher Education Commission and Kasetsart University through a research grant for new researchers (with Associate Professor Dr. Metta Chareonpanich serving as a mentor), National Research University (NRU), National Nanotechnology Center (NANOTEC), Kasetsart University Research and Development Institute (KURDI) and Center of Excellence on Petrochemical and Materials Technology (PETROMAT). He was also a member of the research group in the Design of Nanoscale Materials for Green Nanotechnology with Professor Dr. Jumras Limtrakul as the project leader.

Dr. Thongthai’s research interest involves the design and development of adsorbents for carbon dioxide (CO

2) separation from biogas

and coal-fi red power plant. He started the research project with the synthesis of porous silica material with a high content of silanol groups and a large surface area. This material showed a high CO

2 uptake capacity. However,

the use of the porous silica material alone could not provide the high purity of CO

2 due

to the low selectivity of CO2/N

2. Therefore the

surface of porous silica material was modifi ed

with polyethyleneimine (PEI) to enhance the selective adsorption of CO

2. The PEI-loaded

porous silica material showed an extremely high CO

2 sorption capacity as well as a high

CO2/N

2 selectivity because CO

2 is chemically

adsorbed on amine-loaded porous silica as bidentate. These materials could be potentially used for CO

2 separation from biogas. In case

of coal-fi red power plant, calcium oxide (CaO) looping cycle for CO

2 separation at high

temperature was developed. Waste eggshell having a high content of CaO was used as a CO

2 sorbent because the application of waste

not only provided technology of competitive sorbent processing costs but also offered an approach for the elimination of waste. The results showed that the CO

2 adsorption capacity

of the CaO derived from waste eggshell was higher than that of the commercially available CaO. However, the sharp decay subsequent to a few cycles of carbonation-calcination is found. Therefore the structure and pore size of calcium oxide sorbent was modifi ed with the use of surfactants and biopolymer. Dr. Thongthai demonstrated that surfactants and biopolymer could enhance the specifi c surface area and pore volume of the CaO sorbents as well as their stability following multiple cycles.


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Another fi eld of research interest is the use of catalysts to convert the CO

2 to the useful chemicals and alternative fuel. Dr.

Thongthai synthesized a novel hollow CuO/ZnO nanosphere catalyst for the production of methanol from CO

2 hydrogenation. This catalyst

provided a higher yield of methanol compared to that of commercial ones. He is developing a novel catalyst for a direct synthesis of dimethyl ether from CO

2 hydrogenation and is also determining a

relationship between the physicochemical properties and their catalytic performance. He has participated as a research colleague with Dr. Kajornsak Faungnawakij from NANOTEC to develop the heterogeneous catalyst for biodiesel production.

Until now, Assistant Professor Dr. Thongthai Witoon has published 18 articles in leading international journals such as Applied Energy, Bioresource Technology, Chemical Engineering Journal, Fuel Processing Technology and Materials Chemistry and Physics. He has been regularly invited to be a reviewer for 14 international journals including Applied Surface Science, Ceramics International, Chemical Engineering Journal, Chemical Engineering Science, Colloid and Surface A, Energy & Fuel, Environmental Science & Technology, Industrial & Engineering Chemistry Research, International Journal of Hydrogen Energy, Journal of Industrial and Engineering Chemistry, Journal of Materials Science, Journal of Porous materials, Separation Science and Technology and The Journal of Supercritical Fluids. In addition, he has received several awards and honors including KU Research Star Award 2011, Outstanding Research Presentation Award in the 13th Annual Meeting of The Thailand Research Fund 2013 and Kasetsart University Outstanding Young Researcher Award 2013. His research accomplishments are a result of kind support of Associate Professor Dr. Metta Chareonpanich, Professor Dr. Jumras Limtrakul and all staff members of the Department of Chemical Engineering, Kasetsart University as well as the effort and commitment of past and current students in his research team.



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Dr. Parinya Karndumri was bone on November 7, 1983. He is the only child of Mr. Preecha and Mrs. Prang Karndumri living in Pathumthani. He is married to Miss Thanyarat Udommaneethakit. Dr. Parinya received his bachelor’s degree with fi rst class honors in Physics from Department of Physics, Faculty of Science, Chulalongkorn University in 2006. He got a scholarship from Faculty of Science via Physics Olympic Program. During his study, he was interested in string theory and black hole physics. He then decided to work with Assistant Professor Dr. Auttakit Chatrabhuti for his senior project under the title “Black Holes and p-Branes in Diverse Dimensions”. At the end of his study, Assistant Professor Dr. Auttakit suggested him to apply for the Diploma Programme at The Abdus Salam Centre for Theoretical Physics (ICTP), Trieste, Italy. The institution was founded by a Nobel laureate Professor Abdus Salam from Pakistan. Dr. Parinya got a scholarship from ICTP to study in the area of high energy physics. He was the fi rst Thai student of this programme. After one year of study, he received diploma in High Energy Physics in August 2007 with the highest score of the class. During his study in the diploma programme, he continued his research on black hole physics and string theory under the supervision of Professor Kumar S. Narain, one of the world’s famous

string theory experts. At the end of the diploma programme, he participated in the entrance examination for Ph.D. at International School for Advanced Studies (SISSA) also in Trieste, Italy. He passed the examination and got a full scholarship from SISSA to study in Theory of Elementary Particles Sector in October 2007.

During his Ph.D. study, Dr. Parinya worked on applications of gauged supergravity theories in the AdS/CFT correspondence of string theory under the supervision of Professor Kumar S. Narain and Professor Edi Gava. His Ph.D. thesis concerned with the holographic study of two-dimensional superconformal fi eld theories by using three-dimensional gauged supergravity and holographic RG fl ows in four-dimensional from string theory. One of his results was the discovery of some new gauged supergravities in three dimensions which hadnot been extensively investigated in the physics community since the explicit structure of gauged supergravity in three dimensions had just appeared for about a decade. In the mean time, Dr. Parinya also worked with Assistant Professor Dr. Auttakit on the topic of holography from three-dimensional gauged supergravity and published two papers together. Dr. Parinya received his Ph.D. in Theory of Elementary Particles in September 2011 with 6 research papers published in international journals.



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After his Ph.D., he worked as a postdoctoral fellowship at the Department of Physics, Faculty of Science, Chulalongkorn University from November 1, 2011 to August 31, 2013. During this time, he worked on applications of gauged supergravities in the AdS/CFT correspondence of string theory in three and six dimensions. He was also interested in relations between supergravities, effective theories of string theory, in various dimensions. This research resulted in the discovery of new gauged supergravities in three dimensions and a large number of critical points including various domain wall and RG fl ow solutions. These are very useful in the holographic study of strongly coupled gauge theories in two and fi ve dimensions. He still worked with Assistant Professor Dr. Auttakit on many topics of three-dimensional gauged supergravity and holography. During his postdoctoral fellowship, he published 6 research papers, three of them being single-authored papers. Most of the papers were published in Journal of High Energy Physics with impact factor 5.618.

Dr. Parinya is currently a lecturer at Department of Physics, Faculty of Science, Chulalongkorn University since September 1, 2013. He is a member of Theoretical High Energy and Particle Physics Group. His research aims to understand the AdS/CFT correspondence in string theory by using gauged supergravities in various dimensions. His notable research consists of the discovery of gravity dual (holography) of c-extremization process in two-dimensional conformal fi eld theories within the framework of three-dimensional gauged supergravity and the discovery of many new

gauged supergravities in three dimensions from wraped D3-branes in string theory. These results have been discovered together with an Irish physicist Dr. Eoin O. Colgain. For his own research, Dr. Parinya is now studying gravity duals of gauge theories in fi ve and six

dimensions which are relevant to the study of M5-brane dynamics in M-theory, which is believed to be a unifi ed theory behind all the fi ve string theories and might explain all particles and interactions in our universe within a single theory. Until now, he has published 15 research papers in international journals with 5 single-authored papers.

All of his researches are supported by many organizations such as Thailand Center of Excellence in Physics, The Thailand Research Fund (TRF) via TRF Grant for New Researcher and Chulalongkorn University via Grants for Development of New Faculty Staff.


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His future research aims to understand string/M theory from higher dimensional gauged supergravities by using gauge/gravity correspondence which is widely accepted to be an effi cient method for studying gauge theories and could provide new insight in string/M theory. The main objective of the research is to study N=2 six- and seven-dimensional gauged supergravities in deep detail and classify all possible holographic solutions. The relation between gauge theories in fi ve and six dimensions will be considered as well.

During his work and study, Dr. Parinya has received several awards and honors including Outstanding Academic Achievement Award for fi rst-year students and Outstanding Graduated Award from Professor Dr. Tab Nilanidhi Foundation, Outstanding Academic Achievement Award in Department of Physics, Faculty of Science from Chulalongkorn University, Distinguished Young Scientist Award (in Physical Science and Mathematics) 2013 and 2014 from Faculty of Science, Chulalongkorn University. He has also received several certifi cates from the Research Unit in Faculty of Science on occasions of publishing papers in international journals with an impact factor greater than 5.

Apart from doing research and teaching, Dr. Parinya is also a reviewer for MathReview by American Mathematical Society.



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Dr. Montree Sawangphruk was born on August 3, 1980 in Mueang district, Roi-Et province. He was the second child of Mr. Boonmee and Mrs. Sumlee Sawangphruk. He is married to Miss Nuchsara Samakkoon and has a child, Manasawin Sawangphruk. Dr. Montree fi nished his elementary school from Sraithongwitaya School and high school from Palanchaipittayakhom School in Roi-Et. He received B.Sc. degree with honors in Chemistry in 2003 from Ubon Ratchathani University (UBU). At UBU, he was awarded the Chumphot-Phantip Scholarship and his senior project was about the preparation of silica from rice hulls under the supervision of Assistant Professor Juthamas Chitjaroen. After graduation, he pursued his master’s degree in Physical Chemistry, Department of Chemistry, Kasetsart University (KU) under the supervision of Professor Dr. Jumras Limtrakul. His thesis at KU was about the 1,3-cycloaddition reaction of ozone with single-walled carbon nanotubes. After he fi nished his study at KU in 2006, he received ‘‘Professor Dr. Tab Nilanidhi Award’’ for his outstanding education record. In the same year, he was awarded the Royal Thai Government scholarship via the Commission

on Higher Education (now Offi ce of the Higher Education Commission, OHEC) to study his doctoral degree at the Department of Chemistry, University of Oxford, UK. His supervisor was Professor Dr. John S. Foord and his thesis entitled ‘‘Electrochemical deposition and properties of nanostructured materials’’. At Oxford, he wasawarded the ‘‘Graduate Fellowship in Science and Medicine’’ from St. Catherine’s College, University of Oxford, and ‘‘The Anglo-Thai Society Award for Educational Excellence in Science & Medicine’’ from the Anglo-Thai Society in London, UK. In 2010, he received D. Phil. degree with an excellent fi nal viva examination result.

After graduation, Dr. Montree joined the Department of Chemical Engineering, KU as a junior lecturer. He started his research career at KU with Associate Professor Dr. Metta Chareonpanich being his mentor. Associate Professor Dr. Phungphai Phanawadee who was the head of department at that time provided the space for him to conduct his research. The research work of Dr. Montree was fi nancially supported by the Faculty of Engineering, KU, The Thailand Research Fund (TRF), OHEC and KU since 2011, with Professor Dr. Jumras Limtrakul as his research mentor. With this funding, Dr. Montree could publish a number of good peer-reviewed papers and afterward received further fi nancial supports from (i) the ‘‘National Research University’’ project of OHEC via ‘‘Center for Advanced Studies in Nanotechnology and Its Applications in Chemical, Food and Agricultural Industries’’ at KU, (ii) ‘‘Nanotechnology platform’’ project of National Nanotechnology Center (NANOTEC),



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National Science and Technology Development Agency (NSTDA) through ‘‘NANOTEC-KU-Center of Excellence on Nanoscale Materials Design for Green Nanotechnology’’ at KU, (iii) a scholarship for an M.Eng. Student from ‘‘National Center of Excellence for Petroleum, Petrochemicals and Advance Materials’’, (iv) TRF under the TRF Senior Research Scholar via a research collaboration with Professor Dr. Santi Maensiri (SUT). Furthermore, Dr. Montree has been working with a number of research collaborators since 2011, e.g., Professor John S. Foord (Oxford), Associate Professor Dr. Sunan Limtrakul (KU), Associate Professor Dr. Thumrongrut Mungcharoen (KU), Assistant Professor Dr. Supree Pinitsoontorn (KKU), Assistant Professor Dr. Worawat Meevasana (SUT), Dr. Patcharaporn Siwayaprahm (KU), and Mr. Phayom Boonyoung (IRPC Co., Ltd.).

The research topic that Dr. Montree has been working on is based on ‘‘Syntheses, Characterizations, and Applications of Graphene and its Related Materials’’. Graphene is a material consisting of a monolayer of sp2 bonded carbon atoms with hexagonal pattern. The goals of the research are to produce graphene and its related materials using cheap and abundant carbon resources in Thailand, study new properties of graphene, and apply the graphene materials to address real problems

in Thailand. For the research output, Dr. Montreeand co-workers discovered two new fi ndings about the graphene materials, i.e., antifungal activity and permselective property of reduced graphene oxide. Until now, Dr. Montree published 16 peer-reviewed ISI papers with a total impact factor of 60.06. His latest 12 papers were totally carried out in Thailand and he was the principal investigator. He published 6 papers in high-quality journals, e.g.,


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4 papers in Carbon and 2 papers in Journal of Materials Chemistry A. Especially, his two papers published in Carbon 2013: 60, 109-116 and Journal of Materials Chemistry A 2013, 1, 9630-9636 were the most downloaded articles from ScienceDirect and RSC, respectively, in August 2013. Dr. Montree has been invited to be a reviewer by a number of journals, e.g., Carbon, Journal of Power Sources, Electrochimica Acta, Langmuir, Industrial & Engineering Chemistry Reserach, Journal of Nanoparticle Research, Journal of Applied Polymer Science, Applied Surface Science, Journal of Solid-State Electrochemistry, Energy Technology, Materials Letters, and Power Technology. For the application of graphene, Dr. Montree and his students produced a number of innovative prototype devices and products such as ‘‘graphene-based supercapacitor’’ and ‘‘antifungal products for natural rubber sheets’’. They were awarded two National Invention Awards from the National Research Council of Thailand (NRCT) in 2013 and 2014.

All of these achievements would not be possible without the efforts and commitments of his students and the guidance, encouragement, and support from Professor Dr. Jumras Limtrakul (research mentor), all faculty and technical staffs at the Department of Chemical Engineering, administrative boards of the Faculty of Engineering and KURDI at KU. Especially, an encouragement from his family makes him happily working hard as a teacher, researcher, and leader of the family at the same time.


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