Proteine-difractia Cu Raze X
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Transcript of Proteine-difractia Cu Raze X
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Structura primar,
secundar, teriar i cuaternar a proteinelor
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Structura
primar
Structura secundar
Structura teriar
Structuracuaternar
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Structura primar
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- - Ala ± Glut ± Ser ± His ± Leu ± Pro ± Gly - -
Structura primar
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Structura primara a lizozimului estereprezentata de un lant polipeptidic de
129 aminoacizi.
Structura primar
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Dubla elice ADN. Moleculele de adenina (A) intotdeauna se opunmoleculelor de timina (T), iar guanina (G), citozinei (C).
Structura secundar
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Structura secundar
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Structura secundar
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Structura tertiar
Plierea unui singur lant polipeptidic
intr -o forma tridimensionala =structura tertiara a proteinei
3 principii importante
1. Lanturile secundare sunt consecinta, inprincipal, numeroaselor legaturi dehidrogen.
2. Structurile secundare de tip -helix si-pliat se asociaza frecvent pentru a forma
proteine.
3. Lanturile au tendinta de a se plia in spatiupentru a ocupa mai putin loc.
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T rioz-fosfat-izomeraza
Structura cuaternar
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T rioz-fosfat-izomeraza
Structura cuaternar
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Structura cuaternar - hemoglobin
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Structura cuaternar - mioglobin
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F uncii generale ale proteinelor
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1. Enzime: catalizeaz ruptura
sau formarea unor legturicovalente (mii)
Ex:
- pepsina- ADN-polimeraza
- ribonucleaza
- tripsina- alcool-
dehidrogenaza
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2. Proteine structurale:
susinerea mecanic a celulelor i aesuturilor
Ex:
- colagenul ielastina
- tubulina iactina
- - keratina
- proteoglicanii
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keratina
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Ex:
- Hb. ± oxigen- transferina - fier
- albumina - lipide
- proteine de
transportmembranar: H2, glucoz (GLUT), Ca2+
3. Proteine de transport: transportul
unor molecule mici sau a unor ioni
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4. Proteine motrice: genereaz
micare în celule i esuturi
Ex:
miozina,
actina,
kinezina,
dineina
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5. Proteine de stocare:
a unor molecule mici sau ioni
Ex:
- feritina
- ovalbumina
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6. Proteine semnal: transmitsemnale de la celul la celul
Ex: - hormoni (insulina, tirotropina etc.)- factori de cretere: NGF, EGF
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7. Proteine receptoare:detecteaz semnale i le
transmit mainriei celulare
Ex:-rodopsina,
- receptorul pentruacetilcolin al celuleimusculareprimetesemnalechimice
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8. Proteine reglatoare ale
genelor: seleag de
ADNpentru ainduce sau a inhiba expresia genelor
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9. Proteine cu rol particular
Ex:-proteinele antigel ale petilor de lapolii Nord-Sud
-proteinef luorescente
- proteine cufuncie de adeziv
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lumina produsa =rezultatul reactieiintre luciferina siATP (sub actiuneaunei enzime, luciferaza).
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Funciile proteinelor membranare
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M etode de studiu a structurii proteinelor
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- cristalografia sau difractia
cu raze X- rezonanta magnetiga
nucleara (RMN)
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Difractia cu raze X:studiul regiunilor ordonate
?
Sigla Google din 8 noiembrie 2010: de ce?
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William Henry Bragg siWilliam Lawrence Bragg =
tata si fiu (25 ani)
Premiul Nobel in 1915 pentru contributiala studiul structurilor cristaline
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Ecuatia
luiBragg:
BC + CD = nPdar:
BC = CD = h = AC x sin U
= d x sin U
deci:
2d x sin U = nP
Maxime de difractie: diferena de drum trebuie s fie unnumr întreg, n, de Plungimea de und) ,
A
C
BD
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Difractia cu raze X
2d sin = n·ecuatia Bragg
A
B
C D d
BC + BD = n
BC = BD = AB sin
AB = d
2d sin = n·
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E
cuatialui Bragg
Maxime de difractie:diferena de drum
trebuie s fie un numr
întreg, n, de Plungimea de und)
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R aze X
Cristal
Film, ecran:difracto-
grama2 U
U
a) b) c)
Etapele studiului unei proteine
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a) b) c)
Etape in studiul unei proteine:
a). difractograma cu raze X
b). harta de densitate electronica
a proteinei, realizata pe calculator
c). modelul structurii
conformationele aproteinei
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- une figure de diffraction caractéristique apparaît C, - qui est provoquée par l'interactiondes atomes dans le cristal avec des rayons X D. - Grâce à la complexité des procédures
mathématiques E - F densité électronique - et enfin un modèle de structuretridimensionnelle de la G récepteur est obtenu.
18.94818.948structuresstructures(15.10.02) ont(15.10.02) ontété définisété définis(base de(base dedonnées dedonnées dela structurela structuredesdesprotéines) etprotéines) etpeut êtrepeut être
librementlibrementtéléchar gé àtéléchar gé àl'adressel'adressehttp:// http://
www.rcsb.org www.rcsb.org
/ pdb. / pdb.
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Sur la base de la structure moléculaire d'un groupe de substances ligand avec des effets«similaire», un modèle virtuel de la cible et le récepteur peuvent être créés dans une premièretentative A.Ensuite molécules plus connus pour interagir avec le récepteur sont testees sur le récepteur Bde substitutionet une relation quantitative structure-effet est construit C (en vert: la substance de la formation;en rouge: la substance d'essai).Enfin, le modèle peut être utilisé pour prédire l'activité de nouveaux types de substances D. Cette méthode est donc appelée «de conception indirecte» ou la modélisation des récepteurs».
Pentru cca 90% dintrereceptori nu este
cunoscuta structuratridimensionala
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J. Watson i F. Crick ² premiul Nobel în Medicin iFiziologie 1962 împreun cu M. Wilkins: Stabilirea
structurii ADN-ului prin difracie cu raze X
Imagine dedifracie
cu raze X a ADN
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Imagine dedifracie
cu raze X a ADN
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Difractiarazelor X pe ostructuraordonata esteun fenomende difuzie.Pentrusimplificare,
Braggconsideradifractiarazelor X caun fenomende ref lexie.
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³W e have discovered the secret of life ́ 2003 / 1953
J. Watson i F. Crick ² premiul Nobel în Medicin iFiziologie 1962 împreun cu M. Wilkins: Stabilirea
structurii ADN-ului prin difracie cu raze X
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Difractia cu raze X
- metoda cu pulberi -
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Difractia cu raze X
- metoda cu cristal turnant -
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ADN -ul si ARN -ul
(acizi nucleici)
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< de 36º
10 nucleotizi
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Spirala se stabilizeaza prinlegaturi de hidrogen
ARN mesager , de transfer , ribozomal
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a) b) c)
Etape in studiul unei proteine:
a). difractograma cu raze X
b). harta de densitate electronica
a proteinei, realizata pe calculator
c). modelul structurii
conformationale a proteinei