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    1 Herridge MS, et al. Functional disability 5 years after acute respiratory distress syn-drome. N Engl J Med. 2011; 364 (14): 1293-304.2 Schweickert WD, et al. Early physical and occupational therapy in mechanically ventilat-ed, critically ill patients: a randomised con-trolled trial. Lancet. 2009; 373 (9678): 1874-82.3 Ely EW, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004; 291 (14): 1753-62.4 Girard TD, et al. Efficacy and safety of a paired sedation and ventilator weaning proto-col for mechanically ventilated patients in in-tensive care (Awakening and Breathing Con-trolled trial): a randomised controlled trial. Lancet. 2008; 371 (9607): 126-34.5 Strm T, et al. A protocol of no sedation for critically ill patients receiving mechanical ven-tilation: a randomised trial. Lancet. 2010; 375 (9713): 475-80.6 Barr J, et al. Clinical practice guidelines for the management of pain, agitation, and deliri-um in adult patients in the intensive care unit. s.l. : Crit Care Med. 2013; 41 (1): 263-306.7 http://square.umin.ac.jp/jrcm/contents/guide/page03.html.8 2013; 20(suppl.): 467.9 ?2001; 28 (2): 31-7.

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