毒物分析

授課教師：賴滄海教授03-28-2008

LC-MS of drugs of abuse and related compounds

Rapid Commun. Mass Spectrom.2005;19:1332-1338

Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching

Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography-mass spectrometry

journal of Chromatography B, 814 (2005) 315-323

Doping substances

Diuretics Narcotics β2-Blockers Cannabis Steroids HCG

Erythropoietin Stimulants HGH Insulin,

HBOC

Figure 9.1 Diuretics with thiazide structure are converted by hydrolysis or sulphoxidation during sample transportation, storage or preparation, which may cause analytical problems in GC-MS. Respective artefacts need to be factored into LC-MS screening