Trastuzumab

Reactions 1479, p30 - 23 Nov 2013 ★ S Trastuzumab First report of Tako-Tsubo syndrome: case report A 50-year-old woman developed Tako-Tsubo syndrome following treatment with trastuzumab for invasive ductal carcinoma. The woman started receiving trastuzumab 6 mg/kg 3 weekly in addition to docetaxel and carboplatin for right-sided multi- focal invasive ductal carcinoma; her baseline left ventricular ejection fraction was 54%. After receiving six cycles of docetaxel and carboplatin, trastuzumab 6 mg/kg 3 weekly was continued with radiotherapy. She experienced 30 minutes of intense crushing chest pain with sweating during her 11 th trastuzumab infusion; increased troponin T values (0.15 pcg/ ml) and nausea were also noted. ECG revealed negative T waves on leads V1-3, I and aVL. After 7 days, coronary angiography revealed normal arteries; ventriculography showed systolic bulging at mid-left ventricle level with normal basal and apical contractions. These findings were consistent with ’reverse Tako-Tsubo’. No recurrences of pain were reported, and the woman’s left ventricular function recovered after 6 weeks with standard therapy. Author comment: "This is the first report of Tako-Tsubo syndrome related to trastuzumab". Khanji M, et al. Tako-Tsubo syndrome after trastuzumab - an unusual complication of chemotherapy for breast cancer. Clinical Oncology 25: 329, No. 5, May 2013. Available from: URL: http://dx.doi.org/10.1016/j.clon.2012.12.007 - United Kingdom 803095912 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of Tako-Tsubo syndrome associated with trastuzumab. The WHO ADR database contained 5 reports of stress cardiomyopathy associated with trastuzumab. 1 Reactions 23 Nov 2013 No. 1479 0114-9954/13/1479-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved

Upload
sandra-m
Category

Documents
view
213
download
0

Embed Size (px):

Transcript of Trastuzumab

Reactions 1479, p30 - 23 Nov 2013

★ STrastuzumab

First report of Tako-Tsubo syndrome: case reportA 50-year-old woman developed Tako-Tsubo syndrome

following treatment with trastuzumab for invasive ductalcarcinoma.

The woman started receiving trastuzumab 6 mg/kg 3 weeklyin addition to docetaxel and carboplatin for right-sided multi-focal invasive ductal carcinoma; her baseline left ventricularejection fraction was 54%. After receiving six cycles ofdocetaxel and carboplatin, trastuzumab 6 mg/kg 3 weekly wascontinued with radiotherapy. She experienced 30 minutes ofintense crushing chest pain with sweating during her 11th

trastuzumab infusion; increased troponin T values (0.15 pcg/ml) and nausea were also noted. ECG revealed negative Twaves on leads V1-3, I and aVL. After 7 days, coronaryangiography revealed normal arteries; ventriculographyshowed systolic bulging at mid-left ventricle level with normalbasal and apical contractions. These findings were consistentwith ’reverse Tako-Tsubo’.

No recurrences of pain were reported, and the woman’s leftventricular function recovered after 6 weeks with standardtherapy.

Author comment: "This is the first report of Tako-Tsubosyndrome related to trastuzumab".Khanji M, et al. Tako-Tsubo syndrome after trastuzumab - an unusualcomplication of chemotherapy for breast cancer. Clinical Oncology 25: 329, No. 5,May 2013. Available from: URL: http://dx.doi.org/10.1016/j.clon.2012.12.007 -United Kingdom 803095912

» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of Tako-Tsubosyndrome associated with trastuzumab. The WHO ADRdatabase contained 5 reports of stress cardiomyopathyassociated with trastuzumab.