CNAPCNAP
CENTER FOR NEUROPLASTICITY
AND PAIN (CNAP)
THOMAS GRAVEN-NIELSEN, Prof , DMSc, PhD
DEPARTMENT OF HEALTH SCIENCE AND TECHNOLOGY
AALBORG UNIVERSITY
Winnie
Jensen
Ole Kæseler
Andersen
Lars
Arendt-Nielsen
Herta
Flor
Brian
Cairns
Thomas
Graven-Nielsen
CNAP
Hypothesis: Chronic Pain and Neuroplasticity
No
Pain
Acute
Pain
Chronic
Pain
Maladaptive pain
neuroplasticity
Adaptive pain
neuroplasticity
No
Pain
Acute
Pain
Chronic
Pain
Maladaptive pain
neuroplasticity
Adaptive pain
neuroplasticity
Advantageous
neuroplasticity
Chronic Pain Neuroplasticity
Acute Pain
CNAP
CNAP
Overall Goal: Identify and Modulate Key
Features of Human Pain Neuroplasticity
Maladaptive pain neuroplasticity
Adaptive pain neuroplasticity
Maladaptive and advantageous
Adaptive and advantageous
Advantageous neuroplasticity
Time and Gain Probe
Mechanistic
Human pain
neuroplasticity
Mechanistic
Provoke
CNAP
Adequate Provocation and Probing Biomedical
Technologies: A Core Research Area
Medial Lateral Medial Lateral
0.24
0.12
0
-20246810
-2
0
2
4
6
8
10
0.0
0.1
0.2
0.3
0.4
0.5
-20246810
-2
0
2
4
6
8
10
0.0
0.1
0.2
0.3
0.4
0.5
-20246810
-2
0
2
4
6
8
10
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
-20246810
-2
0
2
4
6
8
10
0.0
0.1
0.2
0.3
0.4
Day 0 (baseline) Day 2 (mild pain)
Day 2 (moderate pain) Day 2 (mild pain)
SPINAL
REFLEX
Probe
Human pain
neuroplasticity
c
Provoke
CNAP
Successful Outcome and Impact
Brain
Spinal cord
Periphery
Provocation
Probe
Probe
Probe
Modulation
Modulation
Maladaptive painneuroplasticity
Maladaptive and advantageous
Adaptive and advantageous
Advantageousplasticity
Adaptive pain neuroplasticity
Human pain neuroplasticity models
Ground-breaking Outcome and Impact
• How to provoke a transition to and away from maladaptive pain neuroplasticity in humans
• Relevant for next generation pain management / paradigm shift
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