Yuan Liu, PhDYuan Liu, PhD
Chief, Office of International ActivitiesChief, Office of International ActivitiesDirector, Computational Neuroscience and Director, Computational Neuroscience and
Neuroinformatics ProgramNeuroinformatics ProgramNINDS, NIHNINDS, NIH
Yuan Liu, PhDYuan Liu, PhD
Chief, Office of International ActivitiesChief, Office of International ActivitiesDirector, Computational Neuroscience and Director, Computational Neuroscience and
Neuroinformatics ProgramNeuroinformatics ProgramNINDS, NIHNINDS, NIH
Penn State Penn State August 28, 2007August 28, 2007
Penn State Penn State August 28, 2007August 28, 2007
NIH GrantsmanshipNIH GrantsmanshipElements of SuccessElements of Success
2Dr. Yuan Liu, NINDS, NIH8/28/2007
Office of the DirectorOffice of the Director
National Instituteon Alcohol Abuseand Alcoholism
National Instituteon Alcohol Abuseand Alcoholism
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National CancerInstitute
National CancerInstitute
National Instituteof Diabetes andDigestive and
Kidney Diseases
National Instituteof Diabetes andDigestive and
Kidney Diseases
National Instituteof Dental andCraniofacial
Research
National Instituteof Dental andCraniofacial
Research
National Instituteon Drug Abuse
National Instituteon Drug Abuse
National Instituteof Environmental Health Sciences
National Instituteof Environmental Health Sciences
National Instituteon Aging
National Instituteon Aging
National Instituteof Child Health
and HumanDevelopment
National Instituteof Child Health
and HumanDevelopment
National Institute onDeafness and Other
CommunicationDisorders
National Institute onDeafness and Other
CommunicationDisorders
National EyeInstitute
National EyeInstitute
National HumanGenome Research
Institute
National HumanGenome Research
Institute
National Heart,Lung, and Blood
Institute
National Heart,Lung, and Blood
Institute
National Instituteof Mental Health
National Instituteof Mental Health
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof General
Medical Sciences
National Instituteof General
Medical Sciences
National Instituteof Nursing Research
National Instituteof Nursing Research
National Libraryof Medicine
National Libraryof Medicine
Center for InformationTechnology
Center for InformationTechnology
Center for Scientific Review
Center for Scientific Review
National Centerfor Complementary
and AlternativeMedicine
National Centerfor Complementary
and AlternativeMedicine
National Instituteof Allergy and
Infectious Diseases
National Instituteof Allergy and
Infectious Diseases
National Centerfor ResearchResources
National Centerfor ResearchResources
Clinical Center
Clinical Center
National Center on Minority Health andHealth Disparities
National Center on Minority Health andHealth Disparities
National Institute of Biomedical Imagingand Bioengineering
National Institute of Biomedical Imagingand Bioengineering
FogartyInternational
Center
FogartyInternational
Center
National Institutes of Health
How does NIH Support Research?How does NIH Support Research?
• GrantsGrants
• Investigator-initiatedInvestigator-initiated research grants (majority) research grants (majority)
• Program Announcements (multiple receipt dates)Program Announcements (multiple receipt dates)
• Request for Applications (one time with set-aside $)Request for Applications (one time with set-aside $)
• ContractsContracts
• Cooperative AgreementsCooperative Agreements
NIH GuideNIH Guide http://grants.nih.gov/grants/guide/index.htmlhttp://grants.nih.gov/grants/guide/index.html
R01R01 February 5February 5 June 5June 5 October 5October 5R21, R03R21, R03 February 16February 16 June 16June 16 October 16October 16
Review Review JuneJune OctoberOctober FebruaryFebruaryCouncil Council SeptemberSeptember JanuaryJanuary MayMayAwardAward DecemberDecember AprilApril JulyJuly
Cycle ICycle I Cycle IICycle II Cycle IIICycle III
There are three overlapping cycles per yearThere are three overlapping cycles per year
When to Submit Your Application?When to Submit Your Application?
What Happens to Your Application? What Happens to Your Application?
PIGrant
Application
Funding Institute
Program DirectorsAdvisory CouncilInstitute Director
Grants Management
Review
Initial Review Group Study Sections
Scientific Review Administrators
CSR
Referral Office
Grant Award
What Should Be in the Application?What Should Be in the Application? What Should Be in the Application?What Should Be in the Application?
Face Page – Title of ProjectFace Page – Title of Project AbstractAbstract Key PersonnelKey Personnel BudgetBudget Biographical SketchBiographical Sketch ResourcesResources Research PlanResearch Plan
Specific AimsSpecific Aims Background and SignificanceBackground and Significance Preliminary StudiesPreliminary Studies Research Design and MethodsResearch Design and Methods Human Subjects and Vertebrate AnimalsHuman Subjects and Vertebrate Animals Literature CitedLiterature Cited Letters of SupportLetters of Support
AbstractAbstract
• Research goal and rationalResearch goal and rational
• General hypothesis and aimsGeneral hypothesis and aims
• Methodological approachesMethodological approaches
• SignificanceSignificance
Specific AimsSpecific Aims
• Hypothesis-driven Hypothesis-driven
• FocusedFocused
• RealisticRealistic
BackgroundBackground
• Intimate familiarity with the fieldIntimate familiarity with the field
• In-depth knowledge about the In-depth knowledge about the researchresearch
• Thorough literature reviewThorough literature review
• Appropriate creditAppropriate credit
Preliminary StudiesPreliminary Studies
• Demonstrate expertise & feasibilityDemonstrate expertise & feasibility
• Appropriate amountAppropriate amount
• Critical interpretationCritical interpretation
Design and MethodsDesign and Methods
• Hypothesis-driven, not “fishing expedition”Hypothesis-driven, not “fishing expedition”
• Use sate-of-the art technologiesUse sate-of-the art technologies
• Address pitfalls and alternative plansAddress pitfalls and alternative plans
• Apply appropriate statistical and/or Apply appropriate statistical and/or informatics analysisinformatics analysis
• Provide adequate detailsProvide adequate details
What are the Review Criteria?What are the Review Criteria?
• SignificanceSignificance
• ApproachApproach
• InnovationInnovation
• InvestigatorInvestigator
• EnvironmentEnvironment
SignificanceSignificance
• Does this study address an important Does this study address an important problem?problem?
• If the aims of the application are achieved, If the aims of the application are achieved, how will scientific knowledge be advanced?how will scientific knowledge be advanced?
• What will be the effect of these studies on What will be the effect of these studies on the concepts or methods that drive this the concepts or methods that drive this field?field?
ApproachApproach
• Are the conceptual framework, design, Are the conceptual framework, design, methods, and analyses adequately methods, and analyses adequately developed, well-integrated, and developed, well-integrated, and appropriate to the aims of the project?appropriate to the aims of the project?
• Does the applicant acknowledge Does the applicant acknowledge potential problem areas and consider potential problem areas and consider alternative tactics? alternative tactics?
InnovationInnovation
• Does the project employ novel concepts, Does the project employ novel concepts, approaches or methods?approaches or methods?
• Are the aims original and innovative?Are the aims original and innovative?
• Does the project challenge existing Does the project challenge existing paradigms or develop new methodologies paradigms or develop new methodologies or technologies? or technologies?
InvestigatorInvestigator
• Is the investigator appropriately Is the investigator appropriately trained and well suited to carry out trained and well suited to carry out this work?this work?
• Is the work proposed appropriate to Is the work proposed appropriate to the experience level of the principal the experience level of the principal investigator and other researchers?investigator and other researchers?
EnvironmentEnvironment
• Does the scientific environment in which Does the scientific environment in which the work will be done contribute to the the work will be done contribute to the probability of success?probability of success?
• Do the proposed experiments take Do the proposed experiments take advantage of unique features of the advantage of unique features of the scientific environment or employ useful scientific environment or employ useful collaborative arrangements?collaborative arrangements?
• Is there evidence of institutional support?Is there evidence of institutional support?
What do the Reviewers Want to Know?What do the Reviewers Want to Know?• WHYWHY is your research important? is your research important?
(background, significance, innovation)(background, significance, innovation)
• WHATWHAT are you proposing to do? are you proposing to do?
(research plan, specific aims)(research plan, specific aims)
• HOWHOW are you going to do it? are you going to do it?
(approaches, experimental design, method and analysis)(approaches, experimental design, method and analysis)
• Are Are YOUYOU the best person to do it? the best person to do it?
(investigator, preliminary data, environment)(investigator, preliminary data, environment)
How is an Application Reviewed?How is an Application Reviewed?• Primary reviewerPrimary reviewer
• Describes application and provides critiques (5-10 min)Describes application and provides critiques (5-10 min)
• Secondary reviewer(s)Secondary reviewer(s)• Adds differences or enhancements to the primary (1-2 min)Adds differences or enhancements to the primary (1-2 min)
• CommitteeCommittee• General discussion (all members)General discussion (all members)
• ScoreScore• First given by assigned reviewersFirst given by assigned reviewers• All committee members then give individual score All committee members then give individual score
• SRASRA• Calculates the score and the percentileCalculates the score and the percentile• Prepares the Summary StatementPrepares the Summary Statement
What are in the Summary Statement?What are in the Summary Statement?What are in the Summary Statement?What are in the Summary Statement?
SUMMARY STATEMENTDr. John Johnson ( Privileged Communication ) Release Date: 03/01/2006(301) [email protected]
SMITH, JOE PHD Application Number: 2 R01 MH99999-06A1UNIVERSITY OF SAN SIMEONDEPT OF PSYCHOPHYSIOLOGY10550 CASTLE ROADSAN SIMEON, CA 93452
Review Group: LAMNeurobiology of Learning and Memory Study Section
Meeting Date: 02/16/2006Council: MAY 2006 PCC: 72-NBTRequested Start: 07/01/2006 Dual IC(s): NSDA Project Title: NEURAL CONTROL OF INVOLUNTARY EXUBERANCE SRG Action: Priority Score: 138 Percentile: 3.5Human Subjects: 10-NO HUMAN SUBJECTS INVOLVEDAnimal Subjects: 30-ANMLS INV.-VERIFIED, NO SRG CONCERNS OR COMMENT
What is the Next Step?What is the Next Step?
Two stages of review:Two stages of review:
• Study SectionStudy Section• Scientific and technical meritScientific and technical merit
• National Advisory CouncilNational Advisory Council• Scientific, clinical and lay representationScientific, clinical and lay representation• Focus on policy and strategyFocus on policy and strategy• Make recommendations to the Institute Make recommendations to the Institute
DirectorDirector
What are the Funding Criteria?What are the Funding Criteria?
• Scientific MeritScientific Merit• Priority score/percentile Priority score/percentile
• Program RelevanceProgram Relevance• Is the project related to the mission of the funding Is the project related to the mission of the funding
institute?institute?
• Program BalanceProgram Balance• Are many similar projects already funded?Are many similar projects already funded?
• Availability of FundsAvailability of Funds• Dose the funding institute have sufficient resources Dose the funding institute have sufficient resources
available at the time?available at the time?
What is the Outcome of Review?What is the Outcome of Review?What is the Outcome of Review?What is the Outcome of Review?
• Fundable Fundable Receive fundingReceive funding
• Gray ZoneGray Zone Contact Program Contact Program DirectorDirector
• UnfundableUnfundable ResubmissionResubmission
How to Write a Successful How to Write a Successful Revised Application?Revised Application?
How to Write a Successful How to Write a Successful Revised Application?Revised Application?
• Respond to Respond to AllAll criticisms criticisms
• Provide explicit responsesProvide explicit responses
• Supply additional data and materialSupply additional data and material
• Be Be politepolite
• Be Be persistentpersistent!!
Pearl of WisdomPearl of WisdomPearl of WisdomPearl of Wisdom
• Do not submit prematurely
• Follow instructions
• Be a “reviewer” of your own application
• Have at least three people read your application prior to submission
• Write clearly!
• Do not submit prematurely
• Follow instructions
• Be a “reviewer” of your own application
• Have at least three people read your application prior to submission
• Write clearly!
“All About Grants” Tutorialshttp://www.niaid.nih.gov/ncn/grants/
The NIH Peer Review Processhttp://cms.csr.nih.gov/AboutCSR/OverviewofPeerReviewProcess.htm
NIH Guidehttp://grants.nih.gov/grants/guide/index.html
NIH CSR Study Section Rosterhttp://www.csr.nih.gov/Roster_proto/sectionI.asp
NIH Institutes Centers and Officeshttp://www.nih.gov/icd/
“All About Grants” Tutorialshttp://www.niaid.nih.gov/ncn/grants/
The NIH Peer Review Processhttp://cms.csr.nih.gov/AboutCSR/OverviewofPeerReviewProcess.htm
NIH Guidehttp://grants.nih.gov/grants/guide/index.html
NIH CSR Study Section Rosterhttp://www.csr.nih.gov/Roster_proto/sectionI.asp
NIH Institutes Centers and Officeshttp://www.nih.gov/icd/
Some Useful WebsitesSome Useful Websites
Funding Opportunities - Bioengineering
• PA-06-418 Exploratory/Developmental Bioengineering Research Grants (EBRG) [R21]
• Innovative, high risk/high impact research in new areas• Minimal or no preliminary data required
• PA-07-279 Bioengineering Research Grants (BRG) [R01]
• Basic and applied multi-disciplinary research• Important biological, bioengineering or medical problems• Hypothesis-driven, discovery-driven or design-directed
• PAR-07-352 Bioengineering Research Partnerships (BRP) [P01]
• Multi-disciplinary research team• Integrative, systems approaches
http://www.becon.nih.gov/becon_funding.htm#becon
Funding Opportunities – Computational & Informatics
• PA-06-411 Exploratory Innovations in Biomedical Computational Science and Technology (R21)
• Innovative, with high risk/high impact research in new areas• Minimal or no preliminary data required
• PAR-07-344 Innovations in Biomedical Computational Science and Technology (R01)
• Database design, graphical interfaces, data querying, retrieval, visualization, manipulation, integration and analytical tools
• Computational modeling & simulation
• PAR-07-235 Continued Development and Maintenance of Software
• Continued development, maintenance, testing and evaluation of existing biomedical informatics/computational biology software and its applications to broader biomedical research communities
http://www.bisti.nih.gov/bistic_funding.cfm
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