TLX, Wnt & neurogenesis. DeCarolis ‘10Ables ‘10 Neurogenesis.
-
Upload
georgina-perkins -
Category
Documents
-
view
219 -
download
1
Transcript of TLX, Wnt & neurogenesis. DeCarolis ‘10Ables ‘10 Neurogenesis.
TLX, Wnt & neurogenesis
DeCarolis ‘10 Ables ‘10
Neurogenesis
Neurogenesis + Disease???Major Depressive DisorderPost Traumatic Stress DisorderAlzheimer'sSchizophrenia
Wnt + neurogenesisWell known in embryonic neural
development
Wnt / β-catenin
Wnt
Β-catenin
Transcription factor
Extracellular ligand
In short…
TLX Orphan Nuclear Receptor
??? Binds to it
“floats” in the nucleus and can act as a transcription factor
Also shown to be important in neural stem cell maintenance/renewal in adult & embryonic brains
Fig 1W
nt p
rom
ote
r re
porte
r
Wnt Promoter
Coding Region
WntPromoter
???1
2
TLX
Wnt
Fig 2
RT-PCR(RNA)
Northern (RNA)
Western(protein)
TLX
Wnt
Β-cateninCyclin
D1
B-catenin reporter Block wnt transcrip
Fig 3
β-catenin
β-catenin
PGSK
Fig 4
Frzb = wnt antagonist
Fig 5
BrdU = fake
thymidine
60%
TLX
Wnt
Β-cateninCyclin
D1
Fig 6
TLX
Wnt
Β-cateninCyclin
D1
Fig 7
TLX
Wnt
Β-cateninCyclin
D1
TLX/Wnt/Β-catenin – now implicated in ADULT:Stem cell proliferation and renewal
Wnt agonists as treatment for disease?