Reunion Anual Madeira 2015 Clinical and Experimental Research. PoteSimultaneous ntial in...
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Vicente Bodí Department of Cardiology, Hospital Clínico Universitaro University of Valencia Group on Translational Research in Ischemic Heart Disease, Incliva, Valencia, Spain Simultaneous Clinical and Experimental Research. Potential in Pathophysiology, Diagnosis and Therapy
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Transcript of Reunion Anual Madeira 2015 Clinical and Experimental Research. PoteSimultaneous ntial in...
Vicente BodíDepartment of Cardiology, Hospital Clínico UniversitaroUniversity of ValenciaGroup on Translational Research in Ischemic Heart Disease, Incliva, Valencia, Spain
Simultaneous Clinical and Experimental Research. Potential in Pathophysiology, Diagnosis and Therapy
No conflicts of interest to disclose
Vicente BodíDepartment of Cardiology, Hospital Clínico UniversitaroUniversity of ValenciaGroup on Translational Research in Ischemic Heart Disease, Incliva, Valencia, Spain
Experimental Research
Experimental model of infarction
Pathophysiology
Therapy
Diagnosis
Experimental model of infarction
Pathophysiology
Therapy
Diagnosis
Swine model of infarction
Hervás, Rev Esp Cardiol 2015 (en prensa)
Swine model of infarction
Swine model of infarction
Experimental model of infarction
Pathophysiology
Therapy
Diagnosis
Microvascular obstruction
Bodí, J Am Coll Cardiol 2005
Bodí, JACC imaging 2009
806040200
1.0
0.9
0.8
0.7
0.6
OMV
No OMV
Su
pe
rviv
en
cia
sin
MA
CE
Semanas
Microvascular obstruction
Reperfusion injury. Proof of concept
NO REPERFUSION 1’ REPERFUSION
Hervás, Rev Esp Cardiol 2015 (en prensa)
Hervás, Rev Esp Cardiol 2015 (en prensa)
Dynamics of microvascular obstruction
Bonanad, Thromb Res 2013
The right ventricle in anterior infarctions
Experimental model of infarction
Pathophysiology
Therapy
Diagnosis
Tam
año
del
in
fart
o (
%)
70
60
50
40
30
20
10
5
0
Isquemia miocárdica en ausencia de reperfusión
Isquemia miocárdica con reperfusión
Isquemia miocárdica con reperfusión y cardioprotección
Reperfusion therapy and reperfusion injury
POSTCONDICIONAMIENTO
Zhao, Am J Physiol Heart Circ Physiol 2003
Advances in therapy
Bodi, Int J Cardiol 2014
Advances in therapy
Experimental model of infarction
Pathophysiology
Therapy
Diagnosis
Diagnosis of myocardial ischemia
Bodí V. J Am Coll Cardiol 2007
Experimental research
Clinical research
Clinical validation
Routine practice
Diagnosis of myocardial ischemia
Bodí V. J Am Coll Cardiol 2012
Conocimiento procedente del
laboratorio
Ciencia y conocimiento clínico
Práctica clínica y adopción de decisiones
Primer valle
Investigación traslacional
Segundo valle
Investigación traslacional
Bodi, J Cardiovasc Trans Res 2014
And now what?
Arantxa Hervás (Biotecnóloga)Elena de Dios (Bióloga)Clara Bonanad (Cardióloga)Gema Miñana (Cardióloga)Ana Díaz (Veterinaria)Inmaculada Noguera (Veterinaria)José Gavara (Bioingeniero)Nerea Pérez (Enfermera)Isabel Selfa (Enfermera)
Cristina Gómez (Enfermera)Fabian Chaustre (Bioingeniero)María J. Forteza (Bióloga)Oliver Husser (Cardiólogo)
GRACIAS!Department of Cardiology, Hospital Clínico Universitaro, University of Valencia, Incliva, Valencia, Spain
