Saudi Biobank

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Saudi Biobank

GENERAL INFORMATION

Name Saudi Biobank Last update 09/11/2013

Principal investigator

Mohammed Al Jumah (Dr.) King Abdulllah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for HealthSciences (KSAU-HS), Saudi Arabia

Contact

Mohammed Al Jumah (Dr.) King Abdulllah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for HealthSciences (KSAU-HS), Saudi ArabiaEmail: [email protected]

Website

http://www.kaimrc.med.sa/Projects/SaudiBiobank/tabid/165/Default.aspx

Funding agencies

King Abdulaziz City for Science and Technology (KACST)King Abdullah International Medical Research Center (KAIMRC)National Guard Health Affairs (NGHA)

OBJECTIVES1. To educate the public about advancements that could come from the study of biological materials.2. To encourage the donation of specimens.3. To quantify disease incidence in various populations and subpopulations.4. To enhance understanding of the natural history and risk factors of diseases, including genome-environment interactions.5. To accelerate the discovery and development of new diagnostics and therapeutics.

Research Focus

Broad approach with no specific target of interest (study built as an infrastructure for a broad range of unspecified scientific activities/questions). Target specific questions of interest (predefined scientific targets like, cardiovascular diseases, social environment, specific health trajectories

etc.) (Health and diseade outcome, health determinants, risk factors and predictors of diseases/conditions)

METHODS

Legend Yes No Unknown

General design

Study design CohortType of participants Individuals, FamiliesSupplementaryinformations

A family-based prospective study was suggested, with the sample unit being considered the family rather than the subject, whennecessary. Finally, we plan to conduct nested case-control studies within the cohort. This will involve sampling of cases as well ascontrols to understand the biology of adverse outcome or to identify novel markers.

Target or finalnumber of participants

200000

Target or finalnumber of families

25000

Target or finalnumber of DNA

No information available

Participant selection / Characteristics of the population

Selection criteria

Country of residence Saudi Arabia

Supplementary informationsThis study will be concerned with two biobanking groups:

1. A prospective family-based study group, with an expected sample of 100,000 people of all ages, comprising about 20,000 to 25,000 families, afteradjusting for the drop-outs, to examine these interactions in a range of common late onset diseases.2. Disease-specific biobanking group, where samples of people affected by certain diseases such as; cancer (10,000), diabetes (10,000), coronaryarteries diseases with one or more risk factors (10,000) (DM, hypertension, etc), hepatitis (5000), obesity (5000), bronchial asthma (5000), chronicrenal impairment and failure (5000), stroke (5000), other diseases will be determined following discussion in the steering and international advisorycommittees etc.( around 100,000 cases) will be allocated from the specialized clinics and primary healthcare clinics.

Data Sources

http://www.p3gobservatory.org:8080/catalogue.htm?studyId=150

1 Public Population Project in Genomics. For more information contact us at observat...
http://www.kaimrc.med.sa/Projects/SaudiBiobank/tabid/165/Default.aspxhttp://www.kaimrc.med.sa/Projects/SaudiBiobank/tabid/165/Default.aspxmailto:[email protected]:[email protected]


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Cross-sectional Longitudinal follow-up

Questionnaires to participants/respondents

Direct physical measures

Biological samples

Sample management

Biological samples

Blood Buccal cells

Cord blood Tissues (Biopsy in case of disease specific group that are lift over from clinical use will be banked.)

Saliva Urine

Genome-Wide Association (GWA) analyses

Plan to proceed to GWA analyses later

GOVERNANCE

Legend Yes No

Allow access to data or samples to external researchers

Data (questionnaire-derived, measured)

Biological samples

STATUSCurrent status

Phase Start End

Preparation phase/Pilot 2010 2010

Baseline recruitment / initial data

collection2013 2016

Follow-up of participants -- --

Current number of participantsrecruited

--

We are in the pilot study phase.Current number of collected DNAsamples

--

COMMENTThe following publication was accepted:Mohammed Al-Jumah, Mostafa A. Abolfotouh, Ibrahim B. Alabdulkareem, Hanan H. Balkhy, Majed I. Al-Jeraisy, Abdulrahman F. Al-Swaid, Eman M.Al-Musaaed, Bandar Al-Knawy.Public Attitude towards Biomedical Research at Outpatient Clinics of King Abdulaziz Medical City Riyadh, Saudi

Arabia. East Mediterranean Health Journal. (WHO). Accepted for publication, November,2009.http://kaimrc.med.sa/Projects/SaudiBiobank/PublicationsonSaudiBiobanking/tabid/300/Default.aspx



Saudi Biobank

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