CorynebacteriumChun-Keung Yu DVM, PhDDepartment of Microbiology and Immunology

Corynebacterium diphtheriae

Other corynebacteria (coryneform)

(exotoxin)

A-BABNAelongation factor EF-2

5

Clinical Diseases

Respiratory diphtheria Cutaneous diphtheria

- Respiratory diphtheria2-6 ()

LfflersPCR ()Elek

Elek test ()

Schick testIntradermal injection of diphtheria toxinNo skin reaction: have NT antibodyEdema + necrosis: no NT antibody, (patient is susceptible to diphtheria)

(1) Penicillinerythromycin(2) DPT - diphtheria toxoid + pertussis + tetanus toxoid = DPT