~.';..--:~f;~;~!~- 'J

r1.'

Ml1Hl1CTEPCTBO BHYTPEHHl1X ,UEJ1POCCl1MCKOM CllE,UEPAll,I1I1 ~rOCY,Il,APCTBEHHOE Yl!PE)KAEHYlE «3KCI1EPTHO-KPYlMYlHAJlYlCTYll!ECKYlYl IJ,EHTPMYlHYlCTEPCTBA BHYTPEHHYlX AEJl POCCYlHCKOH <DEAEPAIJ,m1»

B.11. COPOKHH, O.c. OpJ10Ba, r.B. J1106eUKHJ1,

M.A. Maxapos, M.A. 'uP03.nOB, E.A. CHMOHOB

YCTAHOBJIEHHE OEIIJ;HOCTII lICTOqHlIKAITPOHCXO~~EH~rEPOHHA

MOCKBa 2002

--~---.------

YAK 343.9

Onotipensr Ii peKOMeH;IOBaHbl K orrydnaxoaanmoMeronasecxaa Ii Pe..'laKUIiOHHO-1i3!laTe.'lbCKIiMCOBeTaMlirv 3KU MBA POCCIiIi

COpOKIiH B.H., OpJlOBa O.c., JIlOoeUKIiH F'B, Ii IIp.Ycraaoaneaae 06WHOCTii IiCTO'lHIiKa nponcxoxzreaas

repoaaa: Meronnsecxne pexoueanauaa. - M.: fY 3KUMBA POCCIiIi, 2002. - 80 c.

Ilpaseaeaa MeTo.nIiKa ycrancaneaas 06illHOCTii IiC-TO'lHIiKa npcacxoacneaaa repoaaa C acnonsaoaasnea xpo-MaTorpa<pli'leCKIiX Ii cnexrpansaux MeTO.nOBaaanasa.

)J.nll COTpy.nHIiKOB 3KcnepTHO-KpIiMIiHanIiCTIi'leCKIiXnonpasnenenan opraaos BHYTpeHHlix nen.

© rv 3KU MBA POCCIiIi, 2002

Ilnaa asmycxa .nrreparypu fY 3KU MBA POCCHIi, 2002. n03. 9

BllailliMIiP Hropeaax COPOKIlH,Onsra Cepreesaa OpJlOBa, .Feopraa Bxxropoans JllOoeuKIiH.Maxaan Anexcannpoaax Maxapos,Maxaan Aaaronsesna )J.P03.JOB.EBreHIiH Aaaronseaas CIi:-.10HOB

YCTAHOBJIEHI1E OEllJ,HOCTI1I1CTOQHI1KAIIPOI1CXO)l()lEHIUI rEPOI1HA

MemOOUl{eCKUe peKOMeHOQt!UU

Penaxrop H.K. EYJlblUle6Q

Koppexropst H.B. KYHee6Q, HH. COPOI{UXUHQ--------_____________________________________ 1~

t:itIlonnncaao B nexars 31.01.2002 r. <Il0p:-'laT 60x90 1116.Jlexars otpceraas. Iles. n. 5,0. Y'I.-1i3.n . .'I. 5, I. Tapas; 300 3K3.3aKa3 198.

<IlrYfI «Illeptinncsas ranorpaqnrx»,113623, r. Mocxsa, yrr. Tanorpaqicxas.zr. 10

3TIDlalJ,eTaTa KPHCTaJInhl I1MelOT 6 -PHMhI B xnoPOrhopMe 6 enhll1 user, pacrso-

'¥ ,eH30ne rop5l4eMTH'ieCKH HepacTBopHMhI B BO' e :naHOJ1e, npax.pOnH3yeTC5l B ll.{enOlfax JJ,. fepoHH 6hlCTPO rHJJ,-

11KHCJ10Tax fl1npOHHa pacTBOpHM B . ""poxnoPI1JJ, re-

BOJJ,e 3TaHone A-.rrpaKTHlfecKH HepacTBoPH' , xnopo,¥OpMe H

CPOpMyna repoHHa npeJJ,cTa:.ne:a ;:;~~: 1.CTPYKryPHa5l

CH3Coo

PI1C, J, Crpy KTYPHaJ:! cjJ0pMyna repOI1Ha

fepOHH ynoTpe6n5lIOT nocpeJJ,cTBOMHHbeKIJ,HH BJJ,hlxaHHeM BHyTpHBeHHhlX, -repea HOC 11KTHlfeCKoe JJ,eHCTBHe ypeHl1eM. Hapxo;

JJ,nHTC5l4-6 4' A-.A-.COcTaBnReT 5 Mr Ll' , 3'¥'1JeKTHBHa51.noaa

. .n3hlMaeMhle H3 He06P33lJ,hI, COJJ,epI<all.{He re OHH 3aKOHHoro 060pOTarepOHHOM». p ,H33hIBaIOT «ynH4HbIM

4

Feponn Bhl3blBaeT 5lPKO Bbl6blCTpoe npHBhIKaHHe r

, DOJ1hWYIO0 'n H 'pe6JTeHHH«YJTH4Horo repo·' ; pB HeM HHa» npeJJ,CTaBn51IOTH3JTH

p33nH4HhIX 5lJJ,OBHTbIXJJ,06a . (CTPHXHHHa) a raxxce BOl( HanpHMeTHBHoro Ko~nOHeHTa HHenOCT05lHCTBOCOJJ,ep)!(aHH51ax-

, CJTe;:ZOBaTenbHOBOnepeJJ,03HpOBKH, ' 3MO)!(HOCTb

Y1cTOlfHHKOMnOJTYlfeHH51re .CBepHyBWHtlc51 v pOHHa HBn51eTC51OnHJ1_(P MnelfHblH COK CHOTBO aor

apaver Somniferum L) [J ?] 0 P 0 MaKaCOCTaBnRIOT3JTK " -. CHOBHyIO Maccy onHR

conn HeopraHHlf:~:~bI, xoropue npeJJ,CTaBnRIOTC060H

60 o/c ) K H opraHH4ecKHX KHcnOT (JJ,0 50-o Mac.. pOMe roro B er

~~:TeHHbI, nHnHJJ,hI, CTe~HHbI,O)!(C:;;:I: ::OC~O~~Iaxapa,

, BOCK, KaYlfYK, KpaCRWHe B ' nex-KHcnOTa MeKOHI1H emecrsa, MeKOHOBaH

, , MeKOH03HH H onn ITHhIH 3JTK3JTOHTTHhIHvC OHHH. pHMep-

"" OCTaB ornra H apeMaKa npl1BeJJ,eHB rafin J [3-5]. rn.rx Kop0604eK

BBE,I(EHHE

B nocnenane rOJJ,hIB He3aKOHHOM 060poTe HapKO-

THKOB ace 6onbWYlO -racn. COCTaBJUllOTCHHTeTHl.JeCKHe

HapKOTHl.JeCKHe cpencrsa, B l.JaCTHOCTHrepOI1H, KOTO-

PhIH npOH3BO,llHTCsrB nO,llnOJIbHbIX JIa60paTOpHHx.

ITPH paccneztcsaaaa yronosnsrx zten, CB5l3aHHhlX

co C6hITOM HapKoTHKOB, B3)KHbIM HBnHeTCH BhIHBJIeHl1e

sceii opraHH30BaHHoH rpyrmsi. ITPH 3TOM axryansxcii

CTaHOBHTCHaanaxa cpaaaarensuoro HCCJIeJJ,OBaHHRHe-

CKonhKHX 06P3311,OB repoaaa C uern.io YCTaHOBJIeHH5l

06ll.{HOCTH HCTOttHHKa HX npOHCXO)!(.lJ.eHH5lHJlH npn-HaAne)!(HOCTH accnezryensrx 06beKToB K eAHHoH Macce.

Ilpennaraenas pafiora npeJJ,cTaBJ1ReT MeToAHKY

cpaBHHTenhHoro HccneAOBaHHH 06Pa311,OB repoHHa no

pRAY Kal.JeCTBeHHbIX H KOnHl.JeCTBeHHbIX rrapaaerpos,

KOTopaH n03BOJ1ReT 06beAHHHTb HnH JJ,HcpcpepeHll,Hpo-

sars 06beKThI no HCTOttHHKY HX npOHCXO)!(AeHH5l. BKal.JeCTBe KpHTepHeB cpaBHeHHH paCCMOTpeHhI: saeur-

HHe npH3HaKH; coztepxcaaae repoaaa, all,eTHJ1KOAeHHa,

6-MOHOall,eTHJ1MOPCPHHaB ofisexrax; aanaxae COnyTCT-

BYlOmHX H cpapMaKOnOrHl.JeCKH aKTHBHhIX A06aBOK;

nporpans MHKponpHMeceH; KatteCTBeHHhIH COCTaB aa-nomnrrerreii.

Ilonaoe HCCne,llOBaHHenpezmonaraer HCnOJIb30Ba-

HHe xcvnnexca MeTO,llOB: TOHKOCnOI1HOI1xpOMaTorpa-

qHiH, r330B0I1 H )!(I1AKOCTHOHxpowarorparpaa, xpOMaTO-

Macc-cneKYpOMeTpHH, HHcppaKpaCHOHcneKYpOCKonHH.

B nor-tours 3KcnepTaM npennararcrca cnpaso-nrsriiMaTepHaJJ, a raxzce HJ1nIOCTpaUHHB BH,lle I1K-cneKYpOB,

xpor-rarorparau, Macc-cneKTpOB.

,I(AHIIbIE OE OEbEKTE IICCJIE,I(OBAHIDI

I'epoan (CI1HOHHMhI: AliaueTHnMOPCPHH, AHaMOp-

CPI1H,aueTOMOPCPHH;npyrae H33BaHH5l: «repa», ChinaWhite; CMeCbrepoaaa C KOKaHHOMH33bIBaIOTSpeed ball,

a CMeCb repoana C KOKaHHOM H JIC.n; - Frisco speed

ball) 5lBn5leTC51HapKOTHl.JeCKHMcpeztcrsov aaansresa-pytornero ,lleI1CTBHR.Bnepasre 3TOT HapKoTHK 6hIJl CHH-

Te3HpoBaH B 1874 r., a ero KOMMepl.JeCKOenpoH3BoACT-

BO 6hIJlO OCBoeHOB 1898 r. Caaxana repoas acnonsso-

BaJJC5lKaK cpapMall,eBTHl.JeCKHHnpenapaT B Kal.JeCTBe

3aMeHHTemi MopCPHHa npa nexeaaa HapKoMaHHH. OA-

HaKO scxope BhI5lCHHJlOCh,lITO repoaa 5lBn5leTCHcaMhIM

onacauv H3 H3BeCTHhIXHapKOTHKOB.

fepOHH-OCHOBaHHe (fipyrro-rpopsryna C21H23NOs;

M. M. = 369,4). Ilorryvaevsre nepexpacrannnaauaea H3

3

repoaaa B 3aBHCHMOCTH OT peraona npOH3B01]CTBaPeruon Ha:JBaHHe UBeT KOHCIICTeH- XHMH4eCKaJ! MaCCOBoe Xapaxrepuue 1]06aBKI1,

UHJI <PopMa (cons, COlleplKaHl1e npliMeCH, % Mac. I1plIMe4aHl1eOCHOBaHHe) repcaxa, %

lOro- China White EenblH I10POWOKBOCT04HaJI rH1]pOXIJOPHlI 80 H 50,Tee PelIKO conepaorr Hap-A3HlI HanoMIfHaeT

KOTHIt H n04TH He CTHPaJlbHblii

lOro- «KopHYHe- KOpHYHeBblHconepsorr nanaBepHHa nopOWOK

3anallHaJI BblH caxap»To lKe OCHoBaHHe, 40--60 HapKoTHH - 20-30.

A3HlI pexe rHlIPOXIJO- -nanaaepan - 2-{i,

HeTpHlI aueTlffiKOlleHH - 5-9

OT psose-xo. « OCHoBaHHe, 60-85 Ilanasepnn - lIO 4,pHYHeBoro -1I0 cserno- rHlIPOXIJOPHlI, HapKOTHH - 2-20,KOpHYHeBOro

uHrpaT,TaprpaT aueTHJlK01]eHH - 4-7Her Eenecsnt « rHlIPOXIJOPHlI .ao 90 AUeTIIJIK01]eHH - 2-5 -Mexcnxa «qepHblH KOpHYHeBblH CMOJlo06- HeT CBelleHHH 30--60llerOTb» HJlH'lepHO- pasaas Mac- AUeTllJIKOllel1H - l-{i, HMeeT aanax YK-

KOpH'lHeBbIH ca nanaaepan - 0,5-3, cyca, conepzorr«MeKCHKaH- TeMHO- HeT namrsrx

HapKOTHH - 1-4 1l06aBKy nerrsTo lKeCKUHKOPHY- KOpHYHeBblH

30--60 AueTIIJIKO.llellH - l-{i,HeBbIH» nanasepan - 0,5-3,

lOlKHaJI HeTHapKOTllH - 1-4

EeJlhIH I10POWOKAuepxxa « Donee 90 AUeTIIJIKO!lellH - Me- HHOf.lla conep-xee 3,5 lKaHlle 3-MOHO-

aUeTHJJMopqlllHa60JlbUle. 'leM co-lIeplKaIDle 6-MOHD-aueTH.HMopcjJHHa

CBOHCTBa ofipaauoa

8

KaK )')Ke YKa3bIBaJlOCb,BHeWHI1H BI1.urepoaua Cl1J1bHO3aBI1CI1TOT peraoaa, B KOTOPOMOH6bln npoaaseneu [6, 7].

fepOI1H 113 IOro-BoCTOlJHOH A31111 nOlJTI1 scernanpencraanser C060H nOpOWOK 6enoro usera (ChinaWhite). 3TOT 06beKT B HeI13MeJlbt.{eHHOM sane HanOMI1-aaer CTI1PaJIbHbIJ.! nopOWOK, B KOTOPOM neiicTBYIOllI,eeHat.{aJIO MO)l(eT BCTpet.{aThC5I B sune corm I1nl1 OCHOBa-HI151,-iauie - B Bl1ne runpoxnopana C conepacaaaev oc-HOBHoro KOMnOHeHTa 80 % 11 6onee. TaKoH repOI1Hpenxo COnep)l(I1T HapKOTI1H 11 nOt.{TI1 He COnep)l(I1T na-

nasepaaa.06pa3~bI reponna 113 IOro-3ananHOH A3111160nee

paaaoofipaansr:onny 113 pa3HOBl1nHOCTeH sa COOTBeTCTBYlOllI,l1e

UBeT 11KOHCI1CTeH~111OHa3bIBaIOT «KOpl1t.{HeBbIH caxap».06blt.{HO OH BCTpet.{aeTC5IB Bl1ne csofiozmoro OCHOBaHI15111 CO.neP)l(J1T40-60 % zuraueranaopdraaa, HO I1Horna6bIBaeT B BI1.ne runpoxnopana; MO)l(eT conepacars 20-30 % HapKOTI1Ha, 2-6 % nanasepaaa, 5-9 % aueranxo-neaaa 11cnenossre KOni1'ieCTBa npyrux MKMOl1nOB;

zipyras pa3HOBl1nHOCTb repoana - OT psrxce-xopa-taesoro no CBeTJlO-KOpl1t.{HeBoro usera. 3TOT repo-I1H BCTPet.{aeTc5IB BH,UeOCHOBaHIDI, ranpoxnopnaa, ~I1T-para 11 TapTPaTa. Coaepacanne naauernnaoprpaaa .nOC-

rnraer 60-85 %; ocransusre KOMnOHeHTbI: HapKOTI1H -2-20 %, nanasepaa - no 4 %, auerunxonean - 4-7 %;

TpeTb51 Pa3HOBI1.QHOCTb- 6eJleCbIH nopourox, co-neplKalll,I1H repOI1H B ¢opMe ranpoxnopana; B HeM no90 % OCHOBHoro KOMnOHeHTa 112-5 % auernnxoneana.

MeKCI1KaHCKI1H repOI1H 6bIBaeT nayx Tl1nOB:«sepns: H nerors» (BCTpet.{aeTC5I, KaK npasano, B

CIllA) I1MeeT KOpl1t.{HeBbIH I1nl1 t.{epHO-KOpl1t.{HeBbIHUBeT, t.{aCTOofinanaer 3anaXOM yxcyca; COnep)l(I1T He-xapaxrepusie nn51 Onl151npl1MeCI1 nerra. KOHueHTpaUI151OCHOBHoro KOMnOHeHTa - 30-60 %, auemnxonenaa -1-6 %, nanasepana > 0,5-3 %, HapKoTI1Ha-l-4 %;

«MeKCI1KaHCKI1H KOpl1t.{HeBbIH» I1MeeT TeMHO-KOpl1t.{HeBbIH UBeT; creneas ero OLII1CTKI1MeHbwe; CO-nepscaaae B HeM OCTMbHbIX MKaJlOl1nOB np116n11311-'rensno raxoe )l(e, KaK 11B «LIepHOM nerre».

IO)l(Ho-AMepI1KaHCKHH repoaa BCTpeLIaeTC5Irroaons-HOpenxo 11nOlJTI1scerna OTnI1LIaeTC5IBbICOKHMKaLIeCTBOMOLII1CTKl1(6onee 90 %); npeLl,CTaBJ15IeTco6oH 6enbIH no-pOWOK, CO.ueP)l(aW,I1HMeHee 3,5 % a~eTI1J1KOneI1.Ha;KOH-ueHTPa~l1.5I3-MOHOa~eTl1nMOp¢I1Ha B HeM I1.HOrna60nbwe,LIeMKOH~eHTPa~l1.5I6-MOHOa~eTl1J1MOp¢l1Ha.

Pa3nl1t.{l151CBOHCTB06pa3~OB repoaaa B 3aBI1CI1MO-

era OT peraoaa np0l13BOnCTBa npencrasnensr B Ta6Jl. 2.

7

Ilepen amUHi30M npofiu I1CCIIe.a.yeMblx Be~eCTB

rurarensuo nepeTHpaJII1 B araTOBOH crynxe 11 rovore-

HH3HPOBaJIH BCTpJIXI1BaHHeM. 3aTeM HaBeCKI1 Be~eCTB

MaceoH 5 Mr 3aJIHBaJIH 1 MIl XIl0po¢opMa Ka)K.a.yfO,no-

6aBJIJIJIH xanrno TpH3THIIaMI1Ha 11nocne BCTpJIXI1BaHI1JI

npofis: (B TeLJeHHe 10 MHH) npoBo.a.I1I1HI1CCIIe,llOBaHl1e.

B CBJI3H C BbIWeH3I10)KeHHbIM I1CCIIe.a.OBaHl1e06-

Pa3U.OB repoana aa rtpenver I1XO.a.HOP0,llHOCTH,llOIl)KHOCOCTOJITbH3 cIIe.a.YfOll.(I1X3TanOB:

1. ITpe.a.Bapl1TeIlbHblH OCMOTP H cpaaaenae no

BHellIHHM npH3HaKaM (usery, sanaxy, KOHCI1CTeHl(I1H).

2. BblJIBIIeHHe HaJIW/HJI reponaa, auernnxoaenna,

6-MoHoau.eTHIIMoP¢HHa H ¢apMaKOIlOrl1yeCKI1 aKTHB-HblX .a.o6aBOK.

3. CpaBHeHHe 06Pa3l(OB no KOIlI1LJeCTBeHHoMYco-

.a.ep)KaHHfO reponrra, aueTHIIKo.a.eHHa 11 6-MOHO-au.eTHIIMoP¢HHa.

4. CpaBHHTeIlbHoe HCCIIe,llOBaHl1e COCTaBaMHKpO-npHMeceH.

5. CpaBHeHHe 06pa3UOB no KayeCTBeHHoMY COCTa-By HarrOIlHHTeJIeH.

6. <!>0PMYIlHpoBaHHe BbIBO.'lOB.

12

METO,l.(HKA IICCJIE,l.(OBAHIDI(,llJUI npOBe.a.eHIISI IICCJIellOBaHlfSl Heo6XOllHMO

He MeHee 0,1 r ofipasual)

IIPEL{BAPHTEJIbHOE HCCJ1EL{OBAHHE

Ha 3TOH CTall1111npOBOll.IIT BHeWHI1H OCMOTP(Kal( .

HeBoopY)KeHHbIM rIla30M, TaK 11C nOMOl.UbfO Cpe,llcTB :

OnTHyeCKOH MHKpOCKOnl1l1), B xcne xo ropor-o ¢HI<-

Cl1pYfOT COCTOJIHl1e,ocofieuaocrn ynaKOBKI1 11Maccy

seurec-ra, I1X UBeT, sanax, KOHCI1CTeHUl1fO, rovoreu.HOCTb 11 HaJII1411e MeXaHI14eCKI1X npl1MeceH. OT60p

npe.a.cTaBI1TenbHbIX. npo6 .'lIlJI ,aaIlbHeHwero I1CCJJe-

,llOBaHI1JI npOBOllJIT B COOTBeTCTBl111C MeTo.a.HKoJ;i

«OT60p npof npu I1CCIIe.llOBaHI1I1 HapKOTl1yeCKl1x

Cpe.a.CTB», YTBep)f(,lleHHOH I10CTOJIHHbIM KOMHTeTOM

no KOHTPOIlfO HapKoTHKOB (nporoxorr N!~26 OT 16HOJI6pJI 1993 r.).

.D:anee H3Y4afOT paCTBOpHMOCTb06pa3UOB Be~eCT-

sa B XJJOpo¢opMe, MeTaHoIle, .1113THIIOBOM3¢Hpe H

1lI1CTHJJIIl1pOBaHHoJ;isene C uenuo YCTaHOBJleHI1JIB03-

MO)f(HOro Hanl1411JI B ero COCTaBe HHepTHblX .a.06aBOK

(HanOIlHI1TeIleH) 11onpe.lleneHI1JI. B KaKOH ¢opMe (com

I1ml OCHOBaHl1e) npl1CYTCTBYfOTI1CCJle.1yeMble Be~eCT-

------~~ ..

240000012200000200000018000001600000140000012000001000000800000600000400000

2000001~~~~~~~~~~~~~~~~~~~~~~Jc)18~~To 13.50 14.00 14:50 15:00 15:50 16.00 16.50 17.00 17.50 18.00 18.50

Abundance

1 2

IC. 3. Xponarorpaseaa repoaaa, He cozrepxamero no6aSOK:- aueTHnKOneHH;2 - 6-MoHoaueTHnMoP<PHH;3 - repoHH

3

11

s.

o.u ..

1 2 :$I I I

5;I

7"I

PI1C. 4. Xpoxarorpasoaa "MO.1lenbHoH CMeCH repoaxa Hero conyrcrsyroumx npHMeceH:

1 - MOp<f!HH; 2 - KOlleHH; 3 - 6-MOHOaUeTHflMop<f!HH; 4 - aUeTHflKOlleHH; 5 - repOHH; 6 - nanasepna: 7 _ HapKOTHH

16

Ilepen nposeneaaev ananasa sxcneprnux 06pa3-UOB repoaua rOTOB5IT 11I1cCJIe,nYIOT Mo,neJIbHble CMeCI1.B Kat.IeCTBe Mo,neJIbHbIX cvecea MOT):T 6blTb peKOMeH-,nOBaHbI cnezryroume:

1. PacTBoR repOI1Ha 11 ero convrcTBVlOllI.l1X npl1Me-cei1 (MopCPI1Ha, xonenna, 6-MoHOaueTl1JlMopQll1Ha, aue-Tl1JlKo,neI1Ha, nanasepaaa, HapKoTI1Ha) B no,nBl1)!(Hoi1 ¢a-

se (¢oc¢aTHbIH 6ycpep : aueToHI1TPI1JI - 80:20). KOHueH-TpaU1111 KOMnOHeHTOB B YKa3aHHoi1 Mo,neJIbHoi1 CMeCI1,nOJDKHbI I1MeTb conocrasnvue BeJII1t.II1HbI OT 50 no100 MKr/MJI. ,lVr51YKa3aHHbIX YCJIOBI1Hxpoaarorparpapo-BaHI15l yztaercs noJIYt.II1Tb ,nOCTaTOt.IHOxopowee pasnene-

une KOMnOHeHTOB CMecl1, n03BOJUIIOllI.ee rrposozurrs l1Xl1.lleHTI1¢I1Kaumo no BpeMeHI1 y,nep)!(I1BaHI15I11YcD-cneKT-pav. Onpeneneanyro TPy,nHOCTb npe,nCTaBJUIeT l1,neHTI1-cpl1KaUI15Iaueranxoneaaa, I1MelOllI.erO 3Hat.IeHl1e BpeMeHI1y,nep)!(I1BaHI15I, 6JII13KOe co BpeMeHeM y,nep)!{I1BaHI15I re-pOI1Ha, 11ofipasyioutero aa xpovarorpavve nI1K, t.IaCTI1'1-HO nepexpsrsatonnnica nI1KOM repoaaa (PI1c. 4).

2. PacTBop repOJ1Ha. ero cOrryrCTBYlOllI.l1X npl1Me-ceA 11Ilo6aBoK cpapMaKOJIOrI1'1eCKI1 aKTI1BHbIX seurecrs:aanpaaep, aCKop6I1HOBOH KI1CJIOTbI, anansrnna, npo-xaaaa, Kocpel1Ha 11cpeH06ap611TaJIa B no,nBIDKHoi1: rpase,KOHueHTpaI..(l151 reponaa 11,n06aBoK cpapMaKOJIOrl1t.IeCKI1

aKTI1BHbIX aeuiecrs B Mo,neJIbHoi1 CMeCI1 ,nOJI)!{Ha co-

CTaBJI5ITb 500-600 MKr/MJI; KOHueHTpaUI151 eCTeCTBeH-HbIX conYTCTBYlOllI.l1X npl1MeCeH (MoPCPI1Ha, KOIleI1Ha,6-MoHoaueTHnMopqll1Ha, aueTI1JIKo,neI1Ha, nanasepana,HapKOTI1Ha) - B 6-8 pas MeHbwe . .LJ:JI5IYKa3aHHbIX yCJIO-BI1H xpoMaTOrpa¢l1pOBaHI151 ,no6aBKI1 naaasrx ¢apMa-KOJIOrHt.IeCKI1aKTI1BHbIX seurecrs He 3aTPy,nH51IOTI1IleH-TI1¢I1KaUI1IO 11KOJIJ1'{eCTBeHHOeonpenenenae repoaaa 11aueranxoneaaa, 6:UHaKOOHI1 I1MelOT 3Hat.IeHI15IBpeMeHI1y,nep)!{I1BaHI15I, 6JII13K11eco BpeMeHeM y,nep)!(I1BaHI15I He-KOTOPbIX 113COnyTCTBYIOllI.l1X npI1Mecei1: repoana, 11 06-pa3YJOT C HI1MI1 t.IaCTI1'IHO l1JlI1 nOJIHOCTblO nepexpu-BalOllI.l1eC5Inl1K11(PI1c. 5).

CpaBHI1TeJIbHbli1: aHaJII13 axcneprnsrx 06pa3UOB re-pOI1Ha no HapKOTJ1'{eCKI1aKTI1BHbIM KOMnOHeHTaM npo-BO.ll5lTCJIe,nyIOIUI1M06Pa30M.

HaBecKI1 accnezryexsrx aeurecrs MaccoH no 5-10 Mr noxeutarcr B repMeTI1t.IHO yxynopnsaescsieCKJl5lHKI1, 3aJII1BalOT TOt.IHO oTMepeHHbIM 06beMoMTIO,nBI1)!(HOH CPa3bI C TaKI1M paCt.IeTOM, t.ITo6bIKOJII1t.IeCTBOseurecraa B e,nI1HI1I..(eo6beMa TIO,nBIDKHOH

cpa3bI He npessmrano 500-1000 MKr/MJI, 11 nposonsr3KCTpaKUI11O B YJIbTpa3BYKOBOH BaHHe B .resesae30 MI1H.

15

-'.~...-....~.:'.

DOJlyqeHHble 3KCTpaKTbI CPI1JTbTPYIOT-repea MeM-

OpaHHhIH CPI1JTbTPC nOpl1CTOCTblO He 60Jlee 0,5 MKM.

nerasapyror B YJThTpa3BYKoBOH BaHHe I1JlI1 np0.L\YBa-

lOT renae« He MeHee 10 MI1H 11xpOMaTorpacpl1PYIOT.

Ofiuiee apevs npo60nO.L\rOTOBKI1 C MOMeHTa Ha4aJTa

3KCTpaKU.1111Bem:eCTBa .L\O aaxana xpOMaTorpaqmpo-

BaHI1.sI nonyxeanor-o 3KCTpaKTa He .L\OJ1)KHOnpeau-

urari, 40-50 MI1H .L\Jl.sII1CKJIlOqeHI1.sIB03MOlKHoro rH.L\-pOJlI13a repouaa.

,n:JI.lI BhI.sIBJIeHH.sIrepouna Hero OCHOBHblX eCTeCT-

BeHHbIX COnyrCTBYIOU.{HX npHMeceH npOBO!l.sIT cpasne-

aae BpeMeHI1 Y.L\ep)/<HBaHH.sIKOMnOHeHTOB BeU.{eCTBa

OO"beKTOB co spevene» Y.L\ep)KHBaHH.sI KOMnOHeHTOB

Mo.rr.eJlhHhIX CMeceH, cpaanenne Y<P-cneKTpOB, a raioxe

npl1MeH.llIOT MeTO.L\«.L\06aBOIO>.

KOHu.eHTpau.111Orepoaua B 3KCTpaKTaX onpe.L\eJI5IIOT

MeTO.L\OM a6COJIIOTHOH rpa.L\YHpOBKI1. Do pe3YJ1bTaTaM

rpex napaJIJleJlhHhIX aHaJII130B .nmI Ka/K.IToro CpaBHI1-

BaeMoro ofipasua paCC411TbiBalOT cpezmee 3Ha4eHHe

co.rr.ep)!(aHI1.sI repoaaa (% Mac.) 11 .L\OBepHTenbHble HH-

TepBaJIhI nonyQeHHbIX BeJlH4HH.

KaK 11 npa ra30xpOMaTorpacpHQeCKOM aHallH3e,

co.rr.ep)!(aHl1e au.eTHJlKo.neHHa 11 6-MOHOaUeTHJI-

Mopcpl1Ha paCCQI1TbIBalOT OTHOCHTe.lbHO repouaa no

nnouianss, I1X nI1KOB, npHHHMaSl npn 3TOM nllOlllarurxa repouaa aa 100% .

CO.L\ep)!(aHHe cOOTBeTCTBYIOU.{HXKOMnOHeHTOB (r

pOHHa, 6-MoHOaUeTHJ1MoPCPI1HaI1JlI1 aueTI1J1KO.L\eI1Ha)'

npo6ax cpaanasaevsrx 06be[(TOB C4HTalOT O.nI1HaK

BbIM, ecrra nepeKpbIBalOTcSI .noBepHTellbHble I1HTepBan.

Cpe.nHHX3Ha4eHHH nonyxe-nu,rx BeJlI14HH.

CPABHI1TEJIhHOE HCCJIEllOBAHUE COllEPJKAHlUIMHKPonPIIMEcEi1

,n:J1S1cpaBHeHH5! oObeKTOB no npodiamo MI1KpO-

npl1MeCeH npl1l\·leH5!IOT MeTO.n «OTne4aTKOB nansuea»,

ITPI1 3TOM CpaBHI-iBaeMble aeuiecrsa C4HTalOT OJlHOPO.ll-

HblMI1 no cocrasy MI1KpOnpI1MeCeH, eCJlI1 KOlll1QeCTBO

nl1KOB na I1X xpG.'vlaTorpaMMax, BpeM5! suxona COOTBeT-

CTBYIOU.{I1Xnl1KOB H HX B3al1MHOe COOTHOWeHl1e npax. !THyeCKH cosnaaaror.

HaBeCKI1 06PaJUOB MaCCOH 50-150 Mr 3aJIHBalOT e,

4 MJ10,5% cepnoti KI1CllOTbl, 5 MJI XJ10pocpopMa (MeTl1- c

lleHXJ10pl1.na, TOllYOJIa) 11 narpesaior ua BOJl5lHOH6aHe

npa 40 DC B re-renae 20 MI1H, nepHOJlHyeCKI1 nepesre-

WI1Ba51CMeCb. Ilocne OXJICDK.::reHI1S1H OTCTaHBaHH5!3KC-

rpaxra oT6HpalOT C!10fl OpraHHyeCKOro pacTBOpHTell5!.

18

--9 ..00 o ..~.

...•I

:2I

6I

:37"I

J AA~~ Jr. .•.)( ~

!I\\ \ ~, / ~ ----------210n •..••

22 Or",,", \ ",J b\\ J "'--- /'--,...230n •...• ~\ ~ ~260n •.••

/"'r 1\1 \ --r---2800 .....

1·5 MO<H1·05

17

Pile. 5. Xpouarorpaseaa MOlleJlbHOH eMeell repoaaa, ero conyrcrsyiounoc npIIMeeeH lI1106aBoK ¢apMaKOJlOIWleeKII

aKTIIBHhIXseuiecra: . 7 rt.. 6 6 TaJI.1 - aeKop611HOBaH Kl1eJlOTa; 2 - aHaJIbrMH; 3 - npoxaan; 4 - xorpeaa; 5 - aUeTIIJlKOlleI1H; 6 - repOIIH, - 'l'eHO ap If ,8 - nanasepaa; 9 - HapKOTHH

e, .~.'r' :;;.:;.:;.•....

Abunctance

17.61

900000 1 TIC:l_2K.D 15.~7 15.72

.r700000

15.20

13.11SOOOOO13.75

300000 19.19e.ee

';.51B.38

100000

10.00 12.00 ".00 16.00 15.00 20.00Tlme-> 8.00

PHC. 7. Xpovarorpaxeaa 31<CTpaKTa ofipaaua N2 1

22

4\-----------------------------------------------.

Ba~HeHwHe KOMnOHeHTbl «KHCJJoro» 3KCTpaKTa reponaaTatinuua3-

BpeMJI asrxona

126-14-7

Ha:JBaHHe Flnouiaas naxa.%

4,0915,3525,8606,2936,6996,7077,0907,1987,83110,05710,17010,24210,62411,42011,84012,12012,28612,53313,655

CAS-HHileKC

3563-49-357-44-396-88-8125-40-676-74-4569-31-3550-10-758-8-250-06-6481-81-26703-27-1

561-27-358-74-2

128-62-1

[1HpOBaJlepOH.6ap6HTaJl

MelUlBaKaHHEyra6ap6HTaJl[1eHTo6ap6HTaJlMeKoHHHrl1llpOKOTapHHHKocpeHHC!>eHo6ap6HTaJlTefiaonAueTHilKOIleHHAnernnrefiaonrepoHHIlanaaepax

~HaUeTHilHOpI<OIleHHCaxapoaa oxraauerar

3,6- IlHMeTOI<CH-4(2 [N-aueTHil-N-MeTaMHHO ]3THil- 5-aueTOKcHcpeHaHrpeHHOPMOPCPHH rpaauerarHocxanan

0,002230,7010,004840,004080.007762,080,003030,03180,08370,1750,01030,08370,01584,590,04014,750,0606

0,8671,59

21

OIlPE.ll.EJIEIDIE HAIlOJIHI1TEJIEfi

Ll)ul onpeneneaax HanOJIHI1TeJIei1 B repouue I1C-

.: nOJIb3YlOT MeTO,u I1K-cneKTpOCKOmm.

TIpo60nO,urOTOBKY nposonar C uensro ynaneuan113 ofipasua HapKOTJ1t~eCKH aKTI1BHbIX KOMnOHeHTOB 11

aueTHJIbHbIX np0I13Bo,uHbIX, a raioxe .l106aBOK ipapMa-

KOJIOrl1"IeCKH aKTHBHbIX BemeCTB . .LJ:JIjjaroro K aasec-xe 06pa:3Ua MaCCOH 5-1 ° Mr ztofiaanmor 0,3-0,5 MJI

MeTaHOJIa, KOTOPbIH nOCJIe nepeueunrsaans H OTCTaH-

BaHI1~ .ueKaHTHpYIOT. TaKYIO npouenypy nOBTOpjjlOT

3-4 pasa. He pacTBopHBWI1HCjj B MeTaHOJIe OCTaTOK

BbICYWI1BalOT B TepMOCTaTe npl1 reaneparype OK0J10

50 DC B TelfeHHe 30 MHH H I1CCJle.uYIOT C nowouisto

OnTH"IeCKOrO MHKpocKona.

ECJlH OCTaTOK npencraanser C060H CMeCb KpH-

CTaJIJ10B HJII1 aMopcpHbIX lfaCTHU pa3HbIX ranee, TO C

nosroumo npenaposansnoii HrJlbI ero pa3.ueJ151IOTnacppaKUI1H, xoropue HCCJle.llYIOT no OT.lleJIbHOCTH. .LJ:Jljj

aroro "IaCTHUbI neperapaior B araTOBOH crynxe C 6po-

MI1.ll0M KaJIH5I, npeCCYIOT B Ta6JIeTKH H perHCTpl1pYIOT

I1K-cneKTpbI B rraanaaoae 4000-400 CM-! C paapeurexa-

eM 4 CM-!. TIo nOJ1YlfeHHbIM I1K-cneKTpaM (Hcn0J1b3Yjj

6116J1110TelfHbIH 11J111«PYlfHOH» nOI1CK) onpenenmor OC-

HOBHble HanOJIHI1Teml, conepxauurecs B ofisexrax HC-

CJIe,uOBaHI151.B cnyxae HaJIl1lfl151B pacnopasceaaa 3KC-

nepra I1K-MI1KpOCKOna ornanaer He06xo,uHMOCTb Me-

xaau-recxoro pa3.lleJIeHI151CMeCI1nepen HCCJIe.uOBaHHeM,

TaK KaK CKaHl1pOBaHl1e npoaonarca C pa3HbIX YlfaCTKOB

oTo6paHHOH npofisr.

Onpeneneuae HanOJIHl1TeJ1ei1MeTO,uOMl1K-cneKTpO-

CKonHH ny-nue nposoznm, no neperapanns 06pa3UOB B

cryrnce J11160 orfiapars ,UJIJI sroro OT.lleJ1bHYIO npo6y

aeneperep-roro aeurecrsa.Ha pac, 10-15 rtpasenensr cnexrpsr aanfionee -rac-

TO BCTpelfaIOLUI1XC5IB repouae HanOJ1HI1TeJ1eH.

MeTO.llOM I1K-cneKTpOCKOnl1l1 BbI5IBJ151IOTraxxce

aexoropue cpapMaK0J10rHlfeCKI1 aKTHBHhle .uo6aBKI1. Bxa-recrse cnpaao-moa I1HcpopMaU1111aa c. 80 npaaeziea

l1K-cneKTp XllOpOXI1Ha. B nocnensee BpeM5I XllOPOXI1H

ace -rauie BCTpe4aeTC5I B Ka4eCTBe .ll06aBKI1 B ofipaauax

«Ynuxaoro reponaa».

100,1

90

80

70

60

%T 50

40

30

20

10,2

3700,0 3000 2000 1500

-Icm

25

Pac, 10. HK-cneKTP rmoxoast (nexcrpoasi)

26

\000 500,0

100,1

90

80

70

60

%T 50

40

30

20

10,23700,0 3000

1000 500,0

PHC. 13. HK-cneKTP xpaxsrana

29

1(".1

90

80

7<)

GO%T

50

40

30

20

10,12000 15003700.0 )000

cm-I

1000 500.0

PHC. 14. HK-cneJap ManbT03bI

30

!I!£t,!!I _

.,.

n:p~nO>KEHHE l'

--.. --~--------------

OCHOBHhle H MHHopHhle KOMnOHeHThI

N2 Beuiecrso XHMH'IeCKOe CAS· Mon. Monexy nap- CrpYl\I)'pHaJI IPopMyna npHMe'laHHenln Ha:JBaHHe HH,lJ,eKC Macca Has! <PoPMyna

1 3-MoHoaue- MOpQlliRaH-3,6-.aJJb- - 327 CI9H21N04 KOMnOHCHT

THJIMOP<PHH <pa.-.llHOJl, 7,8-,lvuxerH,ll-

~

«ynH'iHOrOpo-4,5-.aJJbcpa.-3TIOKCH-

" 0 0 .'repoana»

17-MeTHJI-,3-aueTaT

2 6-MoHoaue- MOPCPHHaH-3,6-.aJJb- 2784-73-8 327 CI9H21N04 \To )Ke

THJlMOPCPHH cpa. -.lIHOJI,7,8- zrazreran-po-4,5-.aJJbcpa.-3TIOKCH-17-MeTHJI-,6-aueTaT

~HO ~

3 AJIJIOKPHTI- 5,7,8, 15-TeTparH.llpo- 485-91-6 369,42 C21H23N05 \ llioMepeH KpHIl-TOTIHH 3,4-.lIHMeTOKCH-6-Me- 0 rorraay, Bsute-

THn6eH30[ e][l ,3].lIH- r'I JIeH H3 Chelido-0

oxcono] 4,5-k] [3]6eH30- ~ :::,... nium rnajus L.,3eUHH-14( 6H)-OH I Bocconia cordata

H,C ~6H3

Willd, Sanguina-OCH, ria canadensis L.

H Papaveraceae

35

N2 Beuiecrso XHMH'IecKoe CAS- Mon. Monexynsp- Crpyxrypaas ct>opMynanln uassauae HHllCKC Macca Hal! ct>oPMyna

10 Fanpoxo- S,6,7,8-TeTpanmpo-4- 550-10-7 221,26 CI2H1SNO) O:;XOTapHHH MeTOKCH-6-MeTHn-l,3-

HJC/N

)ztaoxcono] 4,S-g] H30XH-~onHH;8-MeTOKCH-S,6-MeTH- OCHJneaaaoxca-z-ueran-1,2,3,4-TeTpa-

11 I'nayuaa (S)-S,6,6a, 7-TeTpanurpO- 475-81-0 355,43 C21H2SN041,2,9,10-TeTpaMeTOKCH- KOMnOHeHT6-Mernn-4H-.!lH6eH- onHlI30[ de,g]XHHOllI1H; H,C1,2,9,10-TeTpa-MeToKcH-anoMopq,HH;

H,C60JIllHH llHMeTl1lIOBblH H I3¢I1P; 6pOHXOmlTliH; CH,rnayseHT

12 KOllaMHH (S)-I-[(3,4-llHMeToKcHq,e- 21040-59-5 343,42 C2oH2SN04

;:(CH

3

MHHOPHblH-HHn)MeTI1JJ]-1 ,2,3,4-rer-panurPO-6-MeTOKCH-2- CHMeTl1lI-7-H30XHHOnHHon; , 3

1,2,3,4-Tetparnnpo-6-Me- HOxx)/CH, ·onHH oxonoTOKCH-2-MeTI1JJ-I-Bepat-

;P" I N

0,003 %PI1ll-7-H30XHHonHHon H,CO ~

38

39

~-..-.----.-..--..-----------.- -----------------------------~':'i

N2 BeweCTBO XHMH'IeCKOe CAS- Mon. Monexynsp- CrpyKT)'PHaJ! ct>opMyna npHMe'laHHenln uaaaaaae HHaeKC Macca HaJ!ct>opMyna

13 KOlleHH (S .aJJhq,a.,6.aJJbq,a.)- 76-S7-3 299,37 C1SH2INO) H,CO B 3aBHCHMOCTH7,8- llHllerHllpo-4 ,S- I

~"'"'

OT HCTO'lHI1Ka:moKcH-3-MCToKcH-17- npOHCXO)l(.!leHHlIMeTHlIMopq,HHaH-6-01l o. conepscanae B

onaa xoriefiner-cs OT 0,7 JlO

HO" 2,S %

14 KOKYllHH; Mopq,HHaH-6-oH, 7 ,8- 11S-S3-7 329,40 CI9H2)N04 H3COMHHOPHhlH

CHHOMeHHH JlHllerHllpO-4-rH.!lPOK- ~ KOMnOHeHTcH-3,7-JlHMeTOKCH-17- I onHll,r:::.MeTHJl HO

H,, ,~:NCHJ,,

0,r:::.

OCH3

15 KOTapHHH 5,6,7,8-TeTparHllpO-4- 82-54-2 237,26 CI2HISN04 wOI1POJlYKT OKHC-

MeTOKCH-6-MeTHlI-l,3-

HJC,/N 0)

lIeHHlI HapKO-JlHOKCOllO[4,5-g] H30XH- THHaHOllHH-5-on

OH OCH3

- ; ~~

N2 BeweCTBO XHMH'lecKoe CAS- Mon. Monexynsp- ClllY!cr)'PHiIJI<!>opMynanln Ha:3BaHHe HHlleKC Macca HiIJI<p0pMyna

22 MOpqlliH (5 .ansrpa., 6. aJIb¢a.)- 57-27-2 285,34 C17HI9NOJ HO OCHOBHOH aJI-7,8-.11lUlerH.llpo-4,5- KaJIOIUl onaa,:mOKCH-17-MeTHlI- C011ep)!(aHHe BMOp¢HHaH-3,6-11HOll 6e3Bo11HoM

onHH 9-14 %. BNCH) npapone scrpe-

23 Moprpore- 5,6,6a, 7-TeTparlUlpo- 478-53-5 297,35 CISHI9NOJ OH Ofipaayerca H36aHH 10-MeTOKCH-6-MeTHlI- Te6aHHa npa

4H-11H6eH30[ de.gjxa- aarpesaaaa CHOllHH-2,11-11HOll;

HJCOHC1

10-MeTOKCHanoP¢HH-2,11-11HOll;2, 11-11HrIUlPOKCH- 10-MeTOKCHanoP¢HH

24 Hapxoro- [S-(R *,S*)]-6, 7-nHMe- 521-40-4 399,40 C21H21N07

<Coaepxarcs B

lIHH; TOKCH-3-(5,6,7,8-TeTpa- C01l0Me MaKa,ne3MeTHll- rnnpo-a-rnapoxca-e-

~HapKOTHH MeTHll-I,3-nHoKco- .

1I0[4,5-g]H30XHHOllHH-

~5-Hll)-1 (3H)-H306eH30-¢ypaHoH l·i

42

Mon. MoneKynRp- ClllY!cr)'PHali <!>opMyna npHMe'laHHeCAS-BeweCTBo XHMH'lecKoe Hall <!>opMynaHa:3BaHHe HHlleKC Macca

131-28-2 445,47 C2JH27NOsC011ep)!(aHHe B

HapueHH 6-[[ 6-[2-{llHMeTHllaMH- onHH OT 0,1 noHO)3TIUl]-4-MeTOKCH-I ,3-

( 0,5 %6eH30nHOKCOll-5-Hll [aue-THll]-2,3-llHMeTOKCH6eH-30HHM KHCJ1ara;6-[[6-[2-(.11HMeTHllaMH- CHJHO)JTHll ]-2-MeTOKCH-3,4-(MeTHlleHe11HOK-CH)¢eHHll [aneran] -0- CHJ

BeparpHHOBali KHClIOTa

467-14-1 299,37 CISH21NOJMHHOPHblj;j

Heorraa; (5.aJIb¢a.,6.anb¢a.)- H3CO KOMTIOHeHT

p-KoneHH 8,14-.11lUlerlUlpo-4,5- onHlIJnOKCH-3-MeTOKCH-17-MeTHlIMOP¢HHaH-6-01l

NCH3

C16H17NOJTo )!(e

HOpMOp- (5.aJIb¢a.,6.anb¢a.)- 466-97-7 271,32 HO

¢HH; 7,8-.11lUlerlUlpo-4,5-ne3MeTHll- JnOKCHMOP¢HHaH-3,6-MOp¢HH .11HOll

NH

43

35 Ilceaao- (5' .aJlh<pa.,6' .ansdia.)- 125-24-6 568,67 C34H36N206 )J,HMep MOP<PH- .'MOP<PHH 7,7',8,8'-TeTpa.nem.npo- aa, o6pa3YJO-

4,5 :4',5'-.nH3noKcH- LUHi:icli npa ero ••17,17'-.nHMeTHn-[2,2'- OKHcneHHH B .))f.6HMop<pHHaH]-3,3',6,6'- LUenO"lHOHcpe-rerpon; .ne2,2'-6HMOP<PHH;nceenovoprpax

36 Pea.nHH (8.6eTa.)-8-MeTOKCH-16- 2718-25-4 383,40 C21H21N06 Bsinenex H3MeTHn-2,3: 10,11- ceMliH MaKa6Hc[MeTHneHe- Papaver rhoeas6HC(OKcH)]pea.naH; L., Papavera-rhoeadine ceae

l:

N~ BelUeCTBo XHMH4ecKoe CAS- Mon. Monexynsp-nln Ha:lSaHHC HH.LleKC Macca HlIJIQ>opMyna

34 Ilcesnoxo- (5.aJlh<pa.,8.6eTa.)-6,7- 466-96-6 299,37 CIsH21N03.neHH .nH.nem.npo-4,5-:moKcH-

3-MeTOKCH-17-MeTHn-MOP<pHHaH-8-on;nCH-Ko.neHH;HeOH30Ko.neHH

Crpysrypsaa ljlopMyna

MHHOPHhlHKOMnOHeHTonHlI

, n

46

--J\(2 BeweCTSO XHMH4ecKoe CAS- Mon. Monexynsp- CrpYKrypHlIJI ljlopMyna Ilpaaexaaaenln aaasaaae HH.LleKC Macca HlIJIljlopMyna

37 PeTHKynHH 1,2,3,4-TeTparH.npo-l- 485-19-8 329,40 CI9H23N04 H3COMi-lHOPHhIMKOM-

[(3-rH.nPOKCHC4-MeTOK-I

~ nOHeHTonas,cH<peHHn)MeTHn]-6-Me-

~Ilpacyrcrsyer B

TOKCH-2-MeTHn-7-H30- HO BH.Qedl-<j>opMhl.XHHonHHon;

HO /CH3d-¢op:-.la sstne-

coclanoline ':::::: N nena H3 Anona

I reticulata Linn.,~ Anonaceae. Ilpe-

H3CO J<YPCOpMHOrnxano¢HH- HMOP-<pIDffio.n06HhIXarncanOH.QOB

38 CaJlJOTapH- 5,6,8,14-TeTpa.nerH.npo- 1936-18-1 327,38 CI9H21N04 H3COIlpexypcop

.nHH; 4-rH.npOKCH-3,6-

~:MOp<pHHa.Bsr-

<pnopHna- .nHMeTOKCH-17- I nenea H3 Pa3-BHH MeTHnMop<pHHaH-7-oH HO ~ nH"IHhIX BH.nOB

,H Croton H Papa-

I "NCH3ver. B paCTH-

I TenhHOM MaTe-paane npacyr-

H3CO CTByeT B aaae0 (+)-H30Mepa

..

.'

47I

.J

BeweCTBO

Macc-cnem psr OCHOBHblX H MHHOPHblX h:OMrIOHeHTOB

Macc-cncxrpuN~nln.~-----------------T------~---------------------------- _

3-MOHOaUeTHnMOP<PHH

CAS-IIH.leKC

40 80 120 160 200. 240(M)Morphio. 3-i1cetyl-

100 42

50

o

[2] 50rn

162i50~o N''-l 28581 HO"'V 327

7012459 215

280 32~

285

51

N2nln

BeweCTBO CAS-HH.IleKC

Macc-cnexrpu

2 6-MOHOaUeTHnMop<!>HH 2784-73-8 \N

~OHO 0 O~

327100 268

2155043 146

o 40 80 120 160 200 240 220 321r(R) Morphio 8.0 -3,6-a-d io 1. 7. 2-d id e hyd ro-4, 5-a-€JX)xy-17 -m ethy

[2JJ 50rn

268

52

-l';:::("3P;,:~~~~~---------------------r--------~----------------~----------------------- , I

Macc-cnexrpu iBeuiecrao CAS-HHlIeKC

341

n

6703-27-]Aueranxoneau

o 20 60 100 140 180 220 260 300 3iti(M) Morphia an~-O 1. 7.8-d id ehyd ro-4. 5-ep:nrl'j-3-methoxy-I? -tne

100

59

43

50

282

22981 204

282

55

BeLUeCTBO Macc-cnexrpsrCAS-HHlIeKC

6 Auerxnxonon;.nHrH.npoauerHnKolleHH-6-aueraT

56

386]- 72-1

&0-0f[(J '\34~100

50

22630043

o ~~~~~~~~~~~~~~~~~~~A~40 80 120 160 200 240 280 320

(M) Morphm ail ~-O 1.4.5-epoxy-3-m ethoxy-17 -methyl- aceta te

Irn 50

[@1343

284 300

-

o I,ll. 21.? 2~8 I~ II 314 318 UJ

240 250 260 27·0 280 29·0 300 310 32·0 33·0 34t

{Q

InBel1(eCTBO CAS-

Macc-cnexrpu

~ ranpOKOTapHHH 550-10-7100 220

17850

0l. .t ,l 1 [

40 60 80 100 12'0 140 160 120 200 2~(M) H yd rocota rn in e

I l Irn 50 178 220

[@]-

163 205133 118 1.1 Io .1 III.~ ~O,~

120 130 140 150 160 170 180 ~O 200 2i6 2~

59

Beurecrso CAS-HHlleKC

Macc-cnexrpu

10 Fnaynan 475-81-0 355100

50 340

1 ,[ J lo10 60

(M) G la ucm e160 260 310aio110

J II I

rn 50

~

355340

- 312 324281 297

266 '1 ..III, 'il 1111 1L

~50 260 270 2i3'0 29'0 360 sio 320 330 340 350~

60

CAS-BemeCTBON2nln

Macc-cnexrpsr

\ 3 KpHnTOmlH;

KpHTITOKaBHH

482-74-6 148100

I °O,~ Ioo

179 I50

o L::.

35070 110(M)Cryptopm e

150 190 310

rn 50

rn148

179

190135

O~~~~~~~~==~+=~~~100 110 120 130 140 150 160 170 180 190 200

63

.• , ~t... ::}~------ --------

N~nln BemeCTBO CAS- Macc-cnexrpu

HHneKC

14 MeKoHHH 569-3 1-3

o~/ LS00165100 194

14750 17611877

o20 40 60 80 100 120 140 160

(M) 1(3H)-Isobeu2Dfurauoue. 6.7-dimethoxy.

rn 50

[@]165

176194147

118

o~~~~~~~~~~~~~~~~~100 110 120 130 140 150 160 170 180 19(f200

64

•...

BelUeCTBO CAS- Macc-cnexrpu

17 Heornm;/3-KolleHH

467-14-1100

50

,

~OH

299254

l jo50 80

(M)1'1eopiue

HHlleKC

466-97-7

110

I I II

254 299

- ~25" 243 284

o I f II II200 210 220 230 240 250 260 270 280 290 ~O

~..;..•. - ....•~..- -.•._.it: .~.. ,...::;t::.- •••.••

67

\,

~!... -~

N2n1n

BelUeCTBO CAS- Macc-cnexrpu

18 HOPMOPCPHH;

lle3MeTHJlMOPCPHH 100 271

271

15050 201

68

81

o40 70 100

(M) Norm orphiu e130 160 190 220 250

rn 50rn 201

209 226 243 254O~~~~~~~~~~~~~~~~~170 180 190 200 210 220 230 240 250 260 270

.~.

N, Beurecrso CAS- Macc-cnexrpsrnln IIH.1eKC-

21 Ilanaaepna 58-74-2 324100,o~ 338"0 1'1

,0.,50 o '"0

3190 lL . tll . " J ..II J ~

20 60 100 140 180 220 260 300 m(M) Fapiverm e

I I 1Im 50 324 338

m -. -- - 309

293II250 ~1~6 2~? it II0 ..I I

240 250 260 270 280 290 300 310 320 330 ~o

N~nln

CAS·Beurecrso Macc-cnexrpuHHIleKc

22 DopqJHpoKCHH 18104-24-0 179\~Ho \0) .LHO~rYOI

0~0356o 0-.."--

100

5091 162

0 ••11 ~ 1 .•.1 ~I J"

I IA40 90 140 190 240 290 340

(M)Porphyroxiu e

I I II

m 50 356 371

m-

310 339o 281 296 1 322 -II II.

72

. '';;;';''''~'''W?';;;:~.''.li~.''•......"/,~,{·~t~:1,.{'f:.::,:

.~

~I:".,,.

~~:<$~l~;~~F;fi

~i"''!,11·';j~::

N!! Beurecrso CAS- MaCC-CneKTJlblnln HHlleKC

25 nCeS.1l0MopQ)HH 125-24-6 44r 100

C34H36N206568

50~8

81 124

0 ~ I ~ ., I d • I40 120 200 280 360 440 520

A

(M) [2.2'-Bimorphiuau 1-3.3',6.6'-tetrol. 7.7'.8. 8'-tetrad ehyd ro-4:

I I

rn 50

[@J]-

4~8 5~1550

0 540 ,III 11II

460 470 480 490 500 510 520 530 540 550 560L:;..

75

Macc-cneKTJlblCAS-HHlleKC

BellleCTBON2nln

1772718-25-426 Peamm 100

383o0-..1,..0

50

o50 100

(M) Rhoead iue

368 383rn 50

rn352

308 322

76

Jlu r ep a r yp aI. Schmidbauer W. Handbuch der Rauschdrogen II 1. vom

Scheidt. Fischer Taschenbuch Verlag. - 1998.2. Drug Identification Bible. - Third Edition. -' Denver,

Colorado.3. The Merck Index: Twelfth Edition on CD-ROM, ver.12: 1. - 1996.4. Opexoe A.H. XHMHlI aJIKaJIOH.uOB. - M.: AH CCCP, 1955.5. Saxapoe AiIl., JJu6U306 H.M., ACJlaHo6 XA. Jlexapcraenaue

seurecraa H3 pacreaaa H cnocofist HX npoaasoncraa. - Taurxeur:<l>AH, 1980.

6. Recommended Methods for Testing Heroin: United Nations.Division of Narcotic Drugs. - Vienna, 1986.

7. Recommended Methods for Testing Opium, Morphine andHeroin: United Nations. Division of Narcotic Drugs. - Vienna, 1998.

8. Cnosaps TepMHHOB, OTHOCllWHXCli K aJIKOrOJlJO, HapKOTHKaMH ilpyrHM nCHXOaKTHBHblM cpezrcraav. - )KeHeBa, 1996.

9. Clarke's isolation and identification of drugs: TheFarmaceutical Press. - London, 1986.

10. Caeenxo B.T., CeMKUH E.n., COPOKUHB.H. U op. 3Kcnep-TH3a repoaua H aUeTHJlHpOBaHHoro onax. - M.: BHKU MBACCCP, 1991.

11. Senses A.B., Ilouxpamoe K.B., COPOh"UHB.I1., Ceuxu« E.JJ.Hccnenosaaae HapKOTH'IeCKHX openers C npensaparensnoq npo6o-nonroroasoa MeTO.uOM TBep.u0<pa3HOH 3KCTpaKUHH. - M.: 3KUMBA POCCHH, 1996.

12. AzuHch"Uu B.H., Ca6UJlOe«n. COpOKUHB.H., Copoxuua T.H.3KcnepTHoe HCCJle.uOBaHHe aeuiecrs OpraHH'IeCKOH npapoau uanpHHallJ1e)!(HOCTb K HaH60Jlee pacnpocrpaaenauv HapKOHI'IeCKHM HCHJlbHO.udicTBYJOWHM Cpe!lCTBaM. - M.: 3KU MBLI POCCHH, 1995.

HmpOpMaI..J;HH LVIH 3KCrrepTOB (CM. c. 25)

83,2

%T

60

40

20

8,9

4000 3000

I1K-cneKTp XJlOpOXHHa

80

OrJIaBJIeHHeBBEAEHYlE ,........ 3

,lJ,AHHblE 0]) O])bEKTE YlCCJlELIOBAHJ.15I............. 3

METOLIYlKA YlCCJlELIOBAHJ.15I............................. 12Jlpeasaparensxoe HccnellOBaHHe.. . . .. . .. 12BbIlIBJleHHe HaJIH'lHlI repoasa, aueranxoneasa,6-MOHOaUeTHJlMoP<PHHa H <papMaKOJlOrH'leCKHaKTHBHblX .u06aJlOK...... 13Onpeneneaae conepxaans repoaaa H OTHOCHTeJlbHOrOcoziepscaaa« auernnxonenna H 6-MOHOaUeTHJlMOP-cpHHa................................................................. 13

KOJlH'leCTBeHHoe onpeneneaae repoaaaH conyrCTBYJOIllHX npavecea MeTO.uOM ra30BOHxpoMaTorpacpHH............................... 13Kasecraenaoe H KOJlH'leCTBeHHoe HCCJlellOBaHHeMeTO.uOM)!(HllKOCTHOHxpovarorparpaa '" '" 14

CpaBHHTeJlbHOe HCCJlellOBaHHe conepxaaas MHKponpH-MeceH....... 18Onpeneneaue HanOJlHHTeJleH...... .. . . .. 25

<l>OPMYJlHPOBAHHE BbIBOAOB.......................... 32Ilpnnoxenne 1...................................................... 33I1pHnO)!(eHHe 2 =:':: •••••• 49Jhrreparypa.v.... 79

2000 1500

j~!

79