2014

Japan Society for Bioscience,

Biotechnology, and Agrochemistryhttp://www.jsbba.or.jp/

ISSN 2186-1315

2014

250 1

3

250 5

7

450 9

11

112

12DNA 13

15

1050 17

PCB 19

21

23

25

tRNA 27

29

31

33

Nudixhydrolase 35

37 37 37 38 38 39 43 43 442014 502014 51

1

1.

Galvani Volta 20

12.1e/2e

1e/2ePyrroloquin-oline quinone PQQ1996 4 2 21ESR QH-AmDH, 3

HmDHHmDH cysteine tryptophylquinoneCTQ, 2, 3 PQQ Ca2HmDH 6-S-cysteinyl-FMN FeS FDH FAD C

21 1

1

2

3QH-AmDH CTQ

2

ESR3.

METLFER LFERNADH/NADH2 / H/CO2 MET

DET4FDH 2

106 V cm14.

H2O2AsA H2O2 1AsA 45.

2000

LFER MET DET 1/45

4

5DET

3

CL-HPLC1987LC-MS/MS1988PCOOH1

E microRNA 1.

PCOOH CL-HPLC Bruce Ames1990 40

1252PCOOH, 180450 pmol/mLa b

4

3080 p- 2-MxP MxP8095 MxP Lyso-PC 1- 2- PC 4

13-OOH-9Z, 11E-dienoyl; 13-OOH-9E, 11E-dienoyl; 9-OOH-10E, 12Z-dienoyl; 9-OOH-10E, 12E-dienoyl

CL-HPLC

PCOOHSQOOH LC-MS/MS MRM

multiple reaction monitoringSQOOH 6 NMRELSD-HPLC2.T3

E T3 T3

IV 400 mg/day 1 T3T3 T3 T3 RNA T3VE

geranylgeranyl reductase II; GGR2 T33.

PCOOH ICAM-1 PCOOHRho-family GTPase Small G Rac PCOOH

6 mgdeoxy-D-fructosylphosphatidylethanolamine B6 C DNA microRNA microRNA miR-34a, miR-146amiR-29a, miR-29b, miR-34a, miR-125b, miR146a

5

1. 1

4 22 52.

2 4

Web

3.100374

4.

O/W 5

6

1MRIal dente

6.

7

1.

100mol/m2/s CO2 100mol/m2/s CO2 2535mol/m2/s 1975202.2-1

11970 ribulosebisphosphate

RuBP CO2 3050 0.11CO2 3

2 8550kDa DNA

DNA

50 pH2CO2 Galdieria partita 3 CO22 GaldieriaDNA

Galdiereia CO22 RuBP 50 N- 21 305Chromatium 5

RuBP

1CO2

2Vcmax,Kcm,Vomax,Kom Vmax,Km

8

RuBP NADPH NADPH

15

RuBisCO-likeprotein,RLP RLP CO22-2

C4 15 ATP b561 RanGTPase1 COL1 RanGTPase1CLRAN1CLRAN1 3CLCOL1 CONSTANS-Like4COL4CLCOL1 35S CLCOL1 CLCOL1

20073.

202540DNA GFP200mg/ml GFP

-1hsTrx-1 hsTrx-1

14844 1 1 2

1 1

23

45RITE3

NAISTRITE NAISTNAIST

3 RAN1 ABCLRAN1C in vitro in vitro4,5DRAN1

9

Lactobacillus helveticus 2 Val-Pro-ProVPP Ile-Pro-ProIPP

1.

L. helveticus L. helveticus1ACE 2 VPP IPP VPP, IPPPro-Pro2.

VPP, IPP L. helveticus1997 S S

1

U/ml

ACE U/ml

mmHg

control milk 0.00 0 5.07.3Lactobacilli

L. helveticus CP790 0.19 230 58 27.413.3**L. helveticus CP611 0.25 367 70 20.09.6**L. helveticus CP615 0.18 420 51 23.013.4**L. helveticus JCM1006 0.15 182 26 15.29.3*L. helveticus JCM1120 0.10 112 34 6.510.8L. helveticus JCM1004 0.21 186 48 29.313.6**

L. delbrueckii subsp. bulgaricus CP973 0.19 105 22 0.88.2L. delbrueckii subsp. bulgaricus JCM1002 0.11 124 28 4.54.0L. casei CP680 0.01 35 3 0.26.6L. casei JCM1134 0.00 28 9 7.011.2L. casei JCM1136 0.09 25 18 9.67.2L. acidophilus JCM1132 0.00 28 8 8.77.8L. delbrueckii subsp. lactis JCM1105 0.08 18 16 3.33.5

StreptococciS. thermophilus CP1007 0.02 35 3 2.48.1

LactococciL. lactis subsp. lactis CP684 0.00 35 4 7.310.5L. lactis subsp. cremoris CP312 0.02 18 4 5.813.9

Significant differences from the control, **p0.01, *p0.05

10

VPP, IPP ACEL. helveticus CM4 VPP, IPP 23.

L. helveticus VPP, IPP ACE Aspergillus oryzaeVPP, IPP 1004.

S1B to B5.

15

6.

ACE VPP, IPP VPP, IPP VPP, IPP VPP IPP ACE

VPP, IPP VPP IPP

VPP, IPP

1VPP IPP

11

111. 1

ATP ATP

D-Ala-D-Ala ligaseDdlEC 6.3.2.4Ddl D--Bacillus subtilis 168 ywf E

bacilysin ATP ATP-dependent carboxy/thiol ligase L-D--2 L- -L-amino acid -ligaseLalEC6.3.2.28

22. 3

Lal

Lal

1

2Ywf E N C

12

1 Lal 23 Lal 2 4 53.

GlnTyrAlaAlaGlnAlaTyrGln Tyr Gln pH

1 AlaGln GlnUSA SUSTAMINETMAlaGln AlaTyr

1/10

1 K. Tabata, H. Ikeda & S. Hashimoto: J. Bacteriol., 187, 51955202 2005.

2 Y. Shomura, E. Hinokuchi, H. Ikeda, A. Senoo, Y. J. Saito, H. Komori, N. Shibata, Y. Yonetani & Y. Higuchi: Protein Sci. 21, 707716 2012.

3 K. Tabata & S. Hashimoto: Appl. Environ. Microbiol. 73, 63786385 2007.

4 M. Hayashi & K. Tabata: Appl. Environ. Microbiol. 79, 30333039 2013.

5 M. Hayashi, K. Tabata, M. Yagasaki & Y. Yonetani: FEMS Microbiol. Lett. 304, 1219 2010.

Lal

1 Gln Tyr

g/L 25

53.7 Gln

550 AlaGln

0.62 Tyr

17.8 AlaTyr

13

DNA

110

5575Taq DNA Thermus aquaticus

902

18821952197019721982Thermococcus kodakarensis KOD1DNAKOD DNA 1 1.KOD DNA

DNA PCR

PCRDNA

Taq DNA PCR3-5DNAThermus 903-5 Pyrococcus furio-sus Pfu DNA Taq DNA PCRDNA

Thermococcus kodakarensis KOD1 65100 P. furiosus KOD1 KOD DNA Pfu DNA 80

DNA DNA DNA 1XDNA Palm Fingers dNTP KOD DNA Fingers Palm dNTP 2.KOD DNA PCR

KOD DNA Taq DNAPfu DNA Taq DNA 72.5501 DNA3-5PCR

14

KOD DNA PCR1KOD DNA PCR

KOD DNA PCR 3-5KOD DNA 3-5 B DNA Exo I 3-53-5 PCR 2PCRBuffer KOD DNA DNA

GC DNA Primer

PCR Primer KOD DNA PCR3 DNA DNA

DNA PCR

proliferating cell nclear antigen: PCNA PCNA DNA DNADNA DNAKOD DNA PCR

4 PCRPCR Primer

PCR PCR DNA 3-5 2KOD DNA DNA3. KOD DNA

1995KOD DNA PCRKOD DNA 2 PCR1 KOD DNA PCRKOD-Plus-NeoTaq DNA80 1 KOD DNA DNAPCRKOD FX Neo Taq DNA20KOD-Plus-Neo 24 kbKOD FX Neo 40 kb

2013 PCR PCRKOD SYBR qPCR Mix1KOD DNA GENECUBE

18 13 KODKOD DNA PCR 1

1DNA

1 KOD DNA

15

1. Lactobacillus delbrueckii ssp. bulgaricus

Streptococcus thermophilusExopolysaccharide: EPSEPS 2.

38 65 EPS 3.

139 EPS 3 3 EPS

IFN-L. bulgaricus OLL1073R-11073R-11 EPS IFN-IFN-NK1073R-1 EPS NKNK4. NK

1073R-1 EPS NKEPS 3NKEPS NK EPS 1073R-1

S. thermophilus OLS3059 1073R-1 41073R-1 NK NK

Makino et al., J. Dairy Sci. 20065.

NK 1073R-1 EPS BALB/c 21 61073R-1 0.4 ml/day/EPS 1073R-1 0.4 ml 20 g 1073R-1 EPS 7901073R-121 37.5

P0.0018EPS

11073R-1

16

21 11P0.0648

1073R-1EPS 4 NK1073R-1EPS NKIgA, IgG1 1073R-1EPS1073R-1EPS NKNagai et al., Int. Immunopharmacol. 20116.

1073R-1200535200611200721 40

57 21073R-1 81073R-1 90 g 100 ml 11 NK1073R-1 NK2 1073R-1 OR 0.29, P0.10332 6085

NK 121073R-1

NK21073R-1OR 0.44, P0.084332

1073R-1

OR 0.39, P0.0193NK1073R-1 NKP0.028Makino et al., Br. J. Nutr. 20107.

20184519161073R-1EPS

21073R-1 NK

31073R-1

17

ROS1.4--2- ROS ROS

2. ROS 167kDa

EGCg B2EGCg

1

18

DEAD-boxRNA p68 pHEGCg HSA HSAHPLCHSA BHSAHSA EGCg HSAEGCgHSA B3HSA EGCg HSA

4-

3HSA

4

2

19

PCB

PCB

1 10Acidovorax sp. KKS102 PCBbphEGFA1A2A3BCDA4

bphKKS102

KKS102 PCB1bph1bph

bph bphE pE pE bphbph pE bph

bph

pE bph BphS pE 4 BphS bph

pE bphP bphQBphPQ 2bph2KKS102

bph ICEintegrative and conju-gative element bph DNA ICE 5--ICE ICEICE 3PCB PCB

bph PCB/

1bph BphS BphS pE DNA bphBphP BphQ

2ICE bph ICEKKS102Tn4677 integrase integrase

20

1

GenomeMatcher 2 BLAST GenomeMatcher RecordMatcher DataCounter 2 2 RecordMatcher DataCounter & 2Roche

454 KKS102 3 GenoFinisher, AceFileViewer, ShortReadManager KKS102

2A15a07 HCHBHC 5 PCB 10 310 PCR PCRKKS102

21

PGPGD2 J2PG J2PG PG 2

COX-2 Toll Toll-like receptor; TLR1. J2PG

J2 PG 15-deoxy-12,14- PGJ215d-PGJ2 15d-PGJ2

ALS 15d-PGJ2

RAW264.7 LPS 15d-PGJ2 PGD2HPLC PGJ2 12-PGJ2 15d-PGJ212.J2PG

SH-SY5Y15d-PGJ2 15d-PGJ2 15d-PGJ2 15d-PGJ2 15d-PGJ2 p53 Fasp53 15d-PGJ2 ataxia tel-angiectasia-mutatedATM24-oxo-2-nonenalONE p53ATM p53 3.J2PG

15d-PGJ2

1J2PGPGD2 PGJ2 12-PGJ2 12-PGJ2 15d-PGJ2 15d-PGJ2 12-PGJ2 PGJ2 15d-PGJ2

215d-PGJ2 15d-PGJ2 15d-PGJ2 ATM p53

22

NF-kB IkB H-Ras 15d-PGJ2 15d-PGJ2 peroxisome proliferator-activated receptor PPAR 15d-PGJ2 15d-PGJ2 15d-PGJ2 Nrf 2 Keap1 15d-PGJ2 4. 4-oxo-2-nonenalONE

LC-MS/MS LOX-1LOX-1 LOX-1LOX-1 35.

PG TLR PG 2

COX-2TLR TLRCOX-2

J2PG J2 PG

34-oxo-2-nonenalONE LOX-1

23

1 CaTJTJ occludin claudin TJ TJ CaEGF-6IL-61.DFAIII

21DFAIII Ca Ca

DFAIII Caco-2DFAIII TJ Ca DFAIII TJ claudin-1 claudin-1 DFAIII TJ Ca2.

TJ TJ Caco-2TJ 2TJ TJ ZO-2, occludin, claudin-1 TJ claudin-4 occludin

1DFAIII CaA. DFAIII B. Caco-2 CaDFAIII CaC. Caco-2 claudin-1 DFAIII claudin-1

2A. B. Caco-2 Occludin Occludin TJ C. PKCZO-2, claudin-1, occludin claudin-4 occludin

24

protein kinase CPKCTJ TJ 3.TJoccludin

TJ occludin 2 TJ occludin occludin occludin MALDI-TOF-LC/MS/MS 403, 404, 424, 4383RNAioccludin PKC PKCPKC occludin 403, 404PKC 424, 438 occludin Caco-2 TJ TJ occludin occludin TJ4.EGFIL-6

1 Caco-2EGF occludin ZO-1 EGF EGF-phospholipase-C PKCI PKC IL-6 Caco-2IL-6 claudin-2 TJ IL-6 gp130extracellular-signal-regulated kinase ERKphosphatidyl inositol 3-kinasePI3Kclaudin-2 cdx-2 IL-6 claudin-2 IL-6 TJ EGF TJ IL-6 TJ

TJDFAIII EGF IL-6

University of Tennessee Health Science Center UTHSC, College of Medicine, Department of Physiology Radhakrishna K Rao

UTHSC

3TJ occludin A. occludin 403, 404, 424, 438B. 403, 404 TJ 424, 438

25

LA, 9Z12Z-18:2CLA, 18:21CLA CLA -ESA, 9Z11E13E- 18:31EPA DHA CLA EPADHA CLA 1.

ESA ESA 14BF3 /MeOH

2.

ESA37ESA CLA

TGTG TG 3.

ESA ESA ESA ESA ESA CLAESA Ag-HPLCCLA CLA GC-EI/MS 13C-NMR 9Z11E-CLA ESA 13 CLA 2 NADPH 1

26

ESACLA4.

ESA CLA ESA CLA ESA CLA ESA CLA ESA CLA

3ESA ESA ESA ESA ESA Caspase mRNAESAESA ESA CLA ESAEPADHA 5.

HUVEC4 PPAR VEGF 606.

EPADHA EPA DHA

ESA EPA DHA CLA CLA

2014

3ESA ESA

4ESA ESA

213ESA NADPH 139Z11E-CLA

27

tRNA

mRNA tRNA

tRNA tRNA tRNA 1 1 tRNA 11.2-

tRNA 1U342-s2U1As2U 3 tRNA tRNAtRNA mRNAtRNA MnmA tRNA tRNA MnmA tRNA U34

MnmA tRNAGlu I II2MnmA 3 tRNA D tRNA

MnmA tRNA 1 2tRNA 3 tRNA

MnmA N- ATPtRNA ATPMnmA tRNA ATP 3

IIIU34 22 Cys102 Cys199 tRNA 2 Cys199 s2U

3 I II III I tRNA II III U34 U34 Gln151 2

12-A 2-B

2MnmA-tRNAGluI

3TiaS-tRNAIle2-ATP

28

120MnmA tRNA 2.2-

AUA tRNAIle2

tRNAIle2 CAU tRNAIle2 1C34tRNAIle2

AUA C34 202-agm2C1Bagm2C tRNAIle2 AUA tRNAtRNAIle2 tRNAIle2 tRNAagm2C tRNAIle2 AUA agm2C TiaS ATP ATPTiaS tRNAIle2

TiaS, tRNAIle2, ATP 33TiaS 4 IIVtRNA I, II, III IV ATP I TiaS IV tRNAIle2

TiaS ATP AMP ATPC34 23ATP 3 Asp AlaATP agm2C I C34 3

C34 ATP 10 II3 C34 TiaS C34

TiaS, tRNAIle2, AMPcPP, 443 C34 4C34 II AMPcPP TiaS C34 C34 C34 agm2C

RNA 4tRNA s2U agm2C

RNA

29

Camellia sinensis L.

123

31

1

2

3

1.

Epigallocate-chin-3-O-gallate: EGCGEGCG 67kDa 67LR/EGCG 22.

1

2

30

9-Aminoacridine

MALDI-MS

MALDI-MS 1,5-Diaminonaphthalene Bioavailability II3

3.

Camellia sinensis L.4

3 4

31

3836 216Strepto-coccus mutansS. salivarius S. mutans S. salivarius

30601 38

200Saccharomyces cerevisiae Y11-43Lactobacillus plantarum ML11-1111

ML11-11 FISH

2ML11-11

1ABCD SEM

32

pH 2 3

Acetobacter pasteurianus A11-10ML11-11 3 2

3

Escherichia coli K-12E. coli K-12 UMP

2

3AB

33

-d- C-5 -l-A1A1 ABC 1

A11.

A1Kd:109Mp5 A1

X2141 363373 2 p5 2

A1p7 Kd:108M p7 2 2.

AlgQ1 AlgQ2 AlgQ1 AlgQ1 1 2 3 AlgQ1 AlgQ2 AlgQ1 AlgQ2 3.ABC

AlgQ1 AlgQ2 ABC A1ABC AlgM1M2SS: AlgM1M2 AlgSS AlgS ATP AlgM1M2SS AlgQ2 3.2

2AlgQ2 ABC AlgM1 AlgM2 6

AlgQ2AlgSSinward-facing 2AlgSS ATP 1A1

34

AlgM1M2 AlgQ2 AlgM1M2 3082 in vitroAlgQ1 AlgQ2 AlgM1M2SS ATPAlgM1M2 2ABC ABC ATP A1ABC 276 AlgM1M2

A1ABC

ABC ABC A1

X

2ABC

35

Nudix hydrolase

Nudix hydrolaseNUDX-2

nucleoside diphosphate linked to some other moiety X: NDP- X-1 -X 2,500 300 13 24 NUDX ApnA, n45NADPH, CoA, FAD NUDX

Arabidop-sis thalianaNUDXNUDX -2 1.NUDX

28 NUDX AtNUDX127, AtDCP2 GFP AtNUDX111, 25 AtNUDX1218AtNUDX1924, 26, 27 8-oxo-dGTP

AtNUDX1ADP-/NADPHAtNUDX2, 6, 7, 10CoAAtNUDX11, 15ADP-AtNUDX14GDP-AtNUDX9ApnAAtNUDX13, 25, 27FAD

AtNUDX23-4 ppGppAtNUDX26 AtNUDX NUDX NUDX AtNUDX SA2.DNA

ROS DNA RNA

AtNUDX1 8-oxo-dGTP DNA RNA 3.ADP- NADPH ADP PAR DNA

ADP- NADPH AtNUDXAtNUDX2, 6, 7, 10, 14, 19AtNUDX2 PAR ADP- PAR NAD ATP 1AtNUDX7 ADP-NADH PARDNA1AtNUDX6 NADH NPR1 2AtNUDX19 NADPH

1AtNUDX2 AtNUDX7 ADP-NADHNMNHROSPARP ADP-PARG ADP-

36

4. NUDX

AtNUDX26 ppGpp AtNUDX23 FAD AtNUDX11 CoA -CoA AtNUDX15 AtNUDX15a CoA -CoA TCA 5.AtNUDXNADPHNADPH

NADPH/NADPNADH AtNUDX6 AtNUDX7 NADH NADPH AtNUDX6 AtNUDX7 NADH 3

NUDX

FAD CoA NUDX NUDX

2AtNUDX6 NADHROSICS1TRX

3NADPH NMNH ; ROS

37

No. 1 141939 2 151940 3 161941 4 171942 5 181943 6 191944 7 201945 8 211946 L 9 221947 10 231948 11 241949 12 241949 13 251950 14 261951 15 271952 16 281953

No. 1 291954 2 301955 3 311956 4 321957 5 331958 6 341959 7 351960 8 361961 9 371962 10 381963 11 391964 12 401965 13 411966 14 421967 15 431968 16 431968 17 441969 18 441969 19 451970 20 451970 21 461971 22 461971 23 471972 24 471972 25 481973 26 481973 27 491974 28 491974 29 501975 30 501975 31 511976 32 511976 33 521977 34 521977 35 531978 HiochicAcid 36 531978 37 541979 38 541979 39 551980 40 551980 41 561981 S1 42 561981 43 571982 44 571982 45 581983 46 581983 47 591984 48 591984 49 601985 50 601985

38

No. 1 611986 2 611986 3 621987 4 621987 5 631988 6 631988 7 1989 8 1989 9 2 1990 10 2 1990 11 3 1991 12 3 1991 13 4 1992 14 4 1992 15 5 1993 16 5 1993 17 6 1994 18 6 1994 19 7 1995 20 7 1995 21 8 1996 22 8 1996 23 9 1997 24 9 1997 C-P 25 101998 26 101998 27 111999 28 111999 29 122000 30 122000 31 132001 32 132001 33 142002 34 142002 35 152003 36 152003 37 162004 38 162004 His-Asp 39 172005 40 172005 Ca2 41 182006 42 182006 43 192007 44 192007 45 202008 46 202008 47 212009 48 212009 49 222010 ABC 50 222010 51 232011 52 232011 53 242012 54 242012 55 252013 56 252013

No. 1 611986 2 611986 3 621987 4 621987 5 631988 6 631988 7 1989 8 1989 9 2 1990 10 2 1990 11 3 1991 12 3 1991 13 4 1992

39

No. 14 4 1992 15 5 1993 16 5 1993 17 6 1994 18 6 1994 19 7 1995 20 7 1995 21 8 1996 22 8 1996 23 9 1997 24 9 1997 25 101998 26 101998 27 111999 28 111999 X 29 122000 30 122000 31 132001 32 132001 33 142002 34 142002 35 152003 36 152003 37 162004 38 162004 39 172005 40 172005 41 182006 42 182006 43 192007 44 192007 45 202008 46 202008 47 212009 48 212009 49 222010 50 222010 51 232011 52 232011 53 242012 54 242012 55 252013 56 252013

No. 1 431968 2 431968 3 441969 4 441969 5 451970 6 451970 7 461971 8 461971 -d- -d- 9 471972 10 481973 11 491974 12 491974 13 501975 14 511976 15 511976 16 521977

40

No. 17 521977 18 531978 19 531978 20 541979 21 551980 l- 22 551980 23 561981 24 561981 25 571982 26 581983 3- 27 581983 28 591984 29 591984 30 601985 l- 31 611986 32 611986 33 621987 34 621987 35 631988 36 631988 37 1989 7-7ACA 38 1989 39 2 1990 40 2 1990 41 3 1991

41

No. 42 3 1991 43 4 1992 44 4 1992 ATP 45 5 1993 46 5 1993 47 6 1994 Leal,WalterSoares 48 6 1994 49 7 1995 FK506 50 7 1995 51 8 1996 52 8 1996 pre-S2B 53 9 1997 54 9 1997 CoryneformbacteriaMJ-233 55 101998 56 101998 57 111999 58 111999 Bacillus brevis 59 122000 60 122000 d- 61 132001 62 142002

42

No. 63 142002 64 152003 65 152003 Helicobacter pylori 66 162004 67 162004 MicafunginFK463 68 182006 69 182006 - 70 192007 71 192007 72 202008 73 202008 74 212009 l- 75 222010 Corynebacterium glutamicum 76 222010 77 232011 78 232011 FAD 79 242012 80 242012 NRL 81 252013 82 252013

43

No. 1 261951 2 261951

No. 1 271952 2 271952 3 281953 4 281953 5 281953 6 291954 B12 7 291954 8 291954 9 301955 10 301955 11 301955 12 311956 - 13 311955 Asp.versicoler Sterigmatocystin Versicolorin 14 311955 15 321957 16 321955 17 321955 18 331958 Mentha rotundifolia rotundifolone 19 331958 20 331958 Phenolsulphatase 21 341959 22 341959 Hiochicacid 23 341959 24 351960 25 351960 26 351960 Penicillium islanditoxin Islanditoxin 27 361961 28 361961 Phosphoglycerinacidmutase 29 361961 Streptomyces griseus 30 361961 Fungisporin 31 361961 32 361961 33 371962 34 371962 Grayanoxin 35 371962 36 371962 37 371962 38 371962 39 381963 40 381963 41 381963 42 381963 43 381963 X 44 381963 45 391964 46 391964 47 391964 PiericidinA 48 391964 49 391964 Rubrofusarin 50 391964 - 51 401965 destruxinB 52 401965 53 401965 - 54 401965 55 401965 Ciliatine 56 401965 57 411966 58 411966 59 411966 abscisinII 60 411966 BlasticidinS 61 411966 62 411966 63 411966 64 411966 65 411966

44

No. 66 411966 67 421967 68 421967 69 421967 70 421967 71 421967 72 421967 73 421967 74 421967 75 421967

No. 76 431968 77 431968 78 431968 79 431968 80 431968 81 431968 82 431968 p-hydroxybenzoatehydroxylase 83 431968 84 441969 85 441969 86 441969 87 441969 l- 88 441969 89 441969 90 441969 91 441969 92 451970 93 451970 94 451970 95 451970 96 451970 97 451970 Candida utilis 98 451970 99 451970 Protoplastburstingfacter 100 461971 101 461971 102 461971 103 461971 104 461971 105 461971 106 461971 107 461971 108 471972 109 471972 justicidin 110 471972 111 471972 112 471972 Ribonucleotide 113 471972 114 471972 115 471972 116 481973 117 481973 118 481973 x174DNA 119 481973 l- 120 481973 Phytohemagglutinin 121 481973 122 481973 123 481973 124 491974 125 491974 126 491974 J 127 491974 128 491974 129 491974 130 491974 131 491974 132 501975 133 501975 134 501975

45

No. 135 501975 136 501975 Ezomycin 137 501975 138 501975 139 501975 ATP 140 511976 141 511976 Altemaria 142 511976 143 511976 l- 144 511976 l- 145 511976 13C13C 146 511976 147 511976 148 521977 149 521977 150 521977 151 521977 152 521977 - 153 521977 154 521977 2- 155 521977 156 531978 157 531978 d- 158 531978 159 531978 160 531978 161 531978 C3 C4 162 531978 Tunicamycin 163 531978 164 541979 165 541979 166 541979 167 541979 168 541979 169 541979 B6 170 541979 171 541979 172 551980 173 551980 174 551980 175 551980 176 551980 177 551980 178 551980 - 179 551980 180 561981 181 561981 182 561981 Selenomonas ruminantium 183 561981 184 561981 185 561981 186 561981 187 561981 188 561981 189 561981 190 571982 191 571982 192 571982 193 571982 DNA 194 571982 195 571982 196 571982 197 571982 198 571982 DNA 199 571982 in vivo 200 581983 201 581983 202 581983 DNA 203 581983 204 581983 205 581983 206 581983 207 581983 Bacillus subtilis 208 581983 209 581983 210 591984 211 591984 DNA

46

No. 212 591984 213 591984 214 591984 215 591984 216 591984 217 591984 218 591984 219 591984 220 601985 X 221 601985 222 601985 223 601985 224 601985 225 601985 RuBP / 226 601985 227 601985 228 601985 MRCH 229 601985 230 611986 231 611986 232 611986 233 611986 234 611986 235 611986 236 611986 Na 237 611986 238 611986 239 611986 A 240 621987 241 621987 242 621987 243 621987 244 621987 245 621987 PQQ 246 621987 247 621987 248 621987 249 621987 250 631988 251 631988 252 631988 253 631988 254 631988 255 631988 256 631988 257 631988 258 631988 Saccharomyces cerevisiae 259 631988 phoA 260 1989 261 1989 262 1989 263 1989 264 1989 265 1989 266 1989 267 1989 268 1989 269 1989 CO2RuBisCO in vivo 270 2 1990 cAMP 271 2 1990 272 2 1990 273 2 1990 Peptidylargininedeiminase 274 2 1990 275 2 1990 276 2 1990 277 2 1990 278 2 1990 - 279 2 1990 280 3 1991 281 3 1991 282 3 1991 283 3 1991 284 3 1991 285 3 1991 286 3 1991 287 3 1991 288 3 1991

47

No. 289 3 1991 G1G2 290 4 1992 DNA DNA 291 4 1992 P- 292 4 1992 293 4 1992 294 4 1992 295 4 1992 TNF IgG 296 4 1992 297 4 1992 298 4 1992 299 4 1992 300 5 1993 301 5 1993 302 5 1993 DielsAlder 303 5 1993 304 5 1993 305 5 1993 306 5 1993 307 5 1993 308 5 1993 309 5 1993 310 6 1994 311 6 1994 312 6 1994 313 6 1994 314 6 1994 X 315 6 1994 316 6 1994 317 6 1994 318 6 1994 319 6 1994 X - 320 7 1995 321 7 1995 322 7 1995 323 7 1995 324 7 1995 325 7 1995 326 7 1995 Y 327 7 1995 328 7 1995 329 7 1995 d- 330 8 1996 331 8 1996 332 8 1996 333 8 1996 334 8 1996 335 8 1996 336 8 1996 337 8 1996 338 8 1996 339 8 1996 340 9 1997 IGF-I 341 9 1997 342 9 1997 343 9 1997 344 9 1997 345 9 1997 N- 346 9 1997 347 9 1997 348 9 1997 349 9 1997 350 101998 Hydrogenobacter thermophilus TK-6 CO2351 101998 352 101998 N- 353 101998 354 101998 355 101998 356 101998 NMR 357 101998 358 101998 359 101998 360 111999 361 111999 Saccharomyces cerevisiae 362 111999 363 111999 364 111999 365 111999 366 111999 367 111999

48

No. 368 111999 369 111999 B12 370 122000 371 122000 372 122000 373 122000 374 122000 375 122000 376 122000 -HCH 377 122000 378 122000 379 122000 RNARNaseG 380 132001 381 132001 382 132001 2 383 132001 2 384 132001 C 385 132001 386 132001 387 132001 388 132001 389 132001 390 142002 Bisorbicillinoid 391 142002 392 142002 T 393 142002 394 142002 NMR 395 142002 Pichia farinosa SMKT 396 142002 397 142002 SRPRNA 398 142002 399 142002 400 152003 401 152003 402 152003 CCAAT-box 403 152003 404 152003 405 152003 406 152003 407 152003 408 152003 409 152003 410 162004 411 162004 412 162004 413 162004 414 162004 415 162004 416 162004 417 162004 NMR 418 162004 419 162004 421 172005 422 172005 423 172005 424 172005 425 172005 426 172005 427 172005 428 172005 429 172005 430 182006 431 182006 432 182006 O- 433 182006 434 182006 435 182006 436 182006 437 182006 438 182006 439 182006 Ca2 440 192007 441 192007 X

49

No. 442 192007 NAD 443 192007 444 192007 DNA 445 192007 446 192007 447 192007 / 448 192007 449 192007 C1 450 202008 mRNA 451 202008 452 202008 DNA 453 202008 454 202008 455 202008 456 202008 457 202008 ABC 458 202008 DNA 459 202008 460 212009 21COE461 212009 462 212009 463 212009 464 212009 465 212009 466 212009 467 212009 468 212009 469 212009 470 222010 471 222010 472 222010 473 222010 - 474 222010 475 222010 ABC 476 222010 477 222010 478 222010 479 222010 480 232011 T 481 232011 482 232011 483 232011 484 232011 485 232011 486 232011 487 232011 488 232011 489 232011 490 242012 iCeMS491 242012 492 242012 493 242012 494 242012 495 242012 C35 496 242012 497 242012 498 242012 Woroninbody 499 242012 500 252013 501 252013 502 252013 503 252013 tRNA 504 252013 505 252013 506 252013 507 252013 508 252013 509 252013

50

2014250

19541982

19501982

250

19511978

19481977

4

19581984

19621986

2008101

19682004

19641987

19451969

19742001

19581982

19721998

19561979

1050

19772005

19732001

19792006JST

19732005

197520053

19752003

19752003

19732001

19752004RPD

19732001

51

2014

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