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Effects ofEffects of

DiureticsDiureticsExerciseExerciseNo. 9No. 9

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Objective:Objective: To define

diuretics and

note its effects inthe body.

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Observation:Observation:Vol ofVol ofUrineUrine

OutpuOutputt

ColdColdWateWate

rr

CokCok

ee

FurosemiFurosemi

dede

AfterAfter30 min30 min

220 ml 40 ml 153 ml

After 1After 1

hrhr

457 ml 80 ml 453 ml

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Vol ofVol of

UrineUrineOutpuOutpu

tt

ColdColdWateWate

rr

CokCokee

FurosemiFurosemidede

AfterAfter

1.5 hrs1.5 hrs

640 ml 100

ml

713 ml

After 2After 2hrshrs

777 ml 110ml

923 ml

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Conclusion:Conclusion:We therefore conclude

that diuretics are amongstcommonly used drugs. They

act by diminishing sodiumreabsorption at different

sites in the nephron, therebyincreasing urinary sodium

and water losses. The ability

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made diuretics useful in thetreatment of a variety of

conditions particularlyedematous states and

hypertension.

Diuretics help rid your

body of salt and water. Theywork by making your

kidneys put more sodium

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and goes with the blood. That decreases the amount

of fluid flowing through yourblood vessels, which

reduces pressure on walls ofyour arteries.

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Questions:Questions:

1. What is1. What is

diuretics?diuretics?

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Diuretics are called water

pills which help body releasefluids. It helps in loweringblood pressure by causingkidneys to produce moresodium and in turn helps in

removal of fluids throughurination. They are used as

1st line treatment high BP.

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2. What is the2. What is the

mechanism ofmechanism of

action ofaction ofdiuretics?diuretics?

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The diuretics argenerally divided intothree major classes whichare distinguished by thesite at which they impairsodium reabsorption:

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Loop diureticsLoop diuretics inhibit the

sodium-potassium-chloridecotransporter

in the thickascending limb

of loop ofhenle.

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di idi ti lik l d

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diureticsdiuretics unlike loop andthiazide diuretics, some of

these drugs do not actdirectly on sodium transport.

Some drugs in this classantagonize the actions of

aldosterone (aldosteronereceptor antagonists) at

the distal segment of the

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Other

potassium-sparing diureticsdirectly inhibit sodiumchannels associated withthe aldosterone-sensitivesodium pump, andtherefore have similareffects on potassium and

h dro en ion as the

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3. What is the3. What is the

importance ofimportance of

diuretics?diuretics?

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Diuretics are the commonmedication used in the

treatment of high bloodpressure. They are relatively

inexpensive and are widelyavailable. In in addition to highblood pressure, diuretics areoften used to treat otherillnesses like edema and heart

failure Many diuretics can