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CYTOKINES CYTOKINES
MEFST, Medical studies in EnglishMEFST, Medical studies in English
2012/13.2012/13.
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What are cytokines?What are cytokines?
Interleukins (IL 1Interleukins (IL 1--35)35) Interpherons (IF type 1,2,3)Interpherons (IF type 1,2,3)
Colony stimulating factors (CSF)Colony stimulating factors (CSF)
Others (TGFOthers (TGF-- ββ, LIF, MIF), LIF, MIF)
ChemokinesChemokines
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General properties of cytokinesGeneral properties of cytokines II
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General properties of cytokines IIGeneral properties of cytokines II
NOT STOREDNOT STORED
HAVE LOCAL AND SYSTEMIC EFFECTSHAVE LOCAL AND SYSTEMIC EFFECTS
ONE STIMULATES SECRETION OF OTHER ONE STIMULATES SECRETION OF OTHER
HIGH RECEPTOR AFFINITY HIGH RECEPTOR AFFINITY
CHANGE THE LEVEL OF GENE TRANSCRIPTIONCHANGE THE LEVEL OF GENE TRANSCRIPTION(except chemokines, and sometimes TNF)(except chemokines, and sometimes TNF)
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Cytokine receptor familiesCytokine receptor families
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Innate and adaptive immunityInnate and adaptive immunity
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CytokineCytokine classificationclassification
INNATE IMMUNITY CYTOKINESINNATE IMMUNITY CYTOKINES
HEMATOPOIETIC CYTOKINESHEMATOPOIETIC CYTOKINES
IMMUNOSUPPRESSIVE CYTOKINESIMMUNOSUPPRESSIVE CYTOKINES
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INNATE IMMUNITYINNATE IMMUNITYCYTOKINESCYTOKINES
Secreted by macrophagesSecreted by macrophages Stimmulated by LPS, nucleic acids,Stimmulated by LPS, nucleic acids,
Those are:Those are:
TNFTNF--αααααααα , IL , IL--1, IL1, IL--12, IF12, IFαααααααα ii ββββββββ
ILIL--6, IL6, IL--8, IL8, IL--18, IL18, IL--23, IL23, IL--27,…27,…
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Tumor necrosis factorTumor necrosis factor
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TNF receptor cell sygnalingTNF receptor cell sygnaling
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ILIL--1 family1 family
A complex network of proinflamatory A complex network of proinflamatorycytokinescytokines
-- -- ,, , ..., ...
FFunction simmilar to TNFunction simmilar to TNF
Do NOT lead to apoptosis or septicDo NOT lead to apoptosis or septic
shock shock Syntesized from a stored precursorSyntesized from a stored precursor
proteinprotein
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Other innate immunity cytokinesOther innate immunity cytokines
ILIL--1010 Inhibits ILInhibits IL--12 and TNF12 and TNF--αααααααα production, as well asproduction, as well as
MHCMHC – –class II (immunosuppression)class II (immunosuppression)
ILIL--66 Stimulates acuteStimulates acute--phase proteins andphase proteins and
lymphocite T/B growth (adaptive immunity)lymphocite T/B growth (adaptive immunity)
ILIL--1515 Stimulates NK cell proliferationStimulates NK cell proliferation
ILIL--8, IL8, IL--18, IL18, IL--23, IL23, IL--2727
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Adaptive immunity cytokines Adaptive immunity cytokines
Secreted by TSecreted by T--lymphocyteslymphocytes Stimulated by antigenesStimulated by antigenes
Those are:Those are:
ILIL--2, IL2, IL--4, IL4, IL--5, IF5, IF--γγ
ILIL--6, IL6, IL--11, IL11, IL--13, IL13, IL--17,…17,…
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ILIL--55
Activates eosinophiles Activates eosinophiles
Stimulates the production of Th2Stimulates the production of Th2
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(TL, NK, makrofagi)
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Immunosuppression cytokinesImmunosuppression cytokines
produced by CD4+Tproduced by CD4+T--ly, macrophagesly, macrophages
Suppress macrophages and Th1Suppress macrophages and Th1
Those are:Those are:
TGFTGF--ββββββββ , IL , IL--1010 ILIL--4, IL4, IL--13,…13,…
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TGFTGF--ßß
Inhibits lymphocyte T and macrophagesInhibits lymphocyte T and macrophages
Stimulates IgA secretionStimulates IgA secretion
Stimulates production of extracellularStimulates production of extracellularmatrixmatrix (healing and reparation)(healing and reparation)
ILIL--1010 Inhibits macrophagesInhibits macrophages
IILL--44 andand ILIL--1313 Inhibit cellInhibit cell--mediated and stimulatemediated and stimulate
humoral immunityhumoral immunity
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Th1 cell functionTh1 cell function
Proliferation anddifferentiation (IFN-γ, IL-12)
Th2 ll f tiTh2 ll f ti
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Th2 cell functionTh2 cell function
I L - 4I L - 1 0I L - 1 3
Proliferation anddifferentiation (IL-4)
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Th-17lymphocytes
Proliferation anddifferentiation(TGF-β, IL-6, IL-23)
Discovered in 2009.Role in:- host deffense against patogene- tissue inflammation
- autoimmune diseases
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HEMATOPOIETIC CYTOKINESHEMATOPOIETIC CYTOKINES
Produced by bone marrow cells andProduced by bone marrow cells andleukocytesleukocytes
Those are:Those are:
CSFCSF
ILIL--77 ILIL--3 (multi CSF)3 (multi CSF)
ILIL--1, IL1, IL--5, IL5, IL--6, erythropoietin, …6, erythropoietin, …
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