Pontes e Parcerias nos Países de Língua Portuguesa
Coimbra, 5 de Julho de 2016
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
CRISTINA DELERUE-MATOS [email protected]
www.requimte.pt | www.graq.isep.ipp.pt
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Emerging Pollutants
“Pollutants currently not included in routine monitoring
programmes at Union level but which could pose a significant
risk requiring regulation, depending upon their potential
ecotoxicological and toxicological effects and on their levels in
the aquatic environment”
Directive 2013/39/EU
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
EMERGING POLLUTANTS
Drugs of abuse Personal care products
Fuel additives
Pharmaceuticals
Surfactants
Disinfection
byproducts
Endocrine disruptors
Nanomaterials
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
SOURCES AND FATE IN THE ENVIRONMENT
Pharmaceuticals do not need to persist in the
environment, since they are continuously
introduced
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Pharmaceuticals have been detected in the environment worldwide
Nowadays there are a few data of the presence of pharmaceuticals in developing countries
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Number of pharmaceuticals found in drinking water worldwide.
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
ANTIEPILEPTIC DRUGS
DICLOFENAC
CARBAMAZEPINE
IBUPROFEN
SULFAMETHOXAZOLE
NAPROXEN
ESTRONE
17-β-ESTRADIOL
17-α-ETHINYLESTRADIOL
TRIMETROPIN
PARACETAMOL
ANALGESICS
ANALGESICS
ANTIBIOTICS
ANALGESICS
ESTROGENS
ESTROGENS
ESTROGENS
ANTIBIOTICS
ANALGESICS
Number of pharmaceuticals detected in surface water, ground water, tap water and/or drinking water
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Sampling Sample
preparation Chromatographic
separation Detection Results
ANALYTICAL PROCEDURE
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 min
0
25000
50000
75000
100000
125000
150000
175000
200000
225000
250000
Diazepam-d5
Venlafaxine-d6
Fluoxetine-d5
Carbamazepine-d10
Trazodone
Paroxetine
Venlafaxine
Citalopram
SertralineFluoxetineCarbamazepine
Norfluoxetine
Inte
nsity
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
PHARMACEUTICALS DETECTED BY OUR GROUP REQUIMTE/LAQV-ISEP
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: IBUPROFEN
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: PARACETAMOL, PARACETAMOL-GLUCURONIDE AND P-AMINOPHENOL
EVALUATION OF THE PRESENCE OF PHARMACEUTICALS IN PORTUGUESE SEAWATERS
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
IMPACT OF URBAN WASTEWATERS TO THE LOAD OF PHARMACEUTICALS INTO SURFACE WATERS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
PHARMACEUTICALS DETECTED BY OUR GROUP REQUIMTE/LAQV-ISEP
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: IBUPROFEN
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: PARACETAMOL, PARACETAMOL-GLUCURONIDE AND P-AMINOPHENOL
EVALUATION OF THE PRESENCE OF PHARMACEUTICALS IN PORTUGUESE SEAWATERS
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
IMPACT OF URBAN WASTEWATERS TO THE LOAD OF PHARMACEUTICALS INTO SURFACE WATERS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: IBUPROFEN 33 surface water samples (rivers, stream, estuaries)
15 positive samples for the presence of ibuprofen
0
100
200
300
400
500
600
700
800Ib
up
rofe
n c
on
c. (n
g L
-1)
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
PHARMACEUTICALS DETECTED BY OUR GROUP REQUIMTE/LAQV-ISEP
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: IBUPROFEN
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: PARACETAMOL, PARACETAMOL-GLUCURONIDE AND P-AMINOPHENOL
EVALUATION OF THE PRESENCE OF PHARMACEUTICALS IN PORTUGUESE SEAWATERS
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
IMPACT OF URBAN WASTEWATERS TO THE LOAD OF PHARMACEUTICALS INTO SURFACE WATERS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
7 Rivers of the North of Portugal
At least one compound detected in all the studied rivers
Metabolite and transformation product detected in higher concentrations than the parent compound
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: PARACETAMOL, PARACETAMOL-GLUCURONIDE AND P-AMINOPHENOL
0,0
0,5
1,0
1,5
2,0
2,5
3,0
3,5
4,0
Co
nc
. (μ
g L
-1)
Paracetamol Paracetamol-glucuronide p-Aminophenol
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
PHARMACEUTICALS DETECTED BY OUR GROUP REQUIMTE/LAQV-ISEP
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: IBUPROFEN
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: PARACETAMOL, PARACETAMOL-GLUCURONIDE AND P-AMINOPHENOL
EVALUATION OF THE PRESENCE OF PHARMACEUTICALS IN PORTUGUESE SEAWATERS
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
IMPACT OF URBAN WASTEWATERS TO THE LOAD OF PHARMACEUTICALS INTO SURFACE WATERS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
EVALUATION OF THE PRESENCE OF PHARMACEUTICALS IN PORTUGUESE SEAWATERS • 101 Seawater samples were collected in Atlantic Ocean
• 14 Beaches with different bathing water quality (excellent, good, sufficient)
• 5 Cities and surrounding area (Vila do Conde, Matosinhos, Porto, Vila Nova de Gaia, Espinho)
• Analyzed by SPE-UHPLC-MS/MS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Lolić et al., STOTEN 508 (2015) 240
TEMPORAL DISTRIBUTION OF AINES/ANALGESICS ALONG BATHING SEASON 2013
Highest concentrations detected in
August and September
Increase of the population in the
studied area during these months
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
ENVIRONMENTAL RISK ASSESSMENT
Environmental Risk
Assessment
Based on Hazard Quotient (HQ) using 3 trophic
levels (algae, daphnids and fish)
“Worst case scenario” approach
HQ = MEC/PNEC
MEC – Measured Environmental Concentration
PNEC – Predicted No-effect Concentration
• Potential environmental risk HQ ≥ 1
• No risk is expected HQ < 1
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
1.00E-05
1.00E-04
1.00E-03
1.00E-02
1.00E-01
1.00E+00
1.00E+01
Haz
ard
qu
oti
ent
(HQ
)
Fish
Daphnid
1.00E-05
1.00E-04
1.00E-03
1.00E-02
1.00E-01
1.00E+00
1,00E-05
1,00E-04
1,00E-03
1,00E-02
1,00E-01
1,00E+00
Haz
ard
qu
oti
en
t (H
Q)
Título do Gráfico
Acetaminophen
Acetylsalicylic acid
Diclofenac
Ibuprofen
Naproxen
Ketoprofen
ENVIRONMENTAL RISK ASSESSMENT - SEAWATERS
Haz
ard
qu
oti
ent
(HQ
)
Diclofenac
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Algae
1,00E-05
1,00E-04
1,00E-03
1,00E-02
1,00E-01
1,00E+00
Haz
ard
qu
oti
en
t (H
Q)
Título do Gráfico
Acetaminophen
Acetylsalicylic acid
Diclofenac
Ibuprofen
Naproxen
Ketoprofen
ENVIRONMENTAL RISK ASSESSMENT - SEAWATERS
1.00E-05
1.00E-04
1.00E-03
1.00E-02
1.00E-01
1.00E+00
Haz
ard
qu
oti
en
t (H
Q)
Acetaminophen Acetylsalicylic acid Diclofenac Ibuprofen Naproxen Ketoprofen
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
PHARMACEUTICALS DETECTED BY OUR GROUP REQUIMTE/LAQV-ISEP
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: IBUPROFEN
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: PARACETAMOL, PARACETAMOL-GLUCURONIDE AND P-AMINOPHENOL
EVALUATION OF THE PRESENCE OF PHARMACEUTICALS IN PORTUGUESE SEAWATERS
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
IMPACT OF URBAN WASTEWATERS TO THE LOAD OF PHARMACEUTICALS INTO SURFACE WATERS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
Santos et al., STOTEN 461-462 (2013) 302
University General Pediatric Maternity
WWTP
Number of beds
1456 350 110 96
The case study of Coimbra (Portugal)
78 pharmaceuticals
20 therapeutic
classes
SPE-UHPLC-MS/MS
Sampling period:
February-May 2011
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
Santos et al., STOTEN 461-462 (2013) 302
Contamination pattern (relative concentration (%) for each therapeutic class)
0 20 40 60 80 100
Maternity
Pediatric hospital
General hospital
University hospital
Relative percentage (%)
X-ray contrast agent (iopromide)
Analgesics/anti-inflammatories
Antibiotics
Diuretics
Antihypertensives
Psychiatric drugs
β-Blockers
Oral antidiabetic (metformin)
Others
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
IMPACT OF HOSPITAL EFFLUENTS INTO URBAN WASTEWATERS
Higher impact of hospital effluents
Analgesics Antibiotics
NSAIDs
University hospital
General hospital
Pediatric hospital
Maternity hospital
Urban input
Santos et al., STOTEN 461-462 (2013) 302
Psychiatric drugs
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Santos et al., STOTEN 461-462 (2013) 302
0
10
20
30
40
50
60
70
80
90
Re
mo
va
l e
ffic
ien
cy (
%)
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
Removal efficiency of pharmaceuticals in the WWTP goes
from not eliminated to >80%
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
ENVIRONMENTAL RISK ASSESSMENT – WWTP EFFLUENTS
Pharmaceuticals that have a potential environmental risk (HQ > 1)
Pharmaceutical HQ algae
Sulfamethoxazole 62.6
Ciprofloxacin 279
Ofloxacin 22.9
Azithromycin 15.6
Clarithromycin 3.34
Setraline 1.20
Santos et al., STOTEN 461-462 (2013) 302
The level of pharmaceuticals found
in WWTP effluents showed a more
pronounced potential risk for algae
• Antibiotics are among pharmaceuticals that
have a high potential environmental risk
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
PHARMACEUTICALS DETECTED BY OUR GROUP REQUIMTE/LAQV-ISEP
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: IBUPROFEN
PRESENCE OF PHARMACEUTICALS IN PORTUGUESE RIVERS: PARACETAMOL, PARACETAMOL-GLUCURONIDE AND P-AMINOPHENOL
EVALUATION OF THE PRESENCE OF PHARMACEUTICALS IN PORTUGUESE SEAWATERS
CONTRIBUTION OF HOSPITAL EFFLUENTS TO THE LOAD OF PHARMACEUTICALS INTO URBAN WASTEWATERS
IMPACT OF URBAN WASTEWATERS TO THE LOAD OF PHARMACEUTICALS INTO SURFACE WATERS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
IMPACT OF URBAN WASTEWATERS TO THE LOAD OF PHARMACEUTICALS INTO SURFACE WATERS
• The impact of WWTP effluents was evaluated using Lis river as a case study • Sampling points were selected through the river • WWTPs that discharge their effluent into the river were also monitored
9 Sampling points:
Source of Lis River
Upstream WWTP of Olhalvas
Downstream WWTP of Olhalvas
WWTP of Olhalvas (influent and effluent)
Upstream WWTP Norte
Downstream WWTP Norte
WWTP Norte (influent and effluent)
Sampling period: August 2013-June2014
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
WWTP 1 WWTP 2
• Designed for 49,315 p.e.
• Secondary treatment by activated
sludge
• Average capacity: 6250 m3/day
• Designed for 248,685 p.e.
• Secondary treatment by activated
sludge
• Tertiary treament by UV during
bathing season
• Average capacity: 37,997 m3/day
Source: Paíga et al, in preparation
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Ph
arm
ace
uti
cals
Anti-inflammatories/Analgesic
Psychiatric drugs
Antibiotics
Acetaminophen
Naproxen Ketoprofen
Nimesulide Ibuprofen Hydroxyibuprofen Carboxyibuprofen
Diclofenac
Acetylsalicylic acid Salicylic acid
Norfluoxetine Fluoxetine
Citalopram Venlafaxine
Carbamazepine
Paroxetine
Diazepam 10, 11-Epoxicarbamazepine
Sertraline
Trazodone
Trimethoprim
Ofloxacin
Sulfamethoxazole
Sulfamethazine
Sulfamethoxypiridazine
Sulfadimethoxine
Sulfadiazine
Sulfapyridine
Ciprofloxacin
Enrofloxacin
Azithromycin
Clarithromycin
SPE-UHPLC-MS/MS
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016 Source: Paíga et al, submitted
0 10 20 30 40 50 60 70 80 90 100
Azithromycin
Clarithromycin
Ciprofloxacin
Trimethoprim
Sulfamethazine
Sulfamethoxazole
Sulfapyridine
Sulfadiazine
Diazepam
10,11-Epoxycarbamazepine
Carbamazepine
Venlafaxine
Trazodone
Citalopram
Paroxetine
Sertraline
Norfluoxetine
Fluoxetine
Salicylic acid
Diclofenac
Ketoprofen
Acetaminophen
Naproxen
Hydroxyibuprofen
Carboxyibuprofen
Ibuprofen
Frequency of detection (%)
WWTP influent WWTP effluent River
NSAIDs/Analgesics
Psychiatric drugs
Antibiotics
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Source
Upstream WWTP1
Downstream WWTP1
Upstream WWTP2
Downstream WWTP2
An
tib
ioti
cs
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
Car
bam
aze
pin
e
0
50
100
150
200
250
300
Concentration (ng/L)
Downstream WWTP 2
0
50
100
150
200
250
300
Concentration (ng/L) Upstream WWTP 2
0
50
100
150
200
250
300
Concentration (ng/L) Downstream WWTP 1
0
50
100
150
200
250
300
Concentration (ng/L)
Upstream WWTP 1
0
50
100
150
200
250
300
Concentration (ng/L)
Source of Lis River
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016 Source: Paíga et al, submitted
1E+00
1E+01
1E+02
1E+03
1E+04
1E+05
1E+06
Load (
mg/d
/1000 in
habitants
)
Antibiotics (WWTP 1) Antibiotics (WWTP 2)
Psychiatric drugs (WWTP 1) Psychiatric drugs (WWTP 2)
NSAIDs/analgesics (WWTP 1) NSAIDs/analgesics (WWTP 2)
1E+00
1E+01
1E+02
1E+03
1E+04
Load (
mg/d
/1000 in
habitants
)
Antibiotics (WWTP 1) Antibiotics (WWTP 2)
Psychiatric drugs (WWTP 1) Psychiatric drugs (WWTP 2)
NSAIDs/analgesics (WWTP 1) NSAIDs/analgesics (WWTP 2)
1E+00
1E+01
1E+02
1E+03
1E+04
1E+05
1E+06
Load (
mg/d
/1000 in
habitants
)
Antibiotics (WWTP 1) Antibiotics (WWTP 2)
Psychiatric drugs (WWTP 1) Psychiatric drugs (WWTP 2)
NSAIDs/analgesics (WWTP 1) NSAIDs/analgesics (WWTP 2)
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016 Source: Paíga et al, submitted
0 20 40 60 80 100
nov/13
dez/13
jan/14
fev/14
mar/14
abr/14
mai/14
jun/14
jul/14
Removal efficiency (%)
WWTP 2
WWTP 1
WWTP 2 shows a higher removal efficiency of antibiotics than WWTP 1
An
tib
ioti
cs
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016 Source: Paíga et al, submitted
1E-05
1E-04
1E-03
1E-02
1E-01
1E+00
Cipr
oflo
xaci
n
Sulfa
met
hazi
ne
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Azi
thro
myc
in
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Cita
lopr
am
Paro
xetin
e
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
1E-05
1E-04
1E-03
1E-02
1E-01
1E+00
1E+01
Cip
rofl
oxa
cin
Su
lfa
me
tha
zin
e
Su
lfa
me
tho
xazo
le
Cla
rith
rom
yci
n
Ca
rbam
aze
pin
e
Flu
oxe
tin
e
Ser
tra
line
Ace
tam
ino
ph
en
Ibu
pro
fen
Ke
top
rofe
n
Sal
icyl
ic a
cid
Nap
rox
en
Dic
lofe
na
c
Ha
za
rd q
uo
tie
nt
(HQ
)
1E-04
1E-03
1E-02
1E-01
1E+00
1E+01
1E+02
Cipr
oflo
xaci
n
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Azi
thro
myc
in
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Cita
lopr
am
Paro
xetin
e
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
ENVIRONMENTAL RISK ASSESSMENT – LIS RIVER
Ibuprofen
Ciprofloxacin Sulfamethozazole Clarithromycin Azithromycin
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
ENVIRONMENTAL RISK ASSESSMENT WWTP EFFLUENTS
1E-05
1E-04
1E-03
1E-02
1E-01
1E+00
1E+01
Cipr
oflo
xaci
n
Trim
eth
opri
m
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Dia
zep
am
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
1E-07
1E-06
1E-05
1E-04
1E-03
1E-02
1E-01
1E+00
1E+01
Trim
eth
opri
m
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Dia
zepa
m
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
WW
TP
2
WW
TP
1
Ibuprofen Diclofenac
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
1E-04
1E-03
1E-02
1E-01
1E+00
1E+01
Cipr
oflo
xaci
n
Trim
eth
opri
m
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Azi
thro
myc
in
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Cita
lopr
am
Dia
zep
am
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
WW
TP
1
1E-07
1E-06
1E-05
1E-04
1E-03
1E-02
1E-01
1E+00
1E+01
Trim
eth
opri
m
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Azi
thro
myc
in
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Cita
lopr
am
Paro
xetin
e
Dia
zep
am
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
WW
TP
2
ENVIRONMENTAL RISK ASSESSMENT WWTP EFFLUENTS
Acetaminophen
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
1E-03
1E-02
1E-01
1E+00
1E+01
1E+02
Cipr
oflo
xaci
n
Trim
eth
opri
m
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Azi
thro
myc
in
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Cita
lopr
am
Dia
zep
am
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
WW
TP
1
1E-03
1E-02
1E-01
1E+00
1E+01
Trim
eth
opri
m
Sulfa
met
hoxa
zole
Clar
ithr
om
ycin
Azi
thro
myc
in
Carb
amaz
epin
e
Flu
oxet
ine
Sert
ralin
e
Cita
lopr
am
Paro
xetin
e
Dia
zep
am
Ace
tam
ino
phen
Ibu
prof
en
Keto
prof
en
Salic
ylic
aci
d
Nap
roxe
n
Dic
lofe
nac
Ha
za
rd q
uo
tie
nt
(HQ
)
WW
TP
2
ENVIRONMENTAL RISK ASSESSMENT WWTP EFFLUENTS
Ciprofloxacin Sulfamethozazole Clarithromycin Azithromycin Fluoxetine
Sulfamethoxazole Fluoxetine
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
The presence of different therapeutic classes was quantified in portuguese surface waters (rivers, stream, estuaries, seawaters)
Wastewaters are an important source of entrance of pharmaceuticals into the environment
The contribution of hospital effluents to the load of pharmaceuticals to urban wastewaters varies among therapeutic classes and from hospital to hospital
More monitoring studies should be made in order to better understand the level of environmental pollution
Green pharmacy approach is a challenge in nowadays
New remediation technologies and solutions have to be found
CO
NC
LUSI
ON
S:
O problema dos poluentes emergentes e a sua presença em águas superficiais e águas residuais
Cristina Delerue-Matos– 05/07/2016
ACKNOWLEDGEMENTS • Lúcia Helena Moreira Lírio Matias dos Santos • Paula Celeste Batista Paíga
This work received financial support from the European Regional Development Fund (ERDF) through
the COMPETE - Operational Competitiveness Programme and national funds through FCT, under
UID/QUI/50006/2013 and project UTAP-ICDT/CTM-NAN/0025/2014. The authors wish to acknowledge
to the Agência Portuguesa do Ambiente (APA) for providing the seawater samples.
Muito Obrigada/o pela Vossa Atenção/ Thank you for your attention
http://www.graq.isep.ipp.pt
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