固体制剂- Ⅰ (散剂、颗粒剂、片剂、片剂的包衣)
description
Transcript of 固体制剂- Ⅰ (散剂、颗粒剂、片剂、片剂的包衣)
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Noyes-Whiney
Noyes-Whiney
K D V SCsCt
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Noyes-Whiney
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Powders
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1D1D2n
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3
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1
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2
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1
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2
100100100100
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123
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4V
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1. (1) 5,,,, 2 3 4 ,,
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(CRH)(CRH)CRHCRHCRHAB = CRHA CRHBCRH1CRH23CRH
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0.1~0.01g1090.01~0.001g1000.001g1000
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Granules
105500um
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12345
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5131(2000m4250m82.0
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10g200ml5
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tablets1
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tablets
2
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(compressed tablets)(coated tablets)(multilayer tablets)(chewable tablets)(buccal tablets)(sublingual tablets)(solution tablets)(vaginal tablets)(effervescent tablets)(implant tablets)(hyperdemic tablets)
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excipients
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1234
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diluentsfillers5mm50mg
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1.starch 2. sucrose 3. dextrin 4. lactose 5. pregelatinized starch
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6. (microcrystalline celluloseMCC) 7. 8. mannitol
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1. 2. 30%70%
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1 8%15%10%
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2
1MC2HPC3HPMC 550cPas2%5%4CMC-Na 2%10%5EC EC
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3 PVP
10%
PVPPVPK152500PVPK306000PVPK90300000
PVPK303%15%
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4. 10%20%5PEGPEG4000PEG6000PEG6. 50%70%g/g
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1
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2300
3 4
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1.
2CMS-Na 300
3.L-HPC 4.CCNa
5. PVPP
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6.
7.
80
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1
2
350%75%25%50%
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25%50%50%75%
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1
2
3
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4
5PEG PEG4000PEG6000
6
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3.13.23.33.43.5
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25mg
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3.1
()
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1 2 3 50%60%
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YK60
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2025mm
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1.
MCCHPMCPVPMCC
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2.
1 2 3
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1. 2. 3.
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V
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HZD
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1
2
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()
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1
2
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3 4 5
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1 2 3
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CJY300B
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78X-2
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40.3g7.5%0.3g5%202111/3
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5
15min30min2h1h
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6
701985
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7
10mg5%
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1.
Eudragit E100HPMCHPC
2.
151865%75%g/g1002030min40551518
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3.
401015
4.
815
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5.
2%
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5.2 HPMCHPCECPEGPVP PEG
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1
HPMCHPCCMC-NaHPMC
PVPPEG
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,Eudragit
Eudragit E100Eudragit E
Eudragit LEudragit SEudragit L30D
Eudragit L100Eudragit S100
Eudragit RSEudragit RL
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2
Eudragit RSEudragit RL
ECHPMCPEG
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3pH
CAP
Eudragit LEudragit SEudragit L30DEudragit L100Eudragit S100
HPMCPCAP
HPMCAS CAPHPMCP
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2 PEG300PEG400
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3 PEG
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6.1 6.2 6.3 6.4 6.5 6.6 6.7
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6.1 1000 268g 136g 33.4g 266g(17%) q.s 15g 0.25g
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6.1 1/312
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6.2 100mgVB2(1000 5g 50% Q.S. 26g 0.7g 42g
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6.3
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6.4 E1000 E 5g 38.5g 95% 4g 10g 30g 15% 35g 41g 1g
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6.5
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6.5 1000 262g 40g 60g 7g 60g 20g
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6.6 CO2
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6.6 1000 20 325g 2050g 305g 520g
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6.7 1000 30g 10g 25g 1g 23g 1g