Wound08 Yurt
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Transcript of Wound08 Yurt
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Wound Healing, Tissue
Engineering and New Materials
Roger W. Yurt, M.D.
William Randolph Hearst BurnCenter
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Burn Center
Clinical care of burn injured patients
including smoke inhalation and carbon
monoxide poisoning
Clinical care of patients with acute and
chronic woundseg, purpura fulminans
Clinical care of patients with exfoliatingskin disease - TENS
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Skin bank
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HyperbaricOxygen Program
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(Full thickness)
(Partial thickness)
Superficial
Deep
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Wound Closure
Life-saving - large surface areas, closure
ASAP
Cosmetic - life time deficits/defects
Functionjoint, tactile, sight, oral
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Life-saving
Excise &Autograft
Recrop Autograft
Excise & Allograft
Excise & Allograft
Recrop Autograft
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Life-saving
Excise &Autograft
Recrop Autograft
Excise & Integra
Excise & Allograft
Recrop Autograft
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Collaboration with School of Chemical
and Biomolecular Engineering Abraham Stroock
Microfluidic wound dressings
Cabodi M et al J. Biomedical Materials
Research
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ConceptActive Dressing
hydration
sanitation
drug delivery
gene delivery
diagnostics
patient profiling
biochemical
analysis
biochemical regulation
mechanical stimulation
perfusion of tissue
vapor barrier
mechanical barrier
wound bed
flow
Inputs Outputs
Interface
Dressing
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Technical Approach: Soft Lithographysilicone
micro-molding
release
sealing
fluidic connections
monomer
polymerizationmicro-mold
release
photo-patterning
UV light
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Model System
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Extraction
FunctionExtraction
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Delivery
FunctionDelivery
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Prototype Active Wound Dressing
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Collaboration with College of Human
Ecology C.C. Chu
Department of Fiber Science and Apparel
Design
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Newly Invented Biodegradable
Biomaterials: Poly(ester-amide) (PEA)
C (CH2)4
O
C NH CH C
O O
CH2CH(CH3)2
O (CH2)6 O C CH
O
CH2CH(CH3)2
NH C
O
(CH2)4 C
O
NH (CH2)4 CH
COOH
NH
0.75 0.25
Adipic acid L-Leucine 1,6-HexanediolL-Leucine Adipic acid L-Lysine n
Load
(g)
Strain
(%)
Stress
(Kg/mm2)
Modulus
(Kg/mm2)
Toughness
(Kg-mm)
GJ-X 133.1 5.2 881.879.9 0.10480.0041 1.5900.449 1.02100.1354
C. C. Chu, et al., US Patent 6,503,538, January 7, 2003
An example of PEA:
An elastomer: biodegradable rubber band
amino acids as main building blocks
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SEM Image of 3D Microporous
PEA Fibrous Structure
PEA control (no GN) PEA w/ GN loaded
Fiber diameter: 1/1003/100 of human hair
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Collaboration with the Department of
Biomedical Engineering
Moonsoo Jin, C.C. Chu
A novel growth factor and matrix mimetic-enhanced biodegradable scaffold for skin
tissue engineering
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Collaboration with the Department of
Biomedical Engineering
Recently funded seed grant
Jingrowth factors, matrix-mimeticproduction, conjugation and cell culture
Chu3 dimensional PEA scaffold design
and fabrication Burn Centeranimal laboratory and
clinical application
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Burn Research Team
Palmer Q. Joe Bessey, M.D.
Joe Turkowski, M.D.
Suzanne Schwartz, M.D.
Research co-ordinators:
Nicole Alden, RN, MPH
Angela Rabbitts, RN, MS