Presentación de PowerPoint y personal...β-sitosterol colesterol Behrman, E. J.; Gopalan, V....
Transcript of Presentación de PowerPoint y personal...β-sitosterol colesterol Behrman, E. J.; Gopalan, V....
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1.4 Esteroles
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1.5 Colesterol
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β-sitosterol colesterol
Behrman, E. J.; Gopalan, V. Journal of Chemical Education, 2005, 82, 1791-1793.
estigmasterol campesterol
C29-esterol
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Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England. 4
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5 Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England.
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6 Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England.
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Formula Weight : 412.69Formula : C29H48O
estigmasterol
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HPLC
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Cañabate-Díaz, B.; Carretero, S. A.; Fernández-Gutiérrez, A.; Belmonte, V. A.; Garrido, F. A.; Martínez, V. J. L.;
Duran, M. J. Separation and determination of sterols in olive oil by HPLC-MS. Food Chemistry, 2007, 10, 593-598.
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Formula Weight : 386.65 g/molFormula : C27H46O Formula Weight : 412.69 g/mol
Formula : C29H48O
Formula Weight : 414.71g/molFormula : C29H50O
Formula Weight : 416.72 g/molFormula : C29H52O
Formula Weight : 412.69 g/molFormula : C29H48O
Formula Weight : 442.72 g/molFormula : C30H50O2
Formula Weight : 442.72 g/molFormula : C30H50O2
colesterolestigmasterol
-sitosterol
sitostanolfucosterol eritrodiol uvaol
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lanosterol
C30-esterol
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5-avenasterol 16
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ergosterol
C28-esterol
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D2 ergocalciferol D3 cholecalciferol
ergosterol
1.6 Grupo de la vitamina D
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19 Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England.
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D3 cholecalciferol
?
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Law, M. Plant sterol and stanol margarines and health. Brit. Med. J., 2000, 320, 861–864.
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1.7 Esteroides anabólicos
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Structural modifications to the A- and B-rings of testosterone which increase
anabolic activity; substitution at C-17 confers oral or depot activity (i.m. =
intramuscular)
Steroid Analysis. Edited by H.L.J. MAKIN, D.B. GOWER. Springer Dordrecht Heidelberg London New York.
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3: Diosgenin
4: Progesterone
5: Cortisone
6: 11α-hydroxyprogesterone
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1.8 Cardenolides
A B
C D1
2
3
45
67
89
10
11
1218
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Steroid Analysis. Makin H.L.J.; Gower, D.B. 2th Edition. Springer. 2010. UK.
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R = H; digitoxin isolated from foxglove (Digitalis purpurea)
R = OH; digoxin from D. lanata; widely used treatment for heart failure
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Convallatoxin, from lily of the valley (Convallaria majalis)
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Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd. 32
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Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd. 33
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1.9 Sapogeninas
Diosgenina
iso 25R
They are found in many monocotyledon
families, especially the Dioscoreaceae (e.g.
Dioscorea), the Agavaceae (e.g. Agave,
Yucca) and the Liliaceae (e.g. Smilax,
Trillium).
Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England. 34
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Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd.
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Agave sisalana
36 Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd.
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37 Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd.
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38 Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd.
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39 Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd.
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1.10 Alcaloides esteroidales
Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England. 40
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Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd. England. 41
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