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cobas e 411 analyzerPeace of mind in immunology
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Bayer Centaur Abbott Architect Roche Elecsys DPC Ilite 2000
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cobas e 411 analyzerPeace of mind in immunology
Convenience
cobas epacks for convenient handling
cobas ereagent packs are liquid, ready-to-
use and simplify handling
All-in-one cassette packaging for each
parameter combined with calibrators stream-
lines logistics
Automatic pack opening/closing ensures
longer onboard stability
Programming-by-loading concept ensuresseamless, precise data handling
Data review screen provides quick result
traceability
Enhanced data review screen
Elecsys assay performance in external ring-trials
Electrochemiluminescence (ECL) reaction principle
Performance
9 min applications for speed and quality
Over 75 assays offer comprehensive cover-
age of 7 indication areas
High onboard stability and shelf-life allow
continuous availability of both routine and
esoteric parameters
Disposable tips and assay cups for reaction
eliminate risk of carryover
Integrated safety features ensure result
integrity
Confidence
ECL technology: The gold standard
High analytical sensitivity enables large mea-
suring ranges and low sample volume
Measuring ranges: Estradiol 4-4,300 pg/mL;Progesterone 0-6 ng/mL;
Total PSA 0-100 ng/mL;Sample Volume: b-hCG requires 10 L; 3rd Gen
TSH requires 50L Activation with voltage for a controlled reac-
tion allows high precision to avoid unneces-
sary repeats and reruns
Short incubation time enables the timely
availability of innovative applications
Magnet
Ru2base state
TPA
PPP Photon
Platinum Electrode
PTH Precision Monitoring
Reaction Phase - Measuring Cell
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Full workstation consolidation
The cobas e411 analyzer is designed
to deliver accurate results on account
of proven ECL technology
It consolidates routine endocrinologywith cardiac, cancer, bone and infec-
tious disease markers
Serum work area integration
Combined with the cobas c311 ana-
lyzer, the system processes up to 95%
of your serum work area workload
Work area management solutions inte-grate sample and data management
across systems
Seamless laboratory networking
As part of the cobas modular plat-
form, the cobas e411 analyzer offers
consistent results with other cobas e
systems
Universal reagent carriers and ana-
lytical components enable flexible
network solutions
1 CD-ROM, USB & printer ports enableefficient data management
4 cobastouchscreen user interface is
standardized to other cobas systems
7 Disposable tips and cups eliminatecarryover
8 Measuring cell provides unmatched
detection using ECL technology
9 Consumables and liquid waste are easily
accessible
2 Also available rack version with 75sample positions
5 18 channels enable use of up to 18parameters simultaneously
3 30 continuous random access sample
positions with STAT priority
6 Easy removal of disposables via solid
waste container
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COBAS, COBAS C, COBAS E, LIFE NEEDS ANSWERSand ELECSYS are trademarks of Roche.
Other brand or product names are trademarks
of their respective holders.
2010 Roche
Roche Diagnostics Ltd.
CH-6343 RotkreuzSwitzerland
www.roche.com
cobas e 411 analyzerTechnical specifications
System
Fully automated, continuous loading and random access system for immunoassay analysisbased on ECL technology. Available as a disk and rack system.
System components: Analytical module including touchscreen PC
Test Throughput Up to 86 tests/hr
Reagent concept cobas e reagent pack: Ready-to-use reagentsOnboard reagent capacity: 18 channels/reagent slots for up to 18 different assays
Evaporation protection: Automatic closure of reagent lids
Programmable parameters Max 60 assays denable via 2D-barcode including all necessary information (programming by loading)
Sample types Serum, Plasma, Urine and others
Onboard sample capacity Load/unload capacity: Disk: 30 samples Rack: 75 samples on 15 RD standard 5 position rack
Rack types: Routine, STAT, Control, Calibrator
STAT handling: Disk: Any unoccupied position on the sample disk Rack: Dedicated STAT port on rack feeder
Sample container types Primary tubes: 510 mL; 16x100, 16x75, 13x100, 13x75 mm
Sample cup: 2.5 mLCups on tube
Sample volume 10 to 50 L per test, depending on assay protocol
Sample probe Disposable tips for individual sample to avoid carry over; Sample clot detection; Liquid level detection
Sample barcode types PDF417, Code 128, Codabar (NW 7), Interleaved 2 of 5, Code 39
System interfaces Touchscreen PC, RS 232 serial interface, bi-directionalStandard PC ports (USB, ethernet, serial etc) for other communication devices
Sample database 2,000 result s for routine, STAT and controls
Test methods Pre-dened assay protocols (sandwich, competitive, titration)
Calibration methods 2-point calibration per lot or per cobas e reagent pack
QC methods Individual QC; Cumulative QC; Preventive QC after calibration
Rerun/repeat/reex Rerun, repeat and reex supported
Electrical requirements Power requirements: 100120 VAC 50/60 Hz single phase or 200240 VAC 50/60 Hz single phasePower consumption: 1,000 VA
Water/waste requirements Water supply: 3l container
Water quality: 10S/cm or 0.1 mega Ohm, bacteria-freeLiquid waste: 4l container with overow detection or direct drainWater consumption: Approx. 3l for 250 tests/approx. 12 mL/cycle
Regulatory compliance GS, CE, UL, C-UL, CB-report and cert icate
Operating condit ions Ambient temperature: 8 to 32C (64.4F to 89.6F)
Ambient humidity: 20% to 80%Noise output: 60 dbA (stand-by mode), 63 dbA (avg. during operation)
Physical dimensions Width: 120 to 170 cm (disk/rack)Depth: 73 to 95 cm (disk/rack)
Height: 56 cm (w/o PC unit)Weight: Approx. 170 kg (disk) and 210 kg (rack)
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cobas e 411 analyzerPeace of mind in immunochemistry
Powerful, precise and convenient, the cobas e 411 analyzer is the perfect immunochemistry testing solution for laboratories running
50 to 250 samples per day. At the heart of the analyzer, the highly innovative ElectroChemiLuminescence (ECL) technology delivers an
outstanding combination of high analytical sensitivity and wide measuring ranges at short turnaround times. With over 95 assays covering
more than 7 indication areas, the cobas e 411 analyzer uses the same convenient cobas e pack reagent format as all cobas e immunoassaysystems. This standardizes patient results, which is crucial for integrated laboratory networks. Together with the cobas c 311 clinical
chemistry analyzer, it provides a comprehensive serum work area solution.
Powerful testing capabilities
Flexible system offering to fit the laboratorys workflow
(cobas e 411 analyzer available as disk and rack system)
Broad test menu with over 95 assays including innovative markers,
e.g. HE4 and hGH
9 minute STAT applications including Troponin, CK-MB, Myoglobin,
-hCG and PTH provide unmatched response times
Designed for hospitals, emergency laboratories and clinics with
workloads of up to 250 samples per day with up to 86 tests/hour
Unmatched performance
ECL technology
High sensitivity for patient-friendly low sample volumes and fast results
Broad measuring range for fewer repeats and a streamlined workow
High precision over the entire measuring range for reliable results
Intuitive, convenient and connected
Compact sized benchtop analyzer
Common intuitive user interface
Electronic updates and downloads via cobase-services ensureseamless error-free data handling
Work area management solutions integrate sample and data management
across systems
COBAS, COBAS C, COBAS E and LIFE NEEDS ANSWERS are tr ademarks of Roche.
2012 Roche
Figure 1: cobas e411 analyzer (disk system) Figure 2: cobas e411 analyzer (rack system)
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cobas e 411 analyzerComprehensive cobas diagnostic markers
ECL signal response is linear over more than 6 orders of magnitude
Linear ECL signal generation covering more than six orders of
magnitude
Over 95 assays available covering more than 7 indication areas
9 minute STAT applications for rapid emergency sample response
times including Troponin, CK-MB, Myoglobin, -hCG and PTH
References
1. Elecsyswith ECL technology Still light years ahead. Roche internal brochure from 2011, Mat. Nr. 06528481001.
2. cobas e 411 analyzer vs. cobas e 601 analyzer, external correlation data. Data on le.
Figure 3: Linearity of the ECL signal response over a broad range ensures for highsensitivity and broad measuring ranges 1
The cobas e411 analyzer uses the universal cobas epacks. As a
consequence, all results are standardized across the entire cobas
platform and can be transferred easily across laboratory networks
Result standardization across the cobas platform
cobase411analyzer[ng/mL]
cobas e 601 module [ng/mL]
90
80
60
50
70
40
30
20
10
1
0
0 10 20 30 40 50 60 70 80 90 100
Figure 4: CEA method comparison2
P/B regression
Y = 1.018 * X 0.006md(95) = 0.733N = 96 r = 0.9995t = 0.9439
COBAS, COBAS E, LIFE NEEDS ANSWERS and ELECSYS are t rademarks of Roche.
2012 Roche
log
[ECLintensity(counts)]
4
3
2
1
5
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7
8
0
-14 -12 -10 -8 -6 -4
log [(Ru/bpy) )/M]2+3
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cobas e 411 analyzerConvenient, error-free handling
Convenient operation and reliable results
30 sample positions (disk system) and 75 sample positions (rack system)
with continuous random access and exible STAT priority settings
Disposable tips and cups for individual sample pipetting for carry-over
free operation
Electronic updates and downloads via cobase-services ensure seamless,
error-free data handling
Smart reagent concept
Unique, ready-to-use cobasereagent packs deliver maximum
handling convenience and minimize logistical efforts
Flexible disease panel testing with maximum on-board capacity
of 18 parameters
Automatic pack opening and closing prevents evaporation and
ensures long onboard stabilities
COBAS, COBAS E and LIFE NEEDS ANSWERS are trademarks of Roche.
2012 Roche
Figure 5: cobas e411 analyzer (disk system)
Figure 6: Maximum handling convenience
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cobas e 411 analyzerIntelligent design for maximum up-time
COBAS, COBAS C, COBAS E and LIFE NEEDS ANSWERS are tr ademarks of Roche.
2012 Roche
Robust design for reliable performance
Sample clot detection by pressure sensor enables consistent results
without disrupting workflow
Proven Hitachi instrument reliability
Comprehensive serum work area integration
Combined with the cobas c 311 analyzer, the system can process up
to 95% of serum work area workloads with a capacity of up to
250 samples/day
Work area solutions integrate sample and data management across
systems to improve delivery of information and laboratory efciency
Complete SWA
(Serum Work Area)
cobas c 311 analyzercobas e 411 analyzer
Figure 7: Proven Hitachi instrument reliability ensures maximum system up-time
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cobas4000 analyzer seriescobas e411 assay menu
Thyroid function Tumor markers Infectious diseases
Anti-TG AFP Anti-HAV total
Anti-TPO CA 125 II Anti-HAV IgMAnti-TSHR CA 15-3 Anti-HBc
Calcitonin 1 CA 19-9 Anti-HBc IgM
FT3 CA 72-4 Anti-HBe
FT4 CEA Anti-HBs
T3 CYFRA 21-1 Anti-HCV
T4 free PSA HBeAg
T-Uptake NSE HBsAg
Tg total PSA HBsAg confirmatory
Tg hs 1 HBsAg quantification
TSH CMV lgG
Cardiac CMV lgM
CK-MB (mass) CMV IgG Avidity 1
Fertility / hormones CK-MB (mass) STAT HSV-11
ACTH Digoxin HSV-2 1
C peptide Digitoxin HIV Antigen
Cortisol Myoglobin HIV Antigen confirmatory
DHEA-S Myoglobin STAT HIV combi
Estradiol NT-proBNP HIV combi PT 1
FSH Troponin T Rubella IgG
hCG+b Troponin T hs Rubella IgM
hCG STAT Troponin T hs STAT Toxo IgG
Insulin Troponin T STAT Toxo IgM
LH
Progesterone
Prolactin
SHBG
Testosterone
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COBAS, COBAS E and LIFE NEEDS ANSWERS
are trademarks of Roche.
2010 Roche
Roche Diagnostics Ltd.
CH-6343 Rotkreuz
Switzerland
www.roche.com
Maternal care Anemia Bone markers
free bhCG Ferritin b-CrossLaps
PAPP-A Folate Vitamin D3 (25-OH)
PlGF RBC Folate Intact PTH
sFLT-1 Vitamin B12 N-MID Osteocalcin
P1NP
PTH STAT
Rheumatoid Arthritis Critical care
Anti-CCP IL6
BRAHMS PCT Others
S100 IgE
1Assays currently under development
Last Update 02/2010
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