Thai Hepatitis B C guideline 2552

ISBN 978-974-225-231-1

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‡«Á∫‰´µå †www.liversocietythailand.org

2 Chronic Hepatitis B and C 2009

§≥–°√√¡°“√∫√‘À“√ ¡“§¡œ«“√–ªï∫√‘À“√ 2552-2553

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Chronic Hepatitis B and C 2009 3

§≥–°√√¡°“√ª√—∫ª√ÿß·π«∑“ß°“√¥Ÿ·≈√—°…“ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫∫’·≈– ’‡√◊ÈÕ√—ß„πª√–‡∑»‰∑¬ ªï 2552

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πæ.‡Õ°«’√å »√’ª√‘«ÿ≤‘

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§”π”

∂â“‡√“¡’¬“∑’Ë “¡“√∂√—°…“‚√§‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß‰¥âÀ“¬∑ÿ°√“¬ „π√“§“∑’Ë‡ªìπ∑’Ë

¬Õ¡√—∫‰¥â·≈–‰¡à¡’º≈¢â“ß‡§’¬ß°Á§ß‰¡à®”‡ªìπµâÕß¡’·π«∑“ß (Guideline) „π°“√√—°…“ºŸâªÉ«¬

‰«√— µ—∫Õ—°‡ ∫∫’ ·µà‡π◊ËÕß®“° 25% ¢ÕßºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫∫’ ·≈– 10% ¢ÕßºŸâªÉ«¬

‰«√— µ—∫Õ—°‡ ∫´’ ‡∑à“π—Èπ∑’Ë®–‡ ’¬™’«‘µ‡æ√“–‚√§µ—∫ ‡æ√“–©–π—Èπ ¥â«¬ª√– ‘∑∏‘¿“æ¬“∑’Ë¡’Õ¬Ÿà

µ≈Õ¥®π√“§“¬“·≈–°“√¥◊ÈÕ¬“∑’Ë‡ªìπ¢âÕæ‘®“√≥“ ®÷ß®”‡ªìπµâÕß¡’·π«∑“ß°“√¥Ÿ·≈√—°…“ºŸâªÉ«¬

‰«√— µ—∫Õ—°‡ ∫∫’·≈–‰«√— µ—∫Õ—°‡ ∫´’ ‚¥¬‡©æ“–Õ¬à“ß¬‘Ëß ºŸâªÉ«¬∑’Ë‡∫‘°¬“À√◊Õ‰¡à‰¥â‡ ’¬

‡ß‘π‡Õß ‡æ◊ËÕ∑”„Àâ°“√√—°…“‡ªìπ‰ª„π·π«∑“ß‡¥’¬«°—π ·≈–‡°‘¥ª√–‚¬™πå Ÿß ÿ¥µàÕ∑ÿ°ΩÉ“¬

‡À¡“– ¡°—∫‡»√…∞“π–¢Õßª√–‡∑»

¡“§¡‚√§µ—∫ (ª√–‡∑»‰∑¬) ‰¥â®—¥ª√–™ÿ¡·π«∑“ß°“√√—°…“‚√§‰«√— µ—∫Õ—°‡ ∫∫’

·≈–‚√§‰«√— µ—∫Õ—°‡ ∫ ’ ‡¡◊ËÕ«—π∑’Ë 12 ‘ßÀ“§¡ 2552 ‚¥¬¡’ºŸâ∑√ß§ÿ≥«ÿ≤‘®“°‚√ß‡√’¬π·æ∑¬å

·æ∑¬å∑’Ë¥Ÿ·≈ºŸâªÉ«¬„π à«π¿Ÿ¡‘¿“§ ®÷ß‰¥â·π«∑“ß©∫—∫π’È´÷Ëß‡ªìπ©∫—∫∑’Ë 3 ·≈â«

·π«∑“ß∑’Ë®—¥∑”¢÷Èπ‡ªìπ‡æ’¬ß·π«∑“ß ”À√—∫·æ∑¬å„π°“√√—°…“ºŸâªÉ«¬ ‚¥¬‰¡à “¡“√∂

„™âÕâ“ßÕ‘ß∑“ß°ÆÀ¡“¬‰¥â ‡π◊ËÕß®“°°“√ªØ‘∫—µ‘µâÕßª√—∫µ“¡ ∂“π°“√≥å

¡“§¡‚√§µ—∫ (ª√–‡∑»‰∑¬) À«—ß«à“¢âÕ¡Ÿ≈∑—π ¡—¬∑’Ë∑”„Àâ¡’°“√‡ª≈’Ë¬π·ª≈ß°“√

√—°…“‰ª®–°àÕ„Àâ‡°‘¥ª√–‚¬™πå∑—Èß·æ∑¬å·≈–ºŸâªÉ«¬„π°“√√—°…“‚√§µ—∫Õ—°‡ ∫®“°‰«√— µ—∫

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π“¬° ¡“§¡‚√§µ—∫ (ª√–‡∑»‰∑¬)


°“√ª√–‡¡‘πºŸâªÉ«¬∑’Ëµ√«®æ∫«à“¡’ HBsAg ‡ªìπ∫«°

1. µ√«®‡≈◊Õ¥ª√–‡¡‘π¥Ÿ¿“«– HBeAg ·≈– HBeAb

2. µ√«® serum ALT ∂â“§à“Õ¬Ÿà „π√–¥—∫‡°≥±åª°µ‘„Àâµ‘¥µ“¡ serum ALT

∑ÿ° 3-6 ‡¥◊Õπ

3. „π°√≥’∑’Ë HBeAg ‡ªìπ≈∫ ·µàºŸâªÉ«¬¡’ serum ALT º‘¥ª°µ‘ À√◊Õ ¡’ªí®®—¬‡ ’Ë¬ß

µàÕ°“√‡°‘¥‚√§µ—∫ ‡™àπ ºŸâ™“¬Õ“¬ÿ¡“°°«à“ 40 ªï ¡’ª√–«—µ‘µ—∫·¢Áß·≈–¡–‡√Áßµ—∫

„π§√Õ∫§√—« µ√«®√à“ß°“¬æ∫ chronic liver stigmata §à“ ALT Õ¬Ÿà„π‡°≥±å

¡“°°«à“§√÷Ëß¢Õß§à“ª°µ‘ Õ—≈µ√“´“«¥å¡’≈—°…≥–º‘¥ª°µ‘¢Õßµ—∫ §«√µ√«®¥Ÿª√‘¡“≥

serum HBV DNA √à«¡¥â«¬

ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß∑’Ë§«√‰¥â√—∫°“√√—°…“

ºŸâ∑’Ë ¡§«√‰¥â√—∫°“√√—°…“ ‰¥â·°àºŸâªÉ«¬∑’Ë¡’≈—°…≥–¥—ßµàÕ‰ªπ’È

1. HBsAg ∫«°„π‡≈◊Õ¥‰¡àµË”°«à“ 6 ‡¥◊Õπ

2. ¡’À≈—°∞“π∑’Ë∫àß«à“¡’ active HBV viral replication §◊Õ

a. HBeAg ‡ªìπ∫«° À√◊Õ HBV DNA ¡“°°«à“À√◊Õ‡∑à“°—∫ 20,000 IU/ml

b. HBeAg ‡ªìπ≈∫ ·≈–¡’ HBV DNA ¡“°°«à“À√◊Õ‡∑à“°—∫ 2,000 IU/ml

3. √–¥—∫ serum ALT ¡“°°«à“À√◊Õ‡∑à“°—∫ 1.5 upper limit of normal (ULN)

Õ¬à“ßπâÕ¬ 2 §√—ÈßÀà“ß°—π‰¡àπâÕ¬°«à“ 3 ‡¥◊Õπ (¬°‡«âπ„π°√≥’ºŸâªÉ«¬¡’À≈—°∞“π

«à“¡’µ—∫·¢ÁßÀ√◊Õ impending decompensation æ‘®“√≥“„Àâ°“√√—°…“∂÷ß·¡â®–¡’

ALT ª°µ‘ À√◊Õ‰¡à®”‡ªìπµâÕß√ÕÀà“ß°—π‡°‘π 3 ‡¥◊Õπ)

·π«∑“ß°“√¥Ÿ·≈√—°…“ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß„πª√–‡∑»‰∑¬ ªï 2552

Thailand Consensus Recommendations forManagement of Chronic Hepatitis B 2009


4. §«√¡’°“√µ√«®æ¬“∏‘ ¿“æ¢Õßµ—∫„π°√≥’∑’ËºŸâªÉ«¬¡’§à“ ALT πâÕ¬°«à“ 2 ‡∑à“¢Õß§à“ª°µ‘‚¥¬∑’Ë‰¡à¡’≈—°…≥–∑“ß§≈’π‘°À√◊Õ√—ß ’«‘∑¬“«à“¡’µ—∫·¢ÁßÀ√◊ÕºŸâªÉ«¬∑’Ë‰¡à “¡“√∂µ—¥ “‡Àµÿ¢Õßµ—∫Õ—°‡ ∫Õ◊Ëπ√à«¡¥â«¬‡æ◊ËÕ¬◊π¬—π«à“ “‡Àµÿ¢Õß°“√‡æ‘Ë¡¢Õßserum aminotransferase ‡ªìπ®“°‰«√— µ—∫Õ—°‡ ∫∫’ ·≈–¡’≈—°…≥–∑“ßæ¬“∏‘«‘∑¬“∫àß™’È«à“¡’°“√Õ—°‡ ∫≈ÿ°≈“¡¢Õß‡π◊ÈÕµ—∫Õ—π‡π◊ËÕß¡“®“°‰«√— µ—∫Õ—°‡ ∫™π‘¥∫’ ´÷Ëß§«√¡’ HAI necroinflammatory score ¡“°°«à“À√◊Õ‡∑à“°—∫ 3 À√◊Õ¡’ significant fibrosis (equivalent Metavir score ¡“°°«à“À√◊Õ‡∑à“°—∫ 2)

5. §«√µ√«® HCV Ab ·≈– HIV Ab °àÕπ‰¥â√—∫°“√√—°…“∑ÿ°√“¬

6. µâÕß‰¡à¡’‚√§Õ◊Ëπ∑’Ë‡ªìπ “‡ÀµÿÀ≈—°¢Õßµ—∫Õ—°‡ ∫

„π°√≥’∑’ËºŸâªÉ«¬ chronic hepatitis B infection ∑’Ë¬—ß‰¡à¡’¢âÕ∫àß™’È„π°“√√—°…“ À√◊Õ‡ªìπ inactive chronic hepatitis B infection ‰¡à ¡§«√„Àâ¬“µâ“π‰«√— ·µà§«√‰¥â√—∫°“√µ‘¥µ“¡ ALT ‡ªìπ√–¬–Ê ∑ÿ° 3-6 ‡¥◊Õπ °àÕπ„Àâ°“√√—°…“ºŸâªÉ«¬ chronic hepatitis B §«√‰¥â√—∫°“√ª√–‡¡‘π·≈–°“√·π–π”Õ¬à“ß≈–‡Õ’¬¥ ´÷Ëß√«¡∂÷ß¿“«–¢Õß‚√§ ‚√§√à«¡ ¢âÕ®”°—¥À√◊Õ¢âÕÀâ“¡„π°“√„™â¬“ °“√ªØ‘∫—µ‘µ—« §à“„™â®à“¬„π°“√√—°…“·≈–°“√µ‘¥µ“¡√–¬–¬“« (III)

°“√√—°…“∑’Ë‡À¡“– ¡

ë ºŸâªÉ«¬ compensated chronic hepatitis B ∑’Ë¡’ HBeAg ‡ªìπ∫«° “¡“√∂‡≈◊Õ°„™â¬“‰¥â∑ÿ°¢π“π¢÷Èπ°—∫ªí®®—¬¢Õß‰«√— ∫’ ªí®®—¬∑“ßºŸâªÉ«¬ ·≈–√–¬–¢Õß‚√§·æ∑¬å§«√Õ∏‘∫“¬ „ÀâºŸâªÉ«¬∑√“∫∂÷ßª√–‚¬™πå·≈–¢âÕ®”°—¥¢Õß¬“·µà≈–™π‘¥‡æ◊ËÕ„ÀâºŸâªÉ«¬¡’‚Õ°“ √à«¡µ—¥ ‘π„®„π°“√‡≈◊Õ°™π‘¥°“√√—°…“ ¬“∑’Ë„™â√—°…“‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß„πªí®®ÿ∫—π¡’¥—ßµàÕ‰ªπ’È

- Conventional interferon α ¢π“¥ 5-10 MU ©’¥‡¢â“™—Èπ„µâº‘«Àπ—ß 3 §√—ÈßµàÕ —ª¥“Àåπ“π 6 ‡¥◊Õπ

- Pegylated interferon α ¢π“¥ 180 mcg „π°√≥’ Pegylated interferonα -2a À√◊Õ 1.5 mcg/kg „π°√≥’ Pegylated interferon α -2b ©’¥‡¢â“™—Èπ„µâº‘«Àπ—ß —ª¥“Àå≈–§√—Èß π“π 12 ‡¥◊Õπ ¢âÕ¡Ÿ≈°“√√—°…“¥â«¬ Pegylatedinterferon α ∑—Èß 2a ·≈– 2b ‡ªìπ‡«≈“ 6 ‡¥◊Õπ ¬—ß‰¡à‡æ’¬ßæÕ §«√√Õ¥Ÿº≈°“√»÷°…“«‘®—¬∑’Ë‡ª√’¬∫‡∑’¬∫√–¬–‡«≈“ 6 ‡¥◊Õπ °—∫ 12 ‡¥◊Õπ (NEPTUNESTUDY) ´÷Ëß®–∑√“∫º≈¿“¬„πµâπªï æ.». 2553

- Lamivudine 100-150 mg √—∫ª√–∑“π«—π≈–§√—Èß


- Adefovir dipivoxil 10 mg √—∫ª√–∑“π«—π≈–§√—Èß

- Entecavir 0.5 mg √—∫ª√–∑“π«—π≈–§√—Èß µÕπ∑âÕß«à“ß Õ¬à“ßπâÕ¬ 2 ™—Ë«‚¡ß

°àÕπ·≈–À≈—ßÕ“À“√

- Telbivudine 600 mg √—∫ª√–∑“π«—π≈–§√—Èß

- Tenofovir# 300 mg √—∫ª√–∑“π«—π≈–§√—Èß

#ªí®®ÿ∫—π¬—ß‰¡à¡’®”Àπà“¬„π¢âÕ∫àß™’È¢Õß°“√√—°…“‚√§‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß„π

ª√–‡∑»‰∑¬

„Àâæ‘®“√≥“ª√—∫¢π“¥¬“ °√≥’∑’ËºŸâªÉ«¬∑’Ë¡’°“√∑”ß“π¢Õß‰µ∫°æ√àÕß (¥Ÿµ“√“ß°“√

ª√—∫¬“)

µ“√“ß∑’Ë 1 °“√ª√—∫¢π“¥¬“ Lamivudine

Creatinine clearance First dose of Maintenance dose (ml/min) Lamivudine once daily

30 ≤ CrCl < 50 100 mg 50 mg

15 ≤ CrCl < 30 100 mg 25 mg

5 ≤ CrCl < 15 35 mg 15 mg

CrCl < 5 35 mg 10 mg

„πºŸâªÉ«¬‰µ«“¬‡√◊ÈÕ√—ß∑’Ë‰¥â√—∫°“√øÕ°‚≈À‘µ„Àâ Lamivudine 100 ¡‘≈≈‘°√—¡ —ª¥“Àå≈–

§√—ÈßÀ≈—ß°“√øÕ°‚≈À‘µ

µ“√“ß∑’Ë 2 °“√ª√—∫¢π“¥¬“ Adefovir

Creatinine clearance Hemodialysis

(ml/min) patients*

20-49 10-19

Recommended Dose 10 mg 10 mg 10 mg every 7 days

and Dosing Interval every 48 every 72 following dialysis

hours hours

* Dosing recommendation derived in study where high flux dialysis was

conducted three times a week


µ“√“ß∑’Ë 3 °“√ª√—∫¢π“¥¬“ Entecavir

CrCI Usual Dose Lamivudine Refractory

(ml/min) (0.5 mg) (1 mg)

≥ 50 0.5 mg once daily 1 mg once daily

30 to <50 0.25 mg once daily 0.5 mg once daily

or 0.5 mg every or 1 mg every

48 hours 48 hours

10 to <30 0.15 mg once daily 0.3 mg once daily

or 0.5 mg every or 1 mg every

72 hours 72 hours

<10 0.05 mg once daily 0.1 mg once daily

Hemodialysis* or 0.5 mg every or 1 mg every

or CAPD week after dialysis week after dialysis

*Administer after hemodialysis

µ“√“ß∑’Ë 4 ¢π“¥¬“ Telbivudine

Creatinine clearance (ml/min) Dose of Telbivudine

≥ 50 600 mg once daily

30-49 600 mg once every 48 hours

< 30 (not requiring dialysis) 600 mg once every 72 hours

ESRD* 600 mg once every 96 hours

* End stage renal disease

„π°√≥’∑’ËºŸâªÉ«¬¡’¢âÕ®”°—¥‡√◊ËÕß§à“„™â®à“¬À√◊ÕµâÕß‰¥â√—∫¬“∑’Ë¡’ Low genetic barrier

‡™àπ Lamivudine À√◊Õ Telbivudine ¡’¢âÕ·π–π”„π°“√‡≈◊Õ°√—°…“ºŸâªÉ«¬‡æ◊ËÕ„Àâ ‰¥âº≈„π

°“√√—°…“¥’·≈–≈¥°“√¥◊ÈÕ¬“¥—ßµàÕ‰ªπ’È

1. ºŸâªÉ«¬∑’Ë¡’ HBeAg ‡ªìπ∫«° ·≈–¡’ HBV DNA πâÕ¬°«à“ 8 logs IU/ml ·≈– ALT

¡“°°«à“ 2x ULN ®–¡’º≈µàÕ°“√√—°…“¥’·≈–‚Õ°“ ¥◊ÈÕ¬“≈¥≈ßÕ¬à“ß™—¥‡®π


2. §«√µ√«® HBV DNA ∑ÿ° 6 ‡¥◊Õπ ∂â“¬—ßµ√«®æ∫ HBV DNA ¡“°°«à“

60 IU/ml ∑’Ë 6 ‡¥◊Õπ À≈—ß‡√‘Ë¡√—°…“ æ‘®“√≥“‡æ‘Ë¡¬“∑’Ë‡ªìπ non cross-resistant

drugs ‡™àπ Adefovir À√◊Õ Tenofovir

ë ºŸâªÉ«¬ compensated chronic hepatitis B ∑’Ë¡’ HBeAg ‡ªìπ≈∫ “¡“√∂

‡≈◊Õ°„™â¬“‰¥â∑ÿ°¢π“π¢÷Èπ°—∫ªí®®—¬¢Õß‰«√— ∫’ ªí®®—¬∑“ßºŸâªÉ«¬ ·≈–√–¬–¢Õß‚√§

·æ∑¬å§«√Õ∏‘∫“¬„ÀâºŸâªÉ«¬∑√“∫∂÷ßª√–‚¬™πå·≈–¢âÕ®”°—¥¢Õß¬“·µà≈–™π‘¥‡æ◊ËÕ

„ÀâºŸâªÉ«¬¡’‚Õ°“ √à«¡µ—¥ ‘π„®„π°“√‡≈◊Õ°™π‘¥°“√√—°…“ ¬“∑’Ë„™â√—°…“‰«√— µ—∫

Õ—°‡ ∫∫’‡√◊ÈÕ√—ß„πªí®®ÿ∫—π¡’¥—ßµàÕ‰ªπ’È

- Conventional interferon α ¢π“¥ 5-10 MU ©’¥‡¢â“™—Èπ„µâº‘«Àπ—ß 3 §√—Èß

µàÕ —ª¥“Àåπ“π 12 ‡¥◊Õπ

- Pegylated interferon α ¢π“¥ 180 mcg „π°√≥’ Pegylated interferon

α -2a À√◊Õ 1.5 mcg/kg „π°√≥’ Pegylated interferon α -2b ©’¥‡¢â“

™—Èπ„µâº‘«Àπ—ß —ª¥“Àå≈–§√—Èßπ“π 12 ‡¥◊Õπ

- Lamivudine 100-150 mg √—∫ª√–∑“π«—π≈–§√—Èß Õ¬à“ßπâÕ¬ 12 ‡¥◊Õπ

- Adefovir dipivoxil 10 mg √—∫ª√–∑“π«—π≈–§√—Èß Õ¬à“ßπâÕ¬ 12 ‡¥◊Õπ

- Entecavir 0.5 mg √—∫ª√–∑“π«—π≈–§√—Èß µÕπ∑âÕß«à“ß Õ¬à“ßπâÕ¬ 2 ™—Ë«‚¡ß

°àÕπ·≈–À≈—ßÕ“À“√ Õ¬à“ßπâÕ¬ 12 ‡¥◊Õπ

- Telbivudine 600 mg √—∫ª√–∑“π«—π≈–§√—Èß Õ¬à“ßπâÕ¬ 12 ‡¥◊Õπ

- Tenofovir# 300 mg √—∫ª√–∑“π«—π≈–§√—Èß Õ¬à“ßπâÕ¬ 12 ‡¥◊Õπ

#ªí®®ÿ∫—π¬—ß‰¡à¡’®”Àπà“¬„π¢âÕ∫àß™’È¢Õß°“√√—°…“‚√§‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß„π

ª√–‡∑»‰∑¬

„π°√≥’∑’ËºŸâªÉ«¬¡’¢âÕ®”°—¥‡√◊ËÕß§à“„™â®à“¬À√◊ÕµâÕß‰¥â√—∫¬“∑’Ë¡’ Low genetic

barrier ‡™àπ Lamivudine, Telbivudine ¡’¢âÕ·π–π”„π°“√‡≈◊Õ°√—°…“ºŸâªÉ«¬‡æ◊ËÕ„Àâ‰¥â

º≈„π°“√√—°…“¥’·≈–≈¥°“√¥◊ÈÕ¬“¥—ßµàÕ‰ªπ’È

1. ºŸâªÉ«¬∑’Ë¡’ HBeAg ‡ªìπ≈∫ ·≈–¡’ HBV DNA πâÕ¬°«à“ 6 logs IU/ml ®–¡’º≈

µàÕ°“√√—°…“¥’·≈–‚Õ°“ ¥◊ÈÕ¬“≈¥≈ßÕ¬à“ß™—¥‡®π


2. §«√µ√«® HBV DNA ∑ÿ° 6 ‡¥◊Õπ ∂â“¬—ßµ√«®æ∫ HBV DNA ¡“°°«à“

60 IU/ml ∑’Ë 6 ‡¥◊Õπ À≈—ß‡√‘Ë¡√—°…“ Õ“®æ‘®“√≥“‡æ‘Ë¡¬“∑’Ë‡ªìπ non

cross-resistant drugs ‡™àπ Adefovir À√◊Õ Tenofovir „π°√≥’∑’Ë‡√‘Ë¡¥â«¬

low resistant drugs ‡™àπ Lamivudine, Telbuvudine

ë „πºŸâªÉ«¬∑’Ë¡’ hepatic decompensation À√◊Õ¡’§«“¡°—ß«≈«à“®–‡°‘¥ decom-

pensation §«√‡√‘Ë¡¥â«¬ Lamivudine, Telbivudine, Entecavir ·≈–§«√µ√«®

HBV DNA ∑ÿ° 6 ‡¥◊Õπ ‡π◊ËÕß®“°¡’√“¬ß“π Nucleoside analogues Õ“®∑”„Àâ‡°‘¥

Mitochondrial toxicity ‰¥â„πºŸâªÉ«¬∑’Ë¡’ hepatic decompensation ÷Ëß‡ªìπ class

toxicity ¢Õß¬“„π°≈ÿà¡ Entecavir, Lamivudine, Telbivudine ¥—ßπ—Èπ§«√µ‘¥µ“¡

Õ“°“√·≈–‡ΩÑ“√–«—ß°“√‡°‘¥ mitochondrial toxicity „πºŸâªÉ«¬∑’Ë‰¥â√—∫¬“°≈ÿà¡π’È

°“√µ‘¥µ“¡ºŸâªÉ«¬∑’Ë ‰¥â√—∫°“√√—°…“

¢≥–√—°…“ºŸâªÉ«¬§«√‰¥â√—∫°“√µ√«®√–¥—∫ ALT Õ¬à“ßπâÕ¬∑ÿ° 3 ‡¥◊Õπ ·≈–

HBeAg, HBV DNA Õ¬à“ßπâÕ¬∑ÿ°Ê 6 ‡¥◊Õπ „πºŸâªÉ«¬∑’Ë‰¥â√—∫°“√√—°…“¥â«¬ Interferon À√◊Õ

Pegylated interferon §«√‰¥â√—∫°“√µ√«®∑ÿ° 2 —ª¥“Àå„π™à«ß 1-2 ‡¥◊Õπ·√° À≈—ß®“°

π—Èπ∑ÿ° 4-6 —ª¥“Àå ®π ‘Èπ ÿ¥°“√√—°…“‡æ◊ËÕ¥ŸÕ“°“√¢â“ß‡§’¬ß∑’Ë‡°‘¥®“°°“√„™â¬“ ÷Ëß√«¡∂÷ß

°“√µ√«®π—∫‡¡Á¥‡≈◊Õ¥ (complete blood count; CBC) °“√µ√«®°“√∑”ß“π¢Õß thyroid

·≈–Õ“°“√¢â“ß‡§’¬ßÕ◊ËπÊ „πºŸâªÉ«¬∑’Ë‰¥â√—∫ Adefovir À√◊Õ Tenofovir §«√µ√«®°“√∑”ß“π

¢Õß‰µ·≈–√–¥—∫øÕ øÕ√— „π‡≈◊Õ¥√à«¡¥â«¬

ë ¿“¬À≈—ß ‘Èπ ÿ¥°“√√—°…“§«√‰¥â√—∫°“√µ‘¥µ“¡‡™àπ‡¥’¬«°—∫¢≥–„Àâ°“√√—°…“´÷Ëß

√«¡∂÷ß°“√µ√«® ALT ∑ÿ° 3 ‡¥◊Õπ·≈– HBeAg/Anti HBe („π°√≥’∑’ËºŸâªÉ«¬ HBeAg

‡ªìπ∫«°), HBV DNA Õ¬à“ßπâÕ¬∑ÿ°Ê 6 ‡¥◊Õπ „πºŸâªÉ«¬∑’Ë°“√√—°…“‰¥âº≈¥’§◊Õ

À≈—ßÀ¬ÿ¥°“√√—°…“·≈â«Õ¬à“ßπâÕ¬ 6 ‡¥◊Õπ¬—ß¡’√–¥—∫ ALT ª°µ‘·≈–¡’√–¥—∫ HBV

DNA µË”°«à“ 2,000 IU/ml ·≈–§«√µ‘¥µ“¡µàÕ∑ÿ° 6 ‡¥◊Õπ

ë „πºŸâªÉ«¬∑’Ë relapse À√◊Õ‰¡à‰¥âº≈®“°°“√√—°…“§«√µ‘¥µ“¡∑ÿ° 3-6 ‡¥◊Õπ


‡¡◊ËÕ„¥§«√À¬ÿ¥¬“

ë „πºŸâªÉ«¬∑’Ë‰¥â√—∫ Interferon §«√„Àâ¬“‡ªìπ‡«≈“ 6 ‡¥◊Õπ „πºŸâªÉ«¬ HBeAg ‡ªìπ

∫«° ”À√—∫ºŸâªÉ«¬ HBeAg ‡ªìπ≈∫ §«√‰¥â√—∫¬“Õ¬à“ßπâÕ¬ 1 ªï

ë ”À√—∫ Pegylated interferon „πºŸâªÉ«¬ HBeAg ‡ªìπ∫«° §«√‰¥â√—∫°“√√—°…“

6-12 ‡¥◊Õπ ”À√—∫ºŸâªÉ«¬ HBeAg ‡ªìπ≈∫ §«√‰¥â√—∫°“√√—°…“ 1 ªï

ë ”À√—∫ºŸâªÉ«¬∑’Ë‰¥â√—∫¬“ Lamivudine, Telbivudine, Tenofovir, Adefovir dipivoxil

À√◊Õ Entecavir §«√‰¥â√—∫¬“µàÕ‡π◊ËÕßÕ¬à“ßπâÕ¬ 1 ªï

ë ºŸâªÉ«¬∑’Ë HBeAg ‡ªìπ∫«° À“°æ∫«à“¡’ HBeAg seroconversion ‚¥¬µ√«®æ∫

HBeAg seroconversion √à«¡°—∫ µ√«® HBV DNA πâÕ¬°«à“ 400 copies/ml

(60 IU/ml) Õ¬à“ßπâÕ¬ 2 §√—Èß Àà“ß°—πÕ¬à“ßπâÕ¬ 6 ‡¥◊Õπ “¡“√∂æ‘®“√≥“

À¬ÿ¥¬“À≈—ß®“°‰¥â¬“µàÕ‡π◊ËÕßÕ’°Õ¬à“ßπâÕ¬ 6-12 ‡¥◊Õπ

ë ”À√—∫„πºŸâªÉ«¬∑’Ë HBeAg ‡ªìπ≈∫ µâÕß‰¥â√—∫°“√√—°…“√–¬–¬“«®π°«à“¡’ HBsAg

clearance À√◊Õ Õ“®æ‘®“√≥“À¬ÿ¥¬“‰¥âÀ≈—ß®“°µ√«®‰¡àæ∫ HBV DNA 3 §√—Èß

·µà≈–§√—ÈßÀà“ß°—π‰¡àπâÕ¬°«à“ 6 ‡¥◊Õπ ·µàµâÕß‡ΩÑ“√–«—ß°“√°≈—∫‡ªìπ´È”

°“√¥Ÿ·≈ºŸâªÉ«¬ chronic hepatitis B „π ¿“«–æ‘‡»…ë ºŸâªÉ«¬ HBV „π°√≥’ HIV co-infection À“°‰¡à‰¥â√—∫°“√√—°…“¥â«¬ antiretroviral

agents ·≈–¡’§«“¡®”‡ªìπµâÕß‰¥â√—∫°“√√—°…“ hepatitis B §«√‡√‘Ë¡¥â«¬ Adefovir

dipivoxil À√◊Õ Telbivudine ‡æ◊ËÕªÑÕß°—π°“√‡°‘¥ cross resistance

ë ·µà ”À√—∫ºŸâªÉ«¬∑’Ë‰¥â√—∫ anti-retroviral agents Õ¬Ÿà·≈â«À“°‡ªìπ regimens ∑’Ë¡’

Lamivudine À√◊Õ Tenofovir Õ¬Ÿà·≈â«°Á “¡“√∂§«∫§ÿ¡ hepatitis B ‰¥â¥â«¬

‡π◊ËÕß®“°°“√√—°…“¡’§«“¡´—∫ âÕπ·≈–Õ“®∑”„ÀâºŸâªÉ«¬¡’Õ“°“√∑√ÿ¥≈ßÀ√◊Õ‡ªìπ

Õ—πµ√“¬·°à™’«‘µ‰¥â „π°“√√—°…“·π–π”„Àâ àßµàÕ‰ª¬—ßºŸâ‡™’Ë¬«™“≠

ë „π°√≥’∑’ËºŸâªÉ«¬¡’ CD4 count πâÕ¬°«à“ 200 cells/ml ·≈–¡’ liver cirrhosis

·≈â«§«√„Àâ¬“ 2 ¢π“π°àÕπ ‡™àπ Lamivudine ·≈– Tenofovir æ‘®“√≥“‡æ‘Ë¡

anti-retroviral agents ¢π“π∑’Ë 3 À≈—ß®“° HBV DNA πâÕ¬°«à“ 400 copies/

ml ‡æ◊ËÕªÑÕß°—π°“√‡°‘¥µ—∫Õ—°‡ ∫ µ—∫«“¬ ®“°¿“«– immune reconstitution

syndrome


ë ºŸâªÉ«¬∑’Ë¡’ overt hepatic decompensation À√◊Õ impending hepatic

decompensation §«√æ‘®“√≥“‡√‘Ë¡°“√√—°…“¥â«¬ Lamivudine, Telbivudine,

Tenofovir, Entecavir ‡æ√“–≈¥ª√‘¡“≥‰«√— ‰¥â‡√Á«·≈–¡’§«“¡ª≈Õ¥¿—¬„π

ºŸâªÉ«¬°≈ÿà¡π’È

ë °àÕπ„Àâ chemotherapy À√◊Õ immunosuppressive drugs §«√µ√«®°√Õß

ºŸâªÉ«¬°àÕπ«à“¡’ HBsAg À√◊Õ‰¡à À“° HBsAg ‡ªìπ∫«° §«√‰¥â√—∫¬“ Lamivudine

‡æ◊ËÕªÑÕß°—π reactivation ¢Õß hepatitis B ·≈–§«√„Àâ¬“µàÕ‰ªÕ¬à“ßπâÕ¬

12 —ª¥“ÀåÀ≈—ßÀ¬ÿ¥ immunosuppressive drugs (À“°„π°√≥’∑’Ë¡’¢âÕ∫àß™’È

„π°“√√—°…“ chronic hepatitis B „Àâ¬÷¥µ“¡¢âÕ·π–π”¢â“ßµâπ) Õ“®æ‘®“√≥“

„Àâ¬“µàÕ 1 ªï „π°√≥’∑’Ë HBV DNA °àÕπ‡√‘Ë¡ chemotherapy ¡“°°«à“ 2,000

IU/ml

ë „πºŸâªÉ«¬∑’Ë‰¥â√—∫ rituximab À√◊Õ anti CD20 Monoclonal antibody Õ“®

æ‘®“√≥“„Àâ Lamivudine ‡ªìπ‡«≈“ 1 ªï À≈—ß ‘Èπ ÿ¥°“√©’¥ rituximab

ë „πºŸâªÉ«¬∑’Ë‡°‘¥ Lamivudine, Telbivudine À√◊Õ Entecavir resistance §«√

‡æ‘Ë¡¬“µâ“π‰«√— „π°≈ÿà¡∑’Ë‰¡à¡’ cross resistance ‡™àπ Adefovir dipivoxil,

Tenofovir À√◊Õ‡ª≈’Ë¬π‡ªìπ Pegylated interferon

ë „πºŸâªÉ«¬∑’Ë‡°‘¥ Adefovir resistance §«√‡æ‘Ë¡¬“µâ“π‰«√— „π°≈ÿà¡∑’Ë‰¡à¡’ cross

resistance ‡™àπ Lamivudine, Telbivudine À√◊Õ Entecavir À√◊ÕÕ“®

‡ª≈’Ë¬π°“√√—°…“‡ªìπ Pegylated interferon

ë „πºŸâªÉ«¬‡¥Á°Õ“¬ÿ¡“°°«à“ 2 ªï æ‘®“√≥“°“√√—°…“‡™àπ‡¥’¬«°—∫„πºŸâ„À≠à (¬°‡«âπ

°√≥’ HBeAg ‡ªìπ≈∫¬—ß‰¡à¡’¢âÕ¡Ÿ≈™—¥‡®π„π°“√°”Àπ¥·π«∑“ß√—°…“)

¬“∑’Ë¡’°“√»÷°…“·≈–‰¥â√—∫°“√¬Õ¡√—∫„Àâ„™â„π‡¥Á° ‰¥â·°à

- Lamivudine 3 mg/kg/day ‰¡à‡°‘π 100 mg/day

- Adefovir dipivoxil 10 mg „π‡¥Á°∑’ËÕ“¬ÿ¡“°°«à“ 12 ªï, 0.25 mg/kg/day

(‰¡à‡°‘π 10 mg) „π‡¥Á°Õ“¬ÿ 7-12 ªï ·≈– „π‡¥Á°Õ“¬ÿ 2-6 ªï

- Conventional interferon 5-10 million unit per m2 (¢π“¥¬“ Ÿß ÿ¥‰¡à‡°‘π

10 million unit) 3 §√—ÈßµàÕ —ª¥“Àå


ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß°≈ÿà¡µàÕ‰ªπ’È

- ºŸâ™“¬Õ“¬ÿ¡“°°«à“ 40 ªï

- ºŸâÀ≠‘ßÕ“¬ÿ¡“°°«à“ 50 ªï

- ¡’ª√–«—µ‘¡–‡√Áßµ—∫„π§√Õ∫§√—« ‰¡à®”°—¥Õ“¬ÿ

- ºŸâªÉ«¬µ—∫·¢Áß ‰¡à®”°—¥Õ“¬ÿ

§«√‰¥â√—∫°“√‡ΩÑ“√–«—ß°“√‡°‘¥¡–‡√Áßµ—∫ (hepatocellular carcinoma) ‚¥¬‰¥â√—∫

°“√µ√«®Õ—≈µ√“´“«¥å ·≈– serum AFP ∑ÿ° 6 ‡¥◊Õπ

æ‘®“√≥“„Àâ«—§´’πªÑÕß°—π‰«√— µ—∫Õ—°‡ ∫‡Õ„πºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫∫’‡√◊ÈÕ√—ß∑’Ë‰¡à‡§¬

µ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫‡ÕÀ√◊Õµ√«®‰¡àæ∫«à“¡’¿Ÿ¡‘µâ“π∑“πµàÕ‰«√— µ—∫Õ—°‡ ∫‡Õ‚¥¬‡©æ“–

Õ¬à“ß¬‘Ëß „πºŸâªÉ«¬∑’Ë¡’µ—∫·¢Áß

‡Õ° “√Õâ“ßÕ‘ß

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- ºŸâªÉ«¬∑’Ë‰¥â√—∫°“√ª≈Ÿ°∂à“¬Õ«—¬«–°àÕπªï æ.».2538

- ‡¥Á°∑’Ë‡°‘¥®“°¡“√¥“∑’Ë‡ªìπ‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß

- ∫ÿ§≈“°√∑“ß°“√·æ∑¬å∑’Ë∂Ÿ°‡¢Á¡µ”®“°ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß

- ºŸâ∑’Ë¡’ª√–«—µ‘¡’‡æ» —¡æ—π∏å°—∫ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß

2. ºŸâ∑’Ë¡’‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’ §«√‰¥â√—∫§”·π–π”„π°“√À≈’°‡≈’Ë¬ß°“√·æ√à‡™◊ÈÕ ŸàºŸâÕ◊Ëπ

«‘∏’°“√À≈’°‡≈’Ë¬ß°“√·æ√à‡™◊ÈÕ

- ºŸâ∑’Ë¡’‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ ’ ‰¡à§«√∫√‘®“§‡≈◊Õ¥ Õ«—¬«– πÈ”‡™◊ÈÕ À√◊Õ πÈ”Õ ÿ®‘

- ºŸâ∑’Ë¡’‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’ §«√À≈’°‡≈’Ë¬ß°“√„™â·ª√ß ’øíπ ·≈–¢Õß¡’§¡√à«¡

°—∫ºŸâÕ◊Ëπ

- À¬ÿ¥°“√„™â¬“‡ æµ‘¥


- ºŸâ∑’Ë¡’‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ ’ §«√‰¥â√—∫§”·π–π”«à“§«“¡‡ ’Ë¬ß¢Õß°“√µ‘¥µàÕ

∑“ß‡æ» —¡æ—π∏åµË” ®÷ß‰¡à¡’§”·π–π”„ÀâªÑÕß°—π°“√µ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ ´’

¬°‡«âπ„π°√≥’∑’Ëµ‘¥‡™◊ÈÕ HIV √à«¡¥â«¬ ·µà§«√À≈’°‡≈’Ë¬ß°“√¡’‡æ» —¡æ—π∏å

∑“ß∑«“√Àπ—°

3. ºŸâªÉ«¬∑’Ë ß —¬«à“¡’ acute À√◊Õ chronic HCV infection §«√‰¥â√—∫°“√∑¥ Õ∫

À“ anti-HCV ·≈– HCV-RNA viral load

4. °“√∑¥ Õ∫ HCV RNA §«√∑”‡¡◊ËÕºŸâªÉ«¬

- ¡’º≈°“√∑¥ Õ∫ anti-HCV ‡ªìπ∫«°

- ¡’·π«‚πâ¡®–„Àâ°“√√—°…“∂â“µ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’

- ‰¡à “¡“√∂Õ∏‘∫“¬ “‡Àµÿµ—∫Õ—°‡ ∫‰¥â ·≈–¡’º≈°“√∑¥ Õ∫ anti-HCV

‡ªìπ≈∫ ‚¥¬‡©æ“–ºŸâªÉ«¬‰µ«“¬‡√◊ÈÕ√—ß À√◊ÕºŸâªÉ«¬ HIV À√◊Õ ºŸâªÉ«¬∑’Ë‰¥â¬“

°¥¿Ÿ¡‘§ÿâ¡°—π

5. °àÕπ„Àâ°“√√—°…“ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß µâÕß∑”°“√µ√«® genotype ‡æ◊ËÕ

«“ß·ºπ„π°“√√—°…“·≈–§“¥§–‡π°“√µÕ∫ πÕß

6. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫ ’‡√◊ÈÕ√—ß‚¥¬‡©æ“– genotype 1 (À√◊Õ∑’Ë‰¡à„™à genotype

2, 3) §«√‰¥â√—∫°“√‡®“–™‘Èπ‡π◊ÈÕµ—∫¡“µ√«®‡æ◊ËÕ∑√“∫√–¥—∫ fibrosis ¡“

ª√–°Õ∫°“√µ—¥ ‘π„®„π°“√√—°…“

7. °“√µ√«®ª√–‡¡‘π fibrosis ¢Õßµ—∫‚¥¬«‘∏’Õ◊ËπÊ πÕ°‡Àπ◊Õ®“°°“√‡®“–™‘Èπ‡π◊ÈÕµ—∫

‡™àπ fibroscan À√◊Õ«‘∏’Õ◊ËπÊ Õ“®„™â·∑π‰¥â ·µà§«“¡·¡àπ¬”Õ“®¬—ß‰¡à‡ªìπ∑’Ë

¬Õ¡√—∫‡∑à“æ¬“∏‘ ¿“æ¢Õßµ—∫®“°°“√‡®“–™‘Èπ‡π◊ÈÕµ—∫

8. °“√µ—¥ ‘π„®„π°“√√—°…“ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß·µà≈–∫ÿ§§≈¢÷ÈπÕ¬Ÿà°—∫

§«“¡√ÿπ·√ß¢Õß‚√§µ—∫ ‚Õ°“ ‡ ’Ë¬ßµàÕ°“√‡°‘¥º≈¢â“ß‡§’¬ß ‚Õ°“ ∑’Ë®–µÕ∫

πÕßµàÕ°“√√—°…“‚√§Õ◊ËπÊ ∑’ËºŸâªÉ«¬¡’Õ¬Ÿà ·≈–§«“¡æ√âÕ¡¢ÕßºŸâªÉ«¬„π°“√√—°…“

9. °“√√—°…“∑’Ë‡ªìπ¡“µ√∞“π„πªí®®ÿ∫—π¢Õß‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß §◊Õ °“√„™â¬“

√à«¡°—π√–À«à“ß Pegylated interferon alfa ·≈– Ribavirin

10. §«√µ√«®À“ª√‘¡“≥ HCV RNA °àÕπ°“√√—°…“


ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫ ’‡√◊ÈÕ√—ß∑’Ë ¡§«√‰¥â√—∫°“√√—°…“ §◊Õ

- Õ“¬ÿ 18 ªï ¢÷Èπ‰ª (∂â“Õ“¬ÿπâÕ¬°«à“ 18 ªï ¥Ÿ„π¢âÕ§”·π–π”°“√√—°…“„π‡¥Á°)

- HCV RNA positive

- º≈°“√‡®“–µ—∫æ∫«à“¡’ significant fibrosis (Metavir ¡“°°«à“À√◊Õ‡∑à“°—∫

2) „π°√≥’∑’Ë‡ªìπ genotype 1, 4, 6

- ‡ªìπ‚√§µ—∫·¢Áß„π√–¬–‡√‘Ë¡µâπ À√◊Õ¡’ Child-Pugh score πâÕ¬°«à“À√◊Õ

‡∑à“°—∫ 10

- ¡’§«“¡‡¢â“„®·≈–æ√âÕ¡∑’Ë®–√—∫°“√√—°…“

- ‰¡à¡’¢âÕÀâ“¡¢Õß°“√√—°…“

¢âÕÀâ“¡¢Õß°“√√—°…“‚√§µ—∫Õ—°‡ ∫‡√◊ÈÕ√—ß®“°‰«√— ´’ ¡’¥—ßπ’È

- Õ“¬ÿµË”°«à“ 2 ªï

- ¡’ª√–«—µ‘·æâ¬“ Interferon ·≈– Ribavirin

- ¿“«–´÷¡‡»√â“√ÿπ·√ß∑’Ë¬—ß§«∫§ÿ¡‰¡à‰¥â

- µ—Èß§√√¿å À√◊Õ‰¡à‡µÁ¡„®∑’Ë®–¬‘π¬Õ¡„π°“√§ÿ¡°”‡π‘¥

- ºŸâªÉ«¬∑’Ë‰¥â√—∫°“√ºà“µ—¥ª≈Ÿ°∂à“¬Õ«—¬«– (‰µ, À—«„® À√◊Õ ªÕ¥)

- ¡’‚√§∑’ËÕ“®®–·¬à≈ß∂â“‰¥â√—∫ Interferon ‚¥¬‡©æ“– immune mediated

diseases

- ¡’‚√§ª√–®”µ—«∑’Ë¬—ß§«∫§ÿ¡√—°…“‰¡à‰¥â¥’ ‡™àπ §«“¡¥—π‚≈À‘µ Ÿß ‡∫“À«“π

‚√§À≈Õ¥‡≈◊Õ¥ ∂ÿß≈¡‚ªÉßæÕß ‚√§∏—¬√Õ¬¥å

°“√√—°…“ºŸâªÉ«¬∑’Ëµ‘¥‡™◊ÈÕ‰«√— ´’ genotype 1 À√◊Õ 4, 6

11. °“√√—°…“¥â«¬ Pegylated interferon ·≈– Ribavirin §«√«“ß·ºπ ”À√—∫

48 —ª¥“Àå ‚¥¬¡’¢π“¥¬“¥—ßπ’È


- Pegylated interferon alfa-2a 180 µg sc. µàÕ —ª¥“Àå √à«¡°—∫ Ribavirin

„π¢π“¥

1,000 ¡‘≈≈‘°√—¡ ”À√—∫ºŸâ∑’Ë¡’πÈ”Àπ—°πâÕ¬°«à“ 75 °‘‚≈°√—¡

1,200 ¡‘≈≈‘°√—¡ ”À√—∫ºŸâ∑’Ë¡’πÈ”Àπ—°µ—Èß·µà 75 °‘‚≈°√—¡¢÷Èπ‰ª

- Pegylated interferon alfa-2b 1.5 µg/kg sc. µàÕ —ª¥“Àå √à«¡°—∫ Ribavirin

„π¢π“¥

800 ¡‘≈≈‘°√—¡ ”À√—∫ºŸâ∑’Ë¡’πÈ”Àπ—°πâÕ¬°«à“ 65 °‘‚≈°√—¡

1,000 ¡‘≈≈‘°√—¡ ”À√—∫ºŸâ∑’Ë¡’πÈ”Àπ—°µ—Èß·µà 65 ∂÷ß 85 °‘‚≈°√—¡

1,200 ¡‘≈≈‘°√—¡ ”À√—∫ºŸâ∑’Ë¡’πÈ”Àπ—°¡“°°«à“ 85 ∂÷ß 105 °‘‚≈°√—¡

1,400 ¡‘≈≈‘°√—¡ ”À√—∫ºŸâ∑’Ë¡’πÈ”Àπ—°¡“°°«à“ 105 °‘‚≈°√—¡

12. §«√À¬ÿ¥„Àâ°“√√—°…“„π°√≥’∑’ËºŸâªÉ«¬‰¡à‰¥â√—∫°“√µÕ∫ πÕß (no EVR) §◊Õ¡’ HCV

RNA ≈¥≈ßπâÕ¬°«à“ 2 log ∑’Ë —ª¥“Àå∑’Ë 12

13. ºŸâªÉ«¬∑’Ë‰¥â partial EVR ( HCV RNA ≈¥≈ß¡“°°«à“ 2 log ·µà¬—ßµ√«®æ∫ HCV

RNA ∑’Ë 12 —ª¥“Àå) §«√∑”°“√∑¥ Õ∫„À¡à„π —ª¥“Àå∑’Ë 24 ·≈–∂â“ HCV RNA

¬—ß§ß‡ªìπ∫«° §«√À¬ÿ¥°“√√—°…“

14. ºŸâªÉ«¬∑’Ë‰¥â partial EVR ·≈–µ√«®‰¡àæ∫ HCV RNA (À√◊Õ HCV RNA <50 IU/

ml) ∑’Ë 24 —ª¥“Àå Õ“®æ‘®“√≥“¢¬“¬‡«≈“°“√√—°…“ÕÕ°‡ªìπ 72 —ª¥“Àå

15. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß∑’Ë¡’ HCV RNA πâÕ¬°«à“ 400,000 IU/ml °àÕπ

°“√√—°…“ ·≈–¡’ HCV RNA πâÕ¬°«à“ 50 IU/ml ∑’Ë 4 —ª¥“ÀåÀ≈—ß°“√√—°…“

“¡“√∂æ‘®“√≥“„Àâ°“√√—°…“ 24 —ª¥“Àå ∂â“ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß¡’º≈

¢â“ß‡§’¬ß¡“° ∑ÿππâÕ¬ ·≈–‰¡à¡’¿“«–∑’ËÕ“®≈¥ª√– ‘∑∏‘¿“æ¢Õß°“√À“¬ ‡™àπ µ—∫

·¢Áß Õâ«π ¿“«–¥◊ÈÕÕ‘π Ÿ≈‘π œ≈œ

16. ºŸâªÉ«¬∑’Ë√—°…“µàÕ‡π◊ËÕß§√∫ 48-72 —ª¥“Àå §«√µ√«® HCV RNA ∑’Ë¡’§«“¡‰«

Ÿß‡¡◊ËÕ ‘Èπ ÿ¥°“√√—°…“ ·≈–À“°º≈µ√«®‡ªìπ≈∫ §«√‰¥â√—∫°“√µ√«® HCV RNA

∑’Ë 24 —ª¥“ÀåÀ≈—ßÀ¬ÿ¥¬“‡æ◊ËÕª√–‡¡‘π SVR


Diagram √ÿª¢âÕ 12-16 Genotype 1

°“√√—°…“ºŸâªÉ«¬∑’Ëµ‘¥‡™◊ÈÕ‰«√— ´’ genotype 2 À√◊Õ 3

17. °“√√—°…“¥â«¬ Pegylated interferon ·≈– Ribavirin ‡ªìπ‡«≈“ 24 —ª¥“Àå ‚¥¬

°“√„Àâ Ribavirin „π¢π“¥¬“ 800-1400 ¡‘≈≈‘°√—¡µàÕ«—π (µ“¡πÈ”Àπ—°)

18. À≈—ß®“°°“√√—°…“§√∫ 24 —ª¥“Àå·≈â« §«√µ√«® HCV RNA ∑’Ë¡’§«“¡‰« Ÿß

‡¡◊ËÕ ‘Èπ ÿ¥°“√√—°…“ ·≈–∑’Ë 24 —ª¥“ÀåÀ≈—ßÀ¬ÿ¥¬“‡æ◊ËÕª√–‡¡‘π SVR

18.1 ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß Genotype 2, 3 ∑’Ë¡’ HCV RNA πâÕ¬°«à“

400,000 IU/ml °àÕπ°“√√—°…“ ·≈–¡’ HCV RNA πâÕ¬°«à“ 50 IU/ml

À≈—ß√—°…“‰¥â 4 —ª¥“Àå Õ“®æ‘®“√≥“À¬ÿ¥°“√√—°…“∑’Ë 14-16 —ª¥“Àå ∂â“

ºŸâªÉ«¬¡’º≈¢â“ß‡§’¬ß¡“° ∑ÿππâÕ¬ ·≈–‰¡à¡’¿“«–∑’ËÕ“®≈¥ª√– ‘∑∏‘¿“æ

¢Õß°“√À“¬ ‡™àπ µ—∫·¢Áß Õâ«π

18.2 ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß Genotype 2, 3 ∑’Ë‰¡à‰¥â RVR À≈—ß√—°…“

‰¥â 4 —ª¥“Àå Õ“®æ‘®“√≥“¬◊¥√–¬–‡«≈“°“√√—°…“‡ªìπ 48 —ª¥“Àå ‚¥¬

‡©æ“–„π°√≥’∑’Ë‡ªìπ advanced fibrosis

Retreatment „πºŸâªÉ«¬∑’Ë ‰¡à¡’ SVR À≈—ß°“√√—°…“§√—Èß°àÕπ

19. „π¢≥–π’È¬—ß‰¡à·π–π”„Àâ°“√√—°…“„À¡à¥â«¬ Pegylated interferon ·≈– Ribavirin

„πºŸâªÉ«¬∑’Ë‰¡àµÕ∫ πÕßµàÕ°“√√—°…“¥â«¬ Pegylated interferon √à«¡°—∫ Ribavirin

·¡â«à“¡’°“√‡ª≈’Ë¬π™π‘¥¢Õß Pegylated interferon


20. §«√æ‘®“√≥“√—°…“„À¡à¥â«¬ Pegylated interferon ·≈– Ribavirin „πºŸâªÉ«¬

nonresponders À√◊Õ relapsers ∑’Ë‡§¬√—°…“¥â«¬ Conventional interferon

(± Ribavirin) À√◊Õ¥â«¬ Pegylated interferon monotherapy ‚¥¬‡©æ“–

ºŸâªÉ«¬∑’Ë¡’ bridging fibrosis À√◊Õ cirrhosis

21. ‰¡à·π–π” maintenance therapy ¥â«¬ Pegylated interferon „π¢π“¥µË”„π

ºŸâªÉ«¬∑’Ë‰¡àµÕ∫ πÕßµàÕ°“√√—°…“¥â«¬ Pegylated interferon ·≈– Ribavirin

°“√√—°…“„πºŸâªÉ«¬∑’Ë¡’§à“ ALT ª°µ‘

22. „πºŸâªÉ«¬∑’Ë¡’§à“ ALT ª°µ‘ °“√µ—¥ ‘π„®‡√‘Ë¡∑”°“√√—°…“§«√¢÷ÈπÕ¬Ÿà°—∫§«“¡√ÿπ·√ß

¢Õß‚√§µ—∫‚¥¬ª√–‡¡‘πæ¬“∏‘ ¿“æ¢Õßµ—∫‚¥¬°“√∑” liver biopsy §«√„Àâ°“√

√—°…“∂â“æ¬“∏‘ ¿“æµ—∫¡’ fibrosis = F2 À√◊Õ F1 ·µà¡’°“√Õ—°‡ ∫¢Õßµ—∫ª“π

°≈“ßÀ√◊Õ√ÿπ·√ß °“√√—°…“ºŸâªÉ«¬∑’Ë¡’√–¥—∫ ALT ª°µ‘ ‰¡à·µ°µà“ß®“°ºŸâªÉ«¬∑—Ë«‰ª

°“√√—°…“„π‡¥Á°

23. °“√«‘π‘®©—¬‚√§ ·≈– °“√µ√«®„π‡¥Á°§«√ªØ‘∫—µ‘‡À¡◊Õπ°—∫ºŸâ„À≠à

24. ‰¡à·π–π”°“√µ√«® anti-HCV „π‡¥Á°·√°‡°‘¥∑’Ë·¡à¡’‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’ ‡π◊ËÕß®“°

antibody ∑’Ë¡’§à“∫«° Õ“®‡°‘¥®“° anti-HCV ®“°·¡àºà“π¡“¬—ß≈Ÿ° ·π–π”„Àâ

µ√«® anti-HCV ‡¡◊ËÕ‡¥Á°¡’Õ“¬ÿ 18 ‡¥◊Õπ¢÷Èπ‰ª

25. ‡¥Á°Õ“¬ÿ 2-17 ªï ∑’Ëµ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’ Õ“®æ‘®“√≥“„Àâ°“√√—°…“‚¥¬„™â

‡°≥±å‡¥’¬«°—∫ºŸâ„À≠à

26. ºŸâªÉ«¬‡¥Á°§«√‰¥â√—∫°“√√—°…“¥â«¬ Pegylated interferon alpha-2b 1.5 µg/kg

À√◊Õ 60 µg/m2 µàÕ —ª¥“Àå √à«¡°—∫ Ribavirin 15 mg/kg ∑ÿ°«—π

°“√√—°…“„πºŸâªÉ«¬∑’Ë¡’°“√µ‘¥‡™◊ÈÕ HIV √à«¡¥â«¬

27. ºŸâªÉ«¬µ‘¥‡™◊ÈÕ HIV ∑ÿ°§π§«√‰¥â√—∫°“√∑¥ Õ∫ Anti-HCV

28. µ√«® HCV RNA ‡æ◊ËÕ¬◊π¬—π°“√µ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ ’„πºŸâªÉ«¬µ‘¥‡™◊ÈÕ HIV

∑’Ë¡’º≈ anti-HCV ‡ªìπ∫«°


29. §«√µ√«® HCV RNA „πºŸâªÉ«¬∑’Ë¡’¿“«°“√≥å∑”ß“π¢Õßµ—∫º‘¥ª°µ‘ À√◊Õ ß —¬

«à“®–µ‘¥‡™◊ÈÕ‰«√— ’¥â«¬·¡â«à“ anti-HCV ®–‡ªìπ≈∫

30. §«√∑”°“√√—°…“‰«√— µ—∫Õ—°‡ ∫´’„πºŸâªÉ«¬µ‘¥‡™◊ÈÕ HIV √à«¡¥â«¬ ∂â“‚√§µ—∫¡’

‚Õ°“ ≈ÿ°≈“¡ ‚¥¬æ‘®“√≥“®“°ª√–‚¬™πå·≈–º≈¢â“ß‡§’¬ß¢Õß°“√√—°…“√à«¡°—π

ºŸâªÉ«¬∑’Ë ¡§«√æ‘®“√≥“„Àâ°“√√—°…“§«√¡’√–¥—∫ CD4 Õ¬à“ßπâÕ¬ 250 cell/mm3

31. °“√‡√‘Ë¡µâπ√—°…“‰«√— µ—∫Õ—°‡ ∫ ’„πºŸâªÉ«¬ HIV §«√„™â Pegylated interferon

alfa √à«¡°—∫ Ribavirin ‡ªìπ‡«≈“ 48 —ª¥“Àå „πª√‘¡“≥¬“‡™àπ‡¥’¬«°—∫ºŸâªÉ«¬

HCV mono-infection „π∑ÿ° “¬æ—π∏ÿå

32. ∂â“‡ªìπ‰ª‰¥âºŸâªÉ«¬§«√‡ª≈’Ë¬π zidovudine (AZT) ·≈– didanosine (ddI) ‰ª

„™â¬“ antiretroviral agent ¢π“πÕ◊Ëπ∑’ËÕÕ°ƒ∑∏‘Ï§≈â“¬°—π °àÕπ‡√‘Ë¡∑”°“√√—°…“

¥â«¬ Ribavirin ‡æ√“– AZT ·≈– ddI ®–∑”„Àâ‡°‘¥¿“«–´’¥¡“°¢÷Èπ

33. ºŸâªÉ«¬µ‘¥‡™◊ÈÕ HIV ∑’Ë‡ªìπ decompensated liver disease (CTP Class B or

C) ‰¡à§«√√—°…“¥â«¬ Pegylated interferon alfa ·≈– Ribavirin

°“√√—°…“‰«√— µ—∫Õ—°‡ ∫´’ „πºŸâªÉ«¬∑’Ë¡’‚√§‰µ

34. ºŸâªÉ«¬‚√§‰µ‡√◊ÈÕ√—ß∑’Ë√Õ√—∫°“√ª≈Ÿ°∂à“¬‰µ À√◊Õ√Õ√—∫°“√√—°…“ Replacement

therapy §«√‰¥â√—∫°“√µ√«®À“‰«√— µ—∫Õ—°‡ ∫´’

35. °“√µ—¥ ‘π„®‡®“–™‘Èπ‡π◊ÈÕµ—∫¡“µ√«®„πºŸâªÉ«¬‚√§‰µ§«√æ‘®“√≥“‡ªìπ√“¬Ê ¢÷Èπ

Õ¬Ÿà°—∫§«“¡®”‡ªìπ„π°“√√—°…“·≈–§«√æ‘®“√≥“‡ªìπ√“¬∫ÿ§§≈‚¥¬¢÷Èπ°—∫

·ºπ°“√√—°…“¢ÕßºŸâªÉ«¬

36. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß·≈–¡’¿“«–∑’Ë¡’°“√∑”ß“π¢Õß‰µ‡ ◊ËÕ¡≈ß‡≈Á°πâÕ¬

(GFR > 60 ml/min) “¡“√∂∑”°“√√—°…“‡À¡◊ÕπºŸâ∑’Ë¡’°“√∑”ß“π¢Õß‰µª°µ‘

37. ºŸâ∑’Ëµ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ ’‡√◊ÈÕ√—ß∑’Ë¡’¿“«–‰µ«“¬∑’Ë¬—ß‰¡à ‰¥â√—∫°“√√—°…“¥â«¬

hemodialysis “¡“√∂„Àâ°“√√—°…“‚¥¬°“√≈¥¢π“¥¬“¢Õß∑—Èß Pegylated

interferon (alpha-2a, 135 µg/week; alpha-2b, 1 µg/kg/week) ·≈–

Ribavirin (200-800 mg/day) ‚¥¬µ‘¥µ“¡º≈·∑√°´âÕπÕ¬à“ß„°≈â™‘¥


38. °“√√—°…“ºŸâ∑’Ëµ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ ’∑’Ë‰¥â√—∫°“√√—°…“¥â«¬ hemodialysis Õ“®

√—°…“¥â«¬ interferon-alpha (2a À√◊Õ 2b) ª√‘¡“≥¬“ 3 MU t.i.w. À√◊Õ ≈¥

¢π“¥¬“ Pegylated interferon-2a 135 µg/week or 2b 1 µg/kg/week

‡æ’¬ß¢π“π‡¥’¬« Õ“®æ‘®“√≥“„Àâ Ribavirin ·µàµâÕß„™â„π¢π“¥∑’ËµË”¡“°·≈–

µâÕßµ‘¥µ“¡Õ¬à“ß„°≈â™‘¥ ‡æ√“–®–‡°‘¥¿“«– ’¥·≈–º≈¢â“ß‡§’¬ß‰¥â¡“°

39. ‰¡à·π–π”„Àâ°“√√—°…“„πºŸâªÉ«¬∑’Ëµ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ßÀ≈—ß°“√ª≈Ÿ°∂à“¬‰µ

‡æ√“–Õ“®‡°‘¥ graft rejection À√◊Õ graft ∑”ß“πº‘¥ª°µ‘ ¬°‡«âπºŸâªÉ«¬∑’Ë‡°‘¥

fibrosing cholestatic hepatitis

40. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß∑’Ë¡’ cryoglobulinemia ·≈–¡’ mild to moderate

proteinuria À√◊Õ‰µ‡ ◊ËÕ¡ “¡“√∂√—°…“¥â«¬ Interferon ¢π“¥¡“µ√∞“π À√◊Õ

≈¥¢π“¥ Pegylated interferon alfa ·≈– Ribavirin

41. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫ ’‡√◊ÈÕ√—ß∑’Ë¡’ cryoglobulinemia ·≈–¡’ proteinuria

¡“°√à«¡°—∫‰µ«“¬√«¥‡√Á« “¡“√∂√—°…“¥â«¬ rituximab, cyclophosphamide

√à«¡°—∫ methylprednisolone À√◊Õ plasma exchange ·≈–µ“¡¥â«¬

interferon-based treatment

°“√√—°…“ºŸâªÉ«¬‰«√— ´’∑’Ë¡’ compensated and decompensated cirrhosis

42. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’∑’Ë¡’µ—∫·¢Áß„π√–¬–‡√‘Ë¡µâπ (CTP class A), “¡“√∂

√—°…“¥â«¬ Pegylated interferon ·≈– Ribavirin ·µà®–µâÕßµ‘¥µ“¡Õ¬à“ß„°≈â

™‘¥ ‡æ◊ËÕ‡ΩÑ“√–«—ßº≈¢â“ß‡§’¬ß

43. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫ ’∑’Ë¡’µ—∫·¢Áß¡“° (CTP ¡“°°«à“ 9) §«√‰¥â√—∫°“√æ‘®“√≥“

°“√ª≈Ÿ°∂à“¬µ—∫

44. °“√√—°…“¥â«¬ Interferon Õ“®‡√‘Ë¡¥â«¬ª√‘¡“≥¬“µË” ”À√—∫ºŸâªÉ«¬∑’Ëµ—∫·¢Áß¡“°

(CTP class B and C) À√◊ÕºŸâªÉ«¬∑’Ë√Õª≈Ÿ°∂à“¬µ—∫ ·µàµâÕß¥Ÿ·≈„°≈â™‘¥‚¥¬

·æ∑¬åºŸâ‡™’Ë¬«™“≠

45. Õ“®æ‘®“√≥“„™â Growth factor „π°“√√—°…“ anemia ·≈– leukopenia

‡æ◊ËÕ™à«¬≈¥¿“«–·∑√°´âÕπ¢Õß°“√√—°…“ ·≈–ªÑÕß°—π°“√≈¥¢π“¥¢Õß¬“


°“√√—°…“ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫ ’∑’Ë ‰¥â√—∫°“√ª≈Ÿ°∂à“¬Õ«—¬«–

46. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß À≈—ßª≈Ÿ°∂à“¬µ—∫ “¡“√∂„Àâ°“√√—°…“¥â«¬ Pegylated

interferon ·≈– Ribavirin ∂â“¡’À≈—°∞“π«à“¡’æ¬“∏‘ ¿“æµ—∫∑’Ë√ÿπ·√ß

47. Pegylated interferon alfa √à«¡°—∫ Ribavirin ‡ªìπ°“√√—°…“ºŸâªÉ«¬µ—∫Õ—°‡ ∫´’

À≈—ß°“√ª≈Ÿ°∂à“¬µ—∫ ‚¥¬§«√‰¥â√—∫°“√µ‘¥µ“¡Õ¬à“ß„°≈â™‘¥

48. °“√√—°…“¥â«¬ Interferon ‰¡à§«√„™â„πºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß∑’Ëª≈Ÿ°∂à“¬À—«„®

ªÕ¥ ·≈– ‰µ ¬°‡«âπºŸâªÉ«¬∑’Ë‡°‘¥¿“«– fibrosing cholestatic hepatitis

°“√√—°…“ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’©—∫æ≈—π

49. ºŸâªÉ«¬∑’Ë‡ªìπ‰«√— µ—∫Õ—°‡ ∫ ’©—∫æ≈—π§«√‰¥â√—∫°“√√—°…“¥â«¬ Interferon based

therapy

50. “¡“√∂√Õ‡«≈“‰¥â 8 ∂÷ß 12 —ª¥“Àå À≈—ß®“°¡’ acute hepatitis C ‡æ√“–Õ“®

¡’ºŸâªÉ«¬∫“ß√“¬À“¬‡Õß‰¥â

51. °“√√—°…“¥â«¬ Interferon À√◊Õ Pegylated interferon ‡æ’¬ßÕ¬à“ß‡¥’¬«„Àâº≈

°“√√—°…“∑’Ë¥’ ‚¥¬‰¡àµâÕß„™â Ribavirin

52. ·π–π”„Àâ√—°…“‡ªìπ‡«≈“ 12 ∂÷ß 24 —ª¥“Àå Õ“®æ‘®“√≥“√—°…“ 24 —ª¥“Àå„π

√“¬∑’Ëµ‘¥‡™◊ÈÕ genotype 1

53. °“√æ‘®“√≥“„Àâ Ribavirin √à«¡¥â«¬ §«√æ‘®“√≥“‡ªìπ√“¬ Ê

°“√√—°…“ºŸâªÉ«¬‰«√— ´’ ∑’Ë¬—ß§ß©’¥¬“‡ æµ‘¥Õ¬Ÿà

54. “¡“√∂æ‘®“√≥“√—°…“‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’„πºŸâ∑’Ë¬—ß„™â¬“‡ æµ‘¥Õ¬Ÿà À√◊Õ ºŸâ∑’Ë‰¥â

√—∫°“√√—°…“¥â«¬ methadone maintenance program ∂â“ºŸâªÉ«¬‡µÁ¡„®∑’Ë®–

√—°…“·≈–æ∫·æ∑¬åÕ¬à“ß„°≈â™‘¥ ·≈–¬◊π¬—π°“√§ÿ¡°”‡π‘¥

55. ºŸâ ∑’Ë „™â¬“‡ æµ‘¥§«√‰¥â√—∫°“√„Àâ§”ª√÷°…“·≈–ª√–‡¡‘π‚¥¬®‘µ·æ∑¬å‡æ◊ËÕ

ª√–°Õ∫°“√æ‘®“√≥“√—°…“‰«√— µ—∫Õ—°‡ ∫ ’


°“√√—°…“ºŸâªÉ«¬‰«√— ´’∑’Ë¡’ Psychiatric illnesses

56. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’ ·≈–¡’§«“¡º‘¥ª°µ‘∑“ß®‘µ„® “¡“√∂∑”°“√√—°…“‰¥â¥â«¬

Pegylated interferon ·≈– Ribavirin ∂â“Õ“°“√§«“¡º‘¥ª°µ‘∑“ß®‘µ„® “¡“√∂

§«∫§ÿ¡‰¥â ·µà§«√‰¥â√—∫°“√ª√–‡¡‘π·≈–¥Ÿ·≈‚¥¬¡’®‘µ·æ∑¬å√à«¡¥â«¬

°“√¥Ÿ·≈·π–π”

57. ºŸâ∑’Ë¡’‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß∑’Ë‰¡à¡’¿Ÿ¡‘µàÕ‰«√— µ—∫Õ—°‡ ∫‡Õ À√◊Õ ∫’ §«√„Àâ

«—§´’π‡æ◊ËÕªÑÕß°—π°“√µ‘¥‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ 2 ™π‘¥π’È

58. ºŸâ∑’Ë¡’‡™◊ÈÕ‰«√— µ—∫Õ—°‡ ∫ ’‡√◊ÈÕ√—ß §«√ß¥°“√¥◊Ë¡·Õ≈°ÕŒÕ≈å

59. ºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß∑’Ë¡’ advanced fibrosis À√◊Õ cirrhosis ·¡â«à“‰¥â

SVR ®“°°“√√—°…“·≈â« §«√‡ΩÑ“√–«—ß°“√‡°‘¥ HCC µàÕ‰ª

60. ¡’√“¬ß“π§«“¡ —¡æ—π∏å√–À«à“ß°“√≈ÿ°≈“¡¢Õß‚√§„πºŸâªÉ«¬‰«√— µ—∫Õ—°‡ ∫´’‡√◊ÈÕ√—ß

∑’Ë¡’¿“«–Õâ«π ¿“«–¥◊ÈÕ insulin À√◊Õ metabolic syndrome ·≈–°“√¥◊Ë¡ ÿ√“

¥—ßπ—Èπ®÷ß§«√·π–π”ºŸâªÉ«¬„π°“√ªØ‘∫—µ‘µπ‡æ◊ËÕ≈¥¿“«–À√◊Õªí®®—¬¥—ß°≈à“«´÷Ëß

Õ“®∑”„ÀâºŸâªÉ«¬µÕ∫ πÕßµàÕ°“√√—°…“¥’¢÷Èπ À√◊Õ ™à«¬™–≈Õ°“√≈ÿ°≈“¡¢Õß‚√§

„πºŸâªÉ«¬∑’Ë‰¡àµÕ∫ πÕßµàÕ°“√√—°…“

‡Õ° “√Õâ“ßÕ‘ß

1. Asian Pacific Association for the Study of the Liver (APASL) Hepatitis

C Working Party. Asian Pacific Association for the Study of the Liver

consensus statements on the diagnosis, management and treatment

of hepatitis C virus infection. Journal of Gastroenterology and Hepatology

2007; 22: 615-633.

2. Marc G. Ghany, Doris B. Strader, David L. Thomas, and Leonard B.

Seeff. AASLD PRACTICE GUIDELINES Diagnosis, Management, and

Treatment of Hepatitis C: An Update. Hepatology 2009; 49: 1335-1374.

Thai Hepatitis B C guideline 2552

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Transcript of Thai Hepatitis B C guideline 2552