The only EU registered β-mannanase · called β-mannan) into mannose oligosaccharides (MOS)....
Transcript of The only EU registered β-mannanase · called β-mannan) into mannose oligosaccharides (MOS)....
Complies with KB of February, 8 , 1999 (BS 21.04.99) and MB of February, 12, 1999(BS 21.04.99) concerning trade and use of substances destined for animal feeding.
The only EU registered β-mannanase
FOR MORE INFORMATION:VITAMEX N.V. ● Booiebos 5 ● B-9031 DRONGEN - BELGIUMTel.: +32 (0) 9 280 29 71 ● Fax: +32 (0) 9 282 34 27 E-mail: [email protected] ● www.vitamex.com
Hemicell® is a patented fermentation product of Bacillus lentus. The key ingredient in Hemicell® is an endo-1,4-ß-mannanase, which degrades high molecular weight soluble ß-galactomannan fibers (also called β-mannan) into mannose oligosaccharides (MOS).
INTRODUCTION
bIOlOgICAl EFFECTS
Hemicell® improves the performance of monogastric animals by efficiently degrading soluble β-galacto-mannan soluble fibers into smaller mannose oligosaccharides (MOS) that can’t provoke an immune response.
pRODUCT SpECIFICATIONS
1. FORMUlATION Hemicell® -D: ß-mannanase, 390 million units/kg, guaranteed minimumHemicell® -L: dark-brown solution; ß-mannanase, 720 million units/liter, guaranteed minimum
2. DOSAgE
Hemicell® -D: 200 g/metric ton Not thermo stable, for use in mash feed only.
Hemicell® -L: 110 ml/metric tonNot thermo stable. Apply to the cool pelleted feed witha suitable spray system. Dilute with water so 1.0 liter issprayed per metric ton.
3. pACKAgINg
25 kg bags Hemicell® -D208 l drums Hemicell® -L
4. STORAgE
Store Hemicell products dry and cool. Avoid prolonged exposure to temperatures above 25°C.
Hemicell® feed enzyme is the registered trademark of ChemGen Corp. Hemicell® and its use are protected by U.S. Patents 5,429,828;5,476,775 Europe Patent: EP 0531 437China Patent: ZL96107126.5 MADE IN AMERICA
EU registration number: 4a3
the only enzyme for β-mannan degradation
the only enzyme for β-mannan degradation
Hemicell® Lml / metric ton
110 Broilers
Hemicell® Dg / metric ton
200
Complies with KB of February, 8 , 1999 (BS 21.04.99) and MB of February, 12, 1999 (BS 21.04.99) concerning trade and use of substances destined for animal feeding.
Hemicell degradesß-Mannan in feed
Reduced superfluous immune provocation
Improved Animal Performance
Fewer nutrients wasted on immune reactionsLess demand on the immune system
Anabolic activity gains priority over catabolic activity
Higher production of digestive enzymesBetter feed digestibility and nutrient utilization
Better health
More net energy in feed
Hemicell® degrades ß-mannan in feed and, thus, reverses its negative impact on animal performance. Hemicell® is most effective in diets that are rich in soybean meal, sunflower meal, rapeseed meal, sesame meal, palm kernel meal, copra meal and guar meal.
All vegetable feed ingredients contain β-mannan fibers as part of the hemicellulose fraction, and soy-bean meal is the main source of β-mannan in most feeds for monogastric animals. Soluble β-mannan, or β-galactomannan, is a potent anti-nutritional factor, able to provoke a futile response of the innate immune system. During the past decade it has been documented that the relatively low levels of 0.2-0.4% β-galactomannan, found in most swine and poultry feeds, can result in significant performance losses.
ß-mannan has been shown to:
• Waste nutrients by provoking a production of cytokines and acute phase proteins. • Reduce the level of IGF-1 (insulin-like growth factor 1). • Interfere with insulin secretion.• Reduce the efficiency of nutrient deposition for growth / production.• Reduce the rate of glucose absorption.• Reduced water absorption, resulting in higher fecal moisture levels.
1. Hemicell® IMpROVES NUTRIENT UTIlIZATION
Energy by 80-150 Kcal ME/kg feed;Improves the amino acid digestibility by 1.5-2.3 %
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The matrix values for Hemicell® were developed from digestibility experiments and confirmed by animal growth trials. Using them to formulate Hemicell® into the diets offers the best opportunity to reduce feed cost without loss of per-formance.. Using Hemicell® as an ingredient provides the opportunity to save nutrients (energy and amino acids). Results from pen trials and field trials demonstrate the nutritional benefits. The typical trial results are shown in figure 1 in broilers. Tens of millions of commercial poultry have been successfully produced in US, Latin America and Asia following this practice.
2. UNIFORMITY Hemicell® improves body weight uniformity
Broilers - 15-17 %Ducks - 12 %Turkeys - 25-40 %
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broilers 1broilers 2broilers 3Peking Ducks 4
Age(days)
21495442
Control
11.413.411.614.1
Hemicell®
9.9311.39.2
12.3
Improvement %
12,915.720.812.9
3. HEAlTH
Studies have shown that the benefits from Hemicell® increase significantly when the ani-mals are subject to challenges from enteric diseases including Necrotic enteritis and coccidiosis. The magnitude of the effect depends on both the ß-mannan content in the feed and the severity of the disease challenge.
In pen and field trials, Hemicell® has been shown to:reduce mortality;improve growth performance;reduce coccidial lesion scores in broilers;reduce wet feces in poultry;increase IGF-1 secretion in broilers.
Meta-analysis results from four EU studies in broilers in which the recommended dose of Hemicell® feed enzyme was fed resulted in these effects in 42 days (figure 3):
4.2 % increase in weight gain (P<0.0001)3.6 % improvement in feed conversion ratio (7.0 points; P<0.0004), and7.5 % improvement in EPEF (P<0.0001).
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Hemicell® reduces variability, measured as coefficient of variation (CV) of individual body weight, by most acutely improving the performance of the smallest animals in the population. The typical nature of the improvement on flock uniformity by Hemicell® is graphically represented in figure 2. The typical results summarized from many studies in different regions in table 1 shows that Hemicell® reduces CV of body weight by 12 to 26%. Improved uniformity increases process yield, carcass quality and productivity of broilers, breeders and layers.
56,7b
59,1a
109,1109,5
1.93b
1.86a
281b
302a
ADG,g/d ADFI, g/d FCR,g/g EPEF
Control Hemicell®
110
108
106
104
102
100
98
96
94
92
90C,
Contr
ol=
100
bENEFITS
Figure 1: Effect of Hemicell® on 0-45 day broiler performance (Parc Institure, USA). High ME=Low ME + 143 Kcal/kg in starter, grower and finisher diets.
Figure 2: Effect of Hemicell® on body weight uni-formity of 49-day old broilers (PARC Institute, Maryland, USA). Hemicell® reduces CV of body weight from 13.31 % to 11.02 % (P< 0.05).
Table 1: Summary of Hemicell® effect on body weight unifor-mity of broilers and meat ducks.1 Peterson/AA;Summary of 5 companies, USA, 19932 PARC Institute, MD USA, 1998 3 MAFIC, Beijing, China, 20024 Beijing, China, 1995.
Figure 3: Effect of Hemicell® on broiler performance (meta analysis from 4 EU efficacy studies)
2.08
2.12
2.16
2.2
2.24
1.76
1.8
1.84
1.88
1.92
P<0.05
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abb
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ght G
ain,
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Feed
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High ME+Hemicell
High ME Low ME+Hemicell
Low ME
the only enzyme for β-mannan degradation
0
40
80
120
160
1000 1500 2000 2500 3000 3500 4000
Control HemicellCV 13.31 11.02N 905 967P < 0,05
Control
Hemicell
Weight Range (Grams)
Frequency