Enzymes.pptx v1 2019 · 2019-04-11 · RATES OF REACTION AND THEIR DEPENDENCE ON ACTIVATION ENERGY...
Transcript of Enzymes.pptx v1 2019 · 2019-04-11 · RATES OF REACTION AND THEIR DEPENDENCE ON ACTIVATION ENERGY...
Enzymes
2nd yearBiologydepartment
غسق جبار .د.مزھراء سالم . د.أنجالء قاسم . د.م
Locationofenzymes
Zn+2,Mg+2Flavin,heme,Niacin
Cofactors:
The enzyme with its cofactor called Holoenzyme .
The protein portion of the holoenzyme is calledApoenzyme.
In the absence of the appropriate cofactor, theapoenzyme typically does not show biologic activity.
A prosthetic group is a tightly bound coenzyme thatdoes not dissociate from the enzyme
Co-factor=Zn+2
Holoenzyme=Zn+2+theenzyme
Apoenzyme=Onlytheprotein
Carbonicanhydraseenzyme
The EC number : is a unique identifier for each enzymeclassified according to this system. The EC number consists of4 digits. The first digit represents the class of enzyme, thesecond digit strands for the subclass, the third digit representsthe sub-subclass or subgroup and the fourth digit provides theparticular enzyme
E.C.1.1.1.4EnzymeCode
Reactiontype
SubclassSub-Subclass
Thespecificenzymename
Theenzymecodenumber
E.C.2.71.1EnzymeCode
Transferase
TransferofphosphatePhosphateaccepter
Hexokinasephosphotransferase
Substrate binding
Michaelis-Menten plot
Competitive Non-Competitive Un-Competitive