TUGAS IMUNOGENETIKA

“PENYAKIT AUTOSOMAL SAPI (BOS JAVANICUS)

CITRULLINAEMIA (CTLN)”

DI SUSUN OLEH:

Hadlrotus Okvianty MP. 105130107111013/C

PROGRAM STUDI KEDOKTERAN HEWAN

UNIVERSITAS BRAWIJAYA

2012

Penyakit : Bovine citrullinaemia

Citrullinaemia (CTLN) adalah penyakit resesif autosomal disebabkan oleh kekurangan sintetase argininosuccinate (ASS). Onset dewasa tipe II citrullinaemia (CTLN2) ditandai oleh kekurangan ASS hati-spesifik tanpa kelainan pada mRNA hati ASS atau ASS gen (refs 1-17). Gejalanya: mati setelah satu minggu kelahiran akibat defisiensi enzim argininosuccinate synthetase yang terlibat dalam siklus urea hingga penumpukan limbah amonia. Disebabkan gen resesif autosomal. Substitusi C T pada kodon ke-86 ekson 5 gen ASS yang menyebabkan kodon stop prematur. Metode genotiping yang dapat dilakukan Hibridisasi, PCR-SSCP, PCR-RFLP.

Sitrulinemia pertama kali ditemukan pada manusia pada tahun 1962. Sekitar tahun 1989 kelainan ini ditemukan juga pada sapi perah FH. Sitrulinemia merupakan defisisensi enzim argininosuccinate synthase (ASS) yang bersifat menurun. Enzim ASS merupakan salah satu enzim yang berperan penting dalam siklus urea terutama dalam pembentukan urea. ASS berperan dalam mengubah sitrulin dan aspartat menjadi arginin suksinat. Perubahan tersebut dilakukan dengan cara menghidrolisis adenosine triphosphate (ATP) menjadi adenosine monophosphate (AMP) dan pyrophosphate (Pi) pada siklus urea yang terjadi dalam hati. Jika terjadi defisiensi ASS maka akan terjadi pemupukan sitrulin yang menyebabkan pembentukan urea di dalam hati terhenti. Sitrulenemia pada sapi disebabkan perubahan basa pada kodon 86 berupa transisi sitosin (CGA/arginin) menjadi timin (TGA/stop kodon). Mutasi tersebut terjadi pada ekson 5 gen penyandi enzim arginin suksinat sintase kromosom 11. Sapi dengan defisiensi ASS mempunyai jumlah asam amino lebih sedikit dibanding sapi normal. Jumlah asam amino sapi defisiensi ASS sebanyak 85 ssedangkan sapi normal sebanyak 412. Konsentrasi enzim ASS dalam leukosit pada sapi heterozigot sebesar 0,28 – 0,1 miliunit/mg protein. Konsentrasi enzim ASS dalam leukosit pada sapi homozigot sebesar 0,4 – 0,25 miliunit/mg protein. Konsentrasi enzim ASS pada sapi heterozigot lebih kecil dibanding pada sapi normal homozigot. Meskipun bagitu, konsentrasi anzim ASS pada sapi heterozigot. Meskipun begitu, konsentrasi enzim ASS pada sapi heterozigoy masih dalam batas normal. Tanda-tanda klinis sapi resesif homozigot (penderita sitrulinemia) yaitu: mengalami ataxia (lemah otot), kebutaan, sitrulin dalam darah meningkat hingga mencapai 200 kali dibanding normal. Konsentrasi enzim arginin suksinat sintase menurun secara ekstrim di hati, dan biasanya megakibatkan keatian setelah kelahiran.

Pencarian GEN ASS dari NCBI: Bos taurus breed Hereford chromosome 11, Bos_taurus_UMD_3.1, whole genome shotgun sequence

NCBI Reference Sequence: AC_000168.1

FASTA GraphicsLOCUS AC_000168 51999 bp DNA linear CON 02-DEC-2011DEFINITION Bos taurus breed Hereford chromosome 11, Bos_taurus_UMD_3.1, whole genome shotgun sequence.ACCESSION AC_000168 REGION: 100791339..100843337 GPC_000000180VERSION AC_000168.1 GI:258513356

DBLINK BioProject: PRJNA33843KEYWORDS WGS.SOURCE Bos taurus (cattle) ORGANISM Bos taurus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.REFERENCE 1 (bases 1 to 51999) AUTHORS Zimin,A.V., Delcher,A.L., Florea,L., Kelley,D.R., Schatz,M.C., Puiu,D., Hanrahan,F., Pertea,G., Van Tassell,C.P., Sonstegard,T.S., Marcais,G., Roberts,M., Subramanian,P., Yorke,J.A. and Salzberg,S.L. TITLE A whole-genome assembly of the domestic cow, Bos taurus JOURNAL Genome Biol. 10 (4), R42 (2009) PUBMED 19393038COMMENT REFSEQ INFORMATION: Features on this sequence have been produced for build 6 version 1 of the NCBI's genome annotation [see documentation]. The reference sequence is identical to GK000011.2. Assembly Name: Bos_taurus_UMD_3.1 (UMD3.1) The genomic sequence for this RefSeq record is from the whole genome reassembly released by the Center for Bioinformatics and Computational Biology, University of Maryland in December 2009. The original whole genome shotgun project has the project accession DAAA00000000.2. The UMD3.1 assembly was generated using genomic traces submitted by the bovine genome sequencing project (Project ID 12555). In this assembly synteny between the cow and human genomes and independent mapping data were used to assemble roughly 99% of the genome onto the 30 Bos taurus chromosomes.FEATURES Location/Qualifiers source 1..51999 /organism="Bos taurus" /mol_type="genomic DNA" /db_xref="taxon:9913" /chromosome="11" /breed="Hereford" gene 1..51999 /gene="ASS1" /gene_synonym="ASS" /note="Derived by automated computational analysis using gene prediction method: BestRefseq." /db_xref="BGD:BT12411" /db_xref="GeneID:280726" mRNA join(1..38,7716..7825,9983..10051,11362..11550, 17729..17785,19737..19811,22992..23062,23275..23305,

28317..28407,31066..31150,31659..31723,40743..40874, 45990..46146,50498..50563,51738..51999) /gene="ASS1" /gene_synonym="ASS" /product="argininosuccinate synthase 1" /exception="unclassified transcription discrepancy" /note="Derived by automated computational analysis using gene prediction method: BestRefseq." /transcript_id="NM_173892.3" /db_xref="GI:75832051" /db_xref="BGD:BT12411" /db_xref="GeneID:280726" CDS join(7721..7825,9983..10051,11362..11550,17729..17785, 19737..19811,22992..23062,23275..23305,28317..28407, 31066..31150,31659..31723,40743..40874,45990..46146, 50498..50563,51738..51783) /gene="ASS1" /gene_synonym="ASS" /note="Derived by automated computational analysis using gene prediction method: BestRefseq." /codon_start=1 /product="argininosuccinate synthase" /protein_id="NP_776317.1" /db_xref="GI:27806925" /db_xref="BGD:BT12411" /db_xref="GeneID:280726" /translation="MSGKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDF EEARKKALKLGAKKVFIEDISKEFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQ VEIAQREGAKYVSHGATGKGNDQIRFELTCYSLAPQIKVIAPWRMPEFYNRFQGRNDL MEYAKQHGIPVPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPN SPDMLEIEFKKGVPVKVTNVGDGTTHSTALELFLYLNEVAGKHGVGRIDIVENRFIGM KSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFV RHCIAKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPVDATGFI NINSLRLKEYHRLQNKVTAK"ORIGIN 1 gccctgctcc gccgactgct gccgccgctg gtcacccggt aaggaggccc cccgccttcc 61 cactccccag cctaggtcgc cctctgcccg gatccctccg aggaccagcg gaggaggcgg

121 agcggaccgc gcgccccccg ccccgacccc ggttcggacc cggaccggag ggaagggggc 181 ggacgccccg actcccgttg cttaaacgcc ggacgacagg attcctggct ccctggggcc 241 gcggggatgg gaccagggcg tgagtccggg gcgggggggt gctggggagc aggtcgggtt 301 acttgtcgcc tttgcgggcc gaggtccttt ctggatcttc ttccttctct gatccaattt 361 cctttatgcc gcgaacccca caaatggaga acctcgggaa cccggagggt gttggggggg 421 tgcggtttcc gatcttgttt gcccccgctc tgaccgccgt ctctgtctcc attagaacca 481 gagtgccagc ctcacctcgg gcccctcgcg cgcgccccgg gggcttgggc atcttggccc 541 ctcccacagc cccgcctcag tttccccgag cgggtgggct cgggggctcc aggcagcccg 601 ccccgggggg cctcgggtgt ggctgggctc cttcttccgc aggtgcgggg ttgggggcgg 661 tcggtcgccc gcctctgcct tctgaaaggg ctttgcattc tccggccggt ggggtcggcc 721 gcctcgccgg ccgcggtgcc cggtttccgg ctggcaccgg actgtgggag gggccgctcg 781 gcaggaaatg tcagccgtcc tggtggctgt tgcctttggc ccctgggcgg ctgcgccctc 841 cagggaagga aagtctgaaa tggaggaaac tcctctccca gcccgccaga gctcttcctg 901 agggggtccc gtgacctcag tgcccccccc cccacccgac caccacctca gtgttcctct 961 ctgcgaagtg ggggcgtctg ctcccgacag cgccgtctgg ctgctcctcc cgggcaggaa 1021 caaacctatc ctttccccgg ggatggatca aataggtcct gggcttcgat ccctcccctc 1081 cacgcccaga cgagggacag gagagggccg gtttctgggc ccctgcagac ccagccctga 1141 aggcaggcac aaccccacga ctgggtgagg ctttgggtca gcctcgcagc ttcccaagct 1201 tcagtttctc cgttcgtctc agctgacacg ggtttagggc tcagggaaca gtaacaggat 1261 gtgtactgtt aggggacatc cctggaagtc cagtgcctga gactccctgc ttccactgcg 1321 tgcctgctaa gtagattcag ttgtgtccaa ctctttggga cactgtggac tcacagtctg 1381 ccaggctcct ctgtccacag gattctccag gcaagaatac tgaggtgtgt ggctatgccc 1441 tccgtcaagg gatcttcctg accctcttag gtctccagca ttgacaggca ggttctttac 1501 cactagcgac acctgggaag tccgcccaca tgtcccgggg tagcccccca aaattaggag 1561 ggtgcatact gttgagagca ggtcctgggt ccatttgctc actgtctggg gagtgaccca 1621 cttggtgctc ccatgctagg ggctcaggag tgggggtccc tgccctccta tcttaggttc 1681 tggtggggga gggagactgt agcggtgggg gctgccccag gtggagccag ctgctcggtt 1741 atgccaagta ataccagctc tgttgagtcc tgctcggtta tgccaagtaa taccagctct 1801 gttgagtgct cgagagtgag ttggtgaatc ctgcccactg agcacctaga tcccaggcca 1861 ggcctggggt gggtaaagga gagagacccc catttagcac actcttgagc tcccctgagt 1921 acccacctgt gctcccatca gctgcctgct tcccctgggc ttgtgtggtc ccttggctgg 1981 gatggtaact tgggcccagg gccccaggaa cctgacctgg gggtggggcg cgatcccaga 2041 ctcacctgct atgcaagggc tttcctagca ccccatctca tcttggtcct gtgagtcctg 2101 ggaggcaagc caggactgcc agatgccttc atctgaagga acgctgaaca cacagcctct 2161 gaagtgagag ccttgcctgt gggcatccac gtggagggag ataacctctc tgggattcag 2221 ggtctaaggc cctgattttc tgctgaaaca ctttgggcaa agttgatctt ccagactttg 2281 gctccttgtg tggcaggagc ctgacttgag ataggccagg tacccaaagg cattttgaca 2341 gagcagaata aacaaatgaa tgaactcacc tttgctccat aaccaaatgc tgttcggaga 2401 gggtttgagt gagtgcctgt caccagggcc tggtgaggtc tccttaatct tcctacctcc 2461 cgcctccaga cattcttatc aaaactggag tttcaatctt gctaagtcaa ggcattcccc 2521 ggtgacccct cttccctggt ggaagaagtt tgctggagcg ctggtggtct tcccaagaaa 2581 gcccagcatt cctgaatcga tcctcaggcc ccaggaattt gcagctgaca gccagctccg 2641 tatgtagcct agagcaccct caatgctctc aactcatcca tcagatacag aaatagttct 2701 ctgtgcctca ccaagtctgt agatgaaatg agctgaattt atcaaccgaa cattcaggct

2761 gaatcctgat agcggcacct cctggtcaaa gtgtggaatt gcagcctggc tctatcagac 2821 atgaatgaca gcagccagcc aaagggttca agttgcaatc ctgaaatgag caaaccccta 2881 agtcagagag aattctatgg cttaggtaga accaaaaata ttttttaaac gtttttaaaa 2941 actagagaac ccagctcaac tgagttagaa tgtgagggag gggttcctga ggaagagtca 3001 ggtggctgta gccacaacat acagagaaag aaaattggtg attggtggtg attcatgggc 3061 ttcccaggtg gctcaaggca ggatacatgg gtttgatccc tgggtcggga agatcccctg 3121 gagaaggaac tgagtgtcta aacaacagac aagtaaagtg aagagaagac agtctgtggt 3181 ccccttgagg ccagagcgta taggacagag agcagcaaag agcaggtggt ctgcagacgg 3241 cgtaggtttc catcccccag cactgccatc tgctagcttg agacctgggc aagtcttata 3301 atttttctga gccccagctc atcatctgta aacaggtggt aataatagcc ccaccttgaa 3361 atgatcccgt gtggcactaa acatagtaac tgctcttgtc atcctagctc tgatgctgca 3421 gagccacatg aatgttccta gctctgagca gctgccctgg ctggccaggc tcgttcactg 3481 ggagctggca ggatggttct ggccggagcc ctggagaatg tccactgcct tgccaactga 3541 ggtcaggctg gcaggcatct tggaacgaga cccccttctt cccttcccag gtgtccctct 3601 ttggcagccg attggccaga ctggccccga aaaccagggg catgagtgtt ctcagcagag 3661 gtcgtgtgcc tgggagctgg ggcacctacc ctgtgccctc cctggaggtt ggggcaactg 3721 tgaggccgga gctgggagga tggctgagtc ctcaggcagg aagccctgtg tcctggggtg 3781 tcagaaccag aaggactttc aggtggttgt gctgatggtg atactgaggc ttggagagtg 3841 aggggcttgc ccgtcagtgg taggagagtt cagtgggcag aggcgtggtg cccagctctg 3901 ggctctgggc tcctctctga atcttatcaa attcacagtt gctccgtggg gggatgggct 3961 gttcttgctc tcagctcctg gactccaggt ctggagaacc cgccattgct ctctgcccta 4021 gtctcttcca ctcctcctcc cctaaaccaa ggcctccttg cttgcttggc ttcctttagt 4081 ttctgcagca agcaggctgc cgggaccttg ctggtggggg aaggggagag cttcagcagg 4141 aaggcaagag caaagccagt gtcagattgc atcatgttct cagcccacct gccctgctaa 4201 tcttgtacac atgcaggccc aaacatgcca cacacgtgtg tgtgtgtgtg tgtgtgtgtg 4261 tgtgtgtgtg tgtgtgtaga cagaggtaca cgcatgcagt ctcaggtaca tgctcctggg 4321 gaaatgcagg cacacttgtg cacacataca cacacatccc tgcctgcagg cacacgctcc 4381 agggtgcaca cattccatca cgaggttcag acccggaggc tgaggccctc cgcctgtggc 4441 ctggccggca gaagaggttc acgagtttcc ggatgagagt ttccagatga cagcgtgcac 4501 ggaattccag acgtggaggg gattttaacc ctctattttt ataggtgagg agcaggcctc 4561 cagatagcaa aatcagcagc cttgttctga gtgcttgcca cctgccagcc actgagagat 4621 ggtccttgtc tccacagagc tcacagtggg tggcgggggc agagtgcatc gtgactgtgc 4681 tgtgatgggc cacactcgca gggcacggtg caggggggca gtcactgagg cagaaccagg 4741 caggcacagg tggtctgcct ccatggagcc gcccctcccc tactccaggg cccatcctct 4801 ggctccaggg cctttggggg ttggcaaagt gggggtgacc cctagaagct gggtgagttt 4861 tgggctcaca tcagctctcc ctgtcactct gggttgtctg ggccaccagc agcttcccag 4921 accccacacc ttgtcccagg gatccatgcc ctcccccacc ccaccccaga gagggtagcc 4981 ttgtactttt gagtctagct gacttgagtt tgaatctggg ctctgccact tagcagtcaa 5041 atgaggtctt gagcaagttc tttaacccaa gcctcagttt ccctatctct aaaatgggga 5101 tgaaacaaat gcaggctgtc acttataaca aatacgtcca ttatcttgat tgtggtggtg 5161 atttcatggg tgtagacaca ccaaaactta ctaaattgcg cacttttagc tatatgcagt 5221 ttatggttag ttatatctca atagagctgt acaaataatg caacattact ctcctcaccc 5281 caagcagccc cagcacacac aggcacacaa ctaggagcta ggtggctctg ggggtcctga 5341 gtctccctgc tcagcgaggc tgcccaaagg ggcgtccagg ggctgggtac gctgggttca

5401 tggcctctgc tgtcacccag ccactgggcc aagaaaggtg tctggaagcc gcaatctact 5461 ctttcaacct caggcatttc ctaccttgag tccttcctgc ctccctccct cccagatggc 5521 ctgttgcctg gctacggttg ccatgggcac atctgctggc cctaccctgc ctgggactgc 5581 ctggcaggtg gttgaatgaa tgcccactga agggggagtc ttggatattt atccatcaga 5641 actgcctcca acctcactgt ttgtgagata tttccccttc ctagtcctag gggcaggaag 5701 gacatgtgag ccctgggact ggctggtggg cggtctggtg agatgccagg actgcatatg 5761 gcatagggct tcccgtggtt cagacggtaa agaatccgcc taccaatgca tgagacgcaa 5821 gttcgatccc tgggtcagga agatcccctg gagcaggaaa tagcagccct ctccagtatt 5881 cttgcctggg aaatccaatg gacagaggag cctggtgagc tacagtctgt ggggttgcaa 5941 agactttgta actaagcagc agctgctgca gttcatagga tgaatgctct tgcccctcag 6001 ttgggctgtg ttctgccgca gagggctggg tgaccgcttt gctgccaaac ctccaggccc 6061 cttcaggatg caggagcctg catccttgga agcaaggtga caccccttct gggcttacgt 6121 ggatcaaagc agaggtagcc acagtttttc ccaatagcat ctattaagga ccctgacctt 6181 ggtcagtctc tagtgtaaat actcccacca gaaacaagca cgctccctgt aagtgcagga 6241 agctgggacc gtgtccacag aggctagaac cagatggcct ggatccaaat ctagccctgc 6301 catctgctga ccgtaggacc tcaagcaagt gaccctgcct ctctgaccct caatctcctc 6361 ttcagcaaag tgggcacata acagcatcta tgctcagggc cacatggaga gtgcaaggga 6421 agcagggcaa gcccgaatgt agcctgaggc ttctgggagg ggcttctgga ctgaaggaac 6481 agaggctgca aaggcaagga gtgaggaggc cttggtacct tctggaaact tcggtttagc 6541 tgaggagagg gagagattgg tgggaggaca caccgtcctg ctgggaagga cagatctgtc 6601 atctgtacac ccagttactt tctccctctg ggcctcggag ttatgagtta tgggcttccc 6661 aggtggctct agtggtaaag aacccacctg ccatcccagg agacgcaata gacgtgggtt 6721 cgatccctgg gtagggaaga taccctggaa taggaaatgg caacccactc tagtaatctt 6781 gcctggagaa tctcatggac agagaagcct ggcagacaac aggccacggg gtcgcaaaga 6841 gtcagacgca actgagcaca cagggacaga cagtttctgg gccttggatc cccctctgca 6901 cagggagagg aaggtctcca agctcctccc aactaatctt tctggagttg agttctctga 6961 ggtgttgggg gtgcagggct tgtgtttccc ctctcagagg aaattgcatt tgaaaagagc 7021 caaaaacccc tttgtgtgaa cgttcactgg gcccaggtgg aagaggtctg gtgggggcag 7081 ggctctgccc ccagcatcct gtcccccata gagccgagag ggcgccctgc ctcctgggaa 7141 gagctgaggt tctggagcca gacacagacg tgtgctctgc aaccttgagc tagccattta 7201 cctctccgag cttcagttct gcctccccag cggcaggcat gactcccact tcctggggtc 7261 agagtagggg tgctgggtga tctgtatgag gatcccaggg ccatgccctg ccctggccca 7321 gcttagcaag gagatgtgtg ggctgcctga gactcaggag acggcccctc ccgtctcctg 7381 acactgcgac cttggcatcc tgacctcggt cccagcagct cagtcttttg tcttcttctc 7441 cggctggtgg gagattggct acatgcctcc ccctgccaag ccccagcatg gtctgtgggg 7501 atgggcaggg gggtgaaaga ggtgtggctg catgaagggt cagctcctca tgctgatgac 7561 ctgatgacag ctgaacatcc tgttctgaac cccatggtgg cttgtctggg ggataagggt 7621 gcccgaggcc aggagggagc tgctgagagg ggctggcagg cggggtgtgg ggggctggct 7681 ctgggtcact cacattcctt ctcgtctccc tccagtcacg atgtccggca aaggctccgt 7741 ggttctggcc tacagtgggg gcctggacac ctcctgcatc ctcgtgtggc tgaaggagca 7801 aggctatgac gtcattgcct acctggtgag ggggagcccg gcgtgtctgt ctttctacct 7861 gttggccctg ctgcctacct gcccgctgtt actaatccaa gcctgccccc tcacccaagc 7921 ctgtcttaat ctgtagataa attcttgttt actgtctctt tctatctgtt aagtgagctc 7981 ctttgatgtc ccccaggtct gagatgtgcc ccccagagca taaaggaggc tggctttccg

8041 tgcactcgct gaagcgggag tgggggcacc aggagtgagt gtggtggagc tgctaagcca 8101 gcctgtccag ggagggacca aggccttggc ttgggtctgc tgaagaccat ggaaagtcac 8161 ataaacttcc cctttcctgc agccctcagt aattcagcaa agatctaggc tcctacatgg 8221 gctaaggtag atgattggag atcacctaat tctggaacag caaataggcc acaggccaca 8281 ggtaatagat taactaagat gccactcccc catccagggt ccacagcaga tatgcccaat 8341 caaaccagct tcacttctga taaacctgga cataacctct gagtctttct ccataagact 8401 ggcaaattct agaaatccag cttaagccaa acaaaaccaa aaaaaaaaag aaaaccaaca 8461 taaatcagtt tttcatataa ccaagaaggc cagggtaaga tggcttcagg caaggctgaa 8521 tccaggtgct tatccagatt tgcctccatc tcggcttggt gtcattcttg gcctctccac 8581 agggcaggca aggctctcat catcccctag tcttctgaga gaaaggaaag ctttccccag 8641 aggctctgat ggaaaggcca agggaacact cattcactgg cctgagtgcc tgctcaccac 8701 tcatttgtca gtatggtgct cccttggagg cttgtcccta tagtgagcag gaagcacctg 8761 ctctcgtcca tccttgtgtg tgggcttccc aggtggcaca gtggtaaaga acttgcctgc 8821 cagtgcagga gatgtaagag atgaaggttc gatccctggg ttgggaagat cccctggaga 8881 aggaaatggc aacccactcc agtgttcttg cctggagaac gccacggaca gaggagcctg 8941 gcgggctaca gtccacgtgg tctctgaagt gacttagcac tcataagcat ccctgtagaa 9001 agaggtccca ggagagaagg ttctgttccc agaggaaatg aggagggggc actggacagg 9061 agaagtttat tcttgtcaag aatggtttgc agttaaagtc agtctaccac tggtaacagt 9121 gccgacccca cgccactcaa gtggagggtg agggtgaggc ccagggaggg gaagtgtctg 9181 gcccacagcc ccctgctgag agcaagtggt gactttgagt gaatgcaaag agcctggagt 9241 gtgtgctttg agccatggca gcaccaatgg gtggtccgga tcccagacta tcaccaggca 9301 gatttaaaag ctgagtggcc tcagaaaaag cacctgcagc tggactctgg gaacactctg 9361 gaatctgctg agcagaatcc agggtcaagg tctgggcagg aggccacagt gtagccagca 9421 gaaaacatga ctgtgtctag acggggctgt cggaaccaga ggtcgggctc cagcaggcgg 9481 acagctgggc gctcctagcc tgggcctctg cttcccgcca gctctggtgc ccggggcaat 9541 caagttgctg cacttggctg gggcagtaag cagggaatcg ggcagctgct gacaagccaa 9601 cctttgtact ggctttgggg gaatttcggg aaaagattga tgggttcaaa ggcagcttta 9661 gaccttcagt gcagtgacag cgaatgttgc aaccccacag cccaggtgca caggcccaga 9721 ttcagcctgt ccagctcctt gaaactgctt tccagagcct caggcagctc caaggagtac 9781 agcatcccca gaccctggtt cttgtccttt ctccttccta catgacctca gccatccaaa 9841 gaaatcatct gaagacggtt gtgtgtgaaa gacacctgcc caggactcac cctcgggtgg 9901 tggggcgagg tggcggtgac attcttctca gctcttcttt ctgcccctgg gctgatgggt 9961 cctctctgct tctgctcgtc aggccaacat cggccagaaa gaagactttg aggaagccag 10021 gaagaaggcg ctgaagcttg gggccaaaaa ggtaccaagt gtgggcaggg tttggggctg 10081 gaaatgggat ctgacacgtt ggggtcagct gtgggggtcc ctgtcccaga gctccttgcc 10141 tcctacgccc cttccagttg gtcctcttgc ttccaagagt gtgaggtcaa ttccttccgc 10201 tgttggtgtg agaacttctc ttatagctca gctggtaaag aatctgcctg caatgcagga 10261 gacctgggtt caattcctgg gttggaaaga tcccctggag aagggaaagg ctacccactc 10321 cagtgttctg gcctggagaa ttccatggac tgtatagtcc ctggggtcac aaagagttgg 10381 acacgactga gtgactttca ctttgctgtg tgaaccatct tctagtttct cctagcctct 10441 cttgcaccca atcacctccc catcccacct ccccatctgt ctacctcttc ctcatccatc 10501 cattcacctg tgcacccctc atccatctac ctgtccaccc tcccatcctt ccatccactc 10561 aacagtatca gtgagcaggc catcagatga acatggccgt catggtccct gctcacgtaa 10621 gctcacagta cgaaggaaac acagtatctg tgaagtgcaa taaaactcac atcagaagta

10681 ttaggaagct gtcaagttca cagtgtcaga tacaagtttt ccataattct agtttttttg 10741 ctggaaagct tgagttttat cactggcaac aaatactcag ttttccttga agtgacaggg 10801 tcacttcatt tttatgcaaa tcgtggccaa aaacccaagt ctgattgatc ttgttttgcc 10861 tgtcagtcct tcagtcaagt atgaatgatg gtttatgaga agagtggcta atttagctag 10921 taactcactt gggcatgcag cagaaatgct ttgtgtgtgt ttatcatatt ttgtattcca 10981 ttagttgggg cttcatcagt ggctcagtgg taaagaatcc accagcgatg caggagacac 11041 aggagacaca ggttcaatcc ctgggtcagg aagactctgg aggagggcat ggcaacccac 11101 tttaggattc ttgcctgcaa aatcccatgg acagcggagc ctggtgggct atagtctata 11161 gggtcacaga gtcggacaca gccgaagtga catagcatgc actcaagaat cgagatttaa 11221 caaaagtgaa tcgttttcta ctgcattttc aagaccaccc tgttagctgc gtctgcctta 11281 gacacaggcc atcggagact ctgtcttctg acggtgccct gtccttgcca aggctccctc 11341 ccatgggctg ctctcccaca ggtgttcatt gaggacatca gcaaggagtt tgtggaggag 11401 ttcatctggc cggccatcca gtccagcgca ctgtacgagg accgatacct cctgggcacc 11461 tctctcgcca ggccctgcat cgcccgcaag caggtggaga tcgcccagcg agaaggagcc 11521 aagtatgtgt ctcacggcgc cacaggaaag gtgaggccag catgtgtggc tggagagggt 11581 gaggaggggg gctgccaggg ggaagtgggc agcggggcct gatgggcggt cctcggacaa 11641 tcgttggttc ccgcccagaa cagtctgctg tgccgtggac agactggccc gcccagcacg 11701 actaagggga ctatgtgcac acaccggccc gtccactcta agaggaatat ttccagcagc 11761 gagtcaggga cagctccact ctgcaaccca agtgtgtctc ccatgttccc gctgtggtgg 11821 aagccgtgtc accccatttt tgcaaatctg cctctgaggc tcaggctcat ctttttcttt 11881 tttcacgccc agtattatgt atttcaaaac tattttaaaa gatgaaaaac catcaaatat 11941 ccatacatag gggattggct gcataaataa cacaatgcta tgcaatgtag tcatgaaaag 12001 gaacgagcgt gatcacccag aatgcatata gtaagtgaaa aggggcaagg tttacaactg 12061 catgatgcca tacactacat tttgcataag aaagaaatac tggaaagttc agtgaaaact 12121 ctccacagtg agtggaaggg gcaggaatgg aatagatgtc tctgttgtgt ttggtttttt 12181 tggctgcgct gggtcttcat tgcagagcaa gggcttagtt ggctgtggca tgtgggatct 12241 taattcccca accagggatg gaacccgagt cccctgcatt gccaggtgga ttcttaacca 12301 ccagggaaat ccctcttaat aacgtgttgc atagatctga ttttgaaaac ttcaaggttg 12361 aatttaaaag ataaaattca ctaagccatc tatctctaga aactgaaagc agatggaaag 12421 aaacgaacct actgtgtgtc cagtctgtga cgtcatcaca cagaagacag aagtattcca 12481 gtgtgagctc agcacataat atcccactga acagcaggat atgttttgag gtggacatct 12541 ggccaaggtc acagcgggag tcgctgtgca acgcggtgga caagaggcca cccgttccca 12601 gagggcttga gtcccagctg tgtgaccttg agtaaggccc ctgcctttgc tgagcctcag 12661 tttcttcact tgcaaagtgg agaggaggcc ctgtcttcgt ttccagggtg actgcattat 12721 agactgtgag gtgtaaacac caggaatgga gcctctctgg aggccagaag tccaaaacca 12781 aggtgttggc gccctgaagg tgctaggaaa gggttccagg ctctcccctg gcgtccttgg 12841 cttgtgggtg caccacccca ggcctccatc tccacgcgcc atctccttgg gcatcttcac 12901 atttgtcttc cccttgcatg tctggttctg tgtccaaatt tctcctttat cccaggacac 12961 cagtcatacc caccctaatg acctcatctt aactggatga tgttcgtaag actctatttc 13021 caaataaggt cccgttctga agggctgagg gtgggggtgg ggggcggtta gggcttcacc 13081 atattttttc ctttcttttt tctacctttt gtggggacat agttcaatct gagatacacc 13141 ttctccttcc agcccttgtg tgcaggaggg cagacagaag ggggaccctg ggggtataaa 13201 acaggaaaag ccctcagcac tccatcccgc aggtggcaga ctcaagaaac aaaattccta 13261 accatgccag cggcctttgg tcggtgtttc tggagactct ggggcttccc tagtagctca

13321 ggtggtaaag catccgcctg caatgcagga gatccaggtt tcaggaagat ctcctggaga 13381 aggaaatggc aacccactcc agtattcttg cctggagaat cctatggaca gaggaacctg 13441 gcaggctaca gtccatgggg tcgactgagc gacatgactg agcgaccaac acacgcacac 13501 actggagact cttgagctct cagcggacac cccgccaaca gggatggggt gctccagcac 13561 acacgtcccg actggacgca gccccccacc tgaggcagtg cggggtggag ggggcagccc 13621 ctggctcagt gtgacaatga gtcacactca gattatgatg gacgaggcgc cgtttggggg 13681 tggtcttgcc gaacagccac tccaccaggc ggcaccggct cgtgtgtctg gaagctcact 13741 cattcacctg gcgttcagtc agcaagcttg tgtgcgtatc tgtgaagggt ggggtgcgcg 13801 ccaggctcct ctgtccacgg agattctcca ggcaagaaat actgcagtgg attgccattt 13861 cctcctccag gggatcttcc tgacccaggg atcaaacaac ccagggctcc tgcactgcag 13921 atggattctt taccactgag acaccaggga agcccatcaa agcagcttag gttcattatt 13981 tttaaaataa ggccaatttc attttaagag agtctgtggc atttccaact ttcctaagtt 14041 caatggtgcc atggtggcag ggtctggaag tgttacgtgt tggggacgag gttggcagat 14101 gaactcttta ccactatgcc acctgggaag ccattcccag ctacctgtga gctagtctgg 14161 cggggtacag tccatagggt cacaaagagt cagacgctac tgaaggggga catggcaacc 14221 cactccagta ttgcctggga aatcacatgg acagaggagc ctggtgggct acagtgggtg 14281 gggttgcaaa gagccagaca taattgagca cgtaagccca caggtggaaa cagctgccag 14341 cacttgtgtg ctttgctcca tttggacaca agagggcacc agaggctcat gtttcaggcc 14401 ttcctgggct gaccctgcag ggaacctctg tttccctctc tggtcctgca gggcttgggt 14461 tctgagaaga atactgtctg cagtagtttt gtggtctctg gagatctgga gacagtcctg 14521 cagttcagtg tccattagag agacagattt taaacatcac tggggggctc caagagcagc 14581 agcaggaagg ccacagggga cggggggtcc ctgtctgccc tccaccccaa caactcccat 14641 ctcttctggg ggttgatggg catgacttac tcccatgcct tggcttcccc ttgtttacat 14701 gacctgggaa agcccccagc agcctctgaa gatagctgcc tacaagaggg aagcgactgg 14761 ggaggagcag ggaggcctgg agggttccag aggatgccag gcgcgagatg gggttgctgg 14821 ggagagaggg gccacccacc tgcaggggct ggtggtctgt ttgccacccc ccgggacggg 14881 ggcatcagtg acttgaacac atgagatgag catccagagt gagcgaggca gcctgcggaa 14941 ggctggcaac ccagagtcag atccacatgg gacacttgag ccgaactttc tgcaagttgg 15001 gcagtggaga gacccagggc ctcgggccct cattccagcc tgtctcttgc actggctcac 15061 tgactccacc cactgaaccc ttacccagca cgggctttcc tccatgccct gggatgtcca 15121 tatggacaaa gccagttcag tcgtgtccaa ctctgtgacc ccatggaccg cagcccgcca 15181 ggctcctctg tctgtggaat tctccaggca ggaatactgg agtgggttgc catgctcacg 15241 tccaggggat cttcccaacc cggggatcga acctgcatct cttgtattgg cgggcgggtt 15301 ctttatcacc agtgccacct cagaagctcg tatcggggac taatccagca aagggtaatg 15361 gtggccctga ggcgtcagag ggaacaggag tcagcagtga tgtcaagcag gaggggcacc 15421 ccaggctgca ggaagagctt gtgcaaagac ccagaggccc gaggtggcac ctggtgcaga 15481 gagggctggg gcccgcccct tcacagccct tcggggactg cacgggagct ggggtggccc 15541 ttcccgagcc tcctccctcc ctcccctggt tttggaagag gggcctggga ataggagccg 15601 gagggccgtg ggcagcagtt gtgtagacag cgccatctgt gtggctcgtt cgggagcaga 15661 tgggagggcc ccgtgcggtc cccgagggca cagcacctgc attgtacacg tgtgtgtgca 15721 cgtggacaca tggcgggtgt gcaggacgtg atacacatcc ccccttggcc ccctggaacc 15781 tgccagggcc tccctggggc tgggggtcct ggagtcaggg aggggaagga ccggacaggt 15841 ctcggagcct gtctgggaca gagttttcaa ctctggctcc tgcgagggca tctggctcag 15901 gaacagatgg gtgtccccat ggcgatcctg ttaggcagac cccagcccga catgccggtc

15961 cagggaagca caagccacca ttgtgctggg gaaacctgaa gccctggagg aataatcacc 16021 atgatatgca acactagacc atatgcttta cgagtctaaa gtaagcctgc ctctaatcaa 16081 gtaccaccgc cgctgctcca ggaactgtgc agcccactgg gccttgggcg ggcattacca 16141 cctgtgcctc agtttcccat ccatgttgtt attcgatgtt cggtcgctca attgtgtctg 16201 tttgcaaccc cgtggaccgc agcacgccag gcttccctgt ccttcactct ctccccgagt 16261 ttgctcaaat tcacatccat tgagtcggta acgccatcct ctgagatggg gataataatg 16321 gggcgctgct gtgtaaggat ttgtggagtt gtgtatggag ctcagcccca tgacctgaca 16381 gtgagctgtc agggtgggat tggtgccttc tggctgtgtg tccctggaca agcggctcca 16441 tctctctgag cctgaatcgc ctcatctgca aaacagggtt agaaaccccc cgctggtgcc 16501 aggtggctct cccgtgggaa agccagcaca tagtaggccc tcactggagg gaccggacgg 16561 aggccaatgg ggacggctgg tctggcgcgg cccatgggcc tggggagcga tcagagagga 16621 gcagcctcgg ctcctggctc cgaggagagg ggctgaaacc agtatttccg cgtcgcctga 16681 caagactctg gaaaataaca tgttattcct gccgctgcct ggctgcgccc gtgcagtttt 16741 cacagtaggc gagaggtccc tctgttattt ccacagcgct taagcctccc tccaggccgc 16801 cgagttgatg gggggcaggc gggtggctgg aagccattgt ctccagggct ggcgggctgg 16861 gccctctcct cctgcctgag agggcgtgga ccactcaccc gagggggatg gggcagtggg 16921 gccccgtgcc ccgacttggg ctgggctctg tgcccttgga caagcccctc ctacctccgg 16981 acccgtttgt gcagagaagc aaagggcctc ggtggtcatc cgcatccaac ccctctacca 17041 aacagtcact gcatagacga gatacccaag gctcacagag gagagggggc tcccagttca 17101 gtggacacaa cgccatgaaa cccccggaaa tgagcttgat ctcagggctg gtgaggccag 17161 gcaggaagag gctgaggcgt ggcaacctcg aggaggctgc ctgaggtatc atcggagcca 17221 ggcctccagc ccagcaggtg tatgcgcccc cccaccctgc caaagagcgg gcatacatga 17281 tgacccatgt gcgtgccctg tcgcgtccca ggcacacacc cacccatgcc tatgcacgct 17341 gtggccttca gcccctgcct acatccccta catgccacgg acgcaccctc acaccagcgc 17401 acacagaggt cctgatcgtc gcaactcagt actcactgtc acatgggcat cttgtgcata 17461 cacatcctgc acactcgtgt gcccgcacag ctcggctctg cactcaggga gacccgggtt 17521 cgagtccagg gcagaaagcc cgctccaaga aagcccagtg ttcatctttt agacgggttt 17581 gtagcaccca gttcaggagg ggagagcctg tgcggagaca ggagcaccca gggggcaccg 17641 tcgaaggtcg cccagcactg cctctcccct gaaccctccc aaccagtccc cattctgtgg 17701 ctcctgaaat ccccgttgta tgtttcaggg gaacgaccag atccggtttg agctcacctg 17761 ctactcgctg gccccacaga tcaaggtagg atgttgcttc tctcccctga aagggtgggt 17821 gctggtggct gaggcccagg gtggggagag cagggagcgg ggctccctgg gaggttcccc 17881 agacaggggc cttgtggcgg gtggtgccct tcttccatgg gacactccct tcacttactc 17941 cagccgcagg ggacagcact ctgtccctga ccgttcatcc ttcccggaga ggctgccccc 18001 ggcgcctggg taggtcaggc accggacaga aagacaaggc tgcccttcca gcagcatcct 18061 tgtgggtcca gccctgcctt cccatgtgtg gactaggacc gttctgggct gatttcaggg 18121 ctgctcacaa ccctccaccc ctgcgggggg ccaccagctc aggccccctc ctccccggct 18181 gcctgaaccc tgaccccggg ttcttggatt ccttcctggg atggggaaaa ccaggcccag 18241 gcctctgggc gtctagtgaa caaagcccac aacagaacta cactgcgcgc tgcagacaca 18301 agtctcaggg tgattatttc aatttttcta gtggccccgt caaaaaacca agatgaaaaa 18361 cgacaggtga cgtcatttta atgacatgtt tattgaaccc tatatatcca aaatggtatc 18421 attcaacatg ttatcgatgt tgaaatattt tacattcttt cggtacgaag tctttaagac 18481 ccgctgtgtg ctctccactt acaaccggga ccagtcacag ttcgggcctc cgtggccacg 18541 tgtggcccct ggctcccatt ttggacaatg tgggtgggcg tggctccaag cttctttgcg

18601 gccacttctg gctaaagcta caaaagacgt gcccttccca agtctgcagg ggccctcagg 18661 gctttcattt ttttttcttt taagtggaac ctctttctct gcccctttaa ccgaccagcc 18721 agcagctgct tagggggtga gagtggcccg gaggtgagca gtaataagct ctagtgatct 18781 gctttgaccc caaacaccag gaggcagaga agccccccag acagtagctg cctgttgatg 18841 ctgcaggcgt gtgggcctgg gctctggcct gacccccact ctctgttccc acagcaactt 18901 ggggggccag ggtgtctggt ttctgggtct ttgtctgcag aagctaagcc caggggtgga 18961 atggggcttg gtgatggggc gccaggtctc tgggaaccag gatgaggcca gagggtagtc 19021 cgcccaggct ctgctcattc caggacttgg ggtggggggg cgcagtcacc ccagccccac 19081 cggcaccccc agcctagaaa tcaaaccagc ttctccatct agatgacacc tccccacccc 19141 cagttgagca gaggcctggc tgagtccaag gctgagtggg ggctcttctt gggggacctg 19201 tccctgacca cccccccacc cccaggctgg taggatgagt tctgtgcctc caatcaggct 19261 ccaattcccc tcctttcccc cacccagaac agccctaggg gtgggagggt ggcaggaggg 19321 gtgggtcgga ggatgtgctt gagcccctgg agggccaggc tgggtggctt tagtcaccag 19381 gagtgggggg gttctggacc tctggacagg ggtgcatcag gaaacctgag gcttgtctgg 19441 ttcaaaccct cgtgtctcag ttggggagac cgagatccag aaggataggg acctgcctgg 19501 ggacacccag ccattctgcc gtggaactca agctttctcc caagccacct tctggggtag 19561 caggccacgt ccttcccctg cccaatgggg tcccctgccc aaagcccttc ccgtgggcta 19621 cacagacccc ccacccaggt caccggtgga ccctcaggcc ccttatcaga gaggtgggct 19681 ctgcagcttc agcacctgga ggaatcagca ggcctgactc cttgtctcgt gtccaggtca 19741 tcgctccctg gaggatgccc gagttctata accgcttcca gggccgcaac gatctgatgg 19801 agtatgcgaa ggtaaggccg gactccacca tcaccccggc cctcgtcaac tgccccccca 19861 ggcacgtccc tccaaaggct caaggatggg gctggtaccc acgcctgggg accaaacctc 19921 agccctggtg ccctccccca gcacctattc cctgggccgg ccccacagaa ctaactgtgg 19981 tcctcgccag gactgagcat ctctcaggtc accccgcccc agtccaccca gcgggagggc 20041 accggtgccc ctccacttcc cattcagatt gccacctctg cagtgtgtgt cactcagacg 20101 gggcctgtga gcgaggctgt tctctgcccc taattacctg actaattgtc cccggtgctt 20161 tcgcagaagc aggtaagtgc tccgagggcc agaagcagac aaagacttct gcagcaccag 20221 ccctttttga agtacaagtt gcaataaaac agattagaag ttttgcatca agatccttag 20281 ccactcccca gggtaccttt ctttttagcg actcgatggc agcgcttgac aaacagcctc 20341 aatcaatcag acaggggaaa gcaacctggt gcacgcacca gaaaattgct cgggttttta 20401 aatagcagtc gctggggctg gctgtgagct cttgctgcag ccaaggtgcc gcgtggcagg 20461 ggacgcggcg gggacccagc cctgccccta ctgccagcat cccattaaga cctggagagc 20521 ttggaggaaa gatctcctcg accatctgtt gttttattat taaaagggga gtttacaaga 20581 gcaagcccat atgttgccaa acaaattttc aaatagcaga gctattaagg gaacggggtt 20641 agaggctttc ttcctctcct tggtctcctt gaggatatac agaatctgaa gcacgtttta 20701 tcttgaagaa taatgaatct ggagccccgg cccatccccg ttctcacgcc agcagtcgtg 20761 gttggagaca gggctgaccc gtaacactgt tcttcgtttc tgagaagctc ccgagcagaa 20821 gcagctcctg ggttttgcca gaatttctga agtcattgtt tgtcccaagg ctcttggctc 20881 agcttctgtc tcaaataacc ttttaaacag gaaagtttgc cctggcgaga gagtctgggt 20941 cgccaccact gagcctccct cagaggctgg tatcagaatt gagctctgaa aaatctgacc 21001 acgttctaga atgatggcag tgtctctgca cccgggagtg accggaataa ttgagcagca 21061 gccagactgt ccaaaactca gaggcacgca gctgcttcag ctgagacaaa aatcaatggg 21121 gctttgaaaa acccccgctt tcgagatccg ttaagtcgcc caggccgcaa ggtgttatag 21181 ggagactcgt ggcaaacatg catttgtatc actttccatc tcccccaccc aaatccatca

21241 tccaacgcga agaccgctca gaatcacccc atccttatca ctgtcaccgt aattctttta 21301 aagccaacac gcaaggtcgg gtccggaaag cggggcatcg tctgtgtaca cgcgaaaggt 21361 ggttttgttt tctgttgtca gttgcgtcca gagtttccgg ggcgtgggtg tgtgtgttgg 21421 cggggagctc cggacagaga agggagggga aacaagcctc tttggttgag ggcctgtgtt 21481 tggcattcgt gtgtatctcc ctgccgagga agggctgccc gtcctgttct tctctccttg 21541 ctccagcaga gccccagtgg gagagagaaa aggcaagggt gtttccaaac cacccccgca 21601 gaagaaagcc tccaaggaac ctgcccactg gctttctcag ccccctgccc ggggagtctc 21661 ctctgcaggg atttcagccc agttggcaca gacaggatca tggtccccac accgggcctt 21721 ctctgcctgg agacagcaca gggcgatcac gtggatttga ctctgggcac ctctgtgggc 21781 ggcaagcagc ccctgacatt gatcagcctc gaagtgaagt gctccactcg cccgtgtggt 21841 ctccactgaa gagggtgcag gttttagagt ggatgtgggc tgttgcttta aaaacaaagt 21901 gtcatggtaa agctggaaaa atatccagaa ggtttaacct aatttatttt gaaattttaa 21961 ggtggtgatg aaggaaacag caggtccctg gaggaagcct ctagaatctt agttgtgggt 22021 atgagctgag ccagggcaga gagctgtccg gaaagacggg gtactgctag tggagacagg 22081 tgggacccac ctgggcgagg tgctgaaaag gggggcctag gaggcagagc ggaagtcttg 22141 ctggtttaga ggggctgggc taggctggct tagctgtctt ctgtactcgg taaacccggg 22201 agaagcgagc aggatggtat actgtgttgg atccaaccag gtgtcagcct gggtggcaag 22261 ggacagctca gggagcaaat atgtctttaa tacaaaagac cttcaacgtg tcacccacag 22321 cctttcaggc ccagggtctc cagggggtct ccccctaaac aaagaattgg atcatttggg 22381 aagcaaagcg tcatcagacg gagggttact cctctgcagg gctgcagggt ggtgtacgtg 22441 gtaaccacag gcagcagggg agacgtgggc ccaggaagtg cccagccaca ccctgggaac 22501 aagtgtcctg aaccagaggc tctcgtgggc acctcttgct tccttgggtg agcattaagc 22561 acccccgtgg gtgcacgtgc cttggttgaa atccacaatg aaagctgggt ccattccacc 22621 gcccagctca tagggtggca gtccacggac ggtgctggga gaccctcagc acctgaagtg 22681 tggactcaga atcttctgga agaaacctcc aaggtcagca tgcactccac agcgtctcag 22741 acactaggtc ttagagtctc tgcctgggcg tgttcagaaa tggggccatg actccccagg 22801 ccagcctggg gtggggagaa ggagacgtgg gggcaggggg cggtccaggg tcttgttggc 22861 ctgggagcca gagtttgggg gtgccttgac tttgaaagga aactgaggca agcaggcctg 22921 accctcgtgt ccctcaagct gcctcgtgcc aacactgtct taccggtgtt gtcttaacct 22981 cttacctgca gcaacatgga atccccgtcc cagtcacccc caagaacccg tggagcatgg 23041 acgagaacct gatgcatatc aggtaagacg gacctgcctg tccaccgctc tgccaggcct 23101 cggtgagcac ccacccatct gggtcatgtt ggagtggtga cccacagacc tgtggtcccc 23161 gccctcatgg acggagccca gcgacctcag ggagggcaga ccgcctcttg gtgtgtccct 23221 ctgctcctcc cacactgact cccctcctct gtcttccttc tttctcccct gtagctacga 23281 ggctggaatc ctggagaacc ccaaggtaat cccccgttcc cccgagccca ctgtcttttg 23341 gtggtggctg ctccgtgccg acgcggtctg gtgtgtttgt agcctaattt gaaatttcac 23401 ggggggccgg gtatggggct ggggctgagc cctggctgtg ttccccgacc ctccccactg 23461 ggctccctgt cgcctgccca ctcctcactg cgttttttca gatcctcccc cctccctggc 23521 gctctttttt ttcttaattg ctgccacgat gaatagggga aggaaatatt tcagggaacg 23581 gagagtgcga ttgtgagaca ataaagaagc aattaggcag atgagacact tgtgggaggg 23641 cccagtctgt gcccaccagc tcttgggctg cctcggctgc tgccacaggg ggaggtggca 23701 cagatcggag cctcaggacc cgtttgtctg ggcctgggct tcgcacccgc cagctcgccc 23761 gccttggtcc caggtcccca gcctccccag ctggctcccg ctggacctcg gggccctgtt 23821 tgaagttaag gtttttctct cttttggagg ggtggagggg ttcctttgtg tctccccctg

23881 cccaccatgg gagatggggg aggcaggatg aactctatcc tgggaagaaa gaaaaaaaaa 23941 aaatctcttt gtccccccag ggactgtctc cactccctgg ctgatttggg ggtggggtgg 24001 gctgggggtg ggcaggggcc cttgtgcagc tgggccaggg cgggggtgtg ctggggggca 24061 caggatctag gaaggccagc tggagaggat ggtttgggca agggtggagt gagcctggtc 24121 ctgggcagag ctccccgtgg ggaccaggcc ctctggatgg gtgttggtga taacctaacc 24181 tgtaccaggg gctgtttctg gaaccaagcc tggggtctgt attctcctcg gctctgaacc 24241 tcctcatgtc ctgggggagg aaactgaggc ccagaggaat gacccgccct cccggcagcc 24301 tctggttccc aatggcccgc acacctcccc tccccacccg ctcggccctc agcccagccg 24361 tgtcactcag cagagcccac accctcgtcc cctgggggct gatggcccca caaggccgct 24421 gcctgctggt cacaggcttt tccagttcat gcttggctga ccccacgaca ctcaggccag 24481 ccacccctaa ttagccagtc agtcagcgcc cagggggctc ggggaggctg aacagagccc 24541 agcggctcct cttgtggcct atgatgacgc tcttacctca ctgcggggtg caggtccctt 24601 cccctctcgg gcctcctttc taatgaggcc agtgcatgga caaggaagtg ctagccagtg 24661 tatttttcag gattctaccc actagtcaag tgggaaggtg agtgcattcc cagagatctg 24721 ggtctgaatc ttggctttgc ttctatggct gtgcaacctt gggcaagcta cccaacatct 24781 ctgagcctct ggcttcttaa gcaaacagct ggacaaggca atacctgcct cctgggatgt 24841 gaaagccctt ggcctgtcct ggcacagggc ccaaggcctc agccgtggaa ccaggggtcc 24901 cactctccct cctccggccg gctaagattt tttgggggag gaaggagatg aggttccctc 24961 aggagtggat gctctgctct gccctcccag gggaagtagg gagaccacac tcctgctgag 25021 acgtgcaggg ccaagccgag ggacccaggg gctggcccac tccagctccg ctttcccagg 25081 ctgccctgct gcaggtggcg gccagggcag ccccttgcca ccagtaggtc ccagggcccc 25141 aggtgggtgc tactccccac aggggaggaa ctctgcacgc tgggcagccc tggccccctc 25201 tggaggcact ggggagaccg agctcaggga accagtggcc ccctccctcc ccaacccccc 25261 gctccaaaaa aagcctgaga cctgccgagg ggagggtttg aaggcagatg gtggagccat 25321 tttctgcctc catgagggct gattgaaggg caatgaggca gctaatgcga agaaagatag 25381 aaatttactt gctttaactt catacggccc acagtgaaag agttcattca gtcgccggcc 25441 cgccatatct gatggatgaa taaaccattt gccgcatcga tcatgcctct acatcatggt 25501 ttacttcatg ggccatttgc ttccaatttc tccttctcag ccctgtttca tgctttcttt 25561 cgccctctcc ccatcccctc tccctcccca ccaactctct ctctcctttt tttttccttc 25621 actctcttcc ctcccccaac acccccaccc ccccacaacc caagatgaca ttggaagtga 25681 gccctcccgc tgggatggat aaataggtgg tattgatact cagcaacaaa ctatttgtca 25741 tttgaactgg gcttttagga aggcagagta aaaagaaggc aggcgtgagc caccacctcg 25801 gaatgcaaag caaatgtcac tttatttcta tttagttatt ttatttaatc ggtgctgtca 25861 gggtgtcctg cttcccactg caaagagagt ggggatgctg gacccgcctg gtcttcctac 25921 ctcccctctc ctcccgaacg cactctcatc ctgtcccatt ctcgcggtgc tcgcggccgg 25981 ttaagtgctc gcggccagcg cggcaggaga aagtgacaag ccccaggtct gagtctgaag 26041 gcccagtgcg ggtggaggtg ggaggcaggc gagttcagat ggatgggctg gggtctcagc 26101 cctggcaggc agctcggagt tcaacccggg ctggacagtc agcgaggagc ccccggcagg 26161 tggggaagga cctgtgaagt cctgttggtc acccaaaggc cccaagccct ggtttcactt 26221 tgccttttgg ccgaggatag ccctggtccc agggaaggtg gcggttggtt aggtctgggg 26281 agccgggcac gtctctgacc gtatccctcg tgctgtctct catggagcgg gtgggggcgg 26341 gaaacagcac tggacgggcg ttctagagtc ctcagtctga ctcccacacc aggggtgggg 26401 gtggggggtg gccagtggcg gggcggcgtg atggggacag gcggcttctt tggccttggt 26461 ttttccacct ggtccatggg gccatcaggc tggaggtcct caaggaggcc ccccacccct

26521 ccttgggtct gtcttggagg tctgttctgg gtccctgctc ctgcccgcta aggggaaacg 26581 ggaagggatg gtagctggcc tcggaggagc tttgaaggca tgagggcttt attcccagtc 26641 ccatctgagc ccaggagtaa agctagaagg atcactgtcc ctgtttgccc aggactgggt 26701 ggtgggggga gggtctccaa gtttggagcc aggatggttg gtcatcctaa ccacagggag 26761 tgacctcagg ggtcccggtg gccccacctc tctgccccac ctgagcagct cttctccgag 26821 gcaggtgtca ccaggaggct gttccagtca tcctgtcacc tgcagggcac caggccctag 26881 ttggcacctt cttggatgac tttcacgtcc agtaagaaat agaaactgtc tatgtattta 26941 aattgtaagg cagtcaaaag aaagtgttag tcactcagtt gtgtctggta gcctgccagg 27001 ctcctccctc tgtgggattc tccaggcaag agtactagag tgggtagcca ttcccttctc 27061 cattggatct tcccagttga gggatcaaac ctggttctcc cacactgcag gcagatttat 27121 tgtctgagcc gccagggaag cccaaagcag tcaaaagcag gtatcattcc ccctccccac 27181 ccattttaca gatgagaaaa ctgaggctca aagaggcaaa gcaacttgtc acagcctgac 27241 atctcgactc ccggctttgg ggtgttttcc accactctga aatctatcac atcactgttc 27301 aaggcctcat gggtttcccg ccctgggcca tgtggtctcc gccaccccca cacagcctac 27361 gtcacagccc cgacagtccc cgtccgcctc tagttcttcc tcagtaggtg ggggaacagt 27421 tcttgacctc acccaccagg gctgcagaaa acgcaaaggg aactgcagat gcaaagtgac 27481 atgggaatgc ttgcaggctt ttgacagcca gggattgaag ggactgcact tcccaggatg 27541 tcagcaggtg gacaacagct gggccctggg atgcccacgg gacagacttg agcagtcagg 27601 cccaagagcc ccactggcct catcatggca agggtccaag ccgcagcctg caggggtggg 27661 ggggggcggg gacctaggga gttccaggca gccagccgcc cctccaccac cgcatcgagt 27721 cgagaaagag gcccaatttc caacacgccc aagaaaaaat atacataaag gttgatgtgt 27781 tttcaaatgg ggttttgctt cactcttctc ttttctccct gtgtgtatta acctcgggga 27841 ccccagggac ggctctcctt gccggagcac ctgctggggt caggcacagt cattagcttt 27901 gcggtcagtg cagaataaac cccaattccc agtgccgagg agagagagag agagcgcggg 27961 tgtgcccacg cccgctcccg ggaagcccac ctagtgcctc actcccccaa agtcacgctt 28021 ttcctgcctg actggctcct cctgctattc cacctccagc tgtgggggcg tcgaagaaaa 28081 agatgagatc aagttgaggg gaaaaattgt ctgatttctc gagccctttg tttcccaggc 28141 ccctggcaag tggggctggc tccaggtagg ggggctggga ggccggcctg ctggctggac 28201 tggccagccg atggcaagtg ccagcaggac cctggctctg gagagggctg caagagactg 28261 acctggcaca gctcggctca gacacactgt cctccaacct ctttctgtct tatcagaacc 28321 aagcgcctcc aggcctctac acaaagaccc aggacccggc caaagccccc aacagcccgg 28381 acatgctcga gatcgagttc aagaaaggta ggtgcctgcc cagtcaggac tccacgtggt 28441 ggacttttgg ggccctggct ccttgcccct ccttgcctgg gatccccctg ggcatgagcc 28501 ttctgtattc ctcctgtgtt tcccggaagc caggcttcag atggggtctt caaatgttcc 28561 cagctacccc ctccccggat ggcatgatcc atggaagcct tcagatttgg gaggaaaaca 28621 ccccagcggc tgtcccctgg ttggcggaca ccaggtctgg aggaagcatt ctggcgaagt 28681 cactccactt ttctgggcct cagtttcctc atctgtaaac tgggaataaa agcactcgtt 28741 gcctcgtgtt ttcacggtac agagtgagat ctggatgggg tgtatctggt gcaggagtgg 28801 tcaccaagga ggtgctcacc cagtaggaca gccagccttg ggggtcccct ctgaccccac 28861 agctactcct aagctagctg cctggtgcat ctccctacct ccccaccctg ggttcaaagc 28921 tgctgccaca ctcgcttgtg ttctgatttc ctcctcatct tctctgcaac caacatgaac 28981 gtttgctggc ctggcctgag agcccagcct tgagcctggc atgagggaca ccctccccac 29041 ccccaccttg ccttggaaga cagaggggaa ggcaagacat gctgggtaat ggaaggagca 29101 ggacctgctt cagggtgagg gctcaggatg tccaaggaga ggacttttcc aggaggctgc

29161 agaaatcgga gagacttcct ggaggaagtg gcgctgggca ggagctggag gagccaagaa 29221 gggggcgact ccaggcaggg aggctggtcc ttccagccac aggcagggat ggggccgaag 29281 gagagggact cagagacaga tcccagctcc cccctgctag tgtgaccttg ggtctcaggc 29341 ttgttcacct gtaaaacagg ccacagaaat gatgctcata ggtgcttgag catggtggta 29401 ctttaatcat tggcctcctg gcctttctca agggcctggc tgcgccaatg ggcgttttca 29461 tcgttctggc cccacctctg ccatcagttc agacacttga gtgtcaggcc ccctggggac 29521 caaaagccct taaagtctaa ggcccttaag gtcagctgga gcactgagtc cgtcttatgc 29581 ccaccctctg tgacccaggg ccgtgcggat gtggggcctc tgagcatcat ctctgagaag 29641 atggggggta cacccaggcc gcaccccacc ccccacagat cccctggagc cggggagagc 29701 ggtgagggtg ggaggtaagc cggaggccac agacggtcct gcacgctgga caccagctct 29761 gggccccttt tcctctagga atagataggc cagctccaag ggctgagccc gagaagaaac 29821 gtgatccatt ttaatgattt ggggactgtc tagaaaaaaa aaaagtagac ggaggaaccc 29881 tccctgacga ctccccattc actctctagt taatttattt gaagttttaa tctaattatt 29941 aactatttta aaggctaaga ggctttctct ggcggcggca gcagcaatgt ctgctcgtct 30001 ctgggggcag gcctcatcca aggccctgca aggacgacaa taggaccgga gggagagaat 30061 tgagagggga gaggcgggtg ggggcggggc ggtgggcaga ggggcttaag gttcattatt 30121 gggcagactt acatttaata gcaatttaca accaagttat aaaacccctg gaaatggggg 30181 ttaagaatgg ccaggctgac agcccctgag cgaagcccct ccaagcggcg cccggctaat 30241 aaagactcga aagccgctat tgaggcctga ttggcatccg atcgctggct ccatggtaat 30301 gagctgggca gatgggtggg agattagccg ccaactttga acagcttttc tttgtcactg 30361 ttacagctct cttgttaggc cgctaataca tttattgctc atttcacacc gctcgagaaa 30421 gtgccccttg ctattcaaag tcaaccccga acccacccac cgcccccctc ccgccacccc 30481 cttgacttcc ctcccgagcg gtcaccttcc tcctgccgcc ccagacccga cttctcagaa 30541 ttcacgggcg cctccaaaag ctcgccggct gaaacaggca tcttctcgcc ccgatctggg 30601 gtgcggggtc ggggcgtggg ggtccgcctg acagacgcgg cagggggccg tgtgtgtgtg 30661 tgtgtgtgtg tgtgagttca gccacacctc ggccaggcgg gccccccggt aactggtggg 30721 acagaaggtc ctccatcgta agacaatggc ggagcgtgaa attcaattag ttcagggcct 30781 ggttccaatt tcacagcccc taaatgcaaa aggggcagag agaatgggaa gggtggggga 30841 gagcgttttt attgcatttt ccctttcatt ctggggggct ttctcgcccc ttctctctcc 30901 ccagcaggcc tcaacctgca ctgggcttct caaggagtca tttggagtcc atatctgtca 30961 catccattta aggcgttgcg ggcggagggg gagggtggag tggcagccac agactcctcc 31021 gctgagctcc gaccgtgggc cccctgccct ctcctcttgc cctaggggtc cccgtgaagg 31081 tgaccaacgt cggggatggc accacccaca gcacagcgtt ggagcttttc ctgtacctga 31141 atgaagtcgc gtgagtgtct gctgggaaca cactggccag cccctgcttg gaccgctgtg 31201 gctggtggcc ccggcccgag ccttaggggc cgaggaggac aggcccgcgt cctgcagtca 31261 gccctggcac cagccctata ggcgtagggc cctttgcttc tgtacaagag tcccggtggc 31321 cctgggcctt agaagggaac aaccccagag catcttctgc ccccggggat ggtccagttg 31381 agcctttcca ggtctcagct gggttgggga ccaggctaga aggacagctg agcagtgggg 31441 aaggctgggt gccacgccag gccaggccca ggtgggggtg acggaagttg cacactgagc 31501 tcgctgtgcg tcccaggcaa tcccttccct ccttgggcct cagttgcccc acctgtacaa 31561 tgggtggttg gacaactcac ccggctcaga tgtcctctga gtcttgaatc ctgacgccct 31621 gcacatggcc cccagtgacc agatggttct tctcacagtg gcaagcacgg cgtgggccgc 31681 atcgacatcg tggaaaaccg cttcatcggg atgaagtccc ggggtaagtc tggtcgccac 31741 ccctgggggc atggctcggc tcccagaggc ccctgacacc caccatcatg ttccagcgtt

31801 gctactccca ggctgacttt gggcaagtcc tttcaccctg ccagacagtt tcccttatgt 31861 gaagtgggga tgagggacac ttggccactg atttctgatg gcatcaggag aagagctgtc 31921 cccagagcag ggagaggtac agaggagaga ggaggcgggc ccagggcccg gaggtcaggc 31981 actccaatgc cctgggcggc gggtcagcca ggcttagagg caggccacgt agggccgatt 32041 tcgtggtcat taaggtgaca ttgaggaggc cagagggccc ggcagggtgg gaatctcgcc 32101 aggggtgggc gctatgagcc agtcagggcc tgagggcctg tctcatgaca tgagcatgac 32161 atggtcgttg ttcggtcgct aagttgtgtc tggctctttg caaccccatg gactgcagca 32221 caccaggttt ctctgtcctt caccatctcc cagagcttgc tcaaactcat gtctgttgag 32281 ttgatgatgc catccaacca tctcatcctc tgttgccgcc ttctcctcct gccttcagtc 32341 tttcccagca tcagggtctt tcccagtggg tggattcttc acatcaggtg gccaaagtac 32401 tggagcttca gcttcagcat cagtccttcc aatgtatatt cagagttgat ttcctttagg 32461 actggacttt ttgcatgatg ctggggtggg gctctgcctt ggtgctgagt ggctgcccgg 32521 cccatatcca cctctggctg ggcctggaag gaggtgaggc tggtccccaa gcaggtgcag 32581 agcccatggt tccctctcgg tccctcatcg ggtcgtctcg actgcaccca acccccatcc 32641 cgtttgagga gatctcatgt cccccgtgat gaagtgatgt gcgtgcttct gacttccatg 32701 agggaggggc aagccagccg ttaagagtac cggtggtggg attaaggtcc cttgtgtgag 32761 caggtgttca gctcgctttg ctaaggtcaa tttaaaaaga cggcacagct aaagaaaacc 32821 aggccaaggt catggctctt tgtccctcgg gatgtttttc actgagactc taaaatccaa 32881 agagaactga tggcagattt caggtcaggg cattggtcct tgaggcagga tgccagggct 32941 ctcacatgga gttcaggttc acagctcctg gctgatgacc ctggacttgg tagctcagtt 33001 tctgcaggtg caatgtggca ggcgttggga caggagttgg atcattctgg ttctgacctg 33061 tttgaattta tctcaaaagg ggaagaagga agcaacgtgg ctttgcctcc tgtgtgtgtt 33121 ttttttccct ccttgacaag actattactg tgaaaaacaa cctaattgaa agtctcagaa 33181 gaccttgtgg agaacaatat tactaattag ctgctccctt gtaccctctc ttacctttgt 33241 gtcttaccta taccaacatc tgattaaacg tccttttgtc tcactttgcc cttgggaggc 33301 agcacaacgc aaattatctg aggcagactc cggagggacc tcggcgagcc agagcccagc 33361 gcccttgctt tataggcggg gaaaccaagg ctcaaaatca cagccacgtt ggtggtagga 33421 tcaggactaa tgtcgagtcc cagagaggca tggggtggag ggctgagggc ttgaactctg 33481 cactggggta gatccgggtt ctagcccatg tatgttagca ggaactggcc cagtggaaga 33541 gcttcttgaa tgcagcagtc ccatagggat gctgaaaggg tcaaggcggc ctttgccctc 33601 tgggaactgt ccagtctgca ccacgatcgt gtcccttctc tgtccaaggc aggcatcact 33661 gattgtggat gtaaatcaac agtgctgacg atggacagat cgcctgagat cactctgtga 33721 aatggcaccc aagtggactg gactattctg ggaacgcatc ctgaaagagg tggcagaagg 33781 atagacttta cctggtagaa gaaggtggga tagaaaggag tgggagcctt ccagtgtgag 33841 tggcaggagc agccccaagt ggccagatgg gtggtggttt aggtgtgagg ctggccggcc 33901 tcctggaggc ctggcagagg cgcatggaag ggcgggtgtc aggggccagg cttgggcacc 33961 agactcgact gcctgccttg gctccatcac ccttcggaaa gcaacgtagc ctcttcagag 34021 aggcttcatc catgaaatgg gttgttgggc agattgaaca cctctgtgtt gacctatagt 34081 gggtgccgtg cctggaggta ggcttcctac ctgttcccag attgaacttt gaagattgga 34141 gccatgaggt tagcgctcag ttccaactcc cttgcttctt accatccacc tgaggtgaag 34201 attcctggag catagccctc actctgcgca agcactgcgt gtgcaccttt gaggggcttt 34261 ctctaaaagc atagcattta gcctgagagt tgcttgctgt gtatcctcag acaagttgct 34321 ttccggctct gctactccca ccggcaaagg tgggcatgct agaggatctc accttctctc 34381 tctctgcaag ttctaccttg cctattttct gacttgggga gtgagaaaag aaagttgctt

34441 cttaatttta gggggaggtc ttgtttttta tttctccact cccaataagt cactgtgaga 34501 aagaaagagg ggcaatagag gaagacatcg tcggttcgcc caggagactt ttattggtct 34561 acggtcaggg gaaaagctgt taattgtcaa ttatatggag ggcagagcag gaaggtgcta 34621 ttgttcgtag gttgatgtac aagggggaaa tgtcatttgt attgatttta caaagcttag 34681 agttgaaatt ggttaaaggc tttttttttt ttttttttgc cgggttgggg gagggtgggt 34741 gggtaggaag ctggcagtgc taatgtatca ggtctggggt ggccaggtta gtggcacttg 34801 gggccatggg gtcagcaggc cgggggctgg ggaagccgca gatggagtag ctttcgctgt 34861 attgtggctg ttcacatcgt cattatcaca ttatcttttt aactctggag gggggctaat 34921 taagtgaagt aaatgaaatc agtggggagg agaagggggg cgaggcaggc aggagggaag 34981 ctgagaagga gctggcgctg gttcgtccct caccttctcc ccccagcccg gccccatggg 35041 tctcgcctct gccgcttccc tcggtgactc cctccgcact cgcctcctca cctgccttct 35101 gttctcccct ccactcctcc cttccactct cttccatctt cctccctcct tcccatctct 35161 ctcgcatcct cccctcctct ctcacttcct ccttactcca tcactttctg gcgaagaaag 35221 acttaagagt tgccgcccgc ctctccagac ctcccagagt ctccgctcag actgaacatt 35281 ccagattgga gggagacttg tgaggcaaag gtgttcgcat tcccagaagc ccggagtggc 35341 cagcatcaga ggcccaccct gattcccagg gtagggcccg cggggcaccg tgagcataga 35401 ggaaggctag caacccacag ggacttgcct ccccatcacc atggcaactg cctctcttct 35461 tggccatggg atctaagtgg ggagctcttg ggctccagcc cagctcccct cccctggcct 35521 ttctgaatcc cttcctctgg acactgctta cccaaacgac cagaggcagt ggtccaggtg 35581 ccttaacctc cacctctgcc ctcccaccgc cccccacccg aacctccggc cgagttggcc 35641 gatcccactc agttctgcca aattgctcaa tttctgggct aacctggcag cctcgggaaa 35701 acagatgaga aaaatttaag cggctgcagc tgttttggtt cccacctctt cctcctcggt 35761 ccactctccc cccaccccgg ccgcccccgc cccagctcct cgcccttctt ccccacccgc 35821 tcctcggcag taattatggt gtgattgaag ccgctccgca gagaaccgct gacacctctg 35881 tctttttcct gtaaacacgg ggagatgaaa atagacactt gaatccgctg tgcgtgtcac 35941 tcggaagatg tctgttgtct cttccccagc gacaccgaga ctcagctgtc atttcctcct 36001 tctttttgcg cagtggtttg tatgccgact gtcaaaagcc ccaaatccat agtctttaag 36061 catcaggatt ctgtcactgg gttttttttt ttaagtcatt tttttcccca gaagaaatac 36121 acagaaatca tctgtacccc ctacccctgt ggagaggaga aggaaagctt taagacacac 36181 acacacacac acacacgcac acacgacaac agcaacctgc aaacaagctt tttgatcagt 36241 cacaattaac tttaacacct tctaaggcaa ggaacgggaa tattaattgt gctggtgtgt 36301 ttcacggctg cggcttctct tctcgcctat gactcctccc gcagcgccct cggagggctg 36361 acggtcgtgt ggctggtcct gagggctcag cggtgggtga ctgtccacca gacactctct 36421 gttcttttcc tggggacagc tctgatggcg cagtttgggg gtggtggtgg gggacagggg 36481 cttcccaggt gactcagtgg taaagaactg gtctccaatg caggagatgc gggttcaatc 36541 cccaggctgg gaagacaccc ccccccaccc cccggagaag gaaacagcaa cccactccag 36601 tattcttgcc tggagaatcc catggacaga ggaggctggc gggctacagt ccatggtgtc 36661 acaaagagtc agacacgact gagtgactaa ataacaacgg gggtcgaggg ctaggacaag 36721 tcatagctct tccttgatgg aaagcatgga tgtcctctca ccctgccagc gactggtcct 36781 gtttcgtctc tggactgtgg ggaggtgatg ctagggagct ggctacagcg ttccagaaac 36841 gaaaccgcat gcgcaccagg gccattgtgt ctgggtgctc accttcaggc gcgtctcagt 36901 gggacttagg caaaagagca gtcgacactt gccaccttct cctcttacag gcaggttgcc 36961 taggccacag agggggctga ggcagcccga ggtcacacag cagaagtgac ttgcgctgaa 37021 caactgtaaa ggtataagtt gagagggact tctgggctgc actcctgatc tacgaataca

37081 gcttggactc agctggccgg gtgtggacag gagagcaagg aggcagctgg gttccccagg 37141 ggctaaagat gagggcagct cctgcccttg gcctgccgtt gtgactgtgt gtgtaagaac 37201 gggctttgaa agtttctggg tttttccaaa atgtggcaaa agtaataatc aggaagaatt 37261 agaaggccca tttctagtcc agtaaatact gagttcctag tatgtagagt tcagttctga 37321 ctctttggga cctgattgac tctttgggac cccacggact atagcccacc aggctcctct 37381 gtccatggta tttcccaggc aaggatgctg gggtgggttg ccatttcctc ctccagggga 37441 tcagccctac ccagggatcg aacctgtgtc tcttacgtct cctgcattgt caggcagatt 37501 ctttacccct gagccacctg ggaagcccgg tatatagtaa atatatattg agttgctaga 37561 tatatatatt gagttgctag aatgagaaga caaataaggc tttgccatta tcttgctgtt 37621 ggtgactctt ggtgataaag tttctagaaa aactgaaagc ttgccccttt taccttgtgg 37681 ttatttctgt ctttttttat tttttttttg gaagtagatg tttccaaaaa ctctgcagcc 37741 ctctaacatt gtaaacagac tgctgtaaac atcaggcctt tctcagtggc ctggggtcat 37801 cggaagccac ttgtttgtgg ctccctagtg tccccaaatc aacagacatg aatttgagca 37861 aaccccgggc gatggtgaag gacagggaag cctggcgtgc tgcagtccgt ggggtcacca 37921 agagtcagac atgactgagc gactgaacaa ctgtccccag aaggcgccag cccagagcct 37981 gtgctgagtg cttgtctgct tttcacaggc gttctgtgtc cagtgtcccc agtctcacgc 38041 tgtcgttttc tcagccaccc acctgtctcc cacctcgtca gcccttctaa gctccttcgg 38101 ggttgtgtct ctgaggcagt ttgtggacgc ggatgacaga gccggtttga actgtgttta 38161 tgagagtcat gatgaggggt ggtgggggcc tgaggcgctc cccggggagt cgagggcttg 38221 ggcctgctgc gtgaactggg ggatggtggt gttttcctac cggggaaaca gctgtgttta 38281 cccccacaac tgattcagga cagcagaagt ggcccaagag ctgcaggcac acgagtgaaa 38341 caggaccagc gtgtcctagc aacgccttgc ctctctgcgc atgtccccga accccaggat 38401 gtggggggtt tgcagataag agacccgctt ccccatagac aggctctttt ccactctgga 38461 acacctcaga gccttgggaa cactcttcct tggccacagc acctcagatt tgggtgtccc 38521 tttcatgctt ggtgagcact ggatcacttt gcaaaaggcc taagaggcaa ccaagtgcag 38581 agatggaaaa ctcagaggca ggtctcagtc tccccatctg tgaaatgggt gtgttgtgcc 38641 aaatcaggat ttttaaggac tgcttgtgga gtccagggtt tgcaggggga cttctgctcc 38701 ccacagctgg acctcgtctt taattgtata tgttgagttt ccgcctaagg atgtttgaat 38761 cctgagtttg cagctgagtt aggaaaatac aggccatcgt tatgggccct gacatttcta 38821 tggattccca gacttagatt aaagaccaga gaagttctca gaggagaaaa tttctggcta 38881 cttacatcag acacaacctt ggtcatgtcc cctatggact tcagagttta aacaatctct 38941 tcctttctgg tttttgtttt ttttgttttt aagcattttt aaattgtggt aaaatataca 39001 aaacattggg aaaaaatcct gatgctggga aagactgaag gcaaaagaag ggggcagcaa 39061 aggatgagat ggttagatag catcaccgac tcaatgaaca tgaatttgag caaactccag 39121 gagatggtga aggacaggga agtcgggcat gctgcagtcc atgggtttgc aaagagttgg 39181 atatgactta gcaactgaac aacaacaaat acaaaacata aagcttacca tttaaactgt 39241 tttgagggtc ctgttcagta gtattaagga caacattcat gttgctgtgt gagcaccagc 39301 ctgcatctcc agaactcttt catcttctca aagcgaggcc ccgttaaaca ccagctcccc 39361 tctccccctc cccagcccct ggcacccagc tttccacttg gtttctatga actggactct 39421 taggaacctc acgtgagcag gatgacacag tatttgtctc ttggtgattt gtctctggtt 39481 gatttccatg tatcctgtct tcgcatgtat caggacttcc ttttaaggct gaatgtttca 39541 ctatggaaat atctctttct gtttatccat ccatctattg ttgggcattc tgattgcgtc 39601 caccttttgg ttcttgtgca taatgctgcc atgaacgtgg gcgtatgaat ccctcctgtg 39661 gaaagatgac cacgtaaatt ttgaggaaaa ccaaaactct gtccctttaa cgccataaca

39721 ctatttggtg ggaagaaagg gacttttggg ggtggcgttc gtcggggagg gttatgaccg 39781 cttcatcagg acagcagaca caaggcaggt ttatccaagg tgctcacccg aacttgactc 39841 atggggctac actgccagga ttgccggggc caattccgcc tcttggtgcc tcagtgtccc 39901 caaacctagg atggtgccca ttcatcagat ctccctccca gggccacact cagcccaggg 39961 ccaggagccc ccttgtcact tggaggtggt gtggtccaag caggttgttt agcagatgga 40021 agattcaggc cagagatgat ggggaggacg ctggtcaaga ccgtcttccc gcgaccttcc 40081 aggtgtggtc tcatcacctg ctggtccaca gggaagcaga cagcaccact cagggaccgt 40141 tcccagctcc actccagcta cgtccctccc cccaggaggc tcagtttccc cattggtaca 40201 gtggggtcag ccccgagttg accaaggtgg cgaggatttc tcagcagaga cgaggctgca 40261 ggggagccgc cagccgaaac tggcatgtgt gtgcacacgt gtccacgcgt gtgcatgtgt 40321 gtgaacagcc gtcccctccc ctggctccct aggggaaggc aggaagggat gttcagggcc 40381 ctgggctcca gcagaatcgg tttaattaca ggttttcagc tgcgggccgg tgggcatgag 40441 ttggggagga ggggggagcg gctctgaaac cctgtcattt tccagcatct gagggcctct 40501 gcaaaggggg gcatctagac attttctccg caagccgcag agtggactgt cgtggcccca 40561 gcgtgaacat aatggcagat gcattttgca gcaagctggg agtgaatggg tccgaccggc 40621 ttgtctcctg tcagacgagt cattattatt attttttttt tttttgtcat tggctgacag 40681 tttgggtttc atgcgtttct ctcttttttt cttctcttcc ccctgcctgg aaaaatggct 40741 aggtatctac gagaccccag cggggacgat cctttaccac gctcatttag acatcgaggc 40801 cttcaccatg gaccgggaag tgcgcaaaat caagcaaggc ctcggcttga aattcgccga 40861 gctggtctac acgggtgcgt agaccctgca ggggctgcct cccctccctg acccaggggc 40921 accctcttcc tccagtccca acttacccac tgccacctgc gctagagcct ggaagatgca 40981 ggttgaaagg gctggagaga gggcaggagg caaggagcga ggaggggact gtgggacctg 41041 ccttgttcat gaggtcttga gggaagcgcg ccagttcccc ggggcgtctc gctgctctgc 41101 tgcctgcagc ccatgggact gcagaggggg ccagggcagc atcctgccaa gtttcattca 41161 gcatgtgccg ggtacctggc accatgtggg gacacgagcc atcccggagg gccccctccc 41221 ccaagttcct aagagagctg cagccagaaa ccaaggctcc gggcaaaggg aacttataga 41281 gcattaccca actggaagtg gccaagttgg gctggacttc aggtcagcct gtctccaggc 41341 agaacccaga gccactccat gaactgcctc aagccagaga aagcctacct tgaccaagaa 41401 tagggcctga gcactacatg ggccagatcc ccactcagaa gccaccaggg ccacacatac 41461 ccatttcaca ggtgaggaga ctgagtttcc atgcctcatc tgccatctga ccaggcctcc 41521 tgactccaga tccatcccag acattgtaac aggagtgagc agatccaacc tgttgcctgt 41581 ttttgttcag cccataggct aagaccaatt tttacatttt tcagtggttg aggaaatttt 41641 tttttaagta atatgtattt catttaatat gaaaatcata agaaattcaa atttcagcat 41701 ccataaatag ttttttggag aaggaaatgg cccacccatt ccagtattct tgccttgaaa 41761 atcccatgga cagaggagcc tggcaggcta caatctatgg tatcacaaaa gagtcagaca 41821 tgacttcaca actaaacacc aacaaatagt ttttttggca cctccttgct catttgtgtc 41881 catgttgctg tctgtggcca ctttggaacg gctctggcat agctgagtag tagctaggga 41941 agctacatgg cccatagagc ctaaaatatt tactatctgg ccctttctag aaagggctga 42001 ccctattcta taacagtcac atctccctaa tttgagaaat cacgtcataa cagaccctct 42061 cagctgttgg gaggatggcc tgctgttctc tgggagccta gatgtcagaa ggaccctggg 42121 aaagttaata ttcatagcag cagcctggta taagtctcac ctcttccact ggtcctccac 42181 ttggaggttt cacttcctct gaaaccttgg aatagctata actcatcacg gggtttcagg 42241 gcgacatggt ggttattggc tggcattatt tttccctccc attgttccca gcagctttga 42301 aaccccaggg cccccctctt cccaggtaca gacaggtgtt taaataccat tgtctcctgc

42361 agactcttgt gctcagtggg gtttccatgc tgaaaggtgg attttggtta caaagtggga 42421 gagtcattaa gctgtggcag gctgtgatgg gggacagcac ctggccgagg ctgcttctgg 42481 ggcgtccgtg gggctgagcg gggaccaggc tgccaggctc cccacacaag attggctgcc 42541 gactcttgct gcccagccct gaaccgggta ttacctaatc tcagctgcac agaggtgaga 42601 tgaaaatgct tgtccaaggt ttcagagctg ctgagccgtg gcttggagcc caggacaagc 42661 tggcttcaga ggccaagttc tcggccactt cagtagatgc tgggggatgg gaaggtgggc 42721 tgagcccatt tgcgaggggt gactaagggt cactggcatg tacaggccca ccctgggtgt 42781 ctggggcaca ggttggcccc cagctgaggg gctggtgcct ctgcactggg ctgcctgtgt 42841 tgagtccttg ctgtcaccca ctgagccccc taaatcccca aaggttacag tgattaggtt 42901 tcaaaggaaa tgaaacctca gagtggaggc tcctgccagg tagttgttat taagttcagc 42961 caggtgcctc tgatgtccag gcccccatag atgtcaaggt tggcattcgg caccagcctg 43021 ttccctcaac agctccgaag ggctgtgtga taggatttct ctcattaggg atgcataaat 43081 gttagagagt ggggttcagc ttcagcatgt tccttaagcc ccctgtgcct cggtttcttc 43141 ctctgaagag tggagatgag gctgcctgtc ttacagtgag gactcaatac atagatatgg 43201 gcttcccagg tagcatgagt ggtaaagaac ccgcctgcca atgtcagaga tacaagagac 43261 acaggtttga tccctgggtt ggaaagatcc cgtggagaag gaaatggcaa cccactccaa 43321 tattcttgcc tggagaatcc catggacaga gaatcttggt ggagtacagc ccatagggtt 43381 gcaaagagtc ggacacgact gaagcaactt agcacatatg cattgcatag atatttgcaa 43441 agcctctagg agagtgcctg acgtggtctc cgaatgtgaa cataggagaa caaggctttg 43501 cctctggctg ggtagatctt gaatctgtct cctccctcag cctcagtttc ctctcctgta 43561 agataaaggg cactgggcca gatcccttct gttctgtcta gctcccccct gaagatctat 43621 cattctgctc tggcacttgg cttctttgga gccactgtgg tctcagggcc cggggagact 43681 gaggcccaag aaagcccttc tgtctcgggc ccactcccag ctgccccagc ttccgtgacc 43741 actgtctttc ctctcacgcc attctcaaat ttcctaatgt ggctgtatga agtttgcaca 43801 ggcaccctcc ctccaggacc aggcatgggc ctcaccccgc agggtcatcc tggcaggacc 43861 ccagcttcag ggcccctcca tttagggggt gtaggtcacc tctcccctca cctcagtttc 43921 ttcgacagta aaatgggtat aatacacaga ggattgtcat cctaattaac acagagtttg 43981 gctcagcccc acccaccatg cacccccagc ctgggacact cagggtctcc ccagggcagt 44041 tctcagggct cactgtaccc ccaccctggg ttgggtctgc tgagaagaga aacctgagcg 44101 caagacccct gtggaggcag cgggggagac ctgagataaa agcccaggag ctcctactgg 44161 gttctctgcc cccttatctg gctacatcgc ttcctctctt ccaacctgtg aacctaatgg 44221 gctagttacc ctgacttaga aagatggcca agccactggg gcacggggta gggaggggtg 44281 catggccctc agtgtcccct cccacgggag tctgggctac aggcaggagc actccggacc 44341 gtgctgtgtg gtttggaaag gttctctcct tctcgggtgt ctgtcgccct ggatacagtg 44401 aggaccggca gaggccacat tcagatctca aaagcagaag tgctcactga atccccacag 44461 cccctagaga gtggttggta gcacctcact gtgcaaacaa ggagactacg tacagcacag 44521 aggccacacg gcctgccaag gtggagctgg aggtgagcat aggagaggga ggacccaacc 44581 ccttctctcc ctgcccggcc ctccctgaag tctgcaagga cccatcacag ggagggcctg 44641 ctccccattc ccacggacag cctcagcagg tgcccccgga ggcctgagtc tccaacaata 44701 gccacagacc tggggctgac ctgacccttt atcagggcag gagatcacac accatctggc 44761 cccgcagctg cccaggtggg ctcacctttc cagctccgtt tcagagaaat cctacccctc 44821 gccctgtccc tcccccaacc ccgatcatgg cccccctgcc ctcggcagag actgagagga 44881 gccactgtcc agaccctggg aagacgggac tgaacacaca gccctccccg gcctgaggga 44941 ttcggggcgg gaggaggggg tgcaatgcgt ttctcaggca cctcgggcct gttttaggta

45001 cagacggcaa agctgcaaga caatcataca aggcagagtt gttagaactc gggcccactg 45061 aggtcaggtc cagcccccac cactgcagcc tgtgtgatcg gggaaaagtc tcaagtcctt 45121 gagcttaact tcctcgcaca gaaaagagag aagctaagag aaatttagcc ccaagactaa 45181 gactctttgg gaggattcaa agagctagtc caggaacttc cctagtggtc cagcggttga 45241 gactccaagc ttccaatgca gggggcatgg gttagatccc tggtcaaaga cagggcactt 45301 ttttcaaagg ggtctgccca tcctgagggg tggggctctg cctggctctt ggcccagtgt 45361 tcacagcagt cctgagtcca tggcctccac acaataagcc tgctggccct gggagtgggg 45421 gaaggtaggg tcattccccc ttagcagatg ggggaacagg cacagagagg tgaaggcccc 45481 acacacctgg tcttgctgac cccaaaccca ccacccagct gggcaccccc atcactcggt 45541 gacatatatc tgagtcctac ttgaggtctt ctgcctaatt tatcagtccg ctgccctgag 45601 aagactgagc ccccatgggc aaaagatggg ggtctcttca ccgctgtctc cccagcacct 45661 gacctctgga gctccctgaa tatctgtggc atgaagcagt aggttaaaac ccctcctcct 45721 gacccttgag aggtgactgc attgtagcag gggttgggac agaaccctac aaggtcacag 45781 gactgggcag ctgggcttgc tcctcagtgt ggtcatttac aagtgcacac tgagccggga 45841 ctccgcactg aacaacacag atacaggact gcctccctcc caggctcacg tctgccacga 45901 cggggcccca tgtggatcca gttccgtcca catcctgggg cagcaacaca gcgggcctca 45961 ctggcaccct tgtttcttcc tccccacagg tttctggcac agccccgagt gtgaatttgt 46021 ccgccactgc attgccaagt cccaggagcg cgtggaaggg aaagtgcagg tgtccgtctt 46081 caagggccag gtgtacatcc ttggccggga gtccccactg tccctctaca atgaggagct 46141 cgtgaggtag gtgcctccca cccctgcccc cagctgggca cagaccctcg ggtgcagcat 46201 ctcctctcac tgtctttctc agcaaggatg ctcccaagca tgtgcaaggt gtggaggaga 46261 cagtcccgaa gagcattcac accacctctg tcctcgtgga acttacaggc tagatgggga 46321 gaaagcccca gtcagaggat catccgagtg taggattagg gaagctggtg ctggaccacc 46381 cagagatata ggatacctgg gctgggtata ataacgcggg tggggagacg cgtccctgtg 46441 gaagtcatct ctgagctggt ctctgaaaga aaggagtgta ccagggggag aggcagggcc 46501 ggagcatttc cagagagact gtcctgtgca gagagtccaa gtcatggaag aacccagaac 46561 atggcacaag aagaactcca gggtgggagg gccctggagc cagattgtaa aggactgtgg 46621 ctttggtcct ctctggctgc tctggattta agcgaggtgg gagctggcag ggatggacac 46681 aggcctccca gtgggacctg ctggaggctt ggaccagtct gctggatctg ggaatagaga 46741 tcagcagatg gatttggcag atatttagga ggtggaatta aaagggcttg gatggggaga 46801 gagatggaaa agttcagaac caccccaggc tttccagcat gagccgctgg gtagactttg 46861 atggcaatga ctgagttgag agaatgggag aaaatcacgc attgggattt ggacatcttg 46921 agggttagtt ttctttgaga tttgggccag gagaactata gttggcggtt ggacacacag 46981 ggctagagtt aaggagaaac ataggctgaa gacattgggt ggtaaggcca agaggagact 47041 gccaagggga acaacagagt tgggtgagag ggagccagga gggagccttg aagagctgcc 47101 tcccgcgatg ggtcagggtg agggagctga atggctgtgg gagaggttgg ggagccctgg 47161 caggctgggt caaaggtgaa agtgtgaaag ggttagtcgc tgagtctgac tcttgtgacc 47221 ccatgaactg tagcccaata ggctcctctg tccatggaat tctccaagcc agaatactgt 47281 agtgggttgc cattctcttc tccaggggat cttcctgacc cagggatcga acctgggtct 47341 cccacactgc aggcagattc tttagcaggt gcctattagc tgtacctgtg tttgcatctt 47401 gaatgagaga ctggccttga ccatggagcc aagtggcccc tttggaggtc acctggtcaa 47461 acaagaggtg gggacaggca accccacctg atgcaaggcc caggccctgt gtggcccctc 47521 ccggaaggca gtcaggaatt aaagtacgag ttttgtttgg cagtcaatat tatttttctc 47581 tctctgttct ctttgccatg ttgcacttct ctccccccct tcaatctttc taaacacttt

47641 ataagccata aatataaccg aatcagttta gatcagtcgg ggtaaatgtc aaattatctt 47701 ctctctttct ctctctggct ctttcttccc tccccctcca aatctacagc ctctaataat 47761 ctgtccaacc cttcattaag ccttacagtc tcactcgggg agattaaatg aataaagtaa 47821 aaagggaaag gggaaaaaaa gagagaaaag caggagcatt tattctcact gtgtctccga 47881 ccatttccct tttctttctg atttctacat cgctgacttg aaagcccttg agtgacagcg 47941 tcacagggac tggcgaggaa gcccctagag gtagcagaac tggaaatgcc gcggcacagt 48001 aggtagaaag taacgtaatt acagagcagg tcagagccac tcgaatgaac aaaaataaaa 48061 gcacagaggt tttctgtaga ccgtcagggg aggtaaaaaa aaaaaaaatt cattgtaaac 48121 tcttttttcc acagtgcacc cccccaccac cacaccaccc aaacttcagt attttaagag 48181 aggtttttca gttcccgaga aacacctcgg ggactcttag gcagtctggt gggacaggtt 48241 tgtcccagag gtgggcttct ctttggcagg gactgccggg gtggtctgaa gggccagtct 48301 gggggaagag ggtgggagag tttgttttga ctcatgagag atggctggcc agccagggag 48361 aaggggaaca ggatccggcc ctgctttctc cctgggctga atacagggac tcttccaaag 48421 gggcaaggca acttggagag caggagtgag gccaggtgtc caaagtctgt tcgatggttg 48481 gtgggggccg ggggtgggtg gctcaggaag ggctcgtgtt aagctttatc accccagcaa 48541 catctgtaaa agccattcca ggaggccgat gctttagttt ggtccagcct ctccctgccc 48601 agggaagggt cccaagcagc agccccctag aatcttttcc gcttcctgtt aatcggctcc 48661 tggtgacttt ggccacctga gccctagagg agccggtgga ggtgaaaagg agggagcgtg 48721 ggagttccat gtgccagctt caaggtcccg tgaaggtcag ggcgagggca tagtgggggg 48781 aggcccagag cccgcgtccc gacaagccac agtgcagccg ggtgcagaga ctccagttta 48841 caatgatttt tttttttttt ttttaacctc ccctgatgct ctacaagccc acagtacaag 48901 cccacagtcc acaaagagcc agtcaaaggc acagcctcgg ggtctgggaa aaacagcaga 48961 tccccttagc tccccccacc cctcaaaccc ccaccacccc cccctccatc ttacctctct 49021 ggagaagggt tctgaggggg caggccacct ccttgtcagt gagaaccttg agaccgcttt 49081 atcctgaggc tagagttctg cagacatgaa gacaaggggc taattcaggg caggatgcaa 49141 caggggcccc gtgagaaaca ggagggaccc cttcccctgg ggggattcag agggtggcct 49201 ggtggagtca gatgtgaggc cacaacactc tgaacttgtc ctcaaagagc ggatcacagc 49261 cagtaaatta tcgagggcag gtgggtgatt gattgcttat gtctgcaccc gccgcccctc 49321 cacgtgggag ctgctcctgc caggtccttg tttcctcagc atctggctcg gtgcctggcg 49381 ggtagtaggt gcttaataaa tacctgagta aatgaacagg tgaatgaatg atgttagtgg 49441 cactgagtgc ttaccagatg ccagctacat cattttatgt ggagcccgtg acaatgctgg 49501 aggggcttcc ctgctggctc agcaggaaag aatctgcctg caatgctgga gatgtggggt 49561 tcgatccccg ggtccggaag atcccctgga ggagaaatgg cgactcactc cagtattctt 49621 gcctgggaaa tcctgtggat cgaggagcct ggagggctac aatggggtcg agaaagagtc 49681 ggacatgact gagcgactaa acaacgatga caacaaatgg taacgatgaa ggtcctgttt 49741 cacaaatgaa agactggaac tcaaaaagca aaaacatttg ccctaaggtc tgtgctgggg 49801 gtggagccag gatgcacaac caggtgaccg gatctgaacg actgtggttg cgaagggttc 49861 cgaagggcag ctaagcgaga acaatcaaaa gaggaaggct gttgaatcga tggaaactgt 49921 atatggggac aaaaaaaaat ctgttctgct gagggcaatg ggagctgacg gtgccttttt 49981 cacgaccagc tggcatgggg tgggtgccca ggtttgaaga tggattagac tcagtctcac 50041 tcactgggca gacaaggtca aaaaggcttc gtgggcaaat cttgaaggct ggggcctccc 50101 tgcagcttgt gggacaccgt cacgcatgtc tgaggctgtt tggtgtgtaa cctcggcctc 50161 ccaggccttc agaccgctga acatcatcgg ctcctcctgg acaccctgag ggcagaggtg 50221 gctccgatgc gtgtcctgag ggtacgggtg cagtgctctg gttggtggca ggagttcacc

50281 cggctggcac tggcagggcc aggacccagc ccgcccatct gcatggcagg gttgtggctc 50341 cctgctctcc agccccggga cagggtaggg ctccccgaac cggaaggaaa acagtgaaga 50401 gccagagtgc aggcagggtt ggatccacac aggaaacacc tgggtgtctg tgaggctggg 50461 gtcccccgga tgctgacgag ctcccactct tttgcagcat gaacgtgcag ggagactacg 50521 agccggttga tgccactggt ttcatcaaca tcaattccct caggtgagaa gccctggccc 50581 ctgatgggcc ctcagacctt ccaggtgtgg ggagccagct ctgaagggac ctcagtgttc 50641 tgaccactgc tgtgccctag acaagcccca ccttcctgtc cctcaaccac agcatcctca 50701 gtgcctgctc tggacccagc ctccgcagga ccggaaggca cacttgctga cagccaaggg 50761 caacagagtc ccgggcactt gagttccggg tttctgagtt gcctctgaca ctcactccca 50821 tcctctccaa ccacagggac tccaccagga gcccctttcc cgagcagctt agcaagggag 50881 acagccaaga ggtagaaagg agccacagaa ggtcaccaac tcctgccttc tcatccccat 50941 gcaggtctaa ctggagacac ggatctccat ggcccagggt gcgtgataca caccaactga 51001 ggccactcag acctgggttc aagtcctggt tctgcagttt gggttcagac cctttccaaa 51061 cctctggaaa tcactagtag gggtgttaac catacctgcc tcacaggtgt ggtggaagtt 51121 caagtccagg ccatggaaat caagcactcc acccagaccc tggtgcccag gaagggcacg 51181 gtgcctggca accggtctat caggctctgg gttcttaatc actagcttcc ttctcctggg 51241 ggaacggggt caaaaagaag gcacgagtct ttttcctttc cctgataatg tgccctcagc 51301 acagacccac tttctcccag agccagcctc ccgtccctgg agccaagacc gggagagaca 51361 tcgaatccag gcaggccgtc acctccacct ccccggctcc ttcaccctgt gttttatgac 51421 tctaaccctt tcaaatggct ccaaacacac tgggttttca taatggcctc ttcacttctc 51481 ccatcgccag ttaaacgctt tgtctgcaac aatgacaagc aatgttttcc ccctaagata 51541 aattaattac attatcctga ttggagggca ggaggggcca gggcaggaga ggagagaggg 51601 agaataaaaa gagaacttca cacacgtctt aacaaacagc tgccccccgc caccccggct 51661 ctgcctgaat taattgaact gagtgcatgt tgttattgtt aatttacatt ttcctttgtt 51721 ttgaatctgg tttacaggct gaaggaatat catcgcctcc agaacaaggt caccgccaaa 51781 tagaccagct gacaatgcag agctgggccg cctcacttta cccatctccc aagtgtagct 51841 gctaattgtt gtgataattt gtgattgtga cttgttctct gggtctggca gcgtagtggg 51901 ggtgccaggc ctcagctttg ttccaatagt cccctgtagc ccacagaagt ggtccacaga 51961 cggagggatg gggcggggag cggggggctg cagtgagga//