byLisbon,February 3rd,2016
It’sallaboutaTeam…
PhDBiomedicinePost.Doc
Fátima Martins
MSc.BiochemistryPhD Candidate
João Silva
LeakyGut,anemergingdisease
InflammationMalabsorption
TissueDamaging
LeakyGut,anemergingdisease
InflammationMalabsorption
TissueDamaging
LeakyGut,anemergingdisease
• Diabetes• Obesity• ColonCancer• FattyLiver
(NAFLD)• GutSyndrome• CeliacDisease
Normal
LeakyGut&Permeability
Blood-flow
Intestinalwall
Normal
LeakyGut&Permeability
Blood-flow
Intestinalwall
Dietary,behavioural andgenetic factors
Blood-flow
Intestinalwall
Pathological
Pro-inflammatoryagentsBacterialproducts
Deleteriousnutrients
TheNeed…Detectearlytoprevent
• SpecificDietInterventions
• SpecificProbiotics
• EmergingDrugs
TreatLeakyGut
• Early intestinalpermeabilitydetection
• High-throughputapplicationmethod
Healthcareneeds
Non-toxic
AnovelmethodIntestinal
PermeAbility Kit
Perme bility
Blood-flow
Blood-flow
Feces
1
2
3
Non-toxic
IntestinalPermeAbility Kit
Perme bility
1
2
3
Blood-flow
Blood-flow4
Anovelmethod
Non-toxic
IntestinalPermeAbility Kit
Perme bility
1
2
3
Blood-flow
Blood-flow4
Anovelmethod
Urine
Quantitativedetection
Bladder
5
• Privatehospitalsandspecializedclinics(entrymarket)
• PreventionandScreeningHealthCentres (early adopters)
• PublicHospitals,ClinicsandHealthCenters(latemajority)
Customers
PopulationCoverage
Obese/Overweightindevelopingcountries Obese/Overweightindevelopedcountries
1Billion
0.9Billion
WHO– 2014data
CompetitorsbutnotthreatsProductfeatures/customerbenefits
ComplexSugars Biopsy Imaging PermeAbility
Earlydetection + + + +++
Accuracy ++ + + +++
TargetPopulation + + + +++
Cost ++ + + +++
Non-invasive ++ + + +++
Timetoresult 2-5days 2-5days immediate 2h
Theroad…
<
Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Jan2016
Supplierssorting
IPstrategyreportSearchanalysis
Legal®ulatoryconsultancy
HumantrialsCompound productionEthics documentationSample analysis
OtherrelatedcostsM1:decisiononcompoundandpackageproducer
M2:proof-ofconceptinhumans
M3:IPprotectionandlegal®ulatoryreports
2017
€ 100k
Short-termroadmap
ExitStrategy
TRADESALE
Imagingtrackerforintestinallesions(PermeAbilityderived)
Bloodbrainbarrierleakageassessment(PermeAbilityderived)
Non-invasiveinternaltissuesmetabolismsimulation
Pipeline
Point-of-carePermeAbility test
Semi-finalistsofOneStart Europe2015,LondonUK
Prizeof2500€ fromthePortugueseSocietyofDiabetology,February2015
€ 100kinvestment
COHiTECentrepreneurshipdevelopmentprogramcertification
Achievements
by
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