Pemanfaatan Liquid Crystal Dan Supercritical Fluid Dalam Dunia Farmasi Dan Kesehatan

5/19/2018 Pemanfaatan Liquid Crystal Dan Supercritical Fluid Dalam Dunia Farmasi Dan Keseh...

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LIQUID CRYSTAL,

SUPERCRITICAL FLUID,

DAN FREEZE DRYING

Disusun oleh:

Nama : Selly a!is"a

NP : #$%&&%&&%'

Fa"ul(as Fa!masi

Uni)e!si(as Pa*+a+a!an

#%&&



LIQUID CRYSTAL DAN SUPERCRITICAL

FLUID

I Li-ui* C!ys(al

Liquid crystala*alah se.uah .ahan yan/ men/ali! se0e!(i 1ai!an (e(a0i se1a!a

"eselu!uhan memili"i s(!u"(u! yan/ (e!a(u! laya"nya 0a*a(an Fase liquid crystal.e!a*a

*i an(a!a 2ase 1ai!an *an 0a*a(an

3e.e!a0a (i0e *a!i liquid crystal *iman2aa("an se.a/ai 0e!an/"a( *alam

0en/han(a!an o.a( *i *alam (u.uh manusia "a!ena "emam0uannya *alam 0ene(!asi o.a(

.e!0a!(i"el nano "e *alam "uli( a(au +a!in/an (u.uh lainnya *an memili"i "a0asi(as

*alam mele0as 4a( se1a!a .e!(aha0 5timed release6

&& Con(oh *an an2aa(Liquid Crystal

& Con(oh liquid crystal se1a!a alami 5se1a!a .iolo/i6:

a ole"ul lyotrophicse.a/ai su.s(ansi *asa! *a!i sel *an +a!in/an (u.uh

. ole"ul7mole"ul 0en(in/ *alam "ehi*u0an se0e!(i mem.!an 2os2oli0i*, DNA,

!an/"aian 0oli0e0(i*a, *an "oles(e!ol

1 8i!us (anaman .a"au 5

tobacco mosaic virus6

# Con(oh liquid crystal*i se"i(a! "i(a:

a Sa.un

. Ai! yan/ .e!1am0u! sa.un a(au *e(e!+en *en/an "onsen(!asi (e!(en(u

9 Con(oh liquid crystal*alam "eseha(an *an 2a!masi:

a Liquid Crystal Pharmaceutical5LCP6

Liquid Crystal Pharmaceuticala*alah ino)asi o.a(7o.a(an (e!.a!u un(u"

0emulihan a(as .e!.a/ai 0enya"i( LCP *inilai se.a/ai se.uah me(o*e yan/
http://en.wikipedia.org/wiki/Tobacco_mosaic_virushttp://en.wikipedia.org/wiki/Tobacco_mosaic_virushttp://en.wikipedia.org/wiki/Tobacco_mosaic_virus



san/a( aman un(u" 0en/han(a!an o.a( *an *a0a( mem.i*i" a!ea yan/ s0esi2i"

*alam (u.uh *imana a*a 0e!a*an/an +a!in/an a(au *imana (umo! *i(emu"an

LCP (elah (e!.u"(i e2e"(i2 un(u" 0emulihan 0enya"i( yan/ *ise.a."an

oleh "uman a(au )i!us se0e!(i he!0es 5S86, (umo! *i "an*un/ "emih *an

"an"e! 0!os(a( Se1a!a umum (elah *i0e!1aya .ah;a LCP !ela(i2 aman *alam

0en//unaannya se.a/ai o.a(, "a!ena se+auh ini, 0eneli(ian men/in*i"asi"an

.ah;a LCP memili"i "a*a! !a1un yan/ san/a( "e1il

Salah sa(u 1on(oh LCP a*alah o.a( LCP yan/ (e!/olon/ an(i (umo! yan/

*ise.u( Tole1ine Tole1ine men/an*un/ .ahan an(i .a"(e!i *an an(i "uman a(au

)i!us *an men1e/ah 0e!"em.an/.ia"an (umo! yan/ a.no!mal Tole1ine "a*an/

*i"om.inasi"an *en/an LCP lain yan/ *ise.u( A0a(one

A0a(one *i.ua( *a!i *ua senya;a (a" .e!a1un, se.uah senya;a liquid

crystal *an /lu"osa



#& Con(oh *an an2aa( Supercritical Fluid5SCF6

SCF memili"i "e0a*a(an se0e!(i 1ai!an, )is"osi(as se0e!(i /as,

"om0!esi.ili(as se0e!(i /as *an *aya *i2usi yan/ le.ih (in//i *a!i0a*a 1ai!an Si2a(

*a!i SCF, se0e!(i 0ola!i(as, )is"osi(as, *an *i2usi)i(as, *a0a( *iu.ah .e.e!a0a "ali

li0a( *en/an mem)a!iasi"an suhu o0e!asi *an > a(au (e"anan selama 0!oses

(e!se.u( Fle"si.ili(as ini memun/"in"an 0en//unaan SCF un(u" .e!.a/ai a0li"asi

*alam in*us(!i ma"anan *an 2a!masi Pela!u( SCF yan/ umum *i/una"an a*alah

"a!.on *io"si*a, ni(!o/en o"si*a, e(ilena, 0!o0ilena, 0!o0ana, n70en(ana, e(anol,

amonia, *an ai! Namun, C< #a*alah SCF yan/ .anya" *i/una"an *alam

0en/olahan 2a!masi "a!ena si2a(nya yan/ uni" C



Te"nolo/i ini men//una"ansupercritical fluidC



& Pa!(i"el i"!o *an Pa!(i"el Nano

# 3uih 3e!0o!i i"!o

9 Li0osom

? Pela0isan 5coati!#6

@ S(e!ilisasi P!o*u"

$ =om0le"s In"lusi

Dis0e!si Pa*a(

B 3u.u" a"!omole"ul

' 3en(u" Dosis Pa!(i"ula(

#? Supercritical Fluid*alam In*us(!i Fa!masi& e*ia Un(u" =!is(alisasi

Te"nolo/i SF *a0a( *i/una"an un(u" men/hasil"an 0olimo!2 5"!is(al

*a!i se.uah senya;a6 yan/ memili"i "emu!nian (in//i Selain i(u, u"u!an *an

.en(u" *a!i 0olimo!2 *a0a( *i.ua( *en/an men/on(!ol suhu *an > a(au (e"anan

selama 0em!osesan, semen(a!a *e!a+a( "!is(alisasi *a0a( *i(in/"a("an *en/an

memani0ulasi la+u "!is(alisasi 0enin/"a(an "a*a! "!is(alini(as

# E"s(!a"si *an Pemu!nian

Te"ni" e"s(!a"si supercritical fluid *a0a( *i/una"an *alam

memisah"an se.a/ian .esa! "o(o!an "om0le"s o!/ani" *a!i o.a(7

o.a(an e(o*e ini se"a!an/ .anya" *i/una"an *alam in*us(!i se0e!(i 0!o*u"si

"a2ein, e"s(!a"si 0!o*u" alami, *an 0!o*u"si *a!i 0!o*u" .e.as

lema" Pemu!nian melalui (e"nolo/i SCF mem.e!i"an al(e!na(i2 yan/ le.ih

.ai" "a!ena ham0i! o(oma(is, 1e0a(, *an hasil yan/ (in//i

9 Solu.ilisasi



Supercritical fluid (e!u(ama C



FREEZE DRYING

I =om0onen esinFree&e -ryi!#=om0onen7"om0onen yan/ a*a 0a*a mesinfree&e dryi!#:

& Ruan/free&e dryi!#!uan/ 0en/e!in/an 5free&e dryi!# chamber6,

# Pom0a )a"um,

9 =on*enso! =on*enso! (e!.a/i *alam *ua +enis "on*enso! in(e!nal *an "on*enso!

e"s(e!nal

? Gulun/an .e"u yan/ *ihu.un/"an "e se.uah "om0!eso! lema!i es,

& =om0u(e! *an laya! "on(!ol microprocessor,

# /a!ifold,

9 Ra"7!a" 0enyim0anan 5shelves6

II Ca!a =e!+a esinFree&e -ryi!#

a Ca!a "e!+a mesinfree&e dryi!#



Ca!a "e!+a mesinfree&e dryi!#se1a!a umum a*alah se.a/ai .e!i"u(:

& Suhu *alam !uan/free&e dryi!#*i"e1il"an *an .ahan men+a*i .e"u "a!ena ai!

*alam .ahan (elah .e!u.ah men+a*i es 0a*a(

# Pom0a )a"um men*o!on/ u*a!a "elua! *a!i !uan/ free&e dryi!# un(u"

men/e1il"an (e"anan u*a!a.

9 Panas *i.e!i"an 0a*a .ahan *an *i.a;ah (e"anan u*a!a yan/ "e1il, es se1a!a

lan/sun/ .e!u.ah men+a*i ua0 ai! *an *i.uan/ melalui 0om0a

. Taha0an *alam 0!osesfree&e dryi!#

Te!*a0a( ? (aha0an *alam 0!oses free&e dryi!# yan/ len/"a0: 0e!la"uan se.elum

5pretreatme!t6, 0em.e"uan 5free&i!#6, 2ase 0en/e!in/an 0!ime! 5primary dryi!#6, *an

2ase 0en/e!in/an se"un*e! 5seco!dary dryi!#6

1. Perlakuan Sebelum (pretreatment)

Pe!la"uan se.elum 5pretreatme!t6 a*alah me(o*e a;al yan/ mem0e!la"u"an

0!o*u" se.elum 0em.e"uan al7hal yan/ *ila"u"an *alam (aha0 ini a*alah

men/"onsen(!asi"an 0!o*u", !e)isi 2o!mulasi 5misalnya, 0enam.ahan

"om0onen un(u" menin/"a("an s(a.ili(as *an > a(au menin/"a("an

0en/olahan6, menu!un"an (e"anan (in//i ua0 0ela!u( a(au menin/"a("an luas

0e!mu"aan

2. Pembekuan (Freezing)

Dalam la.o!a(o!ium, hal ini se!in/ *ila"u"an *en/an menem0a("an .ahan

*alam la.u free&e0dryi!# *an memu(a! .o(ol *i se.uah !uan/, yan/ *ise.u(

shell free&er, yan/ *i*in/in"an *en/an 0en*in/inan me"anis ya"ni es

"e!in/*an me(anol, a(au ni(!o/en 1ai! Pa*a s"ala yan/ le.ih .esa!,

0em.e"uan ini .iasanya *ila"u"an men//una"an mesin free&e0dryi!# Dalam

lan/"ah ini, 0en(in/ un(u" men*in/in"an .ahan *i .a;ah (i(i" (!i0el, yai(u

suhu (e!en*ah *i mana 2ase 0a*a( *an 1ai! .ahan *a0a( (e!.en(u"

.e!*am0in/an al ini memas(i"an .ah;a su.limasi a"an (e!+a*i *alam (aha0

.e!i"u(nya 3iasanya, suhu 0em.e"uan ini a*alah 7@% C sam0ai 7B% C Fase

0em.e"uan a*alah yan/ 0alin/ 0en(in/ *alam "eselu!uhan 0!oses free&e0

dryi!#, "a!ena 0!o*u" .isa !usa" +i"a *i0e!la"u"an *en/an .u!u" *alam (aha0

ini

3. Fase Pengeringan Primer (primary drying)

Selama 2ase 0en/e!in/an 0!ime!, (e"anan *i(u!un"an, *an 0anas yan/ 1u"u0

*i.e!i"an 0a*a .ahan a/a! "an*un/an ai! yan/ a*a *a0a( menyu.lim Dalam
http://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Dry_ice&usg=ALkJrhhbGycAu6WNXs7pQY87OflH8hNFughttp://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Dry_ice&usg=ALkJrhhbGycAu6WNXs7pQY87OflH8hNFughttp://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Methanol&usg=ALkJrhhtqigXmZhWXSqprr4pTLPIacSEawhttp://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Liquid_nitrogen&usg=ALkJrhiinsX_8nPCPKzKKG56glPm_XuEWAhttp://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Dry_ice&usg=ALkJrhhbGycAu6WNXs7pQY87OflH8hNFughttp://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Dry_ice&usg=ALkJrhhbGycAu6WNXs7pQY87OflH8hNFughttp://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Methanol&usg=ALkJrhhtqigXmZhWXSqprr4pTLPIacSEawhttp://translate.googleusercontent.com/translate_c?hl=id&prev=/search%3Fq%3Dfreeze%2Bdrying%2Bmachine%26hl%3Did%26biw%3D1024%26bih%3D638%26prmd%3Divns&rurl=translate.google.co.id&sl=en&u=http://en.wikipedia.org/wiki/Liquid_nitrogen&usg=ALkJrhiinsX_8nPCPKzKKG56glPm_XuEWA



(aha0 0en/e!in/an 0!ime!, se"i(a! '@ ai! *alam .ahan yan/

*isu.limasi"an Fase ini (e!.ilan/ lam.a( 5.isa .e.e!a0a ha!i *alam in*us(!i6

"a!ena s(!u"(u! .ahan *a0a( .e!u.ah +i"a 0anas yan/ *i(am.ah"an (e!lalu

.anya" Selan+u(nya, !uan/ "on*enso! *in/in>.e"u *an > a(au 0ela( "on*enso!

menye*ia"an 0e!mu"aan .a/i ua0 ai! un(u" men/e!as "em.ali =on*enso! ini

men1e/ah ua0 ai! *alam men1a0ai 0om0a )a"um yan/ *a0a( menu!un"an

"ine!+a 0om0a Suhu "on*enso! .iasanya *i .a;ah 7@% C 57$% F6

4. Fase Pengeringan Sekunder (Secondary Drying)

Taha0 0en/e!in/an se"un*e! .e!(u+uan un(u" men/hilan/"an mole"ul7mole"ul

ai! yan/ (i*a" mem.e"u, "a!ena es (elah *ihilan/"an *alam 2ase 0en/e!in/an

0!ime! Dalam 2ase ini, suhu *inai""an le.ih (in//i *a!i0a*a saa( 2ase

0en/e!in/an 0!ime!, *an .ah"an .isa *i a(as % C, un(u" meme1ah"an

in(e!a"si 2isi"o7"imia yan/ (elah (e!.en(u" an(a!a mole"ul ai! *an .ahan yan/

mem.e"u Te"anan (e!"a*an/ *i(u!un"an a(au *a0a( 0ula *inai""an (e!/an(un/

*a!i 0!o*u" yan/ *iolah Se(elah 0!oses free&e0dryi!# selesai, ala( )a"um

.iasanya !usa" "a!ena /as ine!(, se0e!(i ni(!o/en se.elum .ahan7.ahan (e!se.u(

*ise/el

Pa*a a"hi! o0e!asi, "a*a! sisa ai! (e!a"hi! *alam 0!o*u" san/a( !en*ah, se"i(a!

& sam0ai ?



DAFTAR PUSTA=A

h((0:>>.io(e1ha.ou(1om>o*>nano(e1hnolo/y>a>Li-ui*7C!ys(alsh(ml

h((0:>>.io(e1ha.ou(1om>o*>nano(e1hnolo/y>a>(y0esnano0a!(h(m

h((0:>>*im*ima1om>s1ien1e>s1ien1e1ommon>sho;s1ien1eas0(i(leF!ee4eD!yin/Com0one

n(o22!ee4e*!yin/ma1hineh(m

h((0:>>en;i"i0e*iao!/>;i"i>F!ee4e7*!yin/

h((0:>>en;i"i0e*iao!/>;i"i>Su0e!1!i(i1al2lui*

h((0:>>Ne;*!u/0a!a*i/m:li-ui*1!ys(al0ha!ma1eu(i1als>T!ea(men(Ne;s>Ne;s

Che1"

h((0:>>;;;2!ee4e*!yin/in2o1om>F!ee4eD!ye!1om0onen(sh(ml

h((0:>>;;;0ha!main2one(>!e)ie;s>!e)ie;7su0e!1!i(i1al72lui*7eH(!a1(ion7(e1hnolo/y

Pe!!u(, i1hael #%%%I!!ovatio!s i! Pharmaceutical I!dustry F!an1e: Se0a!eH

Rai, Go0al an* Dee0a" ain #%&% (ece!t Characteri&atio! *!d *pplicability f

Polymorphism Liquid Crystal.In*ia: Sh!i Ram Ins(i(u(e o2 Te1hnolo/y 5Pha!ma1y6

Ji*ya P, i!a *"" #%&% Pembuata! 3omposit 3etoprofe!0Polietile! %li4ol de!#a!

/e!##u!a4a! /etode Particle From %as Saturated Solutio!. Surabaya: Institut

Teknologi Sepuluh Nopember.
http://biotech.about.com/od/nanotechnology/a/Liquid-Crystals.htmlhttp://biotech.about.com/od/nanotechnology/a/typesnanopart.htmhttp://dimdima.com/science/science_common/show_science.asp_titleFreezeDryingComponentoffreezedryingmachine.htmhttp://dimdima.com/science/science_common/show_science.asp_titleFreezeDryingComponentoffreezedryingmachine.htmhttp://en.wikipedia.org/wiki/Freeze-dryinghttp://en.wikipedia.org/wiki/Supercritical_fluidhttp://www.pharmainfo.net/reviews/review-supercritical-fluid-extraction-technologyhttp://biotech.about.com/od/nanotechnology/a/Liquid-Crystals.htmlhttp://biotech.about.com/od/nanotechnology/a/typesnanopart.htmhttp://dimdima.com/science/science_common/show_science.asp_titleFreezeDryingComponentoffreezedryingmachine.htmhttp://dimdima.com/science/science_common/show_science.asp_titleFreezeDryingComponentoffreezedryingmachine.htmhttp://en.wikipedia.org/wiki/Freeze-dryinghttp://en.wikipedia.org/wiki/Supercritical_fluidhttp://www.pharmainfo.net/reviews/review-supercritical-fluid-extraction-technology

Pemanfaatan Liquid Crystal Dan Supercritical Fluid Dalam Dunia Farmasi Dan Kesehatan

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