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3199714cMelim1

14cSd114714

17122108117

4PhmakokinetikanderRatte

5UBusdletal1998Phamla00kineticsofmeloximinin1alsanddlerelevancetohumS

mlMebbs199826q5765

6199714cMeloxiwn2

1712P118120

7JSdlmidetal1995MeloximmetatX1icprofi1eandbiob7nSformadonproductsintherat

XENOBIOTICA1995251112191236

8Themetatxhsmandpharmacdkinedcsof14cUHAC62Xintheminipigfouowingomlandinbwenousadminiion

9TissuedisbibutionprOteinbindingeXCretionbalmceandmetatxlitepattemmplasmaurineandbdearoraladminisbdcnine

maleandmaleminipig

10TbmdkunlYhbeetal1997Singleandreeddosetoxicitystudiesofmeloxicambyoraladminiationinminipigs

6uiPhamacomebics1997533197212

11JSchmidetal1995Phamacdkineticsandmetatx1icpattemaRerirlVenOuSinfusionandoraladminisbdontohsubjects

mMets19952311121213

1211514cBOI

165943277

13BOI161932553

14rIbmokunietal1997OmltoxicibStudiesofmeloxicaminrats

q6iPlmacomics19975312949

15SingledosebxicibStudyLD50ofBIBO8032NAametaboliteofUHAC62XXinratsrinbavenousadminisbdon

16UHAC62XUHACllOSEAUHlXXDSAC2NA

K9

17MeloxIn313E87

18ChronictoxicitystudyonthesubstanceUHAC62inratsbyoraladminionoverapericdof18monsStudyNo68K

volumel

19LongtermngstudyofUHAC62XXinmicePQjectNo418487

20LongtermibedingstudyofUHAC62XinspraguedawleyratsPectNo380586

21AMatsuoetal1997Fenihtystudywidlmeloxicaminratsdosedoralbtxforematingandduringeariodofgestation

Oy6lma00miG199753l5159

22AMatsuoetal1997Reprducdonandteratologyudywidlmeloxiczminratsdosedorauyduringdlericdoforganog

q6Pharmacomehics19975316l73

23AMatsuoetal1997RIductionstudywithmeloxicaminratsdosedorauyduringperinatalandrxShatalpehod

qWPharmacomics19975317586

26

24AMatsuoetal1997dteratologyshldieswithmeloxicaminrabbits

q6PhamlaCOmebics19975318795

25Mubgicstudy11UHAC62ineStyphin1uriumandECOIUmammahanmicrosomeassayAmestestGENTOX

O588

26MutagenicitystudywUHAC62XXchmmo5DmalaionsinhmanlymphocytESinvitroGENrrOXO488

27MutagenicstudyindlemOuSebonemamWmicronucleusassayaReroralbWentGENTOX1491

28G Engehmdtetal1995AndinflammatoryanalgesicantipyreticandrelatdproperdesofmeloxicamaneWnOnSteltidal

antiinflammatoryagentwvourablegasiIaltolerance

hmmRe1995423433

291997Meloxicam

535351366

30

311996MeloxicamPAC62

19965228997

32Ul1AC62

33SumeFriesandTiloGrosser2005rmeCardiovascularPharmaCOlogyofCOX2lIbition

HematologyAMSHmlatOIEducProgrwl200544551

34TiloGrosseretal2006BiologicalbasisforthecardiovascularCOnSequenCeSOfCOX2inhibitiondlqapeuticchallengesand

OpIXd6

JClinInvest20061161415

35EMEACOMhmEFORMEDICINALPRODUCTSFORVETERINARYUSECOX2INHBrItRSINVETERINARY

MEDICINE2005

27

28