MATEO ARANGO DUQUEMEDICINE STUDENT

SPLICING

INTRODUCTION

Splicing is essential in the procces of the proteins.

Let us know genetic errors that produce mutations.

RESEARCHERS DISCOVER

NEW ASPECT OF

GENE REGULATION

(2015 june 12)

RESEARCHERS DISCOVER NEW ASPECT OF GENE

REGULATION (2015 june 12)During alternative

splicing, introns are removed and exons are

joined in different combinations. Through

this mechanism, the information stored in the genes can be processed

in a variety of ways

RESEARCHERS DISCOVER NEW ASPECT OF GENE

REGULATION (2015 june 12)

Exitrons are hidden in the exons and are important in the

expression of human genes.

RESEARCHERS DISCOVER NEW ASPECT OF GENE

REGULATION (2015 june 12)

Exitron are key in

the study of the expression

of breas

t cance

r

RESEARCHERS DISCOVER NEW ASPECT OF GENE REGULATION

(2015 june 12)STUDENT´S OBSERVATION

I think this is really helpfull because they can research a lot of

new options to combine the bind of

the proteins and decide which can

help to improve the human genome and

develop new treatments

A new tool called DeepBind uses deep learning to analyze

how proteins bind to DNA and RNA(27 july 2015)

A NEW TOOL CALLED DEEPBIND USES DEEP LEARNING TO ANALYZE

HOW PROTEINS BIND TO DNA AND RNA

CIFAR Senior Fellow Brendan Frey (University of Toronto), supervising lead authors Babak Alipanahi developed the

method using deep learning .

deep learning a process that uses advances algorithms.

A NEW TOOL CALLED DEEPBIND USES DEEP LEARNING TO ANALYZE HOW PROTEINS BIND

TO DNA AND RNA

They can

look at a new sequence of DNA

or RNA and

compute a

score saying how likely it is that

any of these protei

ns would bind to it.

A NEW TOOL CALLED DEEPBIND USES DEEP LEARNING TO ANALYZE HOW PROTEINS BIND

TO DNA AND RNATheir system identified

new genes that could be implicated in.

- Autism spectrum disorders,

- Hereditary non-polyposis colon cancer

- Spinal muscular atrophy  

They can know that identifying errors in

gene splicing.

A NEW TOOL CALLED DEEPBIND USES DEEP LEARNING TO ANALYZE HOW PROTEINS BIND

TO DNA AND RNASTUDENT´S

OBSERVATIONThe use of this method is going to be a total succes

and i hope that it isnt going to be really

expensive because it would help in further

investigations for example to prevent a lot

of diseases and try to find a way to solve the

problem

MEDICAL UTILITY

MEDICAL UTILITY

Both researches allow

to know the

function of the

correct bind of the proteins to

detect a lot

of mutations in the

human genom

e

MEDICAL UTILITY

The splicing is crucial beacuse

with that process the scientist can identify with the new technology a lot of errors in the

bind of the proteins and can

use that to think in we ways to improve the

human genome

MEDICAL UTILITY

ONE OF THE BEST WAY TO PREVENT A LOT OF HUMAN

DISEASES IS KNOWING THE SEQUENCES THAT

PRODUCE IT AND USING GENE THERAPY THAT THE

REASON SPLICING IS IMPORTANT.

BIBLIOGRAPHY• Canadian Institute for Advanced Research.( 27 July

2015). "DeepBind predicts where proteins bind, uncovering disease-causing mutations." ScienceDaily. ScienceDaily,. <www.sciencedaily.com/releases/2015/07/150727120209.htm>.

• University of Vienna and the Medical University of Vienna. (2015 june 12). ”Researchers discover new aspect of gene regulation”.NewsMedical <http://www.news-medical.net/news/20150612/Researchers-discover-new-aspect-of-gene-regulation.aspx>.

• MARTINEZ SÁNCHEZ, Lina María.VARGAS GRISALES,Natalia.MEJIA CARDONA, Laura.OSORIO OSPINA,Felipe.RAMIREZ PULGARIN,Sergio. Biología molecular. 8. ed. Medellín: UPB. Fac. de Medicina, 2015. 139p.