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1. JokinenTS,MetsähonkalaL,BergamascoL,ViitmaaR,SyrjäP,LohiH,etal.Benignfamilialjuvenileepilepsyin Lagotto Romagnolo dogs. J Vet Intern Med.2007;21(3):464–71.

2. SeppalaEH,JokinenTS,FukataM,FukataY,WebsterMT, Karlsson EK, et al. LGI2 truncation causes aremitting focal epilepsy in dogs. PLoS Genet.2011;7(7):e1002194.

3. Seppala EH, Koskinen LLE, Gulløv CH, Jokinen P,Karlskov-Mortensen P, Bergamasco L, et al.Identificationofanovel idiopathicepilepsy locus inBelgianShepherddogs.PLoSOne.2012;7(3):e33549.

4. StassenW,vanSteenbeekF,vanRhijnN,TenwoldeR,LeegwaterP.IdentificationofanovelepilepsygeneinBoerboeldogs.JVetInternMed.2013;27:30.

5. ShorvonS.Theconceptofsymptomaticepilepsyandthe complexities of assigning cause in epilepsy.EpilepsyBehav.2014;32C:1–8.

6. Kearsley-Fleet L, O’Neill DG, Volk HA, Church DB,BrodbeltDC. Prevalence and risk factors for canineepilepsy of unknown origin in the UK. Vet Rec.2013;172(13):338.

7. Heske L, Nodtvedt A, Jaderlund KH, Berendt M,EgenvallA.Acohortstudyofepilepsyamong665,000insureddogs:incidence,mortalityandsurvivalafterdiagnosis.VetJ.2014;202(3):471–6.

8. FamulaTR,OberbauerAM,BrownKN.Heritabilityofepileptic seizures in the Belgian tervueren. J SmallAnimPract.1997;38(8):349–52.

9. Jaggy A, Faissler D, Gaillard C, Srenk P, Graber H.Genetic aspects of idiopathic epilepsy in Labradorretrievers.JSmallAnimPract.1998;39(6):275–80.

10. KathmannI,JaggyA,BusatoA,BartschiM,GaillardC.Clinical and genetic investigations of idiopathicepilepsyintheBernesemountaindog.JSmallAnimPract.1999;40(7):319–25.

11. NielenAL,KnolBW,vanHagenMA,vanderGaagI.Geneticandepidemiological investigationofabirthcohort of boxers. Tijdschr Diergeneeskd.2003;128(19):586–90.

12. BerendtM,GredalH,PedersenLG,AlbanL,AlvingJ.Across-sectionalstudyofepilepsyinDanishLabradorRetrievers:prevalenceandselectedriskfactors.JVetInternMed.2002;16(3):262–8.

13. PattersonEE,MickelsonJR,DaY,RobertsMC,McVeyAS, O’Brien DP, et al. Clinical characteristics andinheritance of idiopathic epilepsy in Vizslas. J VetInternMed.2004;17(3):319–25.

14. PattersonEE,ArmstrongPJ,O’BrienDP,RobertsMC,Johnson GS, Mickelson JR. Clinical description andmodeofinheritanceofidiopathicepilepsyinEnglishspringer spaniels. J Am Vet Med Assoc.2005;226(1):54–8.

15. CasalML,MunuveRM,JanisMA,WernerP,HenthornPS. Epilepsy in IrishWolfhounds. J Vet InternMed.2006;20(1):131–5.

Page 11: 3!4 FM?M=4VI=a BM[MI=KP ( 0.( KMABIDFEd #gDK]eI ... 88ks Î á n 88 Ð 8 üt ke K u“m” s “m ª s Ú z ! ” e l e n :l ® “m £ L & m £ Lw q = if n if ܵÁs f £ L f

16. Berendt M, Gulløv CH, Christensen SLK,Gudmundsdottir H, Gredal H, Fredholm M, et al.Prevalence and characteristics of epilepsy in theBelgian shepherd variants Groenendael andTervueren born in Denmark 1995–2004. Acta VetScand.2008;50:51.

17. Kloene J, Sewell A, Hamann H, Distl O, Tipold A.Klinische Untersuchungen zu Krampfanfällen beiBorderTerriern.Kleintierpraxis.2008;8(1):5–12.

18. BerendtM,GulløvCH,FredholmM.FocalepilepsyintheBelgianshepherd:evidenceforsimpleMendelianinheritance.JSmallAnimPract.2009;50(12):655–61.

19. Gulløv CH, Toft N, Baadsager MMN, Berendt M.Epilepsy in the Petit Basset Griffon Vendeen:Prevalence,Semiology,andClinicalPhenotype.JVetInternMed.2011;25(6):1372–8.

20. Oberbauer A, Grossman D, Irion D, Schaffer A,EgglestonM,FamulaT.ThegeneticsofepilepsyintheBelgiantervurenandsheepdog.JHeredityVol.2003;94:57–63.

21. OberbauerAM,BelangerJM,GrossmanDI,ReganKR,Famula TR. Genomewide linkage scan for lociassociatedwith epilepsy in Belgian shepherd dogs.BMCGenet.2010;11:35.

22. Ekenstedt KJ, Oberbauer AM. Inherited Epilepsy inDogs.TopCompanionAnimMed.2013;28(2):51–8.

23. HülsmeyerV,ZimmermannR,BrauerC,Sauter-LouisC, Fischer A. Epilepsy in Border Collies: clinicalmanifestation,outcome,andmodeofinheritance.JVetInternMed.2010;24(1):171–8.

24. WeisslJ,HulsmeyerV,BrauerC,TipoldA,KoskinenLL,KyöstiläK,LohiH,Sauter-LouisC,WolfM,FischerA.Disease Progression and Treatment Response ofIdiopathicEpilepsyinAustralianShepherdDogs.JVetIntMed2012;26:116-125.

25. LichtBG,LinS,LuoY,HysonLL,LichtMH,HarperKM,etal.ClinicalcharacteristicsandmodeofinheritanceoffamilialfocalseizuresinStandardPoodles.JAmVetMedAssoc.2007;231(10):1520–8.

26. Hülsmeyer VI, Fischer A, Mandigers P, DeRisio L,BerendtM,RusbridgeC,etal.Currentevidenceforidiopathicepilepsyinpurebreddogs.BMCveterinaryresearch2015.(Inpress).

27. BergAT,BerkovicSF,BrodieMJ,BuchhalterJ,CrossJH,Van Emde BW, et al. Revised terminology andconceptsfororganizationofseizuresandepilepsies:reportoftheILAECommissiononClassificationandTerminology,2005–2009.Epilepsia.2010;51(4):676–85.

28. BergAT,SchefferIE.Newconceptsinclassificationoftheepilepsies: Entering the21st century. Epilepsia.2011;52(6):1058–62.

29. Shorvon SD. The etiologic classification of epilepsy.Epilepsia.2011;52(6):1052–7.

30. FisherRS,VanEmdeBW,BlumeW,ElgerC,GentonP,Lee P, et al. Epileptic seizures and epilepsy:definitions proposed by the International League

AgainstEpilepsy(ILAE)andtheInternationalBureauforEpilepsy(IBE).Epilepsia.2005;46(4):470–2.

31. Proposal for revised clinical andelectroencephalographic classification of epilepticseizures.FromtheCommissiononClassificationandTerminology of the International League AgainstEpilepsy.Epilepsia1981.22(4):489–501.

32. Proposal for revised classification of epilepsies andepileptic syndromes. Commission on ClassificationandTerminologyoftheInternationalLeagueAgainstEpilepsy.Epilepsia1989.30(4):389–399.

33. Guidelines for epidemiologic studies on epilepsy.Commission on Epidemiology and Prognosis,InternationalLeagueAgainstEpilepsy.Epilepsia1993.34(4):592–596.

34. Proposalforclassificationofepilepsiesandepilepticsyndromes. Commission on Classification andTerminology of the International League AgainstEpilepsy.Epilepsia1985.26(3):268–278.

35. Berendt M, Gram L. Epilepsy and seizureclassification in63dogs:a reappraisalofveterinaryepilepsy terminology. J Vet Intern Med.1999;13(1):14–20.

36. PodellM:Seizures.In:BSAVAManualofCanineandFeline Neurology. edn. Edited by Platt S, Olby N.BSAVA;2013.117–135.

37. MarianiCL.TerminologyandClassificationofSeizuresandEpilepsy inVeterinaryPatients.TopCompanionAnimMed.2013;28(2):34–41.

38. LichtBG,LichtMH,HarperKM,LinS,CurtinJJ,HysonLL,etal.Clinicalpresentationsofnaturallyoccurringcanineseizures:similaritiestohumanseizures.EpilepsyBehav.2002;3(5):460–70.

39. SrenkP, JaggyA. Interictal electroencephalographicfindings in a family of golden retrievers withidiopathic epilepsy. J Small Anim Pract.1996;37(7):317–21.

40. Podell M, Fenner WR, Powers JD. Seizureclassification in dogs from a nonreferral-basedpopulation. J Am Vet Med Assoc.1995;206(11):1721–8.

41. Heynold Y, Faissler D, Steffen F, Jaggy A. Clinical,epidemiological and treatment results of idiopathicepilepsyin54labradorretrievers:alongtermstudy.JSmallAnimPract.1997;38(1):7–14.

42. Jaggy A, Bernardini M. Idiopathic epilepsy in 125dogs: a long-term study. Clinical andelectroencephalographicfindings.JSmallAnimPract.1998;39(1):23–9.

43. MoritaT,ShimadaA,TakeuchiT,HikasaY,SawadaM,Ohiwa S, et al. Cliniconeuropathologic findings offamilialfrontallobeepilepsyinShetlandsheepdogs.CanJVetRes.2002;66(1):35–41.

44. ChangY,MellorDJ,AndersonTJ. Idiopathicepilepsyindogs:owners’perspectivesonmanagementwithphenobarbitoneand/orpotassiumbromide. JSmallAnimPract.2006;47(10):574–81.

Page 12: 3!4 FM?M=4VI=a BM[MI=KP ( 0.( KMABIDFEd #gDK]eI ... 88ks Î á n 88 Ð 8 üt ke K u“m” s “m ª s Ú z ! ” e l e n :l ® “m £ L & m £ Lw q = if n if ܵÁs f £ L f

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45. VolkHA,MatiasekLA,LujánFeliu-PascualA,PlattSR,Chandler KE. The efficacy and tolerability oflevetiracetam in pharmacoresistant epileptic dogs.VetJ.2008;176(3):310–9.

46. Pákozdy A, LeschnikM, Tichy AG, Thalhammer JG.Retrospectiveclinicalcomparisonofidiopathicversussymptomaticepilepsyin240dogswithseizures.ActaVetHung.2008;56(4):471–83.

47. BeghiE.Newclassificationproposalsforepilepsy:arealadvancementinthenosographyofthedisease?Epilepsia.2011;52(6):1197–8.discussion1205–1199.

48. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A,Cross JH, Elger CE, et al. ILAE Official Report: Apractical clinical definition of epilepsy. Epilepsia.2014;55(4):475–82.

49. DeRisioL,BhattiS,MuñanaKR,PenderisJ,SteinVM,TipoldA,etal.InternationalVeterinaryEpilepsyTaskForce Consensus Proposal: Diagnostic approach toepilepsyindogs.BMCveterinaryresearch2015.

50. LohiH,YoungEJ,FitzmauriceSN,RusbridgeC,ChanEM, Vervoort M, et al. Expanded repeat in canineepilepsy.Science.2005;307(5706):81.

51. Blume WT, Lüders HO, Mizrahi E, Tassinari C, vanEmde BW, Engel J. Glossary of descriptiveterminology for ictal semiology: report of the ILAEtaskforceonclassificationandterminology.Epilepsia.2001;42(9):1212–8.

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